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Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity.

Steinman L, Ho PP, Robinson WH, Utz PJ, Villoslada P.

Curr Opin Immunol. 2019 Aug 30;61:46-53. doi: 10.1016/j.coi.2019.07.011. [Epub ahead of print] Review.


Contrasting Some Differences in Managing Advanced Unresectable Hepatocellular Carcinoma Between the East and the West.

Lee VHF, Seong J, Yoon SM, Wong TCL, Wang B, Zhang JL, Chiang CL, Ho PPY, Dawson LA.

Clin Oncol (R Coll Radiol). 2019 Aug;31(8):560-569. doi: 10.1016/j.clon.2019.06.002.


The addition of pretreatment plasma Epstein-Barr virus DNA into the eighth edition of nasopharyngeal cancer TNM stage classification.

Lee VH, Kwong DL, Leung TW, Choi CW, O'Sullivan B, Lam KO, Lai V, Khong PL, Chan SK, Ng CY, Tong CC, Ho PP, Chan WL, Wong LS, Leung DK, Chan SY, So TH, Luk MY, Lee AW.

Int J Cancer. 2019 Apr 1;144(7):1713-1722. doi: 10.1002/ijc.31856. Epub 2018 Dec 24.


Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy.

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9182-E9191. doi: 10.1073/pnas.1808648115. Epub 2018 Sep 4.


An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis.

Mahapatra S, Ying L, Ho PP, Kurnellas M, Rothbard J, Steinman L, Cornfield DN.

PLoS One. 2018 Jul 10;13(7):e0199206. doi: 10.1371/journal.pone.0199206. eCollection 2018.


Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models.

Ajami B, Samusik N, Wieghofer P, Ho PP, Crotti A, Bjornson Z, Prinz M, Fantl WJ, Nolan GP, Steinman L.

Nat Neurosci. 2018 Apr;21(4):541-551. doi: 10.1038/s41593-018-0100-x. Epub 2018 Mar 5.


Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4.

Sagan SA, Cruz-Herranz A, Spencer CM, Ho PP, Steinman L, Green AJ, Sobel RA, Zamvil SS.

J Vis Exp. 2017 Aug 21;(126). doi: 10.3791/56185.


Metronomic oral cyclosphosphamide as third-line systemic treatment or beyond in patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma.

Lee VH, Kwong DL, Lam KO, Lai YC, Li Y, Tong CC, Ho PP, Chan WL, Wong LS, Leung DK, Chan SY, Chan FT, Leung TW, Lee AW.

Medicine (Baltimore). 2017 Apr;96(15):e6518. doi: 10.1097/MD.0000000000006518.


Time correlation between mononucleosis and initial symptoms of MS.

Endriz J, Ho PP, Steinman L.

Neurol Neuroimmunol Neuroinflamm. 2017 Feb 27;4(3):e308. doi: 10.1212/NXI.0000000000000308. eCollection 2017 May.


Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma.

Lee VH, Kwong DL, Leung TW, Choi CW, Lai V, Ng L, Lam KO, Ng SC, Sze CK, Tong CC, Ho PP, Chan WL, Wong LS, Leung DK, Chan SY, Khong PL.

Oncotarget. 2017 Jan 17;8(3):5292-5308. doi: 10.18632/oncotarget.14137.


Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.

Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14781-14786. doi: 10.1073/pnas.1617859114. Epub 2016 Dec 8.


Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.

Yu C, Burns JC, Robinson WH, Utz PJ, Ho PP, Steinman L, Frey AB.

J Diabetes Res. 2016;2016:9083103. doi: 10.1155/2016/9083103. Epub 2016 Mar 16.


Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis.

Ho PP, Steinman L.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1600-5. doi: 10.1073/pnas.1524890113. Epub 2016 Jan 25.


Noninvasive assessments of liver fibrosis with transient elastography and Hui index predict survival in patients with chronic hepatitis B.

Wong GL, Chan HL, Yu Z, Wong CK, Leung C, Ho PP, Chan CY, Chung VC, Chan ZC, Tse YK, Chim AM, Lau TK, Chan HY, Tse CH, Wong VW.

J Gastroenterol Hepatol. 2015 Mar;30(3):582-90. doi: 10.1111/jgh.12779.


Prognostic Significance of Standardized Uptake Value of Lymph Nodes on Survival for Stage III Non-small Cell Lung Cancer Treated With Definitive Concurrent Chemoradiotherapy.

Lee VH, Chan WW, Lee EY, Choy TS, Ho PP, Leung DK, Lam KO, Kwong DL, Leung TW, Khong PL.

Am J Clin Oncol. 2016 Aug;39(4):355-62. doi: 10.1097/COC.0000000000000070.


Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation.

Ding Z, Mathur V, Ho PP, James ML, Lucin KM, Hoehne A, Alabsi H, Gambhir SS, Steinman L, Luo J, Wyss-Coray T.

J Exp Med. 2014 Feb 10;211(2):189-98. doi: 10.1084/jem.20120696. Epub 2014 Feb 3.


Liver stiffness-based optimization of hepatocellular carcinoma risk score in patients with chronic hepatitis B.

Wong GL, Chan HL, Wong CK, Leung C, Chan CY, Ho PP, Chung VC, Chan ZC, Tse YK, Chim AM, Lau TK, Wong VW.

J Hepatol. 2014 Feb;60(2):339-45. doi: 10.1016/j.jhep.2013.09.029. Epub 2013 Oct 12.


Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.

Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH.

Nat Immunol. 2013 Nov;14(11):1166-72. doi: 10.1038/ni.2730. Epub 2013 Sep 29.


Association of exon 19 and 21 EGFR mutation patterns with treatment outcome after first-line tyrosine kinase inhibitor in metastatic non-small-cell lung cancer.

Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP.

J Thorac Oncol. 2013 Sep;8(9):1148-55. doi: 10.1097/JTO.0b013e31829f684a.


Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.

Rafalski VA, Ho PP, Brett JO, Ucar D, Dugas JC, Pollina EA, Chow LM, Ibrahim A, Baker SJ, Barres BA, Steinman L, Brunet A.

Nat Cell Biol. 2013 Jun;15(6):614-24. doi: 10.1038/ncb2735. Epub 2013 May 5.


Piet Mondrian's trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011.

Steinman L, Axtell RC, Barbieri D, Bhat R, Brownell SE, de Jong BA, Dunn SE, Grant JL, Han MH, Ho PP, Kuipers HF, Kurnellas MP, Ousman SS, Rothbard JB.

Mult Scler. 2013 Jan;19(1):5-14. doi: 10.1177/1352458512470730.


Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.

Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L.

J Exp Med. 2012 Jul 2;209(7):1325-34. doi: 10.1084/jem.20101974. Epub 2012 Jun 25.


Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation.

Ho PP, Kanter JL, Johnson AM, Srinagesh HK, Chang EJ, Purdy TM, van Haren K, Wikoff WR, Kind T, Khademi M, Matloff LY, Narayana S, Hur EM, Lindstrom TM, He Z, Fiehn O, Olsson T, Han X, Han MH, Steinman L, Robinson WH.

Sci Transl Med. 2012 Jun 6;4(137):137ra73. doi: 10.1126/scitranslmed.3003831.


Lessons learned from studies of natural resistance in murine experimental autoimmune encephalomyelitis.

Tse HY, Li J, Zhao X, Chen F, Ho PP, Shaw MK.

Curr Trends Immunol. 2012;13:1-12.


Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.

Crespo O, Kang SC, Daneman R, Lindstrom TM, Ho PP, Sobel RA, Steinman L, Robinson WH.

J Clin Immunol. 2011 Dec;31(6):1010-20. doi: 10.1007/s10875-011-9579-6. Epub 2011 Aug 17.


Angiotensin II sustains brain inflammation in mice via TGF-beta.

Lanz TV, Ding Z, Ho PP, Luo J, Agrawal AN, Srinagesh H, Axtell R, Zhang H, Platten M, Wyss-Coray T, Steinman L.

J Clin Invest. 2010 Aug;120(8):2782-94. doi: 10.1172/JCI41709. Epub 2010 Jul 12.


c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.

Paniagua RT, Chang A, Mariano MM, Stein EA, Wang Q, Lindstrom TM, Sharpe O, Roscow C, Ho PP, Lee DM, Robinson WH.

Arthritis Res Ther. 2010;12(1):R32. doi: 10.1186/ar2940. Epub 2010 Feb 24.


Autoimmunity against fibrinogen mediates inflammatory arthritis in mice.

Ho PP, Lee LY, Zhao X, Tomooka BH, Paniagua RT, Sharpe O, BenBarak MJ, Chandra PE, Hueber W, Steinman L, Robinson WH.

J Immunol. 2010 Jan 1;184(1):379-90. doi: 10.4049/jimmunol.0901639. Epub 2009 Nov 30.


Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1).

Lanz TV, Opitz CA, Ho PP, Agrawal A, Lutz C, Weller M, Mellor AL, Steinman L, Wick W, Platten M.

Stem Cells Dev. 2010 May;19(5):657-68. doi: 10.1089/scd.2009.0385.


Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease.

Graham KL, Zabel BA, Loghavi S, Zuniga LA, Ho PP, Sobel RA, Butcher EC.

J Immunol. 2009 Nov 15;183(10):6717-23. doi: 10.4049/jimmunol.0803435. Epub 2009 Oct 28.


Treatment with a toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice.

Graham KL, Lee LY, Higgins JP, Steinman L, Utz PJ, Ho PP.

Autoimmunity. 2010 Mar;43(2):140-55. doi: 10.3109/08916930903229239.


Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.

Platten M, Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14948-53. doi: 10.1073/pnas.0903958106. Epub 2009 Aug 19.


Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.

Kidd BA, Ho PP, Sharpe O, Zhao X, Tomooka BH, Kanter JL, Steinman L, Robinson WH.

Arthritis Res Ther. 2008;10(5):R119. doi: 10.1186/ar2523. Epub 2008 Sep 30.


Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis.

Zhao X, Okeke NL, Sharpe O, Batliwalla FM, Lee AT, Ho PP, Tomooka BH, Gregersen PK, Robinson WH.

Arthritis Res Ther. 2008;10(4):R94. doi: 10.1186/ar2478. Epub 2008 Aug 18.


Failure of oral atorvastatin to modulate a murine model of systemic lupus erythematosus.

Graham KL, Lee LY, Higgins JP, Steinman L, Utz PJ, Ho PP.

Arthritis Rheum. 2008 Jul;58(7):2098-104. doi: 10.1002/art.23605.


The aryl hydrocarbon receptor: a regulator of Th17 and Treg cell development in disease.

Ho PP, Steinman L.

Cell Res. 2008 Jun;18(6):605-8. doi: 10.1038/cr.2008.63. No abstract available.


Second-harmonic tomography of tissues.

Guo Y, Ho PP, Savage H, Harris D, Sacks P, Schantz S, Liu F, Zhadin N, Alfano RR.

Opt Lett. 1997 Sep 1;22(17):1323-5.


Second-harmonic tomography of tissues: errata.

Guo Y, Ho PP, Savage H, Harris D, Sacks P, Schantz S, Liu F, Zhadin N, Alfano RR.

Opt Lett. 1998;23(9):733. No abstract available.


Detection of corrosion beneath a paint layer by use of spectral polarization optical imaging.

Ali JH, Wang WB, Ho PP, Alfano RR.

Opt Lett. 2000 Sep 1;25(17):1303-5.


Nondestructive evaluation of incipient corrosion in a metal beneath paint by second-harmonic tomography.

Ying J, Liu F, Ho PP, Alfano RR.

Opt Lett. 2000 Aug 15;25(16):1189-91.


Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.

Luo J, Ho PP, Buckwalter MS, Hsu T, Lee LY, Zhang H, Kim DK, Kim SJ, Gambhir SS, Steinman L, Wyss-Coray T.

J Clin Invest. 2007 Nov;117(11):3306-15.


Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation.

Chora AA, Fontoura P, Cunha A, Pais TF, Cardoso S, Ho PP, Lee LY, Sobel RA, Steinman L, Soares MP.

J Clin Invest. 2007 Feb;117(2):438-47. Epub 2007 Jan 25.


Tolerizing DNA vaccines for autoimmune arthritis.

Ho PP, Higgins JP, Kidd BA, Tomooka B, Digennaro C, Lee LY, de Vegvar HE, Steinman L, Robinson WH.

Autoimmunity. 2006 Dec;39(8):675-82.


Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis.

Paniagua RT, Sharpe O, Ho PP, Chan SM, Chang A, Higgins JP, Tomooka BH, Thomas FM, Song JJ, Goodman SB, Lee DM, Genovese MC, Utz PJ, Steinman L, Robinson WH.

J Clin Invest. 2006 Oct;116(10):2633-42. Epub 2006 Sep 14.


Atrial strain rate echocardiography can predict success or failure of cardioversion for atrial fibrillation: a combined transthoracic tissue Doppler and transoesophageal imaging study.

Wang T, Wang M, Fung JW, Yip GW, Zhang Y, Ho PP, Tse DM, Yu CM, Sanderson JE.

Int J Cardiol. 2007 Jan 8;114(2):202-9. Epub 2006 Jul 5.


Lipid microarrays identify key mediators of autoimmune brain inflammation.

Kanter JL, Narayana S, Ho PP, Catz I, Warren KG, Sobel RA, Steinman L, Robinson WH.

Nat Med. 2006 Jan;12(1):138-43. Epub 2005 Dec 11.


Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite.

Platten M, Ho PP, Youssef S, Fontoura P, Garren H, Hur EM, Gupta R, Lee LY, Kidd BA, Robinson WH, Sobel RA, Selley ML, Steinman L.

Science. 2005 Nov 4;310(5749):850-5. Erratum in: Science. 2006 Feb 17;311(5763):954.


A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease.

Ho PP, Fontoura P, Platten M, Sobel RA, DeVoss JJ, Lee LY, Kidd BA, Tomooka BH, Capers J, Agrawal A, Gupta R, Zernik J, Yee MK, Lee BJ, Garren H, Robinson WH, Steinman L.

J Immunol. 2005 Nov 1;175(9):6226-34.


Prevalence and penetrance variation of male-killing Wolbachia across Indo-Pacific populations of the butterfly Hypolimnas bolina.

Charlat S, Hornett EA, Dyson EA, Ho PP, Loc NT, Schilthuizen M, Davies N, Roderick GK, Hurst GD.

Mol Ecol. 2005 Oct;14(11):3525-30.


Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis.

Fontoura P, Ho PP, DeVoss J, Zheng B, Lee BJ, Kidd BA, Garren H, Sobel RA, Robinson WH, Tessier-Lavigne M, Steinman L.

J Immunol. 2004 Dec 1;173(11):6981-92.

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