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Items: 1 to 50 of 252

1.

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs.

Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga SI, Ikeuchi T, Kaibuchi K, Okano H.

Stem Cell Reports. 2019 Oct 8;13(4):684-699. doi: 10.1016/j.stemcr.2019.08.011. Epub 2019 Sep 19.

PMID:
31543469
2.

Effect of L-DOPA/Benserazide on Propagation of Pathological α-Synuclein.

Shimozawa A, Fujita Y, Kondo H, Takimoto Y, Terada M, Sanagi M, Hisanaga SI, Hasegawa M.

Front Neurosci. 2019 Jun 14;13:595. doi: 10.3389/fnins.2019.00595. eCollection 2019.

3.

Tau isoform expression and phosphorylation in marmoset brains.

Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI.

J Biol Chem. 2019 Jul 26;294(30):11433-11444. doi: 10.1074/jbc.RA119.008415. Epub 2019 Jun 5.

PMID:
31171723
4.

CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway.

Furusawa K, Takasugi T, Chiu YW, Hori Y, Tomita T, Fukuda M, Hisanaga SI.

J Biol Chem. 2019 Jul 12;294(28):10886-10899. doi: 10.1074/jbc.RA118.005385. Epub 2019 May 28.

PMID:
31138646
5.

Cytoplasmic control of Rab family small GTPases through BAG6.

Takahashi T, Minami S, Tsuchiya Y, Tajima K, Sakai N, Suga K, Hisanaga SI, Ohbayashi N, Fukuda M, Kawahara H.

EMBO Rep. 2019 Apr;20(4). pii: e46794. doi: 10.15252/embr.201846794. Epub 2019 Feb 25.

6.

Conformational Changes and Redox Properties of Bimetallic Single Helicates of Hexapyrrole-α,ω-dicarbaldehydes.

Eerdun C, Nguyen THT, Okayama T, Hisanaga S, Setsune JI.

Chemistry. 2019 Apr 17;25(22):5777-5786. doi: 10.1002/chem.201900353. Epub 2019 Mar 27.

PMID:
30746784
7.

Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT1A receptor via phosphorylation.

Takahashi M, Kobayashi Y, Ando K, Saito Y, Hisanaga SI.

Biochem Biophys Res Commun. 2019 Mar 12;510(3):370-375. doi: 10.1016/j.bbrc.2019.01.093. Epub 2019 Jan 31.

8.

S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy.

Chiku T, Hayashishita M, Saito T, Oka M, Shinno K, Ohtake Y, Shimizu S, Asada A, Hisanaga SI, Iijima KM, Ando K.

Neurobiol Aging. 2018 Nov;71:255-264. doi: 10.1016/j.neurobiolaging.2018.07.021. Epub 2018 Aug 3.

PMID:
30172839
9.

Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.

Tarutani A, Arai T, Murayama S, Hisanaga SI, Hasegawa M.

Acta Neuropathol Commun. 2018 Apr 18;6(1):29. doi: 10.1186/s40478-018-0532-2.

10.

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy.

Kimura T, Sharma G, Ishiguro K, Hisanaga SI.

Front Neurosci. 2018 Feb 6;12:44. doi: 10.3389/fnins.2018.00044. eCollection 2018. Review.

11.

PERK-mediated translational control is required for collagen secretion in chondrocytes.

Hisanaga S, Miyake M, Taniuchi S, Oyadomari M, Morimoto M, Sato R, Hirose J, Mizuta H, Oyadomari S.

Sci Rep. 2018 Jan 15;8(1):773. doi: 10.1038/s41598-017-19052-9.

12.

Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.

Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga SI.

J Biol Chem. 2018 Feb 2;293(5):1781-1793. doi: 10.1074/jbc.M117.798918. Epub 2017 Dec 1.

13.

Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy.

Oka M, Fujisaki N, Maruko-Otake A, Ohtake Y, Shimizu S, Saito T, Hisanaga SI, Iijima KM, Ando K.

J Biochem. 2017 Nov 1;162(5):335-342. doi: 10.1093/jb/mvx038.

14.

Pituitary Macroadenoma and Visual Impairment: Postoperative Outcome Prediction with Contrast-Enhanced FIESTA.

Hisanaga S, Kakeda S, Yamamoto J, Watanabe K, Moriya J, Nagata T, Fujino Y, Kondo H, Nishizawa S, Korogi Y.

AJNR Am J Neuroradiol. 2017 Nov;38(11):2067-2072. doi: 10.3174/ajnr.A5394. Epub 2017 Sep 14.

15.

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains.

Krishnankutty A, Kimura T, Saito T, Aoyagi K, Asada A, Takahashi SI, Ando K, Ohara-Imaizumi M, Ishiguro K, Hisanaga SI.

Sci Rep. 2017 Aug 17;7(1):8602. doi: 10.1038/s41598-017-09239-5.

16.

Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice.

Miyake M, Kuroda M, Kiyonari H, Takehana K, Hisanaga S, Morimoto M, Zhang J, Oyadomari M, Sakaue H, Oyadomari S.

PLoS One. 2017 Jun 23;12(6):e0179955. doi: 10.1371/journal.pone.0179955. eCollection 2017.

17.

Cdk5 activity is required for Purkinje cell dendritic growth in cell-autonomous and non-cell-autonomous manners.

Xu B, Kumazawa A, Kobayashi S, Hisanaga SI, Inoue T, Ohshima T.

Dev Neurobiol. 2017 Oct;77(10):1175-1187. doi: 10.1002/dneu.22507. Epub 2017 Jun 12.

18.

Propagation of pathological α-synuclein in marmoset brain.

Shimozawa A, Ono M, Takahara D, Tarutani A, Imura S, Masuda-Suzukake M, Higuchi M, Yanai K, Hisanaga SI, Hasegawa M.

Acta Neuropathol Commun. 2017 Feb 2;5(1):12. doi: 10.1186/s40478-017-0413-0.

19.

Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth.

Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga SI.

J Neurosci. 2017 Jan 25;37(4):790-806. doi: 10.1523/JNEUROSCI.2197-16.2016.

20.

Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production.

Akasaka-Manya K, Kawamura M, Tsumoto H, Saito Y, Tachida Y, Kitazume S, Hatsuta H, Miura Y, Hisanaga SI, Murayama S, Hashimoto Y, Manya H, Endo T.

J Biochem. 2017 Jan;161(1):99-111. doi: 10.1093/jb/mvw056. Epub 2016 Oct 19.

PMID:
28053144
21.

Language/Culture Modulates Brain and Gaze Processes in Audiovisual Speech Perception.

Hisanaga S, Sekiyama K, Igasaki T, Murayama N.

Sci Rep. 2016 Oct 13;6:35265. doi: 10.1038/srep35265.

22.

[The Prion-like Mechanism in Neurodegenerative Diseases-Current Studies and Future Prospects].

Tarutani A, Hisanaga SI, Hasegawa M.

Brain Nerve. 2016 Oct;68(10):1197-1204. Review. Japanese.

PMID:
27703107
23.

Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.

Kimura T, Hosokawa T, Taoka M, Tsutsumi K, Ando K, Ishiguro K, Hosokawa M, Hasegawa M, Hisanaga S.

Sci Rep. 2016 Sep 19;6:33479. doi: 10.1038/srep33479.

24.

Kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons.

Sharma G, Tsutsumi K, Saito T, Asada A, Ando K, Tomomura M, Hisanaga SI.

Genes Cells. 2016 Oct;21(10):1080-1094. doi: 10.1111/gtc.12404. Epub 2016 Sep 7.

25.

Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.

Ando K, Oka M, Ohtake Y, Hayashishita M, Shimizu S, Hisanaga S, Iijima KM.

Biochem Biophys Res Commun. 2016 Sep 16;478(2):929-34. doi: 10.1016/j.bbrc.2016.08.053. Epub 2016 Aug 9.

26.

Risk of Cerebral Infarction in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study (MID study).

Toida T, Sato Y, Nakagawa H, Komatsu H, Uezono S, Yamada K, Ishihara T, Hisanaga S, Kitamura K, Fujimoto S.

Kidney Blood Press Res. 2016;41(4):471-8. doi: 10.1159/000443448. Epub 2016 Jul 15.

27.

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.

Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, Hasegawa M.

J Biol Chem. 2016 Sep 2;291(36):18675-88. doi: 10.1074/jbc.M116.734707. Epub 2016 Jul 5.

28.

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly.

Oikawa T, Nonaka T, Terada M, Tamaoka A, Hisanaga S, Hasegawa M.

J Biol Chem. 2016 Jul 15;291(29):15046-56. doi: 10.1074/jbc.M116.736355. Epub 2016 May 19.

29.

New-onset haematoproteinuria in a 63-year-old man with intraperitoneal lymph node enlargement.

Minakawa A, Hisanaga S, Sato Y, Fujimoto S.

BMJ Case Rep. 2016 Feb 23;2016. pii: bcr2016214366. doi: 10.1136/bcr-2016-214366.

30.

Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.

Shimonaka S, Nonaka T, Suzuki G, Hisanaga S, Hasegawa M.

J Biol Chem. 2016 Apr 22;291(17):8896-907. doi: 10.1074/jbc.M115.713552. Epub 2016 Feb 17.

31.

The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method.

Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S.

Am J Pathol. 2016 Feb;186(2):398-409. doi: 10.1016/j.ajpath.2015.10.009. Epub 2015 Dec 11.

PMID:
26687814
32.

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination.

Takasugi T, Minegishi S, Asada A, Saito T, Kawahara H, Hisanaga S.

J Biol Chem. 2016 Feb 26;291(9):4649-57. doi: 10.1074/jbc.M115.692871. Epub 2015 Dec 2.

33.

Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5.

Takada S, Mizuno K, Saito T, Asada A, Giese KP, Hisanaga S.

PLoS One. 2015 Oct 15;10(10):e0140821. doi: 10.1371/journal.pone.0140821. eCollection 2015.

34.

Glycaemic control is a predictor of infection-related hospitalization on haemodialysis patients: Miyazaki Dialysis Cohort study (MID study).

Toida T, Sato Y, Nakagawa H, Komatsu H, Kikuchi M, Uezono S, Yamada K, Ishihara T, Hisanaga S, Kitamura K, Fujimoto S.

Nephrology (Carlton). 2016 Mar;21(3):236-40. doi: 10.1111/nep.12587.

PMID:
26272229
35.

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.

Takahashi M, Miyata H, Kametani F, Nonaka T, Akiyama H, Hisanaga S, Hasegawa M.

Acta Neuropathol. 2015 Jun;129(6):895-907. doi: 10.1007/s00401-015-1415-2. Epub 2015 Apr 14.

36.

Protracted arthritis in a Japanese patient with familial Mediterranean fever.

Migita K, Hisanaga S, Izumi Y, Kawahara C, Shigemitsu Y, Iwanaga N, Araki T, Kamata M, Izumi M, Kumagai K, Kawakami A.

Mod Rheumatol. 2017 Sep;27(5):905-909. doi: 10.3109/14397595.2015.1031722. Epub 2015 Apr 30.

PMID:
25800639
37.

One-handed single helicates of dinickel(II) benzenehexapyrrole-α,ω-diimine with an amine chiral source.

Eerdun C, Hisanaga S, Setsune J.

Chemistry. 2015 Jan 2;21(1):239-46. doi: 10.1002/chem.201404782. Epub 2014 Nov 4.

PMID:
25370535
38.

Event-related potentials for better speech perception in noise by cochlear implant users.

Soshi T, Hisanaga S, Kodama N, Kanekama Y, Samejima Y, Yumoto E, Sekiyama K.

Hear Res. 2014 Oct;316:110-21. doi: 10.1016/j.heares.2014.08.001. Epub 2014 Aug 23.

PMID:
25158303
39.

Physiological and pathological phosphorylation of tau by Cdk5.

Kimura T, Ishiguro K, Hisanaga S.

Front Mol Neurosci. 2014 Jul 15;7:65. doi: 10.3389/fnmol.2014.00065. eCollection 2014. Review.

40.

Candidate gene analysis using genomic quantitative PCR: identification of ADAMTS13 large deletions in two patients with Upshaw-Schulman syndrome.

Eura Y, Kokame K, Takafuta T, Tanaka R, Kobayashi H, Ishida F, Hisanaga S, Matsumoto M, Fujimura Y, Miyata T.

Mol Genet Genomic Med. 2014 May;2(3):240-4. doi: 10.1002/mgg3.64. Epub 2014 Jan 14.

41.

Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia.

Ito Y, Asada A, Kobayashi H, Takano T, Sharma G, Saito T, Ohta Y, Amano M, Kaibuchi K, Hisanaga S.

Mol Cell Neurosci. 2014 Jul;61:34-45. doi: 10.1016/j.mcn.2014.05.006. Epub 2014 May 27.

PMID:
24877974
42.

Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.

Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, Asada A, Kamada S, Ohshima T, Hisanaga S.

J Biol Chem. 2014 Jul 11;289(28):19627-36. doi: 10.1074/jbc.M113.501148. Epub 2014 May 28.

43.

The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state.

Furusawa K, Asada A, Saito T, Hisanaga S.

J Neurochem. 2014 Aug;130(4):498-506. doi: 10.1111/jnc.12746. Epub 2014 May 19.

44.

Valproic acid downregulates Cdk5 activity via the transcription of the p35 mRNA.

Takahashi M, Ishida M, Saito T, Ohshima T, Hisanaga S.

Biochem Biophys Res Commun. 2014 May 16;447(4):678-82. doi: 10.1016/j.bbrc.2014.04.072. Epub 2014 Apr 19.

PMID:
24755075
45.

LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes.

Takano T, Urushibara T, Yoshioka N, Saito T, Fukuda M, Tomomura M, Hisanaga S.

Mol Biol Cell. 2014 Jun;25(11):1755-68. doi: 10.1091/mbc.E14-01-0675. Epub 2014 Mar 26.

46.

Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration.

Tanabe K, Yamazaki H, Inaguma Y, Asada A, Kimura T, Takahashi J, Taoka M, Ohshima T, Furuichi T, Isobe T, Nagata K, Shirao T, Hisanaga S.

PLoS One. 2014 Mar 17;9(3):e92291. doi: 10.1371/journal.pone.0092291. eCollection 2014.

47.

Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2.

Asada A, Yamazaki R, Kino Y, Saito T, Kimura T, Miyake M, Hasegawa M, Nukina N, Hisanaga S.

Neurosci Lett. 2014 Mar 20;563:112-7. doi: 10.1016/j.neulet.2014.01.046. Epub 2014 Jan 31.

PMID:
24486837
48.

Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.

Saito T, Yano M, Kawai Y, Asada A, Wada M, Doi H, Hisanaga S.

J Biol Chem. 2013 Nov 8;288(45):32433-9. doi: 10.1074/jbc.M113.512293. Epub 2013 Sep 30.

49.

Cyclin I is involved in the regulation of cell cycle progression.

Nagano T, Hashimoto T, Nakashima A, Hisanaga S, Kikkawa U, Kamada S.

Cell Cycle. 2013 Aug 15;12(16):2617-24. doi: 10.4161/cc.25623. Epub 2013 Jul 11.

50.

Validation of a newly proposed histopathological classification in Japanese patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

Iwakiri T, Fujimoto S, Kitagawa K, Furuichi K, Yamahana J, Matsuura Y, Yamashita A, Uezono S, Shimao Y, Hisanaga S, Tokura T, Wada T, Kitamura K, Asada Y.

BMC Nephrol. 2013 Jun 17;14:125. doi: 10.1186/1471-2369-14-125.

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