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CYP2C19 phenotype in South-East Asian Acute Coronary Syndrome patients and impact on major adverse cardiovascular events.

Tan DS, Aw JWX, Winther M, Goh LL, Ong HY, Wee E, Liu J, Ho HK.

J Clin Pharm Ther. 2020 Feb;45(1):52-58. doi: 10.1111/jcpt.13062. Epub 2019 Oct 31.


An Evaluation of DNA Methyltransferase 1 (DNMT1) Single Nucleotide Polymorphisms and Chemotherapy-Associated Cognitive Impairment: A Prospective, Longitudinal Study.

Chan A, Yeo A, Shwe M, Tan CJ, Foo KM, Chu P, Khor CC, Ho HK.

Sci Rep. 2019 Oct 10;9(1):14570. doi: 10.1038/s41598-019-51203-y.


Nanoparticles' interactions with vasculature in diseases.

Tee JK, Yip LX, Tan ES, Santitewagun S, Prasath A, Ke PC, Ho HK, Leong DT.

Chem Soc Rev. 2019 Oct 28;48(21):5381-5407. doi: 10.1039/c9cs00309f. Review.


Association of plasma leptin, pro-inflammatory adipokines and cancer-related fatigue in early-stage breast cancer patients: A prospective cohort study.

Toh YL, Tan CJ, Yeo AHL, Shwe M, Ho HK, Gan YX, Foo KM, Chu P, Olson K, Chan A.

J Cell Mol Med. 2019 Jun;23(6):4281-4289. doi: 10.1111/jcmm.14319. Epub 2019 Apr 23.


Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness.

Tee JK, Setyawati MI, Peng F, Leong DT, Ho HK.

Nanotoxicology. 2019 Jun;13(5):682-700. doi: 10.1080/17435390.2019.1571646. Epub 2019 Feb 19.


Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness.

Peng F, Setyawati MI, Tee JK, Ding X, Wang J, Nga ME, Ho HK, Leong DT.

Nat Nanotechnol. 2019 Mar;14(3):279-286. doi: 10.1038/s41565-018-0356-z. Epub 2019 Jan 28.


Titanium Dioxide Nanoparticles Enhance Leakiness and Drug Permeability in Primary Human Hepatic Sinusoidal Endothelial Cells.

Tee JK, Ng LY, Koh HY, Leong DT, Ho HK.

Int J Mol Sci. 2018 Dec 21;20(1). pii: E35. doi: 10.3390/ijms20010035.


Effects of inorganic nanoparticles on liver fibrosis: Optimizing a double-edged sword for therapeutics.

Tee JK, Peng F, Ho HK.

Biochem Pharmacol. 2019 Feb;160:24-33. doi: 10.1016/j.bcp.2018.12.003. Epub 2018 Dec 6. Review.


Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy.

Tan CJ, Lim SWT, Toh YL, Ng T, Yeo A, Shwe M, Foo KM, Chu P, Jain A, Koo SL, Dent RA, Ng RCH, Yap YS, Lim EH, Loh KW, Chay WY, Lee GE, Tan TJY, Beh SY, Wong M, Chan JJ, Khor CC, Ho HK, Chan A.

Mol Neurobiol. 2019 Jul;56(7):4741-4750. doi: 10.1007/s12035-018-1410-4. Epub 2018 Oct 31.


Magnesium Isoglycyrrhizinate Ameliorates Fibrosis and Disrupts TGF-β-Mediated SMAD Pathway in Activated Hepatic Stellate Cell Line LX2.

Tee JK, Peng F, Tan YL, Yu B, Ho HK.

Front Pharmacol. 2018 Sep 25;9:1018. doi: 10.3389/fphar.2018.01018. eCollection 2018.


Hong Kong Institute of Allergy and Hong Kong Society for Paediatric Immunology Allergy & Infectious Diseases joint consensus statement 2018 on vaccination in egg-allergic patients.

Chua GT, Li PH, Ho MH, Lai E, Ngai V, Yau FY, Kwan MY, Leung TF, Lee TH.

Hong Kong Med J. 2018 Oct;24(5):527-531. doi: 10.12809/hkmj177137.


Inorganic Nanomaterials as Highly Efficient Inhibitors of Cellular Hepatic Fibrosis.

Peng F, Tee JK, Setyawati MI, Ding X, Yeo HLA, Tan YL, Leong DT, Ho HK.

ACS Appl Mater Interfaces. 2018 Sep 26;10(38):31938-31946. doi: 10.1021/acsami.8b10527. Epub 2018 Sep 11.


Data Access and Usage Practices Across a Cohort of Researchers at a Large Tertiary Pediatric Hospital: Qualitative Survey Study.

Ho HKK, Görges M, Portales-Casamar E.

JMIR Med Inform. 2018 May 14;6(2):e32. doi: 10.2196/medinform.8724.


Influence of biological factors on hematological and serum biochemistry values in captive Adélie, Chinstrap, Gentoo, and Macaroni penguins in Pingtung, Taiwan.

Chen SY, Tsai YL, Lin SC, Wu YH, Liao MH, Chang CD, Li TH, Ho HK.

Zoo Biol. 2018 May;37(3):183-195. doi: 10.1002/zoo.21413. Epub 2018 May 3.


Impact of Adjuvant Anthracycline-Based and Taxane-Based Chemotherapy on Plasma VEGF Levels and Cognitive Function in Breast Cancer Patients: A Longitudinal Study.

Ng T, Phey XY, Yeo HL, Shwe M, Gan YX, Ng R, Ho HK, Chan A.

Clin Breast Cancer. 2018 Oct;18(5):e927-e937. doi: 10.1016/j.clbc.2018.03.016. Epub 2018 Apr 6.


Enhanced hepatic differentiation of human amniotic epithelial cells on polyethylene glycol-linked multiwalled carbon nanotube-coated hydrogels.

Zhao C, Lin JS, Choolani M, Dan YY, Pastorin G, Ho HK.

J Tissue Eng Regen Med. 2018 Jul;12(7):1556-1566. doi: 10.1002/term.2672. Epub 2018 May 18.


Improved Bioavailability of Levodopa Using Floatable Spray-Coated Microcapsules for the Management of Parkinson's Disease.

Baek JS, Tee JK, Pang YY, Tan EY, Lim KL, Ho HK, Loo SCJ.

Neuromolecular Med. 2018 Jun;20(2):262-270. doi: 10.1007/s12017-018-8491-0. Epub 2018 Apr 25.


Impact of substrate stiffness on dermal papilla aggregates in microgels.

Tan JJY, Tee JK, Chou KO, Yong SYA, Pan J, Ho HK, Ho PCL, Kang L.

Biomater Sci. 2018 May 29;6(6):1347-1357. doi: 10.1039/c8bm00248g.


Navigating albumin-based nanoparticles through various drug delivery routes.

Tan YL, Ho HK.

Drug Discov Today. 2018 May;23(5):1108-1114. doi: 10.1016/j.drudis.2018.01.051. Epub 2018 Feb 3. Review.


Association of mitochondrial DNA content in peripheral blood with cancer-related fatigue and chemotherapy-related cognitive impairment in early-stage breast cancer patients: a prospective cohort study.

Chae JW, Chua PS, Ng T, Yeo AHL, Shwe M, Gan YX, Dorajoo S, Foo KM, Loh KW, Koo SL, Chay WY, Tan TJY, Beh SY, Lim EH, Lee GE, Dent R, Yap YS, Ng R, Ho HK, Chan A.

Breast Cancer Res Treat. 2018 Apr;168(3):713-721. doi: 10.1007/s10549-017-4640-7. Epub 2018 Jan 8.


Evaluation of plasma brain-derived neurotrophic factor levels and self-perceived cognitive impairment post-chemotherapy: a longitudinal study.

Ng T, Lee YY, Chae JW, Yeo AHL, Shwe M, Gan YX, Ng RCH, Chu PPY, Khor CC, Ho HK, Chan A.

BMC Cancer. 2017 Dec 19;17(1):867. doi: 10.1186/s12885-017-3861-9.


Incidence of thromboembolic and bleeding events in patients with newly diagnosed nonvalvular atrial fibrillation: An Asian multicenter retrospective cohort study in Singapore.

Wee XT, Ho LM, Ho HK, Lee JY, Yap CW, William H, Chan LCE, Tay HC, Goh CEM, Tan DS.

Clin Cardiol. 2017 Dec;40(12):1218-1226. doi: 10.1002/clc.22811. Epub 2017 Dec 18.


Can Hong Kong take advantage of recent advances in allergy prevention?

Lee TH, Ho HK, Leung TF.

Hong Kong Med J. 2017 Oct;23(5):539-40. doi: 10.12809/hkmj175069. No abstract available.


A probe-based qRT-PCR method to profile immunological gene expression in blood of captive beluga whales (Delphinapterus leucas).

Tsai MA, Chen IH, Wang JH, Chou SJ, Li TH, Leu MY, Ho HK, Yang WC.

PeerJ. 2017 Sep 27;5:e3840. doi: 10.7717/peerj.3840. eCollection 2017.


Immunoglobulin G testing in the diagnosis of food allergy and intolerance.

Lee TH, Wu YY, Chan JK, Ho HK, Li PH, Rosa Duque JS; Hong Kong Institute of Allergy.

Hong Kong Med J. 2017 Aug;23(4):419-20. doi: 10.12809/hkmj176310. No abstract available.


Investigation of the effect of plasma albumin levels on regorafenib-induced hepatotoxicity using a validated liquid chromatography-tandem mass spectrometry method.

Pang YY, Tan YL, Ho HK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:220-224. doi: 10.1016/j.jchromb.2017.07.023. Epub 2017 Jul 17.


Singapore Healthy Older People Everyday (HOPE) Study: Prevalence of Frailty and Associated Factors in Older Adults.

Merchant RA, Chen MZ, Tan LWL, Lim MY, Ho HK, van Dam RM.

J Am Med Dir Assoc. 2017 Aug 1;18(8):734.e9-734.e14. doi: 10.1016/j.jamda.2017.04.020. Epub 2017 Jun 13.


Genetically modified foods and allergy.

Lee TH, Ho HK, Leung TF.

Hong Kong Med J. 2017 Jun;23(3):291-5. doi: 10.12809/hkmj166189. Epub 2017 May 5. Review.


2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population.

Cheung BM, Cheng CH, Lau CP, Wong CK, Ma RC, Chu DW, Ho DH, Lee KL, Tse HF, Wong AS, Yan BP, Yan VW.

Hong Kong Med J. 2017 Apr;23(2):191-201. doi: 10.12809/hkmj165045.


Finely Tuned Asymmetric Platinum(IV) Anticancer Complexes: Structure-Activity Relationship and Application as Orally Available Prodrugs.

Yap SQ, Chin CF, Hong Thng AH, Pang YY, Ho HK, Ang WH.

ChemMedChem. 2017 Feb 20;12(4):300-311. doi: 10.1002/cmdc.201600577. Epub 2017 Jan 11.


Impact of TNF-α (rs1800629) and IL-6 (rs1800795) Polymorphisms on Cognitive Impairment in Asian Breast Cancer Patients.

Chae JW, Ng T, Yeo HL, Shwe M, Gan YX, Ho HK, Chan A.

PLoS One. 2016 Oct 4;11(10):e0164204. doi: 10.1371/journal.pone.0164204. eCollection 2016.


Towards the development of an enzyme replacement therapy for the metabolic disorder propionic acidemia.

Darvish-Damavandi M, Ho HK, Kang TS.

Mol Genet Metab Rep. 2016 Jul 27;8:51-60. doi: 10.1016/j.ymgmr.2016.06.009. eCollection 2016 Sep.


BSA and ABCB1 polymorphism affect the pharmacokinetics of sunitinib and its active metabolite in Asian mRCC patients receiving an attenuated sunitinib dosing regimen.

Chae JW, Teo YL, Ho HK, Lee J, Back HM, Yun HY, Karlsson MO, Kwon KI, Chan A.

Cancer Chemother Pharmacol. 2016 Sep;78(3):623-32. doi: 10.1007/s00280-016-3104-9. Epub 2016 Aug 2.


Phase I Metabolic Stability and Electrophilic Reactivity of 2-Phenylaminophenylacetic Acid Derived Compounds.

Pang YY, Tan YM, Chan EC, Ho HK.

Chem Res Toxicol. 2016 Jul 18;29(7):1118-31. doi: 10.1021/acs.chemrestox.6b00042. Epub 2016 Jun 14.


Prevalence of KRAS, BRAF, PI3K and EGFR mutations among Asian patients with metastatic colorectal cancer.

Phua LC, Ng HW, Yeo AH, Chen E, Lo MS, Cheah PY, Chan EC, Koh PK, Ho HK.

Oncol Lett. 2015 Oct;10(4):2519-2526. Epub 2015 Aug 3.


Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones.

Ngai MH, So CL, Sullivan MB, Ho HK, Chai CL.

ChemMedChem. 2016 Jan 5;11(1):72-80. doi: 10.1002/cmdc.201500475. Epub 2015 Nov 23.


Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression.

Duan Y, Wong W, Chua SC, Wee HL, Lim SG, Chua BT, Ho HK.

Int J Oncol. 2016 Jan;48(1):358-66. doi: 10.3892/ijo.2015.3244. Epub 2015 Nov 13.


Spontaneous and specific myogenic differentiation of human mesenchymal stem cells on polyethylene glycol-linked multi-walled carbon nanotube films for skeletal muscle engineering.

Zhao C, Andersen H, Ozyilmaz B, Ramaprabhu S, Pastorin G, Ho HK.

Nanoscale. 2015 Nov 21;7(43):18239-49. doi: 10.1039/c5nr04303d.


Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles.

Tang SQ, Lee YY, Packiaraj DS, Ho HK, Chai CL.

Chem Res Toxicol. 2015 Oct 19;28(10):2019-33. doi: 10.1021/acs.chemrestox.5b00247. Epub 2015 Oct 6.


Gene Detection in Complex Biological Media Using Semiconductor Nanorods within an Integrated Microfluidic Device.

Bi X, Adriani G, Xu Y, Chakrabortty S, Pastorin G, Ho HK, Ang WH, Chan Y.

Anal Chem. 2015 Oct 20;87(20):10292-8. doi: 10.1021/acs.analchem.5b01942. Epub 2015 Sep 30.


Oxidative stress by inorganic nanoparticles.

Tee JK, Ong CN, Bay BH, Ho HK, Leong DT.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 May;8(3):414-38. doi: 10.1002/wnan.1374. Epub 2015 Sep 10. Review.


Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer.

Ng T, Teo SM, Yeo HL, Shwe M, Gan YX, Cheung YT, Foo KM, Cham MT, Lee JA, Tan YP, Fan G, Yong WS, Preetha M, Loh WJ, Koo SL, Jain A, Lee GE, Wong M, Dent R, Yap YS, Ng R, Khor CC, Ho HK, Chan A.

Neuro Oncol. 2016 Feb;18(2):244-51. doi: 10.1093/neuonc/nov162. Epub 2015 Aug 19.


Mitochondria-acting hexokinase II peptides carried by short-length carbon nanotubes with increased cellular uptake, endosomal evasion, and enhanced bioactivity against cancer cells.

Yoong SL, Lau WL, Liu AY, Prendergast D, Ho HK, Yu VC, Lee C, Ang WH, Pastorin G.

Nanoscale. 2015 Sep 7;7(33):13907-17. doi: 10.1039/c5nr00980d. Epub 2015 Jul 29.


Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study.

Cheung YT, Ng T, Shwe M, Ho HK, Foo KM, Cham MT, Lee JA, Fan G, Tan YP, Yong WS, Madhukumar P, Loo SK, Ang SF, Wong M, Chay WY, Ooi WS, Dent RA, Yap YS, Ng R, Chan A.

Ann Oncol. 2015 Jul;26(7):1446-51. doi: 10.1093/annonc/mdv206. Epub 2015 Apr 28.


Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients.

Teo YL, Wee HL, Chue XP, Chau NM, Tan MH, Kanesvaran R, Wee HL, Ho HK, Chan A.

Pharmacogenomics J. 2016 Feb;16(1):47-53. doi: 10.1038/tpj.2015.13. Epub 2015 Mar 17.


Hepatotoxic potential of asarones: in vitro evaluation of hepatotoxicity and quantitative determination in herbal products.

Patel DN, Ho HK, Tan LL, Tan MM, Zhang Q, Low MY, Chan CL, Koh HL.

Front Pharmacol. 2015 Feb 20;6:25. doi: 10.3389/fphar.2015.00025. eCollection 2015.


Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib.

Ho HK, Chan JC, Hardy KD, Chan EC.

Drug Metab Rev. 2015 Feb;47(1):21-8. doi: 10.3109/03602532.2014.1003648. Epub 2015 Feb 2. Review.


Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury.

Tan CY, Saw TY, Fong CW, Ho HK.

Redox Biol. 2015;4:308-20. doi: 10.1016/j.redox.2015.01.013. Epub 2015 Jan 20.


Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.

Huleatt PB, Khoo ML, Chua YY, Tan TW, Liew RS, Balogh B, Deme R, Gölöncsér F, Magyar K, Sheela DP, Ho HK, Sperlágh B, Mátyus P, Chai CL.

J Med Chem. 2015 Feb 12;58(3):1400-19. doi: 10.1021/jm501722s. Epub 2015 Jan 28.


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