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Items: 1 to 50 of 238

1.

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration.

Xiong Y, Piao W, Brinkman CC, Li L, Kulinski JM, Olivera A, Cartier A, Hla T, Hippen KL, Blazar BR, Schwab SR, Bromberg JS.

Sci Immunol. 2019 Mar 15;4(33). pii: eaav1263. doi: 10.1126/sciimmunol.aav1263.

PMID:
30877143
2.

A Study of Burkholderia pseudomallei in the Environment of Farms in Thanlyin and Hmawbi Townships, Myanmar.

Win MM, Hla T, Phyu KP, Aung WW, Nyein Win KK, Aye SN, Wah TT, Aye KM, Htwe TT, Htay MT, San KK, Dance D.

Am J Trop Med Hyg. 2019 Feb 18. doi: 10.4269/ajtmh.18-0678. [Epub ahead of print]

3.

Lipid Mediators, M2 Macrophages, and Pathological Neovascularization.

Swendeman SL, Hla T.

Trends Mol Med. 2018 Dec;24(12):977-978. doi: 10.1016/j.molmed.2018.10.003. Epub 2018 Nov 15.

PMID:
30448396
4.

Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation.

Montrose DC, Zhou XK, McNally EM, Sue E, Wang H, Nishiguchi R, Verma A, Elemento O, Simpson KW, Yang P, Hla T, Dannenberg AJ.

Am J Pathol. 2018 Dec;188(12):2811-2825. doi: 10.1016/j.ajpath.2018.08.016. Epub 2018 Sep 28.

PMID:
30273600
5.

Bioactive lysolipids in cancer and angiogenesis.

Hisano Y, Hla T.

Pharmacol Ther. 2019 Jan;193:91-98. doi: 10.1016/j.pharmthera.2018.07.006. Epub 2018 Jul 23. Review.

6.

Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury.

Burg N, Swendeman S, Worgall S, Hla T, Salmon JE.

Arthritis Rheumatol. 2018 Nov;70(11):1879-1889. doi: 10.1002/art.40558.

PMID:
29781582
7.

Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.

Ghosh M, Thangada S, Dasgupta O, Khanna KM, Yamase HT, Kashgarian M, Hla T, Shapiro LH, Ferrer FA.

PLoS One. 2018 Mar 8;13(3):e0194053. doi: 10.1371/journal.pone.0194053. eCollection 2018.

8.

A dark side to omega-3 fatty acids.

Yanagida K, Hla T.

Nature. 2017 Dec 14;552(7684):180-181. doi: 10.1038/d41586-017-07678-8. No abstract available.

9.

Bioluminescence imaging of G protein-coupled receptor activation in living mice.

Kono M, Conlon EG, Lux SY, Yanagida K, Hla T, Proia RL.

Nat Commun. 2017 Oct 27;8(1):1163. doi: 10.1038/s41467-017-01340-7.

10.

The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis.

Mendelson K, Pandey S, Hisano Y, Carellini F, Das B, Hla T, Evans T.

Elife. 2017 Sep 28;6. pii: e21992. doi: 10.7554/eLife.21992.

11.

Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism.

Singh RK, Haka AS, Brumfield A, Grosheva I, Bhardwaj P, Chin HF, Xiong Y, Hla T, Maxfield FR.

J Lipid Res. 2017 Oct;58(10):1977-1987. doi: 10.1194/jlr.M076398. Epub 2017 Aug 16.

12.

An engineered S1P chaperone attenuates hypertension and ischemic injury.

Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T.

Sci Signal. 2017 Aug 15;10(492). pii: eaal2722. doi: 10.1126/scisignal.aal2722.

13.

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J.

Elife. 2017 Jun 27;6. pii: e29849. doi: 10.7554/eLife.29849. No abstract available.

14.

S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure.

Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A.

Hypertension. 2017 Aug;70(2):426-434. doi: 10.1161/HYPERTENSIONAHA.117.09088. Epub 2017 Jun 12.

15.

Quality Versus Quantity: Making HDL Great Again.

Galvani S, Hla T.

Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1018-1019. doi: 10.1161/ATVBAHA.117.309441. No abstract available.

16.

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.

Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, Chaluvadi VS, Dustin ML, Hla T, Elemento O, Chipuk JE, Schwab SR.

Nature. 2017 Jun 1;546(7656):158-161. doi: 10.1038/nature22352. Epub 2017 May 24.

17.

Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.

Yanagida K, Liu CH, Faraco G, Galvani S, Smith HK, Burg N, Anrather J, Sanchez T, Iadecola C, Hla T.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4531-4536. doi: 10.1073/pnas.1618659114. Epub 2017 Apr 10.

18.

Malaria epidemiology in central Myanmar: identification of a multi-species asymptomatic reservoir of infection.

Ghinai I, Cook J, Hla TT, Htet HM, Hall T, Lubis IN, Ghinai R, Hesketh T, Naung Y, Lwin MM, Latt TS, Heymann DL, Sutherland CJ, Drakeley C, Field N.

Malar J. 2017 Jan 5;16(1):16. doi: 10.1186/s12936-016-1651-5.

19.

HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver.

Ding BS, Liu CH, Sun Y, Chen Y, Swendeman SL, Jung B, Chavez D, Cao Z, Christoffersen C, Nielsen LB, Schwab SR, Rafii S, Hla T.

JCI Insight. 2016 Dec 22;1(21):e87058. doi: 10.1172/jci.insight.87058.

20.

Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient.

Yanagida K, Hla T.

Annu Rev Physiol. 2017 Feb 10;79:67-91. doi: 10.1146/annurev-physiol-021014-071635. Epub 2016 Oct 21. Review.

21.

Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.

Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E.

Circ Res. 2016 Sep 30;119(8):e110-26. doi: 10.1161/CIRCRESAHA.116.308929. Epub 2016 Aug 31.

22.

Sphingosine kinases are not required for inflammatory responses in macrophages.

Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T.

J Biol Chem. 2016 May 20;291(21):11465. doi: 10.1074/jbc.A113.483750. No abstract available.

23.

Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.

Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C.

FASEB J. 2016 Jun;30(6):2351-9. doi: 10.1096/fj.201500064. Epub 2016 Mar 8.

24.

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J.

Elife. 2015 Dec 23;4. pii: e10592. doi: 10.7554/eLife.10592. Erratum in: Elife. 2017 Jun 27;6:.

25.

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.

Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM.

Nat Med. 2015 Nov;21(11):1290-7. doi: 10.1038/nm.3980. Epub 2015 Oct 26.

26.

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.

Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M, Giordano FJ, Jiang XC, Hla T, Di Lorenzo A.

Nat Med. 2015 Sep;21(9):1028-1037. doi: 10.1038/nm.3934. Epub 2015 Aug 24.

27.

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.

Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T.

Sci Signal. 2015 Aug 11;8(389):ra79. doi: 10.1126/scisignal.aaa2581. Erratum in: Sci Signal. 2015 Oct 27;8(400):er8. Obinata, Hideru [added].

28.

Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma.

Li MH, Swenson R, Harel M, Jana S, Stolarzewicz E, Hla T, Shapiro LH, Ferrer F.

J Pharmacol Exp Ther. 2015 Sep;354(3):261-8. doi: 10.1124/jpet.115.224519. Epub 2015 Jun 23.

29.

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.

Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T.

Nature. 2015 Jul 16;523(7560):342-6. doi: 10.1038/nature14462. Epub 2015 Jun 8.

30.

Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis.

Mendelson K, Lan Y, Hla T, Evans T.

Dev Dyn. 2015 Aug;244(8):948-54. doi: 10.1002/dvdy.24288. Epub 2015 Jul 6.

31.

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.

Proia RL, Hla T.

J Clin Invest. 2015 Apr;125(4):1379-87. doi: 10.1172/JCI76369. Epub 2015 Apr 1. Review.

32.
33.

ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages.

Lu YC, Chang SH, Hafner M, Li X, Tuschl T, Elemento O, Hla T.

Cell Rep. 2014 Dec 24;9(6):2330-43. doi: 10.1016/j.celrep.2014.11.030. Epub 2014 Dec 18.

34.

Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications.

Camm J, Hla T, Bakshi R, Brinkmann V.

Am Heart J. 2014 Nov;168(5):632-44. doi: 10.1016/j.ahj.2014.06.028. Epub 2014 Jul 11. Review.

35.

C16:0-ceramide signals insulin resistance.

Hla T, Kolesnick R.

Cell Metab. 2014 Nov 4;20(5):703-705. doi: 10.1016/j.cmet.2014.10.017. Epub 2014 Nov 4.

36.

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.

Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18309-14. doi: 10.1073/pnas.1412172111. Epub 2014 Nov 24.

37.

Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.

Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T.

J Lipid Res. 2014 Dec;55(12):2665-75. doi: 10.1194/jlr.P054163. Epub 2014 Oct 7.

38.

Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development.

Xiong Y, Yang P, Proia RL, Hla T.

J Clin Invest. 2014 Nov;124(11):4823-8. doi: 10.1172/JCI77685. Epub 2014 Sep 24.

39.

Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model.

Murakami K, Kohno M, Kadoya M, Nagahara H, Fujii W, Seno T, Yamamoto A, Oda R, Fujiwara H, Kubo T, Morita S, Nakada H, Hla T, Kawahito Y.

PLoS One. 2014 Sep 8;9(9):e106792. doi: 10.1371/journal.pone.0106792. eCollection 2014.

40.

The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.

Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A.

Cell Rep. 2014 Sep 11;8(5):1497-508. doi: 10.1016/j.celrep.2014.07.059. Epub 2014 Aug 28.

41.

Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma.

Li MH, Harel M, Hla T, Ferrer F.

J Pediatr Surg. 2014 Aug;49(8):1286-91. doi: 10.1016/j.jpedsurg.2014.04.001. Epub 2014 May 16.

42.

Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development.

Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO.

Cancer Res. 2014 Sep 15;74(18):5322-35. doi: 10.1158/0008-5472.CAN-14-0726. Epub 2014 Aug 1.

43.

S1P control of endothelial integrity.

Xiong Y, Hla T.

Curr Top Microbiol Immunol. 2014;378:85-105. doi: 10.1007/978-3-319-05879-5_4. Review.

44.

Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis.

Chang SH, Hla T.

Curr Opin Hematol. 2014 May;21(3):235-40. doi: 10.1097/MOH.0000000000000040. Review.

PMID:
24714527
45.

Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction.

Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA.

J Urol. 2014 May;191(5 Suppl):1508-16. doi: 10.1016/j.juro.2013.10.072. Epub 2014 Mar 26.

PMID:
24679864
46.

Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond.

Garris CS, Blaho VA, Hla T, Han MH.

Immunology. 2014 Jul;142(3):347-53. doi: 10.1111/imm.12272. Review.

47.

An update on the biology of sphingosine 1-phosphate receptors.

Blaho VA, Hla T.

J Lipid Res. 2014 Aug;55(8):1596-608. doi: 10.1194/jlr.R046300. Epub 2014 Jan 23. Review.

48.

Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1.

Li X, Lu YC, Dai K, Torregroza I, Hla T, Evans T.

Blood. 2014 Feb 27;123(9):1384-92. doi: 10.1182/blood-2013-09-526962. Epub 2014 Jan 14.

49.

Sphingosine 1-phosphate signalling.

Mendelson K, Evans T, Hla T.

Development. 2014 Jan;141(1):5-9. doi: 10.1242/dev.094805. Review.

50.

Sphingosine kinases are not required for inflammatory responses in macrophages.

Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T.

J Biol Chem. 2013 Nov 8;288(45):32563-73. doi: 10.1074/jbc.M113.483750. Epub 2013 Sep 30. Erratum in: J Biol Chem. 2016 May 20;291(21):11465. Lee, Hyeuk Jong [corrected to Lee, Hyuek Jong].

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