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Items: 25

1.

Coactivator condensation at super-enhancers links phase separation and gene control.

Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA.

Science. 2018 Jul 27;361(6400). pii: eaar3958. doi: 10.1126/science.aar3958. Epub 2018 Jun 21.

2.

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism.

Schuijers J, Manteiga JC, Weintraub AS, Day DS, Zamudio AV, Hnisz D, Lee TI, Young RA.

Cell Rep. 2018 Apr 10;23(2):349-360. doi: 10.1016/j.celrep.2018.03.056.

3.

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.

Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R.

Cell. 2018 Feb 22;172(5):979-992.e6. doi: 10.1016/j.cell.2018.01.012. Epub 2018 Feb 15.

4.

YY1 Is a Structural Regulator of Enhancer-Promoter Loops.

Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA.

Cell. 2017 Dec 14;171(7):1573-1588.e28. doi: 10.1016/j.cell.2017.11.008. Epub 2017 Dec 7.

5.

New Insights into Genome Structure: Genes of a Feather Stick Together.

Hnisz D, Young RA.

Mol Cell. 2017 Sep 7;67(5):730-731. doi: 10.1016/j.molcel.2017.08.023.

6.

Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes.

Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, Mansour MR, Young RA.

Nat Commun. 2017 Jun 1;8:15797. doi: 10.1038/ncomms15797.

7.

A Phase Separation Model for Transcriptional Control.

Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA.

Cell. 2017 Mar 23;169(1):13-23. doi: 10.1016/j.cell.2017.02.007. Review.

8.

Transcriptional Addiction in Cancer.

Bradner JE, Hnisz D, Young RA.

Cell. 2017 Feb 9;168(4):629-643. doi: 10.1016/j.cell.2016.12.013. Review.

9.

Small genomic insertions form enhancers that misregulate oncogenes.

Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, Mansour MR, Young RA.

Nat Commun. 2017 Feb 9;8:14385. doi: 10.1038/ncomms14385.

10.

Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control.

Hnisz D, Day DS, Young RA.

Cell. 2016 Nov 17;167(5):1188-1200. doi: 10.1016/j.cell.2016.10.024. Review.

11.

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas.

Clark VE, Harmancı AS, Bai H, Youngblood MW, Lee TI, Baranoski JF, Ercan-Sencicek AG, Abraham BJ, Weintraub AS, Hnisz D, Simon M, Krischek B, Erson-Omay EZ, Henegariu O, Carrión-Grant G, Mishra-Gorur K, Durán D, Goldmann JE, Schramm J, Goldbrunner R, Piepmeier JM, Vortmeyer AO, Günel JM, Bilgüvar K, Yasuno K, Young RA, Günel M.

Nat Genet. 2016 Oct;48(10):1253-9. doi: 10.1038/ng.3651. Epub 2016 Aug 22.

12.

Activation of proto-oncogenes by disruption of chromosome neighborhoods.

Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA.

Science. 2016 Mar 25;351(6280):1454-1458. doi: 10.1126/science.aad9024. Epub 2016 Mar 3.

13.

3D Chromosome Regulatory Landscape of Human Pluripotent Cells.

Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA.

Cell Stem Cell. 2016 Feb 4;18(2):262-75. doi: 10.1016/j.stem.2015.11.007. Epub 2015 Dec 10.

14.

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.

Hnisz D, Schuijers J, Lin CY, Weintraub AS, Abraham BJ, Lee TI, Bradner JE, Young RA.

Mol Cell. 2015 Apr 16;58(2):362-70. doi: 10.1016/j.molcel.2015.02.014. Epub 2015 Mar 19.

15.

Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes.

Dowen JM, Fan ZP, Hnisz D, Ren G, Abraham BJ, Zhang LN, Weintraub AS, Schujiers J, Lee TI, Zhao K, Young RA.

Cell. 2014 Oct 9;159(2):374-387. doi: 10.1016/j.cell.2014.09.030.

16.

A histone deacetylase complex mediates biofilm dispersal and drug resistance in Candida albicans.

Nobile CJ, Fox EP, Hartooni N, Mitchell KF, Hnisz D, Andes DR, Kuchler K, Johnson AD.

MBio. 2014 Jun 10;5(3):e01201-14. doi: 10.1128/mBio.01201-14.

17.

Super-enhancers in the control of cell identity and disease.

Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA.

Cell. 2013 Nov 7;155(4):934-47. doi: 10.1016/j.cell.2013.09.053. Epub 2013 Oct 10.

18.

Master transcription factors and mediator establish super-enhancers at key cell identity genes.

Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA.

Cell. 2013 Apr 11;153(2):307-19. doi: 10.1016/j.cell.2013.03.035.

19.

A histone deacetylase adjusts transcription kinetics at coding sequences during Candida albicans morphogenesis.

Hnisz D, Bardet AF, Nobile CJ, Petryshyn A, Glaser W, Schöck U, Stark A, Kuchler K.

PLoS Genet. 2012;8(12):e1003118. doi: 10.1371/journal.pgen.1003118. Epub 2012 Dec 6.

20.

The histone acetyltransferase Hat1 facilitates DNA damage repair and morphogenesis in Candida albicans.

Tscherner M, Stappler E, Hnisz D, Kuchler K.

Mol Microbiol. 2012 Dec;86(5):1197-214. doi: 10.1111/mmi.12051. Epub 2012 Oct 17.

21.

Targeting chromatin in fungal pathogens as a novel therapeutic strategy: histone modification gets infectious.

Hnisz D, Tscherner M, Kuchler K.

Epigenomics. 2011 Apr;3(2):129-32. doi: 10.2217/epi.11.7. No abstract available.

PMID:
22122275
22.

Morphological and molecular genetic analysis of epigenetic switching of the human fungal pathogen Candida albicans.

Hnisz D, Tscherner M, Kuchler K.

Methods Mol Biol. 2011;734:303-15. doi: 10.1007/978-1-61779-086-7_15.

PMID:
21468996
23.

The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicans.

Hnisz D, Majer O, Frohner IE, Komnenovic V, Kuchler K.

PLoS Pathog. 2010 May 13;6(5):e1000889. doi: 10.1371/journal.ppat.1000889.

24.

TNFalpha shedding and epidermal inflammation are controlled by Jun proteins.

Guinea-Viniegra J, Zenz R, Scheuch H, Hnisz D, Holcmann M, Bakiri L, Schonthaler HB, Sibilia M, Wagner EF.

Genes Dev. 2009 Nov 15;23(22):2663-74. doi: 10.1101/gad.543109.

25.

Transcriptional loops meet chromatin: a dual-layer network controls white-opaque switching in Candida albicans.

Hnisz D, Schwarzmüller T, Kuchler K.

Mol Microbiol. 2009 Oct;74(1):1-15. doi: 10.1111/j.1365-2958.2009.06772.x. Epub 2009 Jun 23.

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