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Items: 1 to 50 of 81

1.

Distinct sites in tropomyosin specify shared and isoform-specific regulation of myosins II and V.

Barua B, Sckolnick M, White HD, Trybus KM, Hitchcock-DeGregori SE.

Cytoskeleton (Hoboken). 2018 Apr;75(4):150-163. doi: 10.1002/cm.21440. Epub 2018 Mar 26.

PMID:
29500902
2.

Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.

Christensen JR, Hocky GM, Homa KE, Morganthaler AN, Hitchcock-DeGregori SE, Voth GA, Kovar DR.

Elife. 2017 Mar 10;6. pii: e23152. doi: 10.7554/eLife.23152.

3.

Tropomyosin Structure, Function, and Interactions: A Dynamic Regulator.

Hitchcock-DeGregori SE, Barua B.

Subcell Biochem. 2017;82:253-284. doi: 10.1007/978-3-319-49674-0_9. Review.

PMID:
28101865
4.

Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation.

Zheng W, Hitchcock-DeGregori SE, Barua B.

J Muscle Res Cell Motil. 2016 Oct;37(4-5):131-147. Epub 2016 Jul 4.

PMID:
27376658
5.

Evolutionarily conserved sites in yeast tropomyosin function in cell polarity, transport and contractile ring formation.

Cranz-Mileva S, MacTaggart B, Russell J, Hitchcock-DeGregori SE.

Biol Open. 2015 Jul 17;4(8):1040-51. doi: 10.1242/bio.012609.

6.

A systematic nomenclature for mammalian tropomyosin isoforms.

Geeves MA, Hitchcock-DeGregori SE, Gunning PW.

J Muscle Res Cell Motil. 2015 Apr;36(2):147-53. doi: 10.1007/s10974-014-9389-6. Epub 2014 Nov 5. Review.

7.

Hugh E. Huxley: the compleat biophysicist.

Hitchcock-DeGregori SE, Irving TC.

Biophys J. 2014 Oct 7;107(7):1493-501. doi: 10.1016/j.bpj.2014.07.069.

8.

Regulation of nonmuscle myosin II by tropomyosin.

Barua B, Nagy A, Sellers JR, Hitchcock-DeGregori SE.

Biochemistry. 2014 Jun 24;53(24):4015-24. doi: 10.1021/bi500162z. Epub 2014 Jun 12.

9.

A molecular evolution approach to study the roles of tropomyosin in fission yeast.

Cranz-Mileva S, Pamula MC, Barua B, Desai B, Hong YH, Russell J, Trent R, Wang J, Walworth NC, Hitchcock-DeGregori SE.

PLoS One. 2013 Oct 22;8(10):e76726. doi: 10.1371/journal.pone.0076726. eCollection 2013.

10.

Probing the flexibility of tropomyosin and its binding to filamentous actin using molecular dynamics simulations.

Zheng W, Barua B, Hitchcock-DeGregori SE.

Biophys J. 2013 Oct 15;105(8):1882-92. doi: 10.1016/j.bpj.2013.09.003.

11.

A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin.

Barua B, Fagnant PM, Winkelmann DA, Trybus KM, Hitchcock-DeGregori SE.

J Biol Chem. 2013 Apr 5;288(14):9602-9. doi: 10.1074/jbc.M113.451161. Epub 2013 Feb 18.

12.

Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin.

Barua B, Winkelmann DA, White HD, Hitchcock-DeGregori SE.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18425-30. doi: 10.1073/pnas.1212754109. Epub 2012 Oct 22.

13.

The role of tropomyosin domains in cooperative activation of the actin-myosin interaction.

Oguchi Y, Ishizuka J, Hitchcock-DeGregori SE, Ishiwata S, Kawai M.

J Mol Biol. 2011 Dec 16;414(5):667-80. doi: 10.1016/j.jmb.2011.10.026. Epub 2011 Oct 20.

14.

Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin.

Barua B, Pamula MC, Hitchcock-DeGregori SE.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10150-5. doi: 10.1073/pnas.1101221108. Epub 2011 Jun 3.

15.

Systematic analysis of tropomodulin/tropomyosin interactions uncovers fine-tuned binding specificity of intrinsically disordered proteins.

Uversky VN, Shah SP, Gritsyna Y, Hitchcock-DeGregori SE, Kostyukova AS.

J Mol Recognit. 2011 Jul-Aug;24(4):647-55. doi: 10.1002/jmr.1093.

PMID:
21584876
16.

Tropomyosin period 3 is essential for enhancement of isometric tension in thin filament-reconstituted bovine myocardium.

Kawai M, Lu X, Hitchcock-Degregori SE, Stanton KJ, Wandling MW.

J Biophys. 2009;2009:380967. doi: 10.1155/2009/380967. Epub 2009 Oct 13.

17.

What makes tropomyosin an actin binding protein? A perspective.

Hitchcock-DeGregori SE, Singh A.

J Struct Biol. 2010 May;170(2):319-24. doi: 10.1016/j.jsb.2009.12.013. Epub 2009 Dec 29.

18.

A peek into tropomyosin binding and unfolding on the actin filament.

Singh A, Hitchcock-Degregori SE.

PLoS One. 2009 Jul 24;4(7):e6336. doi: 10.1371/journal.pone.0006336.

19.

Tropomyosin: function follows structure.

Hitchcock-DeGregori SE.

Adv Exp Med Biol. 2008;644:60-72. Review.

PMID:
19209813
20.

Structure of the N terminus of a nonmuscle alpha-tropomyosin in complex with the C terminus: implications for actin binding.

Greenfield NJ, Kotlyanskaya L, Hitchcock-DeGregori SE.

Biochemistry. 2009 Feb 17;48(6):1272-83. doi: 10.1021/bi801861k.

21.

Tropomyosin's periods are quasi-equivalent for actin binding but have specific regulatory functions.

Singh A, Hitchcock-DeGregori SE.

Biochemistry. 2007 Dec 25;46(51):14917-27. Epub 2007 Dec 4.

PMID:
18052203
22.

Molecular basis of tropomyosin binding to tropomodulin, an actin-capping protein.

Kostyukova AS, Hitchcock-Degregori SE, Greenfield NJ.

J Mol Biol. 2007 Sep 21;372(3):608-18. Epub 2007 Jun 2.

23.

Tropomyosin regulates elongation by formin at the fast-growing end of the actin filament.

Wawro B, Greenfield NJ, Wear MA, Cooper JA, Higgs HN, Hitchcock-DeGregori SE.

Biochemistry. 2007 Jul 10;46(27):8146-55. Epub 2007 Jun 15.

24.

Tropomyosin: regulator of actin filaments.

Hitchcock-DeGregori SE, Greenfield NJ, Singh A.

Adv Exp Med Biol. 2007;592:87-97. Review. No abstract available.

PMID:
17278358
25.

Chemotaxis: Cofilin in the driver's seat.

Hitchcock-Degregori SE.

Curr Biol. 2006 Dec 19;16(24):R1030-2.

26.

Solution NMR structure of the junction between tropomyosin molecules: implications for actin binding and regulation.

Greenfield NJ, Huang YJ, Swapna GV, Bhattacharya A, Rapp B, Singh A, Montelione GT, Hitchcock-DeGregori SE.

J Mol Biol. 2006 Nov 17;364(1):80-96. Epub 2006 Aug 17.

PMID:
16999976
27.
28.

Structural requirements of tropomodulin for tropomyosin binding and actin filament capping.

Kostyukova AS, Rapp BA, Choy A, Greenfield NJ, Hitchcock-DeGregori SE.

Biochemistry. 2005 Mar 29;44(12):4905-10.

PMID:
15779917
29.

Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin.

Gupton SL, Anderson KL, Kole TP, Fischer RS, Ponti A, Hitchcock-DeGregori SE, Danuser G, Fowler VM, Wirtz D, Hanein D, Waterman-Storer CM.

J Cell Biol. 2005 Feb 14;168(4):619-31.

30.

Structure and tropomyosin binding properties of the N-terminal capping domain of tropomodulin 1.

Greenfield NJ, Kostyukova AS, Hitchcock-DeGregori SE.

Biophys J. 2005 Jan;88(1):372-83. Epub 2004 Oct 8.

31.

Effect of the structure of the N terminus of tropomyosin on tropomodulin function.

Kostyukova AS, Hitchcock-DeGregori SE.

J Biol Chem. 2004 Feb 13;279(7):5066-71. Epub 2003 Dec 2.

32.

Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding.

Singh A, Hitchcock-DeGregori SE.

Biochemistry. 2003 Dec 9;42(48):14114-21.

PMID:
14640678
33.

Now, swing your partner! 3D-domain switching of WASP activates Arp2/3 complex.

Hitchcock-DeGregori SE.

Nat Struct Biol. 2003 Aug;10(8):583-4. No abstract available.

PMID:
12886288
34.

Tropomyosin ends determine the stability and functionality of overlap and troponin T complexes.

Palm T, Greenfield NJ, Hitchcock-DeGregori SE.

Biophys J. 2003 May;84(5):3181-9.

35.

The structure of the carboxyl terminus of striated alpha-tropomyosin in solution reveals an unusual parallel arrangement of interacting alpha-helices.

Greenfield NJ, Swapna GV, Huang Y, Palm T, Graboski S, Montelione GT, Hitchcock-DeGregori SE.

Biochemistry. 2003 Jan 28;42(3):614-9.

PMID:
12534273
36.

Functions of tropomyosin's periodic repeats.

Hitchcock-DeGregori SE, Song Y, Greenfield NJ.

Biochemistry. 2002 Dec 17;41(50):15036-44.

PMID:
12475253
37.

Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge.

DesMarais V, Ichetovkin I, Condeelis J, Hitchcock-DeGregori SE.

J Cell Sci. 2002 Dec 1;115(Pt 23):4649-60.

38.
39.

Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region.

Palm T, Graboski S, Hitchcock-DeGregori SE, Greenfield NJ.

Biophys J. 2001 Nov;81(5):2827-37. Erratum in: Biophys J 2002 May;82(5):2826.

40.

Solution NMR structure and folding dynamics of the N terminus of a rat non-muscle alpha-tropomyosin in an engineered chimeric protein.

Greenfield NJ, Huang YJ, Palm T, Swapna GV, Monleon D, Montelione GT, Hitchcock-DeGregori SE.

J Mol Biol. 2001 Sep 28;312(4):833-47.

PMID:
11575936
41.

Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin.

Blanchoin L, Pollard TD, Hitchcock-DeGregori SE.

Curr Biol. 2001 Aug 21;11(16):1300-4.

42.

Deciphering the design of the tropomyosin molecule.

Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C.

Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8496-501. Epub 2001 Jul 3.

43.

Importance of internal regions and the overall length of tropomyosin for actin binding and regulatory function.

Hitchcock-DeGregori SE, Song Y, Moraczewska J.

Biochemistry. 2001 Feb 20;40(7):2104-12.

PMID:
11329279
44.

Alteration of tropomyosin function and folding by a nemaline myopathy-causing mutation.

Moraczewska J, Greenfield NJ, Liu Y, Hitchcock-DeGregori SE.

Biophys J. 2000 Dec;79(6):3217-25.

45.

Independent functions for the N- and C-termini in the overlap region of tropomyosin.

Moraczewska J, Hitchcock-DeGregori SE.

Biochemistry. 2000 Jun 13;39(23):6891-7.

PMID:
10841770
46.

The ends of tropomyosin are major determinants of actin affinity and myosin subfragment 1-induced binding to F-actin in the open state.

Moraczewska J, Nicholson-Flynn K, Hitchcock-DeGregori SE.

Biochemistry. 1999 Nov 30;38(48):15885-92.

PMID:
10625454
47.

Altered regulatory function of two familial hypertrophic cardiomyopathy troponin T mutants.

Mukherjea P, Tong L, Seidman JG, Seidman CE, Hitchcock-DeGregori SE.

Biochemistry. 1999 Oct 5;38(40):13296-301.

PMID:
10529204
48.

Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function

Golitsina N, An Y, Greenfield NJ, Thierfelder L, Iizuka K, Seidman JG, Seidman CE, Lehrer SS, Hitchcock-DeGregori SE.

Biochemistry. 1999 Mar 23;38(12):3850. No abstract available.

PMID:
10090775
49.

Mutations in the N- and D-helices of the N-domain of troponin C affect the C-domain and regulatory function.

Smith L, Greenfield NJ, Hitchcock-DeGregori SE.

Biophys J. 1999 Jan;76(1 Pt 1):400-8.

50.

The structure of the N-terminus of striated muscle alpha-tropomyosin in a chimeric peptide: nuclear magnetic resonance structure and circular dichroism studies.

Greenfield NJ, Montelione GT, Farid RS, Hitchcock-DeGregori SE.

Biochemistry. 1998 May 26;37(21):7834-43.

PMID:
9601044

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