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Items: 20


Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease.

Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA.

Am J Respir Cell Mol Biol. 2019 Sep 9. doi: 10.1165/rcmb.2018-0359OC. [Epub ahead of print]


Effects of Lumacaftor-Ivacaftor Therapy on Cystic Fibrosis Transmembrane Conductance Regulator Function in Phe508del Homozygous Patients with Cystic Fibrosis.

Graeber SY, Dopfer C, Naehrlich L, Gyulumyan L, Scheuermann H, Hirtz S, Wege S, Mairbäurl H, Dorda M, Hyde R, Bagheri-Hanson A, Rueckes-Nilges C, Fischer S, Mall MA, Tümmler B.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1433-1442. doi: 10.1164/rccm.201710-1983OC.


Impaired mucus clearance exacerbates allergen-induced type 2 airway inflammation in juvenile mice.

Fritzsching B, Hagner M, Dai L, Christochowitz S, Agrawal R, van Bodegom C, Schmidt S, Schatterny J, Hirtz S, Brown R, Goritzka M, Duerr J, Zhou-Suckow Z, Mall MA.

J Allergy Clin Immunol. 2017 Jul;140(1):190-203.e5. doi: 10.1016/j.jaci.2016.09.045. Epub 2016 Nov 16.


Intestinal Current Measurements Detect Activation of Mutant CFTR in Patients with Cystic Fibrosis with the G551D Mutation Treated with Ivacaftor.

Graeber SY, Hug MJ, Sommerburg O, Hirtz S, Hentschel J, Heinzmann A, Dopfer C, Schulz A, Mainz JG, Tümmler B, Mall MA.

Am J Respir Crit Care Med. 2015 Nov 15;192(10):1252-5. doi: 10.1164/rccm.201507-1271LE. No abstract available.


Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease.

Fritzsching B, Zhou-Suckow Z, Trojanek JB, Schubert SC, Schatterny J, Hirtz S, Agrawal R, Muley T, Kahn N, Sticht C, Gunkel N, Welte T, Randell SH, Länger F, Schnabel P, Herth FJ, Mall MA.

Am J Respir Crit Care Med. 2015 Apr 15;191(8):902-13. doi: 10.1164/rccm.201409-1610OC.


Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema.

Trojanek JB, Cobos-Correa A, Diemer S, Kormann M, Schubert SC, Zhou-Suckow Z, Agrawal R, Duerr J, Wagner CJ, Schatterny J, Hirtz S, Sommerburg O, Hartl D, Schultz C, Mall MA.

Am J Respir Cell Mol Biol. 2014 Nov;51(5):709-20. doi: 10.1165/rcmb.2013-0407OC.


Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.

Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA.

Am J Respir Crit Care Med. 2014 May 1;189(9):1082-92. doi: 10.1164/rccm.201311-1932OC.


Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease.

Graeber SY, Zhou-Suckow Z, Schatterny J, Hirtz S, Boucher RC, Mall MA.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):410-7. doi: 10.1165/rcmb.2013-0050OC. Erratum in: Am J Respir Cell Mol Biol. 2014 Apr;50(4):838.


CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice.

Johannesson B, Hirtz S, Schatterny J, Schultz C, Mall MA.

PLoS One. 2012;7(8):e44059. doi: 10.1371/journal.pone.0044059. Epub 2012 Aug 24.


The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.

Roth EK, Hirtz S, Duerr J, Wenning D, Eichler I, Seydewitz HH, Amaral MD, Mall MA.

PLoS One. 2011;6(8):e24445. doi: 10.1371/journal.pone.0024445. Epub 2011 Aug 31.


In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography.

Wielpütz MO, Eichinger M, Zhou Z, Leotta K, Hirtz S, Bartling SH, Semmler W, Kauczor HU, Puderbach M, Mall MA.

Eur Respir J. 2011 Nov;38(5):1060-70. doi: 10.1183/09031936.00149810. Epub 2011 Apr 8.


Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice.

Anagnostopoulou P, Dai L, Schatterny J, Hirtz S, Duerr J, Mall MA.

Eur Respir J. 2010 Dec;36(6):1436-47. doi: 10.1183/09031936.00181209. Epub 2010 Apr 22. Erratum in: Eur Respir J. 2011 Mar;37(3):727.


Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice.

Zhou Z, Treis D, Schubert SC, Harm M, Schatterny J, Hirtz S, Duerr J, Boucher RC, Mall MA.

Am J Respir Crit Care Med. 2008 Dec 15;178(12):1245-56. doi: 10.1164/rccm.200803-442OC. Epub 2008 Oct 10.


CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis.

Hirtz S, Gonska T, Seydewitz HH, Thomas J, Greiner P, Kuehr J, Brandis M, Eichler I, Rocha H, Lopes AI, Barreto C, Ramalho A, Amaral MD, Kunzelmann K, Mall M.

Gastroenterology. 2004 Oct;127(4):1085-95.


Assessment of CFTR function in rectal biopsies for the diagnosis of cystic fibrosis.

Mall M, Hirtz S, Gonska T, Kunzelmann K.

J Cyst Fibros. 2004 Aug;3 Suppl 2:165-9. Review.


The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon.

Mall M, Kreda SM, Mengos A, Jensen TJ, Hirtz S, Seydewitz HH, Yankaskas J, Kunzelmann K, Riordan JR, Boucher RC.

Gastroenterology. 2004 Jan;126(1):32-41.


Activation of ion secretion via proteinase-activated receptor-2 in human colon.

Mall M, Gonska T, Thomas J, Hirtz S, Schreiber R, Kunzelmann K.

Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G200-10.


Meeting patients' needs for educational materials.

Hirtz SA.

J Pediatr Nurs. 1995 Aug;10(4):271-2. No abstract available.


Effect of heparin reversal following endarterectomy in an atherosclerotic animal model.

Giannotta SL, Hirtz SK, Hyman S.

Bull Clin Neurosci. 1984;49:52-62.


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