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T cells and the skin: from protective immunity to inflammatory skin disorders.

Ho AW, Kupper TS.

Nat Rev Immunol. 2019 Apr 16. doi: 10.1038/s41577-019-0162-3. [Epub ahead of print] Review.


Disruption of sleep, sleep-wake activity rhythm, and nocturnal melatonin production in breast cancer patients undergoing adjuvant chemotherapy: prospective cohort study.

Li W, Kwok CC, Chan DC, Ho AW, Ho CS, Zhang J, Wing YK, Wang F, Tse LA.

Sleep Med. 2019 Mar;55:14-21. doi: 10.1016/j.sleep.2018.11.022. Epub 2018 Dec 14.


Post-fracture care gap: a retrospective population-based analysis of Hong Kong from 2009 to 2012.

Cheung MY, Ho AW, Wong SH.

Hong Kong Med J. 2018 Dec;24(6):579-583. doi: 10.12809/hkmj187227. Epub 2018 Nov 19.


NLRP10 Enhances CD4+ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release.

Vacca M, Böhme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A.

Front Immunol. 2017 Nov 2;8:1462. doi: 10.3389/fimmu.2017.01462. eCollection 2017.


Successful Use of Cyclosporin A for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Three Children.

St John J, Ratushny V, Liu KJ, Bach DQ, Badri O, Gracey LE, Ho AW, Raff AB, Sugai DY, Schalock P, Kroshinsky D.

Pediatr Dermatol. 2017 Sep;34(5):540-546. doi: 10.1111/pde.13236.


Early surgery for Hong Kong Chinese elderly patients with hip fracture reduces short-term and long-term mortality.

Liu SK, Ho AW, Wong SH.

Hong Kong Med J. 2017 Aug;23(4):374-80. doi: 10.12809/hkmj165005. Epub 2017 Jun 28.


C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis.

Khameneh HJ, Ho AW, Laudisi F, Derks H, Kandasamy M, Sivasankar B, Teng GG, Mortellaro A.

Front Pharmacol. 2017 Jan 23;8:10. doi: 10.3389/fphar.2017.00010. eCollection 2017.


Operative outcome of Hong Kong centenarians with hip fracture.

Cheung MY, Ho AW, Wong SH.

Hong Kong Med J. 2017 Feb;23(1):63-6. doi: 10.12809/hkmj164823. Epub 2016 Dec 14.


Clustered Papulovesicles in a Fully Vaccinated Child.

Simons EA, Ho AW, Huang JT.

JAMA Pediatr. 2016 Dec 1;170(12):1225-1226. doi: 10.1001/jamapediatrics.2016.0441. No abstract available.


The Syk-NFAT-IL-2 Pathway in Dendritic Cells Is Required for Optimal Sterile Immunity Elicited by Alum Adjuvants.

Khameneh HJ, Ho AW, Spreafico R, Derks H, Quek HQ, Mortellaro A.

J Immunol. 2017 Jan 1;198(1):196-204. Epub 2016 Nov 28.


Prevalence of pre-sarcopenia and sarcopenia in Hong Kong Chinese geriatric patients with hip fracture and its correlation with different factors.

Ho AW, Lee MM, Chan EW, Ng HM, Lee CW, Ng WS, Wong SH.

Hong Kong Med J. 2016 Feb;22(1):23-9. doi: 10.12809/hkmj154570. Epub 2015 Dec 18.


Neck Circumference-Height Ratio as a Predictor of Sleep Related Breathing Disorder in Children and Adults.

Ho AW, Moul DE, Krishna J.

J Clin Sleep Med. 2016 Mar;12(3):311-7. doi: 10.5664/jcsm.5572.


Excess mortality for operated geriatric hip fracture in Hong Kong.

Man LP, Ho AW, Wong SH.

Hong Kong Med J. 2016 Feb;22(1):6-10. doi: 10.12809/hkmj154568. Epub 2015 Oct 9.


Photo quiz. An 86-Year-Old Man With Bilateral Chronic Wounds of the Legs. Bilateral invasive squamous cell carcinomas (Marjolin ulcers).

Cohen JM, Lederer PA, Russell-Goldman E, Sampson CE, Lin JY, Ho AW, Asmal M.

Clin Infect Dis. 2015 Oct 1;61(7):1147, 1199-200. doi: 10.1093/cid/civ278. No abstract available.


Targeted Therapies in Melanoma: Translational Research at Its Finest.

Ho AW, Tsao H.

J Invest Dermatol. 2015 Aug;135(8):1929-1933. doi: 10.1038/jid.2015.14. No abstract available.


Prevalence of Interictal Epileptiform Discharges in Children Less Than One Year of Age Referred for Polysomnography.

Adeleye A, Ho AW, Nettel-Aguirre A, Kirk V, Buchhalter J.

Neurodiagn J. 2015 Jun;55(2):122-32.


JAAD grand rounds quiz. A case of oral melanosis.

Ho AW, Sato R, Ramsdell A.

J Am Acad Dermatol. 2014 Nov;71(5):1030-3. doi: 10.1016/j.jaad.2012.08.016. Epub 2014 Oct 15. No abstract available.


GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis.

Zhou Q, Ho AW, Schlitzer A, Tang Y, Wong KH, Wong FH, Chua YL, Angeli V, Mortellaro A, Ginhoux F, Kemeny DM.

J Immunol. 2014 Jul 15;193(2):496-509. doi: 10.4049/jimmunol.1303138. Epub 2014 Jun 18.


A novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy.

Goh AX, Bertin-Maghit S, Ping Yeo S, Ho AW, Derks H, Mortellaro A, Wang CI.

MAbs. 2014 May-Jun;6(3):765-73. doi: 10.4161/mabs.28614. Epub 2014 Mar 26.


Gamma interferon regulates contraction of the influenza virus-specific CD8 T cell response and limits the size of the memory population.

Prabhu N, Ho AW, Wong KH, Hutchinson PE, Chua YL, Kandasamy M, Lee DC, Sivasankar B, Kemeny DM.

J Virol. 2013 Dec;87(23):12510-22. doi: 10.1128/JVI.01776-13. Epub 2013 Sep 11.


The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.

Ho AW, Garg AV, Monin L, Simpson-Abelson MR, Kinner L, Gaffen SL.

PLoS One. 2013 Jul 29;8(7):e70168. doi: 10.1371/journal.pone.0070168. Print 2013.


IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses.

Schlitzer A, McGovern N, Teo P, Zelante T, Atarashi K, Low D, Ho AW, See P, Shin A, Wasan PS, Hoeffel G, Malleret B, Heiseke A, Chew S, Jardine L, Purvis HA, Hilkens CM, Tam J, Poidinger M, Stanley ER, Krug AB, Renia L, Sivasankar B, Ng LG, Collin M, Ricciardi-Castagnoli P, Honda K, Haniffa M, Ginhoux F.

Immunity. 2013 May 23;38(5):970-83. doi: 10.1016/j.immuni.2013.04.011.


Role of human Toll-like receptors in naturally occurring influenza A infections.

Lee N, Wong CK, Hui DS, Lee SK, Wong RY, Ngai KL, Chan MC, Chu YJ, Ho AW, Lui GC, Wong BC, Wong SH, Yip SP, Chan PK.

Influenza Other Respir Viruses. 2013 Sep;7(5):666-75. doi: 10.1111/irv.12109. Epub 2013 Apr 1.


Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection.

Kandasamy M, Ying PC, Ho AW, Sumatoh HR, Schlitzer A, Hughes TR, Kemeny DM, Morgan BP, Ginhoux F, Sivasankar B.

PLoS Pathog. 2013 Jan;9(1):e1003115. doi: 10.1371/journal.ppat.1003115. Epub 2013 Jan 10.


NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.

Ge MQ, Ho AW, Tang Y, Wong KH, Chua BY, Gasser S, Kemeny DM.

J Immunol. 2012 Sep 1;189(5):2099-109. doi: 10.4049/jimmunol.1103474. Epub 2012 Aug 6.


Antigen-specific effector CD8 T cells regulate allergic responses via IFN-γ and dendritic cell function.

Tang Y, Guan SP, Chua BY, Zhou Q, Ho AW, Wong KH, Wong KL, Wong WS, Kemeny DM.

J Allergy Clin Immunol. 2012 Jun;129(6):1611-20.e4. doi: 10.1016/j.jaci.2011.12.976. Epub 2012 Mar 3.


Influenza A virus infection results in a robust, antigen-responsive, and widely disseminated Foxp3+ regulatory T cell response.

Betts RJ, Prabhu N, Ho AW, Lew FC, Hutchinson PE, Rotzschke O, Macary PA, Kemeny DM.

J Virol. 2012 Mar;86(5):2817-25. doi: 10.1128/JVI.05685-11. Epub 2011 Dec 28.


Partial depletion of natural CD4⁺CD25⁺ regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection.

Betts RJ, Ho AW, Kemeny DM.

PLoS One. 2011;6(11):e27849. doi: 10.1371/journal.pone.0027849. Epub 2011 Nov 18.


Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells.

Ho AW, Prabhu N, Betts RJ, Ge MQ, Dai X, Hutchinson PE, Lew FC, Wong KL, Hanson BJ, Macary PA, Kemeny DM.

J Immunol. 2011 Dec 1;187(11):6011-21. doi: 10.4049/jimmunol.1100987. Epub 2011 Oct 31.


Hand numbness and carpal tunnel syndrome after volar plating of distal radius fracture.

Ho AW, Ho ST, Koo SC, Wong KH.

Hand (N Y). 2011 Mar;6(1):34-8. doi: 10.1007/s11552-010-9283-7. Epub 2010 Jun 12.


Atlanto-axial deformity secondary to a neglected odontoid fracture: a report of six cases.

Ho AW, Ho YF.

J Orthop Surg (Hong Kong). 2010 Aug;18(2):235-40.


SEF/IL-17R (SEFIR) is not enough: an extended SEFIR domain is required for il-17RA-mediated signal transduction.

Onishi RM, Park SJ, Hanel W, Ho AW, Maitra A, Gaffen SL.

J Biol Chem. 2010 Oct 22;285(43):32751-9. doi: 10.1074/jbc.M110.121418. Epub 2010 Aug 20.


IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.

Ho AW, Shen F, Conti HR, Patel N, Childs EE, Peterson AC, Hernández-Santos N, Kolls JK, Kane LP, Ouyang W, Gaffen SL.

J Immunol. 2010 Jul 15;185(2):1063-70. doi: 10.4049/jimmunol.0903739. Epub 2010 Jun 16.


Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis.

Cheung PF, Wong CK, Ho AW, Hu S, Chen DP, Lam CW.

Int Immunol. 2010 Jun;22(6):453-67. doi: 10.1093/intimm/dxq027. Epub 2010 Apr 21.


IL-17RC: a partner in IL-17 signaling and beyond.

Ho AW, Gaffen SL.

Semin Immunopathol. 2010 Mar;32(1):33-42. doi: 10.1007/s00281-009-0185-0. Epub 2009 Dec 13. Review.


Expression of regulatory genes for lymphoplasmacytic cell differentiation in Waldenstrom Macroglobulinemia.

Leleu X, Hunter ZR, Xu L, Roccaro AM, Moreau AS, Santos DD, Hatjiharissi E, Bakthavachalam V, Adamia S, Ho AW, Soumerai J, Patterson CJ, Manning RJ, Hamilton S, Verselis S, Fox E, Carrasco R, Ghobrial IM, Treon SP.

Br J Haematol. 2009 Apr;145(1):59-63. doi: 10.1111/j.1365-2141.2009.07592.x. Epub 2009 Feb 6.


Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis.

Conti HR, Shen F, Nayyar N, Stocum E, Sun JN, Lindemann MJ, Ho AW, Hai JH, Yu JJ, Jung JW, Filler SG, Masso-Welch P, Edgerton M, Gaffen SL.

J Exp Med. 2009 Feb 16;206(2):299-311. doi: 10.1084/jem.20081463. Epub 2009 Feb 9.


Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia.

Leleu X, Xu L, Jia X, Sacco A, Farag M, Hunter ZR, Moreau AS, Ngo HT, Hatjiharissi E, Ho AW, Santos DD, Adamia S, O'Connor K, Ciccarelli B, Soumerai J, Manning RJ, Patterson CJ, Roccaro AM, Ghobrial IM, Treon SP.

Blood. 2009 Jan 15;113(3):626-34. doi: 10.1182/blood-2007-10-116848. Epub 2008 Nov 3.


Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways.

Ho AW, Wong CK, Lam CW.

Immunobiology. 2008;213(7):533-44. doi: 10.1016/j.imbio.2008.01.003. Epub 2008 Feb 20.


Clinical relevance of soluble HLA class I molecules in Waldenstrom Macroglobulinemia.

Moreau AS, Sebti Y, Duhamel A, Roccaro AM, Coiteux V, Gastinne T, Le Friec G, Burwick N, Amiot L, Ho AW, Poulain S, Hennache B, Hunter ZR, Dessaint JP, Ghobrial IM, Treon SP, Facon T, Zorn E, Leleu X.

Eur J Haematol. 2008 Jun;80(6):503-9. doi: 10.1111/j.1600-0609.2008.01060.x. Epub 2008 Mar 10.


CD27-CD70 interactions in the pathogenesis of Waldenstrom macroglobulinemia.

Ho AW, Hatjiharissi E, Ciccarelli BT, Branagan AR, Hunter ZR, Leleu X, Tournilhac O, Xu L, O'Connor K, Manning RJ, Santos DD, Chemaly M, Patterson CJ, Soumerai JD, Munshi NC, McEarchern JA, Law CL, Grewal IS, Treon SP.

Blood. 2008 Dec 1;112(12):4683-9. doi: 10.1182/blood-2007-04-084525. Epub 2008 Jan 23.


Aberrant expression of soluble co-stimulatory molecules and adhesion molecules in type 2 diabetic patients with nephropathy.

Wong CK, Ho AW, Tong PC, Yeung CY, Chan JC, Kong AP, Lam CW.

J Clin Immunol. 2008 Jan;28(1):36-43. Epub 2007 Nov 17.


Novel agents in the treatment of Waldenström's macroglobulinemia.

Treon SP, Hatjiharissi E, Leleu X, Moreau AS, Roccaro A, Hunter ZR, Soumerai JD, Ciccarelli B, Xu L, Sacco A, Ngo HT, Jia X, Yang C, Adamia S, Branagan AR, Ho AW, Santos DD, Tournilhac O, Manning RJ, Leduc R, O'Connor K, Nelson M, Patterson CJ, Ghobrial I.

Clin Lymphoma Myeloma. 2007 Aug;7 Suppl 5:S199-206. Review.


Establishment of BCWM.1 cell line for Waldenström's macroglobulinemia with productive in vivo engraftment in SCID-hu mice.

Ditzel Santos D, Ho AW, Tournilhac O, Hatjiharissi E, Leleu X, Xu L, Tassone P, Neri P, Hunter ZR, Chemaly MA, Branagan AR, Manning RJ, Patterson CJ, Moreau AS, Ciccarelli B, Adamia S, Kriangkum J, Kutok JL, Tai YT, Zhang J, Pilarski LM, Anderson KC, Munshi N, Treon SP.

Exp Hematol. 2007 Sep;35(9):1366-75.


Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.

Marks RE, Ho AW, Robbel C, Kuna T, Berk S, Gajewski TF.

Blood. 2007 Sep 15;110(6):1982-8. Epub 2007 Jun 1.


Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy.

Wong CK, Ho AW, Tong PC, Yeung CY, Kong AP, Lun SW, Chan JC, Lam CW.

Clin Exp Immunol. 2007 Jul;149(1):123-31. Epub 2007 Apr 11.


Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy.

Hatjiharissi E, Hansen M, Santos DD, Xu L, Leleu X, Dimmock EW, Ho AW, Hunter ZR, Branagan AR, Patterson CJ, Kortsaris A, Verselis S, Fox E, Treon SP.

Clin Lymphoma Myeloma. 2007 Jan;7(4):286-90.


T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.

Zha Y, Marks R, Ho AW, Peterson AC, Janardhan S, Brown I, Praveen K, Stang S, Stone JC, Gajewski TF.

Nat Immunol. 2006 Nov;7(11):1166-73. Epub 2006 Oct 8. Erratum in: Nat Immunol. 2006 Dec;7(12):1343.


Hepatitis C viral infection is not associated with Waldenström's macroglobulinemia.

Leleu X, O'Connor K, Ho AW, Santos DD, Manning R, Xu L, Hatjiharissi E, Moreau AS, Branagan AR, Hunter ZR, Dimmock EA, Soumerai J, Patterson C, Ghobrial I, Treon SP.

Am J Hematol. 2007 Jan;82(1):83-4.


Sulthiame therapy for continuous spike and wave in slow-wave sleep.

Wirrell E, Ho AW, Hamiwka L.

Pediatr Neurol. 2006 Sep;35(3):204-8.


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