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An Influenza A Vaccine Based on the Extracellular Domain of Matrix 2 Protein Protects BALB/C Mice Against H1N1 and H3N2.

Ong HK, Yong CY, Tan WS, Yeap SK, Omar AR, Razak MA, Ho KL.

Vaccines (Basel). 2019 Aug 19;7(3). pii: E91. doi: 10.3390/vaccines7030091.


Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus.

Yong CY, Ong HK, Yeap SK, Ho KL, Tan WS.

Front Microbiol. 2019 Aug 2;10:1781. doi: 10.3389/fmicb.2019.01781. eCollection 2019. Review.


Infectious hematopoietic necrosis virus: advances in diagnosis and vaccine development.

Yong CY, Ong HK, Tang HC, Yeap SK, Omar AR, Ho KL, Tan WS.

PeerJ. 2019 Jul 16;7:e7151. doi: 10.7717/peerj.7151. eCollection 2019.


Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure.

Uddin GM, Zhang L, Shah S, Fukushima A, Wagg CS, Gopal K, Al Batran R, Pherwani S, Ho KL, Boisvenue J, Karwi QG, Altamimi T, Wishart DS, Dyck JRB, Ussher JR, Oudit GY, Lopaschuk GD.

Cardiovasc Diabetol. 2019 Jul 5;18(1):86. doi: 10.1186/s12933-019-0892-3.


Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture, and the Stress and Antifungal Resistance of Candida glabrata.

Chew SY, Ho KL, Cheah YK, Sandai D, Brown AJP, Than LTL.

Int J Mol Sci. 2019 Jun 28;20(13). pii: E3172. doi: 10.3390/ijms20133172.


Crystal structure and epitope analysis of house dust mite allergen Der f 21.

Pang SL, Ho KL, Waterman J, Rambo RP, Teh AH, Mathavan I, Harris G, Beis K, Say YH, Anusha MS, Sio YY, Chew FT, Ng CL.

Sci Rep. 2019 Mar 20;9(1):4933. doi: 10.1038/s41598-019-40879-x.


Antibacterial Envelope to Prevent Cardiac Implantable Device Infection.

Tarakji KG, Mittal S, Kennergren C, Corey R, Poole JE, Schloss E, Gallastegui J, Pickett RA, Evonich R, Philippon F, McComb JM, Roark SF, Sorrentino D, Sholevar D, Cronin E, Berman B, Riggio D, Biffi M, Khan H, Silver MT, Collier J, Eldadah Z, Wright DJ, Lande JD, Lexcen DR, Cheng A, Wilkoff BL; WRAP-IT Investigators.

N Engl J Med. 2019 May 16;380(20):1895-1905. doi: 10.1056/NEJMoa1901111. Epub 2019 Mar 17.


Thermally-responsive Virus-like Particle for Targeted Delivery of Cancer Drug.

Thong QX, Biabanikhankahdani R, Ho KL, Alitheen NB, Tan WS.

Sci Rep. 2019 Mar 8;9(1):3945. doi: 10.1038/s41598-019-40388-x.


Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata.

Chew SY, Ho KL, Cheah YK, Ng TS, Sandai D, Brown AJP, Than LTL.

Sci Rep. 2019 Feb 26;9(1):2843. doi: 10.1038/s41598-019-39117-1.


Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.

Ho KL, Zhang L, Wagg C, Al Batran R, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, Lopaschuk GD.

Cardiovasc Res. 2019 Sep 1;115(11):1606-1616. doi: 10.1093/cvr/cvz045.


Expression, purification and characterization of the dimeric protruding domain of Macrobrachium rosenbergii nodavirus capsid protein expressed in Escherichia coli.

Chong LC, Ganesan H, Yong CY, Tan WS, Ho KL.

PLoS One. 2019 Feb 1;14(2):e0211740. doi: 10.1371/journal.pone.0211740. eCollection 2019.


Effects of herbal medicine for xerostomia in head and neck cancer patients: an observational study in a tertiary cancer hospital.

Lim RJ, Nik Nabil WN, Chan SY, Wong YF, Han LX, Gong JY, Ho KL, Shew YS, Xu L.

Support Care Cancer. 2019 Sep;27(9):3491-3498. doi: 10.1007/s00520-019-4646-2. Epub 2019 Jan 24.


Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors.

Verma S, Rawat S, Ho KL, Wagg CS, Zhang L, Teoh H, Dyck JE, Uddin GM, Oudit GY, Mayoux E, Lehrke M, Marx N, Lopaschuk GD.

JACC Basic Transl Sci. 2018 Aug 26;3(5):575-587. doi: 10.1016/j.jacbts.2018.07.006. eCollection 2018 Oct.


Structure of the Macrobrachium rosenbergii nodavirus: A new genus within the Nodaviridae?

Ho KL, Gabrielsen M, Beh PL, Kueh CL, Thong QX, Streetley J, Tan WS, Bhella D.

PLoS Biol. 2018 Oct 22;16(10):e3000038. doi: 10.1371/journal.pbio.3000038. eCollection 2018 Oct.


Crystal structure and functional analysis of human C1ORF123.

A Rahaman SN, Mat Yusop J, Mohamed-Hussein ZA, Aizat WM, Ho KL, Teh AH, Waterman J, Tan BK, Tan HL, Li AY, Chen ES, Ng CL.

PeerJ. 2018 Sep 28;6:e5377. doi: 10.7717/peerj.5377. eCollection 2018.


An implantable cardioverter defibrillator in a patient with triple mechanical valves.

Tan AWX, Ho KL, Ching CK, Chua KCM.

Clin Case Rep. 2018 Jul 23;6(9):1795-1800. doi: 10.1002/ccr3.1721. eCollection 2018 Sep.


Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient.

Ma D, Liu Z, Loh LJ, Zhao Y, Li G, Liew R, Islam O, Wu J, Chung YY, Teo WS, Ching CK, Tan BY, Chong D, Ho KL, Lim P, Yong RYY, Panama BK, Kaplan AD, Bett GCL, Ware J, Bezzina CR, Verkerk AO, Cook SA, Rasmusson RL, Wei H.

Sci Rep. 2018 Jul 26;8(1):11246. doi: 10.1038/s41598-018-29574-5.


Peptide inhibitors of Macrobrachium rosenbergii nodavirus.

Thong QX, Wong CL, Ooi MK, Kueh CL, Ho KL, Alitheen NB, Tan WS.

J Gen Virol. 2018 Sep;99(9):1227-1238. doi: 10.1099/jgv.0.001116. Epub 2018 Jul 24.


A novel three base-pair deletion in domain two of the cardiac sodium channel causes Brugada syndrome.

Tan BY, Wang L, Uttamchandani M, Barajas-Martinez H, Dumaine R, Morin N, Ching CK, Ho KL, Chong DTT, Chow W, Yap EPH, Moochhala S, Hu D, Yong RYY, Teo WS.

J Electrocardiol. 2018 Jul - Aug;51(4):667-673. doi: 10.1016/j.jelectrocard.2018.03.009. Epub 2018 Mar 21.


Bipolar transurethral vapourisation versus monopolar transurethral resection of prostate: a randomised controlled trial.

Ng CF, Yee CH, Chan CK, Wong HM, Chiu PK, Tsu JH, Teoh JY, Ho KL.

Hong Kong Med J. 2017 Jun;23 Suppl 2(3):32-34. No abstract available.


Loss of Metabolic Flexibility in the Failing Heart.

Karwi QG, Uddin GM, Ho KL, Lopaschuk GD.

Front Cardiovasc Med. 2018 Jun 6;5:68. doi: 10.3389/fcvm.2018.00068. eCollection 2018. Review.


Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease.

Chen Y, Au WK, Chan D, Sit KY, Zhen Z, Ho KL, Wong D, Ho LM, Yap D, Lam YM, Lau CP, Tse HF, Chan TM, Yiu KH.

Int Heart J. 2018 Jul 31;59(4):759-765. doi: 10.1536/ihj.17-460. Epub 2018 Jun 20.


Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet.

Al Batran R, Gopal K, Martin MD, Ho KL, Almutairi M, Aburasayn H, Eaton F, Campbell JE, Ussher JR.

Diabetologia. 2018 Aug;61(8):1849-1855. doi: 10.1007/s00125-018-4643-x. Epub 2018 Jun 1.


Targeted Delivery of Cell Penetrating Peptide Virus-like Nanoparticles to Skin Cancer Cells.

Gan BK, Yong CY, Ho KL, Omar AR, Alitheen NB, Tan WS.

Sci Rep. 2018 May 31;8(1):8499. doi: 10.1038/s41598-018-26749-y.


A Dual Bioconjugated Virus-Like Nanoparticle as a Drug Delivery System and Comparison with a pH-Responsive Delivery System.

Biabanikhankahdani R, Ho KL, Alitheen NB, Tan WS.

Nanomaterials (Basel). 2018 Apr 13;8(4). pii: E236. doi: 10.3390/nano8040236.


Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria.

Wu MZ, Chen Y, Au WK, Chan D, Sit KY, Ho KL, Ho LM, Lam YM, Lau CP, Chan TM, Tse HF, Yiu KH.

J Cardiol. 2018 Sep;72(3):247-254. doi: 10.1016/j.jjcc.2018.01.018. Epub 2018 Mar 26.


Vibrational spectra of small methylamine clusters accessed by an ab initio anharmonic approach.

Huang QR, Li YC, Ho KL, Kuo JL.

Phys Chem Chem Phys. 2018 Mar 14;20(11):7653-7660. doi: 10.1039/c8cp00533h.


Treading slowly through hypoxic waters: dichloroacetate to the rescue!

Uddin GM, Ho KL, Lopaschuk GD.

J Physiol. 2018 Aug;596(15):2957-2958. doi: 10.1113/JP275898. Epub 2018 Mar 23. No abstract available.


Structural and kinetic studies of a novel nerol dehydrogenase from Persicaria minor, a nerol-specific enzyme for citral biosynthesis.

Tan CS, Hassan M, Mohamed Hussein ZA, Ismail I, Ho KL, Ng CL, Zainal Z.

Plant Physiol Biochem. 2018 Feb;123:359-368. doi: 10.1016/j.plaphy.2017.12.033. Epub 2017 Dec 26.


Implantation of a dual-chamber permanent pacemaker in a pregnant patient guided by intracardiac echocardiography and electroanatomic mapping.

Chua KCM, Lim ETS, Chong DTT, Tan BY, Ho KL, Ching CK.

HeartRhythm Case Rep. 2017 Sep 29;3(11):542-545. doi: 10.1016/j.hrcr.2017.09.003. eCollection 2017 Nov. No abstract available.


Virus like particles as a platform for cancer vaccine development.

Ong HK, Tan WS, Ho KL.

PeerJ. 2017 Nov 15;5:e4053. doi: 10.7717/peerj.4053. eCollection 2017.


Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging.

Li H, Harriss BI, Phinikaridou A, Lacerda S, Ramniceanu G, Doan BT, Ho KL, Chan CF, Lo WS, Botnar RM, Lan R, Richard C, Law GL, Long NJ, Wong KL.

Nanotheranostics. 2017 May 8;1(2):186-195. doi: 10.7150/ntno.18619. eCollection 2017.


Prevalence of Cardiac Arrhythmias in Asian Patients With Obstructive Sleep Apnea: A Singapore Sleep Center Experience.

Neo WL, Ng ACW, Rangabashyam M, Hao Y, Ho KL, Senin SRB, Toh ST.

J Clin Sleep Med. 2017 Nov 15;13(11):1265-1271. doi: 10.5664/jcsm.6794.


A Smart Europium-Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations.

Li H, Xie C, Lan R, Zha S, Chan CF, Wong WY, Ho KL, Chan BD, Luo Y, Zhang JX, Law GL, Tai WCS, Bünzli JG, Wong KL.

J Med Chem. 2017 Nov 9;60(21):8923-8932. doi: 10.1021/acs.jmedchem.7b01162. Epub 2017 Oct 19.


Glucuronide and Sulfate Conjugates of Bisphenol A: Chemical Synthesis and Correlation Between Their Urinary Levels and Plasma Bisphenol A Content in Voluntary Human Donors.

Ho KL, Yuen KK, Yau MS, Murphy MB, Wan Y, Fong BM, Tam S, Giesy JP, Leung KS, Lam MH.

Arch Environ Contam Toxicol. 2017 Oct;73(3):410-420. doi: 10.1007/s00244-017-0438-1. Epub 2017 Aug 2.


Use of indocyanine green angiography in microsurgical subinguinal varicocelectomy - lessons learned from our initial experience.

Cho CL, Ho KL, Chan WK, Chu RW, Law IC.

Int Braz J Urol. 2017 Sep-Oct;43(5):974-979. doi: 10.1590/S1677-5538.IBJU.2017.0107.


A Simple Add-and-Display Method for Immobilisation of Cancer Drug on His-tagged Virus-like Nanoparticles for Controlled Drug Delivery.

Biabanikhankahdani R, Bayat S, Ho KL, Alitheen NBM, Tan WS.

Sci Rep. 2017 Jul 13;7(1):5303. doi: 10.1038/s41598-017-05525-4.


FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression.

Gopal K, Saleme B, Al Batran R, Aburasayn H, Eshreif A, Ho KL, Ma WK, Almutairi M, Eaton F, Gandhi M, Park EA, Sutendra G, Ussher JR.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H479-H490. doi: 10.1152/ajpheart.00191.2017. Epub 2017 Jul 7.


Remote magnetic catheter navigation versus conventional ablation in atrial fibrillation ablation: Fluoroscopy reduction.

Lim PCY, Toh JJH, Loh JKXY, Lee ECY, Chong DTT, Tan BY, Ho KL, Ching CK, Teo WS.

J Arrhythm. 2017 Jun;33(3):167-171. doi: 10.1016/j.joa.2016.08.007. Epub 2016 Nov 10.


Relation of Cardiac Arrhythmias to Hypoxic Time and Lowest Oxygen Saturation in Patients with Obstructive Sleep Apnoea in an Asian Context: A Singapore Sleep Centre Study.

Ng AC, Neo WL, Rangabashyam M, Hao Y, Ho KL, Toh ST.

Ann Acad Med Singapore. 2017 May;46(5):210-212. No abstract available.


Cryo-Electron Microscopy Structure of the Macrobrachium rosenbergii Nodavirus Capsid at 7 Angstroms Resolution.

Ho KL, Kueh CL, Beh PL, Tan WS, Bhella D.

Sci Rep. 2017 May 18;7(1):2083. doi: 10.1038/s41598-017-02292-0.


Uptake and biotransformation of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in four marine microalgae species.

Po BH, Ho KL, Lam MH, Giesy JP, Chiu JM.

Sci Rep. 2017 Mar 13;7:44263. doi: 10.1038/srep44263.


Crystallization and X-ray crystallographic analysis of recombinant TylP, a putative γ-butyrolactone receptor protein from Streptomyces fradiae.

Mohd-Sharif N, Shaibullah S, Givajothi V, Tan CS, Ho KL, Teh AH, Baharum SN, Waterman J, Ng CL.

Acta Crystallogr F Struct Biol Commun. 2017 Feb 1;73(Pt 2):109-115. doi: 10.1107/S2053230X17001212. Epub 2017 Jan 31.


Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma.

Lee CH, Huang G, Chan PH, Hai J, Yeung CY, Fong CH, Woo YC, Ho KL, Yiu MK, Leung F, Lau TW, Tse HF, Lam KS, Siu CW.

PLoS One. 2017 Feb 3;12(2):e0171495. doi: 10.1371/journal.pone.0171495. eCollection 2017.


Exploration of hydrogen bond networks and potential energy surfaces of methanol clusters using a two-stage clustering algorithm.

Hsu PJ, Ho KL, Lin SH, Kuo JL.

Phys Chem Chem Phys. 2016 Dec 21;19(1):544-556. doi: 10.1039/c6cp07120a.


pH-responsive Virus-like Nanoparticles with Enhanced Tumour-targeting Ligands for Cancer Drug Delivery.

Biabanikhankahdani R, Alitheen NBM, Ho KL, Tan WS.

Sci Rep. 2016 Nov 24;6:37891. doi: 10.1038/srep37891.


An ab initio anharmonic approach to study vibrational spectra of small ammonia clusters.

Ho KL, Lee LY, Katada M, Fujii A, Kuo JL.

Phys Chem Chem Phys. 2016 Nov 9;18(44):30498-30506.


Numerical algebraic geometry for model selection and its application to the life sciences.

Gross E, Davis B, Ho KL, Bates DJ, Harrington HA.

J R Soc Interface. 2016 Oct;13(123). pii: 20160256.


Glucuronide and sulfate conjugates of tetrabromobisphenol A (TBBPA): Chemical synthesis and correlation between their urinary levels and plasma TBBPA content in voluntary human donors.

Ho KL, Yuen KK, Yau MS, Murphy MB, Wan Y, Fong BM, Tam S, Giesy JP, Leung KS, Lam MH.

Environ Int. 2017 Jan;98:46-53. doi: 10.1016/j.envint.2016.09.018. Epub 2016 Oct 4.


Sperm retrieval rate and pregnancy rate in infertile couples undergoing in-vitro fertilisation and testicular sperm extraction for non-obstructive azoospermia in Hong Kong.

Ko JK, Chai J, Lee VC, Li RH, Lau E, Ho KL, Tam PC, Yeung WS, Ho PC, Ng EH.

Hong Kong Med J. 2016 Dec;22(6):556-62. Epub 2016 Sep 30.

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