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Items: 1 to 50 of 138

1.

Health care and life expectancy.

Hitchings GH.

Science. 1993 Dec 10;262(5140):1632.

PMID:
8259500
2.

Antagonists of nucleic acid derivatives as medicinal agents.

Hitchings GH.

Annu Rev Pharmacol Toxicol. 1992;32:1-6. Review. No abstract available.

PMID:
1605564
3.

Biochemical approach to new medications.

Hitchings GH.

Int J Tissue React. 1992;14(2):49-54.

PMID:
1399321
4.

The third Paul Ehrlich lecture. Basic research as forerunner of new medications.

Hitchings GH.

Med Res Rev. 1991 Jan;11(1):1-15. No abstract available.

PMID:
1994151
5.

Properties of purine and pyrimidine analogs.

Hitchings GH.

Adv Enzyme Regul. 1991;31:433-43. Review. No abstract available.

PMID:
1877398
6.

Biochemical approach to new medications.

Hitchings GH.

Adv Exp Med Biol. 1991;309A:1-6. Review. No abstract available.

PMID:
1789185
7.

Industry is responding to the crisis in biomedical-research brainpower.

Hitchings GH, Peck MG.

N Engl J Med. 1990 Apr 5;322(14):1011-2. No abstract available.

PMID:
2314442
8.

Nobel lecture in physiology or medicine--1988. Selective inhibitors of dihydrofolate reductase.

Hitchings GH Jr.

In Vitro Cell Dev Biol. 1989 Apr;25(4):303-10. No abstract available.

PMID:
2654121
9.

Substrate-inhibitor cooperative interactions with microbial dihydrofolate reductases.

Baccanari DP, Tansik RL, Hitchings GH.

Adv Enzyme Regul. 1987;26:3-15.

PMID:
3314400
10.

Layer on layer: the Bruce F. Cain memorial Award lecture.

Hitchings GH, Elion GB.

Cancer Res. 1985 Jun;45(6):2415-20. No abstract available.

11.

A biochemical approach to chemotherapy.

Hitchings GH.

Drug Intell Clin Pharm. 1982 Nov;16(11):843-8.

PMID:
6890894
12.

The purine metabolism of protozoa.

Hitchings GH.

Adv Enzyme Regul. 1982;20:375-86.

PMID:
7113802
13.

Differences among immunosuppressive agents.

Hitchings GH.

Ann Rheum Dis. 1982;41 Suppl 1:9-11.

14.

Dihydrofolate reductases as targets for inhibitors.

Hitchings GH, Smith SL.

Adv Enzyme Regul. 1980;18:349-71. No abstract available.

PMID:
7446303
15.

Arterial pressure studies during carotid angiography.

Phillips G, Hitchings GM, Campkin TV.

Br J Anaesth. 1977 Feb;49(2):163-7.

16.

Trimethoprim/sulfonamide: rational combination therapy.

Hitchings GH, Singleton SW.

Compr Ther. 1976 May;2(5):55-63. Review. No abstract available.

PMID:
776520
17.

Panel on public service drugs and new uses for old drugs.

Atkinson AJ Jr, Finkel MJ, Burns JJ, Hitchings GH, Kemp BA, de Dennis SR.

Clin Pharmacol Ther. 1975 Nov;18(5 Pt 2):659-62. No abstract available.

PMID:
1102245
18.

Pharmacology of allopurinol.

Hitchings GH.

Arthritis Rheum. 1975 Nov-Dec;18(6 Suppl):863-70. No abstract available.

PMID:
1201131
19.

Specific TLC determination of trimethoprim and sulfamethoxazole in plasma.

Sigel CW, Grace ME, Nichol CA, Hitchings GH.

J Pharm Sci. 1974 Aug;63(8):1212-5. No abstract available.

PMID:
4854354
20.

The molecular basis for the effects of allopurinol on pyrimidine metabolism.

Fyfe JA, Nelson DJ, Hitchings GH.

Adv Exp Med Biol. 1974;41:621-8. No abstract available.

PMID:
4832588
21.
22.

Mechanism of action of trimethoprim-sulfamethoxazole. I.

Hitchings GH.

J Infect Dis. 1973 Nov;128:Suppl:433-6 p. No abstract available.

PMID:
4758044
23.

Biochemical background of trimethoprim-sulphamethoxazole.

Hitchings GH.

Med J Aust. 1973 Jun 30;1(2):Suppl:5-9. No abstract available.

PMID:
4580589
24.

A comparison of the specificities of xanthine oxidase and aldehyde oxidase.

Krenitsky TA, Neil SM, Elion GB, Hitchings GH.

Arch Biochem Biophys. 1972 Jun;150(2):585-99. No abstract available.

PMID:
5044040
25.

Folate antagonists as antibacterial and antiprotozoal agents.

Hitchings GH.

Ann N Y Acad Sci. 1971 Nov 30;186:444-51. Review. No abstract available.

PMID:
5002439
26.

Crystals in skeletal muscle.

Hitchings GH.

Br Med J. 1971 Nov 27;4(5786):555-6. No abstract available.

27.

Trimethoprim: biochemical basis for sulphonamide potentiation.

Hitchings GH.

S Afr Med J. 1970 Aug 15;44(32):Suppl:1-2. No abstract available.

PMID:
5505880
28.

Species differences among dihydrofolate reductases as a basis for chemotherapy.

Hitchings GH.

Postgrad Med J. 1969 Nov;45:Suppl:7-10. No abstract available.

PMID:
5361314
29.

Chemotherapy and comparative biochemistry: G. H. A. Clowes memorial lecture.

Hitchings GH.

Cancer Res. 1969 Nov;29(11):1895-903. Review. No abstract available.

30.

Adenine phosphoribosyltransferase from monkey liver. Specificity and properties.

Krenitsky TA, Neil SM, Elion GB, Hitchings GH.

J Biol Chem. 1969 Sep 10;244(17):4779-84. No abstract available.

31.

A quarter century of chemotherapy.

Hitchings GH.

JAMA. 1969 Sep 1;209(9):1339-40. No abstract available.

PMID:
4895871
32.

Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates.

Ferone R, Burchall JJ, Hitchings GH.

Mol Pharmacol. 1969 Jan;5(1):49-59. No abstract available.

PMID:
4392112
33.

Studies on condensed pyrimidine systems. 23. Synthesis of 2,4-diaminopyrido[2,3-d]pyrimidines from beta-keto esters.

Hurlbert BS, Ledig KW, Stenbuck P, Valenti BF, Hitchings GH.

J Med Chem. 1968 Jul;11(4):703-7. No abstract available.

PMID:
5671228
34.

Renal clearance of oxipurinol, the chief metabolite of allopurinol.

Elion GB, YĆ¼ TF, Gutman AB, Hitchings GH.

Am J Med. 1968 Jul;45(1):69-77. No abstract available.

PMID:
5658870
35.

Studies on condensed pyrimidine systems. XXV. 2,4-diaminopyrido[2,3-d]pyrimidines. Biological data.

Hurlbert BS, Ferone R, Herrmann TA, Hitchings GH, Barnett M, Bushby SR.

J Med Chem. 1968 Jul;11(4):711-7. No abstract available.

PMID:
4970356
36.

Inhibition of human purine nucleoside phosphorylase. Studies with intact erythrocytes and the purified enzyme.

Krenitsky TA, Elion GB, Henderson AM, Hitchings GH.

J Biol Chem. 1968 Jun 10;243(11):2876-81. No abstract available.

37.

Purine thioglycosides. I. S-Glycosides of 6-mercaptopurine.

Goodman I, Salce L, Hitchings GH.

J Med Chem. 1968 May;11(3):516-21. No abstract available.

PMID:
5656489
38.

Trimethoprim, a sulphonamide potentiator.

Bushby SR, Hitchings GH.

Br J Pharmacol Chemother. 1968 May;33(1):72-90. No abstract available.

39.

[Extracorporal enzyme therapy].

Hitchings GH.

Rev Fr Etud Clin Biol. 1968 Jan;13(1):15-6. French. No abstract available.

PMID:
5653553
40.

The role of metabolites and antimetabolites in the control of folate coenzyme synthesis.

Burchall JJ, Hitchings GH.

Adv Enzyme Regul. 1968;6:323-33. Review. No abstract available.

PMID:
4976451
41.

Role of inhibitors in studies of comparative enzymology.

Hitchings GH.

Fed Proc. 1967 Jul-Aug;26(4):1078-81. No abstract available.

PMID:
6028773
42.

Ribonucleosides of allopurinol and oxoallopurinol. Isolation from human urine, enzymatic synthesis, and characterization.

Krenitsky TA, Elion GB, Strelitz RA, Hitchings GH.

J Biol Chem. 1967 Jun 10;242(11):2675-82. No abstract available.

43.

Symposium on immunosuppressive drugs. Summary and concluding remarks.

Hitchings GH.

Fed Proc. 1967 May-Jun;26(3):958-60. Review. No abstract available.

PMID:
5337290
44.

Effects of allopurinol in relation to purine biosynthesis.

Hitchings GH.

Ann Rheum Dis. 1966 Nov;25(6 Suppl):601-7. doi: 10.1136/ard.25.Suppl_6.601. Review. No abstract available.

45.

Folate cofactor biosynthesis by Plasmodium berghei. Comparison of folate and dihydrofolate as substrates.

Ferone R, Hitchings GH.

J Protozool. 1966 Aug;13(3):504-6. No abstract available.

PMID:
4381842
46.

Metabolic studies of allopurinol, an inhibitor of xanthine oxidase.

Elion GB, Kovensky A, Hitchings GH.

Biochem Pharmacol. 1966 Jul;15(7):863-80. No abstract available.

PMID:
5967902
47.

Thioguanine in deoxyribonucleic acid from tumors of 6-mercaptopurine-treated mice.

Scannell JP, Hitchings GH.

Proc Soc Exp Biol Med. 1966 Jul;122(3):627-9. No abstract available.

PMID:
5918923
48.

Species differences among dihydrofolate reductases.

Hitchings GH, Burchall JJ.

Fed Proc. 1966 May-Jun;25(3):881-3. No abstract available.

PMID:
5941012
49.

Resistance to inhibitors of dihydrofolate reductase in strains of Lactobacillus casei and Proteus vulgaris.

Singer S, Elion GB, Hitchings GH.

J Gen Microbiol. 1966 Feb;42(2):185-96. No abstract available.

PMID:
5912585
50.

Inhibitors of dihydrofolic acid reductase in the therapy of infectious diseases.

Hitchings GH.

Bibl Nutr Dieta. 1966;8:226-37. No abstract available.

PMID:
5331137

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