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HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation.
Rouhiainen A, Zhao X, Vanttola P, Qian K, Kulesskiy E, Kuja-Panula J, Gransalke K, Grönholm M, Unni E, Meistrich M, Tian L, Auvinen P, Rauvala H. Rouhiainen A, et al. Sci Rep. 2016 Sep 9;6:32960. doi: 10.1038/srep32960. Sci Rep. 2016. PMID: 27608812 Free PMC article.
Here we show that HMGB4 and the highly similar rat Transition Protein 4 (HMGB4L1) are expressed in neuronal cells. ...In conclusion, our data suggests that HMGB4 is a factor that regulates chromatin and expression of neuronal differentiation markers....
Here we show that HMGB4 and the highly similar rat Transition Protein 4 (HMGB4L1) are expressed in neuronal cells. ...In conclusion, …
HMGB4, a novel member of the HMGB family, is preferentially expressed in the mouse testis and localizes to the basal pole of elongating spermatids.
Catena R, Escoffier E, Caron C, Khochbin S, Martianov I, Davidson I. Catena R, et al. Biol Reprod. 2009 Feb;80(2):358-66. doi: 10.1095/biolreprod.108.070243. Epub 2008 Nov 5. Biol Reprod. 2009. PMID: 18987332
We identified HMGB4, a novel member of the HMGB family lacking the acidic tail typically found in this family. HMGB4 is strongly and preferentially expressed in the adult mouse testis and weakly in the brain, but not in many other tissues. ...
We identified HMGB4, a novel member of the HMGB family lacking the acidic tail typically found in this family. HMGB4 is strong …
Binding interaction of HMGB4 with cisplatin-modified DNA.
Park S, Lippard SJ. Park S, et al. Biochemistry. 2012 Aug 28;51(34):6728-37. doi: 10.1021/bi300649v. Epub 2012 Aug 17. Biochemistry. 2012. PMID: 22901013 Free PMC article.
The binding affinities of the two individual DNA-binding domains of HMGB4 to DNA carrying a cisplatin 1,2-intrastrand d(GpG) cross-link are weaker than those of the DNA-binding domains of HMGB1. ...The residue Phe37 plays a critical role in stabilizing the binding complex …
The binding affinities of the two individual DNA-binding domains of HMGB4 to DNA carrying a cisplatin 1,2-intrastrand d(GpG) cross-li …
Omics and Male Infertility: Highlighting the Application of Transcriptomic Data.
Omolaoye TS, Omolaoye VA, Kandasamy RK, Hachim MY, Du Plessis SS. Omolaoye TS, et al. Life (Basel). 2022 Feb 14;12(2):280. doi: 10.3390/life12020280. Life (Basel). 2022. PMID: 35207567 Free PMC article. Review.
Likewise, 56 genes were common between NOA versus NOA and OA (ADAD1, BANF2, BCL2L14, C12orf50, C20orf173, C22orf23, C6orf99, C9orf131, C9orf24, CABS1, CAPZA3, CCDC187, CCDC54, CDKN3, CEP170, CFAP206, CRISP2, CT83, CXorf65, FAM209A, FAM71F1, FAM81B, GALNTL5, GTSF1, H1FNT, HEMGN, …
Likewise, 56 genes were common between NOA versus NOA and OA (ADAD1, BANF2, BCL2L14, C12orf50, C20orf173, C22orf23, C6orf99, C9orf131, C9orf …
Nucleocytoplasmic distribution of the Arabidopsis chromatin-associated HMGB2/3 and HMGB4 proteins.
Pedersen DS, Merkle T, Marktl B, Lildballe DL, Antosch M, Bergmann T, Tönsing K, Anselmetti D, Grasser KD. Pedersen DS, et al. Plant Physiol. 2010 Dec;154(4):1831-41. doi: 10.1104/pp.110.163055. Epub 2010 Oct 12. Plant Physiol. 2010. PMID: 20940346 Free PMC article.
By time-lapse fluorescence microscopy, it was observed that the HMGB2 and HMGB4 proteins tagged with photoactivatable green fluorescent protein can shuttle between the nucleus and the cytoplasm, while HMGB1 remains nuclear. ...Collectively, our results show that, in contra …
By time-lapse fluorescence microscopy, it was observed that the HMGB2 and HMGB4 proteins tagged with photoactivatable green fluoresce …
The role of high mobility group protein B3 (HMGB3) in tumor proliferation and drug resistance.
Wen B, Wei YT, Zhao K. Wen B, et al. Mol Cell Biochem. 2021 Apr;476(4):1729-1739. doi: 10.1007/s11010-020-04015-y. Epub 2021 Jan 11. Mol Cell Biochem. 2021. PMID: 33428061 Review.
The high mobility group protein B (HMGB) family (including HMGB1, HMGB2, HMGB3, and HMGB4) can regulate the mechanisms of DNA replication, transcription, recombination, and repair, and act as cytokines to mediate responses to infection, injury, and inflammation. HMGB1/2/3 …
The high mobility group protein B (HMGB) family (including HMGB1, HMGB2, HMGB3, and HMGB4) can regulate the mechanisms of DNA replica …
Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity.
Awuah SG, Riddell IA, Lippard SJ. Awuah SG, et al. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):950-955. doi: 10.1073/pnas.1615327114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096358 Free PMC article.
We find that loss of HMGB4 elicits resistance to cisplatin as evidenced by cell proliferation and apoptosis assays. ...Our findings also reveal characteristic HMGB4-dependent differences in cell cycle progression following cisplatin treatment. ...
We find that loss of HMGB4 elicits resistance to cisplatin as evidenced by cell proliferation and apoptosis assays. ...Our findings a …
HMGB proteins: interactions with DNA and chromatin.
Stros M. Stros M. Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):101-13. doi: 10.1016/j.bbagrm.2009.09.008. Biochim Biophys Acta. 2010. PMID: 20123072 Review.
Mammalian HMGBs contain two HMG-boxes arranged in tandem, share more than 80% identity and differ in the length (HMGB1-3) or absence (HMGB4) of the acidic C-tails. The acidic tails consist of consecutive runs of only Glu/Asp residues of various length, and modulate the DNA …
Mammalian HMGBs contain two HMG-boxes arranged in tandem, share more than 80% identity and differ in the length (HMGB1-3) or absence (HMG …
High-mobility group boxes mediate cell proliferation and radiosensitivity via retinoblastoma-interaction-dependent and -independent mechanisms.
Wang LL, Meng QH, Jiao Y, Xu JY, Ge CM, Zhou JY, Rosen EM, Wang HC, Fan SJ. Wang LL, et al. Cancer Biother Radiopharm. 2012 Jun;27(5):329-35. doi: 10.1089/cbr.2012.1199. Epub 2012 Jun 1. Cancer Biother Radiopharm. 2012. PMID: 22655796 Free PMC article.
An identical LXCXE motif is present in the HMGB1-3 protein sequences, whereas a near-consensus LXCXD (leucine-X-cysteine-X-asparagine; X=any amino acid) motif is found in the HMGB4 protein. In this study, we have demonstrated that like HMGB1, HMGB2-3 also associated with t …
An identical LXCXE motif is present in the HMGB1-3 protein sequences, whereas a near-consensus LXCXD (leucine-X-cysteine-X-asparagine; X=any …
Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns.
Siebert-Kuss LM, Krenz H, Tekath T, Wöste M, Di Persio S, Terwort N, Wyrwoll MJ, Cremers JF, Wistuba J, Dugas M, Kliesch S, Schlatt S, Tüttelmann F, Gromoll J, Neuhaus N, Laurentino S. Siebert-Kuss LM, et al. Life Sci Alliance. 2022 Nov 29;6(2):e202201633. doi: 10.26508/lsa.202201633. Print 2023 Feb. Life Sci Alliance. 2022. PMID: 36446526 Free PMC article.
We demonstrate our analyses' potential to identify novel highly germ cell-specific markers (TSPY4 and LUZP4 for spermatogonia; HMGB4 for round spermatids) and identified putatively misregulated genes in male infertility (RWDD2A, CCDC183, CNNM1, SERF1B). ...
We demonstrate our analyses' potential to identify novel highly germ cell-specific markers (TSPY4 and LUZP4 for spermatogonia; HMGB4 …
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