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Items: 1 to 50 of 500

1.

Microfluidic Nanoassembly of Bioengineered Chitosan-Modified FcRn-Targeted Porous Silicon Nanoparticles @ Hypromellose Acetate Succinate for Oral Delivery of Anti-Diabetic Peptides.

Martins J, Liu D, Fontana F, Ferreira M, Correia A, Valentino S, Kemell M, Moslova K, Mäkilä EM, Salonen JJ, Hirvonen J, Sarmento B, Santos HA.

ACS Appl Mater Interfaces. 2018 Dec 7. doi: 10.1021/acsami.8b20821. [Epub ahead of print]

PMID:
30525379
2.

Comparison of three multiplex real-time PCR assays for detection of enteric viruses in patients with diarrhea.

Hirvonen JJ.

Eur J Clin Microbiol Infect Dis. 2019 Feb;38(2):241-244. doi: 10.1007/s10096-018-3418-0. Epub 2018 Nov 9.

PMID:
30414091
3.

Dynamic large-scale network synchronization from perception to action.

Hirvonen J, Monto S, Wang SH, Palva JM, Palva S.

Netw Neurosci. 2018 Oct 1;2(4):442-463. doi: 10.1162/netn_a_00039. eCollection 2018.

4.

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine.

Li W, Li Y, Liu Z, Kerdsakundee N, Zhang M, Zhang F, Liu X, Bauleth-Ramos T, Lian W, Mäkilä E, Kemell M, Ding Y, Sarmento B, Wiwattanapatapee R, Salonen J, Zhang H, Hirvonen JT, Liu D, Deng X, Santos HA.

Biomaterials. 2018 Dec;185:322-332. doi: 10.1016/j.biomaterials.2018.09.024. Epub 2018 Sep 19.

5.

High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions.

Selin M, Nummelin S, Deleu J, Ropponen J, Viitala T, Lahtinen M, Koivisto J, Hirvonen J, Peltonen L, Kostiainen MA, Bimbo LM.

Biomacromolecules. 2018 Oct 8;19(10):3983-3993. doi: 10.1021/acs.biomac.8b00931. Epub 2018 Sep 12.

PMID:
30207704
6.

Brain neurokinin-1 receptor availability in never-medicated patients with major depression - A pilot study.

Nyman M, Eskola O, Kajander J, Jokinen R, Penttinen J, Karjalainen T, Nummenmaa L, Hirvonen J, Burns D, Hargreaves R, Solin O, Hietala J.

J Affect Disord. 2019 Jan 1;242:188-194. doi: 10.1016/j.jad.2018.08.084. Epub 2018 Aug 25.

PMID:
30193189
7.

Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions.

Liu D, Lipponen K, Quan P, Wan X, Zhang H, Mäkilä E, Salonen J, Kostiainen R, Hirvonen J, Kotiaho T, Santos HA.

ACS Biomater Sci Eng. 2018 Jul 9;4(7):2308-2313. doi: 10.1021/acsbiomaterials.8b00343. Epub 2018 Jun 14.

8.

Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography.

Hirvonen J, Zanotti-Fregonara P, Gorelick DA, Lyoo CH, Rallis-Frutos D, Morse C, Zoghbi SS, Pike VW, Volkow ND, Huestis MA, Innis RB.

Biol Psychiatry. 2018 Nov 15;84(10):715-721. doi: 10.1016/j.biopsych.2018.07.009. Epub 2018 Jul 21.

PMID:
30121138
9.

Aerobic exercise modulates anticipatory reward processing via the μ-opioid receptor system.

Saanijoki T, Nummenmaa L, Tuulari JJ, Tuominen L, Arponen E, Kalliokoski KK, Hirvonen J.

Hum Brain Mapp. 2018 Oct;39(10):3972-3983. doi: 10.1002/hbm.24224. Epub 2018 Jun 8.

PMID:
29885086
10.

Engineered Multifunctional Albumin-Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin.

Martins JP, D'Auria R, Liu D, Fontana F, Ferreira MPA, Correia A, Kemell M, Moslova K, Mäkilä E, Salonen J, Casettari L, Hirvonen J, Sarmento B, Santos HA.

Small. 2018 Jul;14(27):e1800462. doi: 10.1002/smll.201800462. Epub 2018 May 31.

PMID:
29855134
11.

Production of pure drug nanocrystals and nano co-crystals by confinement methods.

Fontana F, Figueiredo P, Zhang P, Hirvonen JT, Liu D, Santos HA.

Adv Drug Deliv Rev. 2018 Jun;131:3-21. doi: 10.1016/j.addr.2018.05.002. Epub 2018 May 5. Review.

PMID:
29738786
12.

μ-opioid receptor system mediates reward processing in humans.

Nummenmaa L, Saanijoki T, Tuominen L, Hirvonen J, Tuulari JJ, Nuutila P, Kalliokoski K.

Nat Commun. 2018 Apr 16;9(1):1500. doi: 10.1038/s41467-018-03848-y.

13.

Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue.

Lahesmaa M, Eriksson O, Gnad T, Oikonen V, Bucci M, Hirvonen J, Koskensalo K, Teuho J, Niemi T, Taittonen M, Lahdenpohja S, U Din M, Haaparanta-Solin M, Pfeifer A, Virtanen KA, Nuutila P.

Diabetes. 2018 Jul;67(7):1226-1236. doi: 10.2337/db17-1366. Epub 2018 Apr 12.

14.

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction.

Kinnunen SM, Tölli M, Välimäki MJ, Gao E, Szabo Z, Rysä J, Ferreira MPA, Ohukainen P, Serpi R, Correia A, Mäkilä E, Salonen J, Hirvonen J, Santos HA, Ruskoaho H.

Sci Rep. 2018 Mar 15;8(1):4611. doi: 10.1038/s41598-018-22830-8.

15.

Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy.

Li W, Liu Z, Fontana F, Ding Y, Liu D, Hirvonen JT, Santos HA.

Adv Mater. 2018 Jun;30(24):e1703740. doi: 10.1002/adma.201703740. Epub 2018 Mar 13. Review.

PMID:
29534311
16.

Simultaneous PET-MRI Confirms That Cerebral Blood Flow Does Not Confound PET Neuroreceptor Activation Studies.

Nummenmaa L, Tuominen L, Hirvonen J.

ACS Chem Neurosci. 2018 Feb 21;9(2):159-161. doi: 10.1021/acschemneuro.7b00489. Epub 2018 Jan 5.

PMID:
29303246
17.

Drug nanocrystals - Versatile option for formulation of poorly soluble materials.

Peltonen L, Hirvonen J.

Int J Pharm. 2018 Feb 15;537(1-2):73-83. doi: 10.1016/j.ijpharm.2017.12.005. Epub 2017 Dec 17.

PMID:
29262301
18.

Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regeneration.

Zanjanizadeh Ezazi N, Shahbazi MA, Shatalin YV, Nadal E, Mäkilä E, Salonen J, Kemell M, Correia A, Hirvonen J, Santos HA.

Int J Pharm. 2018 Jan 30;536(1):241-250. doi: 10.1016/j.ijpharm.2017.11.065. Epub 2017 Nov 28.

PMID:
29195917
19.

Whole-Brain Source-Reconstructed MEG-Data Reveal Reduced Long-Range Synchronization in Chronic Schizophrenia.

Hirvonen J, Wibral M, Palva JM, Singer W, Uhlhaas P, Palva S.

eNeuro. 2017 Oct 17;4(5). pii: ENEURO.0338-17.2017. doi: 10.1523/ENEURO.0338-17.2017. eCollection 2017 Sep-Oct.

20.

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics.

Liu Z, Li Y, Li W, Xiao C, Liu D, Dong C, Zhang M, Mäkilä E, Kemell M, Salonen J, Hirvonen JT, Zhang H, Zhou D, Deng X, Santos HA.

Adv Mater. 2018 Jun;30(24):e1703393. doi: 10.1002/adma.201703393. Epub 2017 Oct 11.

PMID:
29024054
21.

Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females.

Tuominen L, Miettunen J, Cannon DM, Drevets WC, Frokjaer VG, Hirvonen J, Ichise M, Jensen PS, Keltikangas-Järvinen L, Klaver JM, Knudsen GM, Takano A, Suhara T, Hietala J.

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):963-970. doi: 10.1093/ijnp/pyx071.

22.

Competence-Based Pharmacy Education in the University of Helsinki.

Katajavuori N, Salminen O, Vuorensola K, Huhtala H, Vuorela P, Hirvonen J.

Pharmacy (Basel). 2017 Jun 1;5(2). pii: E29. doi: 10.3390/pharmacy5020029.

23.

The Second Round of the PHAR-QA Survey of Competences for Pharmacy Practice.

Atkinson J, De Paepe K, Pozo AS, Rekkas D, Volmer D, Hirvonen J, Bozic B, Skowron A, Mircioiu C, Marcincal A, Koster A, Wilson K, van Schravendijk C.

Pharmacy (Basel). 2016 Sep 21;4(3). pii: E27. doi: 10.3390/pharmacy4030027.

24.

Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs.

Figueiredo P, Ferro C, Kemell M, Liu Z, Kiriazis A, Lintinen K, Florindo HF, Yli-Kauhaluoma J, Hirvonen J, Kostiainen MA, Santos HA.

Nanomedicine (Lond). 2017 Nov;12(21):2581-2596. doi: 10.2217/nnm-2017-0219. Epub 2017 Sep 29.

PMID:
28960138
25.

Current developments and applications of microfluidic technology toward clinical translation of nanomedicines.

Liu D, Zhang H, Fontana F, Hirvonen JT, Santos HA.

Adv Drug Deliv Rev. 2018 Mar 15;128:54-83. doi: 10.1016/j.addr.2017.08.003. Epub 2017 Aug 8. Review.

PMID:
28801093
26.

Accuracy of 837 pedicle screw positions in degenerative lumbar spine with conventional open surgery evaluated by computed tomography.

Saarenpää I, Laine T, Hirvonen J, Hurme S, Kotilainen E, Rinne J, Korhonen K, Frantzén J.

Acta Neurochir (Wien). 2017 Oct;159(10):2011-2017. doi: 10.1007/s00701-017-3289-7. Epub 2017 Aug 10.

PMID:
28799104
27.

Erratum. Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese. Diabetes 2013;62:2747-2751.

Tuulari JJ, Karlsson HK, Hirvonen J, Hannukainen JC, Bucci M, Helmiö M, Ovaska J, Soinio M, Salminen P, Savisto N, Nummenmaa L, Nuutila P.

Diabetes. 2017 Oct;66(10):2724. doi: 10.2337/db17-er10a. Epub 2017 Aug 1. No abstract available.

28.

Feeding Releases Endogenous Opioids in Humans.

Tuulari JJ, Tuominen L, de Boer FE, Hirvonen J, Helin S, Nuutila P, Nummenmaa L.

J Neurosci. 2017 Aug 23;37(34):8284-8291. doi: 10.1523/JNEUROSCI.0976-17.2017. Epub 2017 Jul 26.

29.

Opioid Release after High-Intensity Interval Training in Healthy Human Subjects.

Saanijoki T, Tuominen L, Tuulari JJ, Nummenmaa L, Arponen E, Kalliokoski K, Hirvonen J.

Neuropsychopharmacology. 2018 Jan;43(2):246-254. doi: 10.1038/npp.2017.148. Epub 2017 Jul 19.

30.

Multifunctional Nanotube-Mucoadhesive Poly(methyl vinyl ether-co-maleic acid)@Hydroxypropyl Methylcellulose Acetate Succinate Composite for Site-Specific Oral Drug Delivery.

Kerdsakundee N, Li W, Martins JP, Liu Z, Zhang F, Kemell M, Correia A, Ding Y, Airavaara M, Hirvonen J, Wiwattanapatapee R, Santos HA.

Adv Healthc Mater. 2017 Oct;6(20). doi: 10.1002/adhm.201700629. Epub 2017 Jul 17.

PMID:
28714596
31.

Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling.

Ferreira MPA, Ranjan S, Kinnunen S, Correia A, Talman V, Mäkilä E, Barrios-Lopez B, Kemell M, Balasubramanian V, Salonen J, Hirvonen J, Ruskoaho H, Airaksinen AJ, Santos HA.

Small. 2017 Sep;13(33). doi: 10.1002/smll.201701276. Epub 2017 Jul 17.

PMID:
28714245
32.

Comparison of liposomal drug formulations for transdermal iontophoretic drug delivery.

Malinovskaja-Gomez K, Espuelas S, Garrido MJ, Hirvonen J, Laaksonen T.

Eur J Pharm Sci. 2017 Aug 30;106:294-301. doi: 10.1016/j.ejps.2017.06.025. Epub 2017 Jun 15.

PMID:
28625748
33.

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines.

Balasubramanian V, Liu Z, Hirvonen J, Santos HA.

Adv Healthc Mater. 2018 Jan;7(1). doi: 10.1002/adhm.201700432. Epub 2017 Jun 1. Review.

PMID:
28570787
34.

Social Laughter Triggers Endogenous Opioid Release in Humans.

Manninen S, Tuominen L, Dunbar RI, Karjalainen T, Hirvonen J, Arponen E, Hari R, Jääskeläinen IP, Sams M, Nummenmaa L.

J Neurosci. 2017 Jun 21;37(25):6125-6131. doi: 10.1523/JNEUROSCI.0688-16.2017. Epub 2017 May 23.

35.

A multifunctional nanocomplex for enhanced cell uptake, endosomal escape and improved cancer therapeutic effect.

Almeida PV, Shahbazi MA, Correia A, Mäkilä E, Kemell M, Salonen J, Hirvonen J, Santos HA.

Nanomedicine (Lond). 2017 May 19. doi: 10.2217/nnm-2017-0034. [Epub ahead of print]

PMID:
28524813
36.

Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes.

Nummelin S, Selin M, Legrand S, Ropponen J, Seitsonen J, Nykänen A, Koivisto J, Hirvonen J, Kostiainen MA, Bimbo LM.

Nanoscale. 2017 Jun 1;9(21):7189-7198. doi: 10.1039/c6nr08102a.

PMID:
28513636
37.

Neurotransmitters behind pain relief with transcranial magnetic stimulation - positron emission tomography evidence for release of endogenous opioids.

Lamusuo S, Hirvonen J, Lindholm P, Martikainen IK, Hagelberg N, Parkkola R, Taiminen T, Hietala J, Helin S, Virtanen A, Pertovaara A, Jääskeläinen SK.

Eur J Pain. 2017 Oct;21(9):1505-1515. doi: 10.1002/ejp.1052. Epub 2017 May 11.

PMID:
28493519
38.

Microfluidic-assisted fabrication of carriers for controlled drug delivery.

Liu D, Zhang H, Fontana F, Hirvonen JT, Santos HA.

Lab Chip. 2017 May 31;17(11):1856-1883. doi: 10.1039/c7lc00242d. Review.

PMID:
28480462
39.

Surface modification of acetaminophen particles by atomic layer deposition.

Kääriäinen TO, Kemell M, Vehkamäki M, Kääriäinen ML, Correia A, Santos HA, Bimbo LM, Hirvonen J, Hoppu P, George SM, Cameron DC, Ritala M, Leskelä M.

Int J Pharm. 2017 Jun 15;525(1):160-174. doi: 10.1016/j.ijpharm.2017.04.031. Epub 2017 Apr 18.

PMID:
28432020
40.

A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging.

Janoniene A, Liu Z, Baranauskiene L, Mäkilä E, Ma M, Salonen J, Hirvonen J, Zhang H, Petrikaite V, Santos HA.

ACS Appl Mater Interfaces. 2017 Apr 26;9(16):13976-13987. doi: 10.1021/acsami.7b04038. Epub 2017 Apr 11.

PMID:
28383881
41.

Receptor-Mediated Surface Charge Inversion Platform Based on Porous Silicon Nanoparticles for Efficient Cancer Cell Recognition and Combination Therapy.

Zhang F, Correia A, Mäkilä E, Li W, Salonen J, Hirvonen JJ, Zhang H, Santos HA.

ACS Appl Mater Interfaces. 2017 Mar 22;9(11):10034-10046. doi: 10.1021/acsami.7b02196. Epub 2017 Mar 8.

PMID:
28248078
42.

Intracellular responsive dual delivery by endosomolytic polyplexes carrying DNA anchored porous silicon nanoparticles.

Shahbazi MA, Almeida PV, Correia A, Herranz-Blanco B, Shrestha N, Mäkilä E, Salonen J, Hirvonen J, Santos HA.

J Control Release. 2017 Mar 10;249:111-122. doi: 10.1016/j.jconrel.2017.01.046. Epub 2017 Feb 1.

PMID:
28159519
43.

Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle-Like Functions.

Balasubramanian V, Correia A, Zhang H, Fontana F, Mäkilä E, Salonen J, Hirvonen J, Santos HA.

Adv Mater. 2017 Mar;29(11). doi: 10.1002/adma.201605375. Epub 2017 Jan 23.

PMID:
28112838
44.

In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells.

Figueiredo P, Lintinen K, Kiriazis A, Hynninen V, Liu Z, Bauleth-Ramos T, Rahikkala A, Correia A, Kohout T, Sarmento B, Yli-Kauhaluoma J, Hirvonen J, Ikkala O, Kostiainen MA, Santos HA.

Biomaterials. 2017 Mar;121:97-108. doi: 10.1016/j.biomaterials.2016.12.034. Epub 2017 Jan 2.

PMID:
28081462
45.

Comparison of Xpert Norovirus and RidaGene Norovirus assays for the detection of noroviruses in clinical fecal specimens.

Aho-Laukkanen E, Hirvonen JJ, Saha K.

Eur J Clin Microbiol Infect Dis. 2017 Jun;36(6):1019-1022. doi: 10.1007/s10096-016-2884-5. Epub 2017 Jan 6.

PMID:
28063001
46.

Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation.

Liu D, Zhang H, Cito S, Fan J, Mäkilä E, Salonen J, Hirvonen J, Sikanen TM, Weitz DA, Santos HA.

Nano Lett. 2017 Feb 8;17(2):606-614. doi: 10.1021/acs.nanolett.6b03251. Epub 2017 Jan 13.

PMID:
28060521
47.

Preparation and biological evaluation of ethionamide-mesoporous silicon nanoparticles against Mycobacterium tuberculosis.

Vale N, Correia A, Silva S, Figueiredo P, Mäkilä E, Salonen J, Hirvonen J, Pedrosa J, Santos HA, Fraga A.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):403-405. doi: 10.1016/j.bmcl.2016.12.060. Epub 2016 Dec 26.

PMID:
28057421
48.

Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy.

Fontana F, Shahbazi MA, Liu D, Zhang H, Mäkilä E, Salonen J, Hirvonen JT, Santos HA.

Adv Mater. 2017 Feb;29(7). doi: 10.1002/adma.201603239. Epub 2016 Dec 23.

PMID:
28009461
49.

Novel portable platform for molecular detection of toxigenic Clostridium difficile in faeces: a diagnostic accuracy study.

Hirvonen JJ, Matero P, Siebert C, Kauppila J, Vuento R, Tuokko H, Boisset S.

Eur J Clin Microbiol Infect Dis. 2017 May;36(5):783-789. doi: 10.1007/s10096-016-2860-0. Epub 2016 Dec 17.

PMID:
27988815
50.

High angular resolution diffusion-weighted imaging in mild traumatic brain injury.

Mohammadian M, Roine T, Hirvonen J, Kurki T, Ala-Seppälä H, Frantzén J, Katila A, Kyllönen A, Maanpää HR, Posti J, Takala R, Tallus J, Tenovuo O.

Neuroimage Clin. 2016 Nov 17;13:174-180. eCollection 2017.

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