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Items: 1 to 50 of 124

1.

AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.

Rab MAE, van Oirschot BA, Kosinski PA, Hixon J, Johnson K, Chubukov V, Dang L, Pasterkamp G, van Straaten S, van Solinge WW, van Beers EJ, Kung C, van Wijk R.

Haematologica. 2020 Jan 23. pii: haematol.2019.238865. doi: 10.3324/haematol.2019.238865. [Epub ahead of print]

2.

Adopting Graduate Competencies in Opioid Prescribing for Massachusetts Physician Assistant Programs: A Statewide Public Health Response.

White SE, Altongy-Magee K, Cooper C, Hixon J, Honda T, Milch C, Murphy R, Riethle T, Walker L, Berkowitz O.

J Physician Assist Educ. 2019 Dec;30(4):207-213. doi: 10.1097/JPA.0000000000000276.

PMID:
31664008
3.

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.

Hixon JA, Andrews C, Kashi L, Kohnhorst CL, Senkevitch E, Czarra K, Barata JT, Li W, Schneider JP, Walsh STR, Durum SK.

Leukemia. 2020 Jan;34(1):35-49. doi: 10.1038/s41375-019-0531-8. Epub 2019 Aug 22.

PMID:
31439943
4.

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.

Akkapeddi P, Fragoso R, Hixon JA, Ramalho AS, Oliveira ML, Carvalho T, Gloger A, Matasci M, Corzana F, Durum SK, Neri D, Bernardes GJL, Barata JT.

Leukemia. 2019 Sep;33(9):2155-2168. doi: 10.1038/s41375-019-0434-8. Epub 2019 Mar 8.

5.

Response to Distress Varies by Social Impairment and Familiarity in Infants at Risk for Autism.

Dowd AC, Martinez K, Davidson BC, Hixon JG, Neal-Beevers AR.

J Autism Dev Disord. 2018 Nov;48(11):3885-3898. doi: 10.1007/s10803-018-3653-3.

PMID:
29931435
6.

Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations.

Senkevitch E, Li W, Hixon JA, Andrews C, Cramer SD, Pauly GT, Back T, Czarra K, Durum SK.

Oncotarget. 2018 Apr 27;9(32):22605-22617. doi: 10.18632/oncotarget.25194. eCollection 2018 Apr 27.

7.

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Aiello FB, Guszczynski T, Li W, Hixon JA, Jiang Q, Hodge DL, Massignan T, Di Lisio C, Merchant A, Procopio AD, Bonetto V, Durum SK.

Cell Signal. 2018 Jul;47:131-141. doi: 10.1016/j.cellsig.2018.03.008. Epub 2018 Mar 24.

PMID:
29581031
8.

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.

Cramer SD, Hixon JA, Andrews C, Porter RJ, Rodrigues GOL, Wu X, Back T, Czarra K, Michael H, Cam M, Chen J, Esposito D, Senkevitch E, Negi V, Aplan PD, Li W, Durum SK.

Leukemia. 2018 Aug;32(8):1795-1882. doi: 10.1038/s41375-017-0001-0. Epub 2018 Feb 15. No abstract available.

PMID:
29535426
9.

Cross-Linguistic Cognate Production in Spanish-English Bilingual Children With and Without Specific Language Impairment.

Grasso SM, Peña ED, Bedore LM, Hixon JG, Griffin ZM.

J Speech Lang Hear Res. 2018 Mar 15;61(3):619-633. doi: 10.1044/2017_JSLHR-L-16-0421.

10.

Drinking Level Versus Drinking Pattern and Cigarette Smoking Among Older Adults.

Holahan CJ, Brennan PL, Schutte KK, Holahan CK, Hixon JG, Moos RH.

Alcohol Clin Exp Res. 2018 Apr;42(4):795-802. doi: 10.1111/acer.13607. Epub 2018 Feb 27.

11.

Automated Artifact-Detection Procedure for Vaginal Photoplethysmography.

Pulverman CS, Meston CM, Hixon JG.

J Sex Marital Ther. 2018;44(6):566-590. doi: 10.1080/0092623X.2018.1436627. Epub 2018 Mar 6.

PMID:
29400613
12.

One Session of Autogenic Training Increases Acute Subjective Sexual Arousal in Premenopausal Women Reporting Sexual Arousal Problems.

Stanton AM, Hixon JG, Nichols LM, Meston CM.

J Sex Med. 2018 Jan;15(1):64-76. doi: 10.1016/j.jsxm.2017.11.012.

PMID:
29289376
13.

Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10-Dependent, T-Cell-Independent Attenuation of Colonic Mucosal Innate Immune Responses.

McLean MH, Andrews C, Hanson ML, Baseler WA, Anver MR, Senkevitch E, Staniszewska AK, Smith C, Davies LC, Hixon J, Li W, Shen W, Steidler L, Durum SK.

Inflamm Bowel Dis. 2017 Nov;23(11):1983-1995. doi: 10.1097/MIB.0000000000001274.

14.

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.

Kung C, Hixon J, Kosinski PA, Cianchetta G, Histen G, Chen Y, Hill C, Gross S, Si Y, Johnson K, DeLaBarre B, Luo Z, Gu Z, Yao G, Tang H, Fang C, Xu Y, Lv X, Biller S, Su SM, Yang H, Popovici-Muller J, Salituro F, Silverman L, Dang L.

Blood. 2017 Sep 14;130(11):1347-1356. doi: 10.1182/blood-2016-11-753525. Epub 2017 Jul 31.

15.

Late-Life Drinking Problems: The Predictive Roles of Drinking Level vs. Drinking Pattern.

Holahan CJ, Brennan PL, Schutte KK, Holahan CK, Hixon JG, Moos RH.

J Stud Alcohol Drugs. 2017 May;78(3):435-441.

16.

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice.

Shen W, Li W, Hixon JA, Andrews C, Durum SK.

J Vis Exp. 2017 Jan 25;(119). doi: 10.3791/54710.

17.

Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases.

Aprelikova O, Tomlinson CC, Hoenerhoff M, Hixon JA, Durum SK, Qiu TH, He S, Burkett S, Liu ZY, Swanson SM, Green JE.

PLoS One. 2016 May 12;11(5):e0155262. doi: 10.1371/journal.pone.0155262. eCollection 2016.

18.

Effects of Age of English Exposure, Current Input/Output, and grade on bilingual language performance.

Bedore LM, Peña ED, Griffin ZM, Hixon JG.

J Child Lang. 2016 May;43(3):687-706. doi: 10.1017/S0305000915000811. Epub 2016 Feb 26.

19.

IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice.

Shen W, Hixon JA, McLean MH, Li WQ, Durum SK.

Front Immunol. 2016 Jan 19;6:662. doi: 10.3389/fimmu.2015.00662. eCollection 2015.

20.

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.

Jin S, Chen J, Chen L, Histen G, Lin Z, Gross S, Hixon J, Chen Y, Kung C, Chen Y, Fu Y, Lu Y, Lin H, Cai X, Yang H, Cairns RA, Dorsch M, Su SM, Biller S, Mak TW, Cang Y.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9088-93. doi: 10.1073/pnas.1510757112. Epub 2015 Jul 6.

21.

Uncovering category specificity of genital sexual arousal in women: The critical role of analytic technique.

Pulverman CS, Hixon JG, Meston CM.

Psychophysiology. 2015 Oct;52(10):1396-408. doi: 10.1111/psyp.12467. Epub 2015 Jun 29.

PMID:
26118962
22.

Adaptive immunity to murine skin commensals.

Shen W, Li W, Hixon JA, Bouladoux N, Belkaid Y, Dzutzev A, Durum SK.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2977-86. doi: 10.1073/pnas.1401820111. Epub 2014 Jul 7.

23.

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment.

Johnson GE, Soeteman-Hernández LG, Gollapudi BB, Bodger OG, Dearfield KL, Heflich RH, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA.

Environ Mol Mutagen. 2014 Oct;55(8):609-23. doi: 10.1002/em.21870. Epub 2014 May 6.

24.

The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001-2002 and 2007-2008 National Health and Nutrition Examination Surveys.

Suh M, Abraham L, Hixon JG, Proctor DM.

J Expo Sci Environ Epidemiol. 2014 Nov;24(6):579-87. doi: 10.1038/jes.2013.67. Epub 2013 Oct 23.

PMID:
24149973
25.

Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice.

Hanson ML, Hixon JA, Li W, Felber BK, Anver MR, Stewart CA, Janelsins BM, Datta SK, Shen W, McLean MH, Durum SK.

Gastroenterology. 2014 Jan;146(1):210-221.e13. doi: 10.1053/j.gastro.2013.09.060. Epub 2013 Oct 9.

26.

Evaluation of impact of shale gas operations in the Barnett Shale region on volatile organic compounds in air and potential human health risks.

Bunch AG, Perry CS, Abraham L, Wikoff DS, Tachovsky JA, Hixon JG, Urban JD, Harris MA, Haws LC.

Sci Total Environ. 2014 Jan 15;468-469:832-42. doi: 10.1016/j.scitotenv.2013.08.080. Epub 2013 Sep 25. Erratum in: Sci Total Environ. 2014 Jul 15;487:574.

27.

HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.

Hasley RB, Hong C, Li W, Friesen T, Nakamura Y, Kim GY, Park JH, Hixon JA, Durum S, Hu Z, Sneller MC, Oguariri R, Imamichi T, Lane HC, Catalfamo M.

AIDS. 2013 Jul 31;27(12):1867-77. doi: 10.1097/QAD.0b013e3283618487.

PMID:
23965471
28.

A chronic oral reference dose for hexavalent chromium-induced intestinal cancer.

Thompson CM, Kirman CR, Proctor DM, Haws LC, Suh M, Hays SM, Hixon JG, Harris MA.

J Appl Toxicol. 2014 May;34(5):525-36. doi: 10.1002/jat.2907. Epub 2013 Aug 14.

29.

Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water.

O'Brien TJ, Ding H, Suh M, Thompson CM, Parsons BL, Harris MA, Winkelman WA, Wolf JC, Hixon JG, Schwartz AM, Myers MB, Haws LC, Proctor DM.

Mutat Res. 2013 Jun 14;754(1-2):15-21. doi: 10.1016/j.mrgentox.2013.03.008. Epub 2013 Apr 9.

30.

The power of connection and support in community engagement: Las Mujeres Nobles de Harlandale.

Fowler S, Venuto M, Ramirez V, Martinez E, Pollard J, Hixon J, Shaw J, Lesser J.

Issues Ment Health Nurs. 2013 Apr;34(4):294-7. doi: 10.3109/01612840.2012.719584. No abstract available.

PMID:
23566193
31.

Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.

Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, Wang S, Qian K, Saunders J, Driggers E, Woo HK, Kunii K, Murray S, Yang H, Yen K, Liu W, Cantley LC, Vander Heiden MG, Su SM, Jin S, Salituro FG, Dang L.

Chem Biol. 2012 Sep 21;19(9):1187-98. doi: 10.1016/j.chembiol.2012.07.021.

32.

High-throughput molecular and histopathologic profiling of tumor tissue in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery.

Stauffer JK, Orentas RJ, Lincoln E, Khan T, Salcedo R, Hixon JA, Back TC, Wei JS, Patidar R, Song Y, Hurd L, Tsokos M, Lai EW, Eisenhofer G, Weiss W, Khan J, Wigginton JM.

Cancer Invest. 2012 Jun;30(5):343-63. doi: 10.3109/07357907.2012.664670.

33.

Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action.

Thompson CM, Proctor DM, Suh M, Haws LC, Hébert CD, Mann JF, Shertzer HG, Hixon JG, Harris MA.

Toxicol Sci. 2012 Jan;125(1):79-90. doi: 10.1093/toxsci/kfr280. Epub 2011 Oct 19.

34.

Genetic and hormonal sensitivity to threat: testing a serotonin transporter genotype × testosterone interaction.

Josephs RA, Telch MJ, Hixon JG, Evans JJ, Lee H, Knopik VS, McGeary JE, Hariri AR, Beevers CG.

Psychoneuroendocrinology. 2012 Jun;37(6):752-61. doi: 10.1016/j.psyneuen.2011.09.006. Epub 2011 Oct 5.

35.

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.

Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT.

Nat Genet. 2011 Sep 4;43(10):932-9. doi: 10.1038/ng.924.

PMID:
21892159
36.

Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity.

Longo KA, Govek EK, Nolan A, McDonagh T, Charoenthongtrakul S, Giuliana DJ, Morgan K, Hixon J, Zhou C, Kelder B, Kopchick JJ, Saunders JO, Navia MA, Curtis R, DiStefano PS, Geddes BJ.

J Pharmacol Exp Ther. 2011 Oct;339(1):115-24. doi: 10.1124/jpet.111.183764. Epub 2011 Jul 20. Erratum in: J Pharmacol Exp Ther. 2012 Mar;340(3):810.

PMID:
21775475
37.

Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.

Thompson CM, Proctor DM, Haws LC, Hébert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG, Zacharewski TR, Harris MA.

Toxicol Sci. 2011 Sep;123(1):58-70. doi: 10.1093/toxsci/kfr164. Epub 2011 Jun 28.

38.

Serotonin transporter promoter region (5-HTTLPR) polymorphism predicts resting respiratory sinus arrhythmia.

Ellis AJ, Beevers CG, Hixon JG, McGeary JE.

Psychophysiology. 2011 Jul;48(7):923-6. doi: 10.1111/j.1469-8986.2010.01154.x. Epub 2010 Nov 23.

39.

Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps.

Qi Y, Longo KA, Giuliana DJ, Gagne S, McDonagh T, Govek E, Nolan A, Zou C, Morgan K, Hixon J, Saunders JO, Distefano PS, Geddes BJ.

BMC Physiol. 2011 Jan 6;11:1. doi: 10.1186/1472-6793-11-1.

40.

Identity fusion and self-sacrifice: arousal as a catalyst of pro-group fighting, dying, and helping behavior.

Swann WB Jr, Gómez A, Huici C, Morales JF, Hixon JG.

J Pers Soc Psychol. 2010 Nov;99(5):824-41. doi: 10.1037/a0020014.

PMID:
20649370
41.

Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.

Li WQ, Guszczynski T, Hixon JA, Durum SK.

Mol Cell Biol. 2010 Feb;30(3):590-600. doi: 10.1128/MCB.01006-09. Epub 2009 Nov 23.

42.

Visualization and identification of IL-7 producing cells in reporter mice.

Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, Cherry J, Naf D, Sternberg LR, McVicar DW, Farr AG, Germain RN, Rogers K, Jenkins NA, Copeland NG, Durum SK.

PLoS One. 2009 Nov 10;4(11):e7637. doi: 10.1371/journal.pone.0007637.

43.

Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow.

Salcedo R, Hixon JA, Stauffer JK, Jalah R, Brooks AD, Khan T, Dai RM, Scheetz L, Lincoln E, Back TC, Powell D, Hurwitz AA, Sayers TJ, Kastelein R, Pavlakis GN, Felber BK, Trinchieri G, Wigginton JM.

J Immunol. 2009 Apr 1;182(7):4328-38. doi: 10.4049/jimmunol.0800471.

44.

Enhanced gastrointestinal motility with orally active ghrelin receptor agonists.

Charoenthongtrakul S, Giuliana D, Longo KA, Govek EK, Nolan A, Gagne S, Morgan K, Hixon J, Flynn N, Murphy BJ, Hernández AS, Li J, Tino JA, Gordon DA, DiStefano PS, Geddes BJ.

J Pharmacol Exp Ther. 2009 Jun;329(3):1178-86. doi: 10.1124/jpet.108.150193. Epub 2009 Feb 27.

PMID:
19252061
45.

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

Mazzucchelli R, Hixon JA, Spolski R, Chen X, Li WQ, Hall VL, Willette-Brown J, Hurwitz AA, Leonard WJ, Durum SK.

Blood. 2008 Oct 15;112(8):3283-92. doi: 10.1182/blood-2008-02-137414. Epub 2008 Jul 29.

46.

A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.

Kalhan R, Smith LJ, Nlend MC, Nair A, Hixon JL, Sporn PH.

Clin Exp Allergy. 2008 Jan;38(1):103-12. Epub 2007 Nov 2.

47.

Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors.

Khan T, Stauffer JK, Williams R, Hixon JA, Salcedo R, Lincoln E, Back TC, Powell D, Lockett S, Arnold AC, Sayers TJ, Wigginton JM.

J Immunol. 2006 May 15;176(10):6302-12.

48.

Multicolor fluorescence-based approaches for imaging cytokine-induced alterations in the neovascularization, growth, metastasis, and apoptosis of murine neuroblastoma tumors.

Stauffer JK, Khan T, Salcedo R, Hixon JA, Lincoln E, Back TC, Wigginton JM.

J Immunother. 2006 Mar-Apr;29(2):151-64.

PMID:
16531816
49.

Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma.

Khan T, Hixon JA, Stauffer JK, Lincoln E, Back TC, Brenner J, Lockett S, Nagashima K, Powell D, Wigginton JM.

J Natl Cancer Inst. 2006 Feb 1;98(3):190-202.

PMID:
16449679
50.

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, Barker J, Yau WT, Amouzegh P, Flegg A, Hamelin E, Thomas RJ, Kates M, Jones S, Navia MA, Saunders JO, DiStefano PS, Curtis R.

J Med Chem. 2005 Dec 15;48(25):8045-54. Erratum in: J Med Chem. 2007 Mar 8;50(5):1086.

PMID:
16335928

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