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Items: 41

1.

Methylated SEPTIN9 plasma test for colorectal cancer detection may be applicable to Lynch syndrome.

Hitchins MP, Vogelaar IP, Brennan K, Haraldsdottir S, Zhou N, Martin B, Alvarez R, Yuan X, Kim S, Guindi M, Hendifar AE, Kalady MF, DeVecchio J, Church JM, de la Chapelle A, Hampel H, Pearlman R, Christensen M, Snyder C, Lanspa SJ, Haile RW, Lynch HT.

BMJ Open Gastroenterol. 2019 May 28;6(1):e000299. doi: 10.1136/bmjgast-2019-000299. eCollection 2019.

2.

A systematic review of studies of DNA methylation in the context of a weight loss intervention.

Aronica L, Levine AJ, Brennan K, Mi J, Gardner C, Haile RW, Hitchins MP.

Epigenomics. 2017 May;9(5):769-787. doi: 10.2217/epi-2016-0182. Review.

3.

SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.

Kuroiwa-Trzmielina J, Wang F, Rapkins RW, Ward RL, Buchanan DD, Win AK, Clendenning M, Rosty C, Southey MC, Winship IM, Hopper JL, Jenkins MA, Olivier J, Hawkins NJ, Hitchins MP.

Clin Cancer Res. 2016 Dec 15;22(24):6266-6277. Epub 2016 Jun 7.

4.

Finding the needle in a haystack: identification of cases of Lynch syndrome with MLH1 epimutation.

Hitchins MP.

Fam Cancer. 2016 Jul;15(3):413-22. doi: 10.1007/s10689-016-9887-3. Review.

PMID:
26886015
5.

Constitutional epimutation as a mechanism for cancer causality and heritability?

Hitchins MP.

Nat Rev Cancer. 2015 Oct;15(10):625-34. doi: 10.1038/nrc4001. Epub 2015 Sep 18. Review.

PMID:
26383139
6.

Allele Quantification Pyrosequencing® at Designated SNP Sites to Detect Allelic Expression Imbalance and Loss-of-Heterozygosity.

Kwok CT, Hitchins MP.

Methods Mol Biol. 2015;1315:153-71. doi: 10.1007/978-1-4939-2715-9_12.

PMID:
26103898
7.

The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.

Rapkins RW, Wang F, Nguyen HN, Cloughesy TF, Lai A, Ha W, Nowak AK, Hitchins MP, McDonald KL.

Neuro Oncol. 2015 Dec;17(12):1589-98. doi: 10.1093/neuonc/nov064. Epub 2015 Apr 24.

8.

Milestones of Lynch syndrome: 1895-2015.

Lynch HT, Snyder CL, Shaw TG, Heinen CD, Hitchins MP.

Nat Rev Cancer. 2015 Mar;15(3):181-94. doi: 10.1038/nrc3878. Epub 2015 Feb 12. Review.

PMID:
25673086
9.

Expression of GBGT1 is epigenetically regulated by DNA methylation in ovarian cancer cells.

Jacob F, Hitchins MP, Fedier A, Brennan K, Nixdorf S, Hacker NF, Ward R, Heinzelmann-Schwarz VA.

BMC Mol Biol. 2014 Oct 7;15:24. doi: 10.1186/1471-2199-15-24.

10.

Dawning of the epigenetic era in hereditary cancer.

Hitchins MP, Lynch HT.

Clin Genet. 2014 May;85(5):413-6. doi: 10.1111/cge.12369. No abstract available.

PMID:
24588205
11.

The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype.

Kwok CT, Vogelaar IP, van Zelst-Stams WA, Mensenkamp AR, Ligtenberg MJ, Rapkins RW, Ward RL, Chun N, Ford JM, Ladabaum U, McKinnon WC, Greenblatt MS, Hitchins MP.

Eur J Hum Genet. 2014 May;22(5):617-24. doi: 10.1038/ejhg.2013.200. Epub 2013 Oct 2.

12.

The role of epigenetics in Lynch syndrome.

Hitchins MP.

Fam Cancer. 2013 Jun;12(2):189-205. doi: 10.1007/s10689-013-9613-3. Review.

PMID:
23462881
13.

The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients.

McDonald KL, Rapkins RW, Olivier J, Zhao L, Nozue K, Lu D, Tiwari S, Kuroiwa-Trzmielina J, Brewer J, Wheeler HR, Hitchins MP.

Eur J Cancer. 2013 Jan;49(2):360-8. doi: 10.1016/j.ejca.2012.08.012. Epub 2012 Sep 10.

PMID:
22975219
14.

Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry.

Ward RL, Dobbins T, Lindor NM, Rapkins RW, Hitchins MP.

Genet Med. 2013 Jan;15(1):25-35. doi: 10.1038/gim.2012.91. Epub 2012 Aug 9.

15.

Alu in Lynch syndrome: a danger SINE?

Hitchins MP, Burn J.

Cancer Prev Res (Phila). 2011 Oct;4(10):1527-30. doi: 10.1158/1940-6207.CAPR-11-0417.

16.

Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR.

Hitchins MP, Rapkins RW, Kwok CT, Srivastava S, Wong JJ, Khachigian LM, Polly P, Goldblatt J, Ward RL.

Cancer Cell. 2011 Aug 16;20(2):200-13. doi: 10.1016/j.ccr.2011.07.003.

17.

Identification of new cases of early-onset colorectal cancer with an MLH1 epimutation in an ethnically diverse South African cohort.

Hitchins MP, Owens SE, Kwok CT, Godsmark G, Algar UF, Ramesar RS.

Clin Genet. 2011 Nov;80(5):428-34. doi: 10.1111/j.1399-0004.2011.01660.x. Epub 2011 May 4.

PMID:
21375527
18.

Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.

Wong JJ, Hawkins NJ, Ward RL, Hitchins MP.

Mod Pathol. 2011 Mar;24(3):396-411. doi: 10.1038/modpathol.2010.212. Epub 2010 Nov 19.

19.

Inheritance of epigenetic aberrations (constitutional epimutations) in cancer susceptibility.

Hitchins MP.

Adv Genet. 2010;70:201-43. doi: 10.1016/B978-0-12-380866-0.60008-3. Review.

PMID:
20920750
20.

De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one.

Goel A, Nguyen TP, Leung HC, Nagasaka T, Rhees J, Hotchkiss E, Arnold M, Banerji P, Koi M, Kwok CT, Packham D, Lipton L, Boland CR, Ward RL, Hitchins MP.

Int J Cancer. 2011 Feb 15;128(4):869-78. doi: 10.1002/ijc.25422.

21.

Epimutations and cancer predisposition: importance and mechanisms.

Hesson LB, Hitchins MP, Ward RL.

Curr Opin Genet Dev. 2010 Jun;20(3):290-8. doi: 10.1016/j.gde.2010.02.005. Epub 2010 Mar 31. Review.

PMID:
20359882
22.

Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome.

Kwok CT, Ward RL, Hawkins NJ, Hitchins MP.

Fam Cancer. 2010 Sep;9(3):345-56. doi: 10.1007/s10689-009-9314-0.

PMID:
20063070
23.

Epigenetic changes in childhood asthma.

Kumar RK, Hitchins MP, Foster PS.

Dis Model Mech. 2009 Nov-Dec;2(11-12):549-53. doi: 10.1242/dmm.001719.

24.

Favoritism in DNA methylation.

Hitchins MP, Ward RL.

Cancer Prev Res (Phila). 2009 Oct;2(10):847-9. doi: 10.1158/1940-6207.CAPR-09-0178. Epub 2009 Sep 29. Review.

25.

MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.

Hawkins NJ, Lee JH, Wong JJ, Kwok CT, Ward RL, Hitchins MP.

Mod Pathol. 2009 Dec;22(12):1588-99. doi: 10.1038/modpathol.2009.130. Epub 2009 Sep 4.

26.

Constitutional (germline) MLH1 epimutation as an aetiological mechanism for hereditary non-polyposis colorectal cancer.

Hitchins MP, Ward RL.

J Med Genet. 2009 Dec;46(12):793-802. doi: 10.1136/jmg.2009.068122. Epub 2009 Jun 29. Review.

PMID:
19564652
27.

Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers.

Packham D, Ward RL, Ap Lin V, Hawkins NJ, Hitchins MP.

Diagn Mol Pathol. 2009 Jun;18(2):62-71. doi: 10.1097/PDM.0b013e318182af52.

PMID:
19430299
28.

MLH1 germ-line epimutations: is there strong evidence of its inheritance?

Hitchins MP, Ward RL.

Gastroenterology. 2008 Jan;134(1):359-60. doi: 10.1053/j.gastro.2007.11.054. No abstract available.

PMID:
18166368
29.

Erasure of MLH1 methylation in spermatozoa-implications for epigenetic inheritance.

Hitchins MP, Ward RL.

Nat Genet. 2007 Nov;39(11):1289. No abstract available.

PMID:
17968340
30.

Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer.

Hitchins MP, Lin VA, Buckle A, Cheong K, Halani N, Ku S, Kwok CT, Packham D, Suter CM, Meagher A, Stirzaker C, Clark S, Hawkins NJ, Ward RL.

Cancer Res. 2007 Oct 1;67(19):9107-16.

31.

Inheritance of a cancer-associated MLH1 germ-line epimutation.

Hitchins MP, Wong JJ, Suthers G, Suter CM, Martin DI, Hawkins NJ, Ward RL.

N Engl J Med. 2007 Feb 15;356(7):697-705.

32.

Genomic imprinting in fetal growth and development.

Hitchins MP, Moore GE.

Expert Rev Mol Med. 2002 May 9;4(11):1-19. doi: 10.1017/S146239940200457X. Review.

PMID:
14987379
33.

Investigation of UBE3A and MECP2 in Angelman syndrome (AS) and patients with features of AS.

Hitchins MP, Rickard S, Dhalla F, Fairbrother UL, de Vries BB, Winter R, Pembrey ME, Malcolm S.

Am J Med Genet A. 2004 Mar 1;125A(2):167-72. Erratum in: Am J Med Genet A. 2005 Jun 15;135(3):346. Fairbrother, Una L [added].

PMID:
14981718
34.

DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed.

Hitchins MP, Bentley L, Monk D, Beechey C, Peters J, Kelsey G, Ishino F, Preece MA, Stanier P, Moore GE.

Mamm Genome. 2002 Dec;13(12):686-91.

PMID:
12514746
35.

Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32.

Nakabayashi K, Bentley L, Hitchins MP, Mitsuya K, Meguro M, Minagawa S, Bamforth JS, Stanier P, Preece M, Weksberg R, Oshimura M, Moore GE, Scherer SW.

Hum Mol Genet. 2002 Jul 15;11(15):1743-56.

PMID:
12095916
36.

Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q.

Hitchins MP, Abu-Amero S, Apostolidou S, Monk D, Stanier P, Preece MA, Moore GE.

J Med Genet. 2002 Mar;39(3):E13. No abstract available.

37.

Silver-Russell syndrome: a dissection of the genetic aetiology and candidate chromosomal regions.

Hitchins MP, Stanier P, Preece MA, Moore GE.

J Med Genet. 2001 Dec;38(12):810-9. Review.

38.

Maternal repression of the human GRB10 gene in the developing central nervous system; evaluation of the role for GRB10 in Silver-Russell syndrome.

Hitchins MP, Monk D, Bell GM, Ali Z, Preece MA, Stanier P, Moore GE.

Eur J Hum Genet. 2001 Feb;9(2):82-90.

39.

Conflicting reports of imprinting status of human GRB10 in developing brain: how reliable are somatic cell hybrids for predicting allelic origin of expression?

Mergenthaler S, Hitchins MP, Blagitko-Dorfs N, Monk D, Wollmann HA, Ranke MB, Ropers HH, Apostolidou S, Stanier P, Preece MA, Eggermann T, Kalscheuer VM, Moore GE.

Am J Hum Genet. 2001 Feb;68(2):543-5. No abstract available.

40.

Biallelic expression of IGFBP1 and IGFBP3, two candidate genes for the Silver-Russell syndrome.

Wakeling EL, Hitchins MP, Abu-Amero SN, Stanier P, Moore GE, Preece MA.

J Med Genet. 2000 Jan;37(1):65-7. No abstract available.

41.

Report of the fourth international workshop on human chromosome 15 mapping 1997.

Morton CC, Christian SL, Donlon TA, Driscoll DJ, Fink JK, Gabriel JM, Gotway G, Greally JM, Hitchins MP, Howard HC, Ji Y, Leonard S, Lerner T, Magenis E, Malcolm S, Ohta T, Rainier S, Rees M, Riley B, Robinson WP, Saitoh S, Schultz R, Sell S, Sharp JD, Nicholls RD, et al.

Cytogenet Cell Genet. 1999;84(1-2):12-21. No abstract available.

PMID:
10343092

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