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Items: 1 to 50 of 275

1.

Scn4b regulates the hypnotic effects of ethanol and other sedative drugs.

Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA.

Genes Brain Behav. 2019 Feb 28:e12562. doi: 10.1111/gbb.12562. [Epub ahead of print]

PMID:
30817077
2.

Cross-species molecular dissection across alcohol behavioral domains.

Farris SP, Riley BP, Williams RW, Mulligan MK, Miles MF, Lopez MF, Hitzemann R, Iancu OD, Colville A, Walter NAR, Darakjian P, Oberbeck DL, Daunais JB, Zheng CL, Searles RP, McWeeney SK, Grant KA, Mayfield RD.

Alcohol. 2018 Nov;72:19-31. doi: 10.1016/j.alcohol.2017.11.036. Epub 2017 Dec 6. Review.

3.

Regional Differences and Similarities in the Brain Transcriptome for Mice Selected for Ethanol Preference From HS-CC Founders.

Colville AM, Iancu OD, Lockwood DR, Darakjian P, McWeeney SK, Searles R, Zheng C, Hitzemann R.

Front Genet. 2018 Aug 28;9:300. doi: 10.3389/fgene.2018.00300. eCollection 2018.

4.

Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs.

Iancu OD, Colville AM, Wilmot B, Searles R, Darakjian P, Zheng C, McWeeney S, Kawane S, Crabbe JC, Metten P, Oberbeck D, Hitzemann R.

Alcohol Clin Exp Res. 2018 May 22. doi: 10.1111/acer.13777. [Epub ahead of print]

PMID:
29786871
5.

A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.

Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L.

Mol Psychiatry. 2018 Jun;23(6):1466-1473. doi: 10.1038/mp.2017.97. Epub 2017 May 2.

6.

Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID).

Hitzemann R, Oberbeck D, Iancu O, Darakjian P, McWeeney S, Spence S, Schlumbohm J, Metten P, Crabbe J.

Alcohol. 2017 May;60:115-120. doi: 10.1016/j.alcohol.2017.02.176. Epub 2017 Apr 12.

7.

NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality.

Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, Lehne B, Loh M, Tan ST, Boerwinkle E, Grams ME, Sekula P, Li M, Wilmot B, Moon JG, Scheet P, Cucca F, Xiao X, Lyytikäinen LP, Delgado G, Grammer TB, Kleber ME, Sedaghat S, Rivadeneira F, Corre T, Kutalik Z, Bergmann S, Nielson CM, Srikanth P, Teumer A, Müller-Nurasyid M, Brockhaus AC, Pfeufer A, Rathmann W, Peters A, Matsumoto M, de Andrade M, Atkinson EJ, Robinson-Cohen C, de Boer IH, Hwang SJ, Heid IM, Gögele M, Concas MP, Tanaka T, Bandinelli S, Nalls MA, Singleton A, Tajuddin SM, Adeyemo A, Zhou J, Doumatey A, McWeeney S, Murabito J, Franceschini N, Flessner M, Shlipak M, Wilson JG, Chen G, Rotimi CN, Zonderman AB, Evans MK, Ferrucci L, Devuyst O, Pirastu M, Shuldiner A, Hicks AA, Pramstaller PP, Kestenbaum B, Kardia SLR, Turner ST, Study LC, Briske TE, Gieger C, Strauch K, Meisinger C, Meitinger T, Völker U, Nauck M, Völzke H, Vollenweider P, Bochud M, Waeber G, Kähönen M, Lehtimäki T, März W, Dehghan A, Franco OH, Uitterlinden AG, Hofman A, Taylor HA, Chambers JC, Kooner JS, Fox CS, Hitzemann R, Orwoll ES, Pattaro C, Schlessinger D, Köttgen A, Snieder H, Parsa A, Cohen DM.

J Am Soc Nephrol. 2017 Aug;28(8):2311-2321. doi: 10.1681/ASN.2016080892. Epub 2017 Mar 30.

8.

On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome.

Iancu OD, Colville A, Walter NAR, Darakjian P, Oberbeck DL, Daunais JB, Zheng CL, Searles RP, McWeeney SK, Grant KA, Hitzemann R.

Addict Biol. 2018 Jan;23(1):196-205. doi: 10.1111/adb.12501. Epub 2017 Feb 28.

9.

Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice.

Colville AM, Iancu OD, Oberbeck DL, Darakjian P, Zheng CL, Walter NA, Harrington CA, Searles RP, McWeeney S, Hitzemann RJ.

Genes Brain Behav. 2017 Apr;16(4):462-471. doi: 10.1111/gbb.12367. Epub 2017 Feb 9.

10.

Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection.

Chesler EJ, Gatti DM, Morgan AP, Strobel M, Trepanier L, Oberbeck D, McWeeney S, Hitzemann R, Ferris M, McMullan R, Clayshultle A, Bell TA, Manuel de Villena FP, Churchill GA.

G3 (Bethesda). 2016 Dec 7;6(12):3893-3902. doi: 10.1534/g3.116.035527.

11.

Cosplicing network analysis of mammalian brain RNA-Seq data utilizing WGCNA and Mantel correlations.

Iancu OD, Colville A, Oberbeck D, Darakjian P, McWeeney SK, Hitzemann R.

Front Genet. 2015 May 13;6:174. doi: 10.3389/fgene.2015.00174. eCollection 2015.

12.

Splicing landscape of the eight collaborative cross founder strains.

Zheng CL, Wilmot B, Walter NA, Oberbeck D, Kawane S, Searles RP, McWeeney SK, Hitzemann R.

BMC Genomics. 2015 Feb 5;16:52. doi: 10.1186/s12864-015-1267-0.

13.

Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects.

Metten P, Iancu OD, Spence SE, Walter NA, Oberbeck D, Harrington CA, Colville A, McWeeney S, Phillips TJ, Buck KJ, Crabbe JC, Belknap JK, Hitzemann RJ.

Alcohol Clin Exp Res. 2014 Dec;38(12):2915-24. doi: 10.1111/acer.12574.

14.

Coexpression and cosplicing network approaches for the study of mammalian brain transcriptomes.

Iancu OD, Colville A, Darakjian P, Hitzemann R.

Int Rev Neurobiol. 2014;116:73-93. doi: 10.1016/B978-0-12-801105-8.00004-7. Review.

PMID:
25172472
15.

Introduction to sequencing the brain transcriptome.

Hitzemann R, Darakjian P, Walter N, Iancu OD, Searles R, McWeeney S.

Int Rev Neurobiol. 2014;116:1-19. doi: 10.1016/B978-0-12-801105-8.00001-1. Review.

16.

The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.

Hitzemann R, Bottomly D, Iancu O, Buck K, Wilmot B, Mooney M, Searles R, Zheng C, Belknap J, Crabbe J, McWeeney S.

Mamm Genome. 2014 Feb;25(1-2):12-22. doi: 10.1007/s00335-013-9495-6. Epub 2013 Dec 31. Review.

17.

Genetic factors involved in risk for methamphetamine intake and sensitization.

Belknap JK, McWeeney S, Reed C, Burkhart-Kasch S, McKinnon CS, Li N, Baba H, Scibelli AC, Hitzemann R, Phillips TJ.

Mamm Genome. 2013 Dec;24(11-12):446-58. doi: 10.1007/s00335-013-9484-9. Epub 2013 Nov 13.

18.

Differential network analysis reveals genetic effects on catalepsy modules.

Iancu OD, Oberbeck D, Darakjian P, Kawane S, Erk J, McWeeney S, Hitzemann R.

PLoS One. 2013;8(3):e58951. doi: 10.1371/journal.pone.0058951. Epub 2013 Mar 21.

19.

Selection for drinking in the dark alters brain gene coexpression networks.

Iancu OD, Oberbeck D, Darakjian P, Metten P, McWeeney S, Crabbe JC, Hitzemann R.

Alcohol Clin Exp Res. 2013 Aug;37(8):1295-303. doi: 10.1111/acer.12100. Epub 2013 Mar 29.

20.

Genes, behavior and next-generation RNA sequencing.

Hitzemann R, Bottomly D, Darakjian P, Walter N, Iancu O, Searles R, Wilmot B, McWeeney S.

Genes Brain Behav. 2013 Feb;12(1):1-12. doi: 10.1111/gbb.12007. Epub 2012 Dec 28. Review.

21.

Effects of sodium butyrate on methamphetamine-sensitized locomotor activity.

Harkness JH, Hitzemann RJ, Edmunds S, Phillips TJ.

Behav Brain Res. 2013 Feb 15;239:139-47. doi: 10.1016/j.bbr.2012.10.046. Epub 2012 Nov 5.

22.

Detection of expression quantitative trait Loci in complex mouse crosses: impact and alleviation of data quality and complex population substructure.

Iancu OD, Darakjian P, Kawane S, Bottomly D, Hitzemann R, McWeeney S.

Front Genet. 2012 Aug 27;3:157. doi: 10.3389/fgene.2012.00157. eCollection 2012.

23.

Utilizing RNA-Seq data for de novo coexpression network inference.

Iancu OD, Kawane S, Bottomly D, Searles R, Hitzemann R, McWeeney S.

Bioinformatics. 2012 Jun 15;28(12):1592-7. doi: 10.1093/bioinformatics/bts245. Epub 2012 May 3.

24.

Heritability of serum sodium concentration: evidence for sex- and ethnic-specific effects.

Wilmot B, Voruganti VS, Chang YP, Fu Y, Chen Z, Taylor HA, Wilson JG, Gipson T, Shah VO, Umans JG, Flessner MF, Hitzemann R, Shuldiner AR, Comuzzie AG, McWeeney S, Zager PG, Maccluer JW, Cole SA, Cohen DM.

Physiol Genomics. 2012 Feb 13;44(3):220-8. doi: 10.1152/physiolgenomics.00153.2011. Epub 2011 Dec 20.

25.

Gene networks and haloperidol-induced catalepsy.

Iancu OD, Darakjian P, Malmanger B, Walter NA, McWeeney S, Hitzemann R.

Genes Brain Behav. 2012 Feb;11(1):29-37. doi: 10.1111/j.1601-183X.2011.00736.x. Epub 2011 Nov 11.

26.

Modeling the diagnostic criteria for alcohol dependence with genetic animal models.

Crabbe JC, Kendler KS, Hitzemann RJ.

Curr Top Behav Neurosci. 2013;13:187-221. doi: 10.1007/7854_2011_162. Review.

27.

Computational detection of alternative exon usage.

Laderas TG, Walter NA, Mooney M, Vartanian K, Darakjian P, Buck K, Harrington CA, Belknap J, Hitzemann R, McWeeney SK.

Front Neurosci. 2011 May 13;5:69. doi: 10.3389/fnins.2011.00069. eCollection 2011.

28.

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.

Johnsen AK, Valdar W, Golden L, Ortiz-Lopez A, Hitzemann R, Flint J, Mathis D, Benoist C.

Arthritis Rheum. 2011 Sep;63(9):2630-40. doi: 10.1002/art.30425.

29.

Protein database and quantitative analysis considerations when integrating genetics and proteomics to compare mouse strains.

Fei SS, Wilmarth PA, Hitzemann RJ, McWeeney SK, Belknap JK, David LL.

J Proteome Res. 2011 Jul 1;10(7):2905-12. doi: 10.1021/pr200133p. Epub 2011 May 9.

30.

Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays.

Bottomly D, Walter NA, Hunter JE, Darakjian P, Kawane S, Buck KJ, Searles RP, Mooney M, McWeeney SK, Hitzemann R.

PLoS One. 2011 Mar 24;6(3):e17820. doi: 10.1371/journal.pone.0017820.

31.

Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse.

Iancu OD, Darakjian P, Walter NA, Malmanger B, Oberbeck D, Belknap J, McWeeney S, Hitzemann R.

BMC Genomics. 2010 Oct 19;11:585. doi: 10.1186/1471-2164-11-585.

32.

A method for mapping intralocus interactions influencing excessive alcohol drinking.

Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK.

Mamm Genome. 2010 Feb;21(1-2):39-51. doi: 10.1007/s00335-009-9239-9. Epub 2009 Dec 22.

33.

Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice.

Boudreau E, Chen G, Li X, Buck K, Hitzemann R, Hickman D.

Lab Anim (NY). 2010 Jan;39(1):23-5. doi: 10.1038/laban0110-23.

34.

Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice.

Chen G, Reilly MT, Kozell LB, Hitzemann R, Buck KJ.

Alcohol. 2009 Sep;43(6):411-20. doi: 10.1016/j.alcohol.2009.05.003.

35.

High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs.

Walter NA, Bottomly D, Laderas T, Mooney MA, Darakjian P, Searles RP, Harrington CA, McWeeney SK, Hitzemann R, Buck KJ.

BMC Genomics. 2009 Aug 17;10:379. doi: 10.1186/1471-2164-10-379.

36.

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.

Tian W, Fu Y, Garcia-Elias A, Fernández-Fernández JM, Vicente R, Kramer PL, Klein RF, Hitzemann R, Orwoll ES, Wilmot B, McWeeney S, Valverde MA, Cohen DM.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14034-9. doi: 10.1073/pnas.0904084106. Epub 2009 Aug 4.

37.

Electrolytic lesions of the medial nucleus accumbens shell selectively decrease ethanol consumption without altering preference in a limited access procedure in C57BL/6J mice.

Dhaher R, Finn DA, Oberbeck DL, Yoneyama N, Snelling CC, Wu W, Hitzemann RJ.

Pharmacol Biochem Behav. 2009 Apr;92(2):335-42.

PMID:
19353807
38.

Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice.

Hitzemann R, Edmunds S, Wu W, Malmanger B, Walter N, Belknap J, Darakjian P, McWeeney S.

Psychopharmacology (Berl). 2009 May;203(4):713-22. doi: 10.1007/s00213-008-1418-y. Epub 2008 Dec 4.

39.

Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus.

Chen G, Kozell LB, Hitzemann R, Buck KJ.

J Neurosci. 2008 Sep 24;28(39):9840-9. doi: 10.1523/JNEUROSCI.1713-08.2008.

40.

Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines.

Hitzemann R, Malmanger B, Belknap J, Darakjian P, McWeeney S.

Pharmacol Biochem Behav. 2008 Oct;90(4):525-33. doi: 10.1016/j.pbb.2008.04.004.

41.

Internet resources for genomic, bioinformatics, and medical genetics information.

Phillips TJ, Belknap JK, Hitzemann RJ, Buck KJ, Cunningham CL, Crabbe JC.

Curr Protoc Neurosci. 2003 May;Appendix 5:Appendix 5A. doi: 10.1002/0471142301.nsa05as22.

PMID:
18428575
42.

Conclusions.

Hitzemann R, Oberbeck D.

Alcohol Res Health. 2008;31(3):278. No abstract available.

43.

Single-nucleotide polymorphism masking.

Walter NA, McWeeney SK, Peters ST, Belknap JK, Hitzemann R, Buck KJ.

Alcohol Res Health. 2008;31(3):270-1. Review.

44.

Quantitative trait locus analysis: multiple cross and heterogeneous stock mapping.

Hitzemann R, Belknap JK, McWeeney SK.

Alcohol Res Health. 2008;31(3):261-5. Review.

45.

Strategies to study the neuroscience of alcoholism: introduction.

Hitzemann R, Oberbeck D.

Alcohol Res Health. 2008;31(3):231-2.

46.

Lesions of the extended amygdala in C57BL/6J mice do not block the intermittent ethanol vapor-induced increase in ethanol consumption.

Dhaher R, Finn D, Snelling C, Hitzemann R.

Alcohol Clin Exp Res. 2008 Feb;32(2):197-208. Epub 2007 Dec 20.

PMID:
18162080
47.

SNPs matter: impact on detection of differential expression.

Walter NA, McWeeney SK, Peters ST, Belknap JK, Hitzemann R, Buck KJ.

Nat Methods. 2007 Sep;4(9):679-80. No abstract available.

48.

Characterization of the quantitative trait locus for haloperidol-induced catalepsy on distal mouse chromosome 1.

Hofstetter JR, Hitzemann RJ, Belknap JK, Walter NA, McWeeney SK, Mayeda AR.

Genes Brain Behav. 2008 Mar;7(2):214-23. Epub 2007 Aug 13.

49.

Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci.

Malmanger B, Lawler M, Coulombe S, Murray R, Cooper S, Polyakov Y, Belknap J, Hitzemann R.

Mamm Genome. 2006 Dec;17(12):1193-204. Epub 2006 Dec 1.

PMID:
17143586
50.

Neuropsychological function and delay discounting in methamphetamine-dependent individuals.

Hoffman WF, Moore M, Templin R, McFarland B, Hitzemann RJ, Mitchell SH.

Psychopharmacology (Berl). 2006 Oct;188(2):162-70. Epub 2006 Aug 17.

PMID:
16915378

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