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Items: 49


Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila.

Kottler B, Faville R, Bridi JC, Hirth F.

Curr Biol. 2019 Jan 18. pii: S0960-9822(19)30019-3. doi: 10.1016/j.cub.2019.01.017. [Epub ahead of print]


Thimerosal inhibits Drosophila melanogaster tyrosine hydroxylase (DmTyrH) leading to changes in dopamine levels and impaired motor behavior: implications for neurotoxicity.

Bianchini MC, Gularte COA, Nogara PA, Krum BN, Gayer MC, Bridi JC, Roos DH, Roehrs R, Fachinetto R, Pinton S, Ávila DS, Hirth F, Rocha JBT, Puntel RL.

Metallomics. 2018 Dec 5. doi: 10.1039/c8mt00268a. [Epub ahead of print]


A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration.

Solomon DA, Stepto A, Au WH, Adachi Y, Diaper DC, Hall R, Rekhi A, Boudi A, Tziortzouda P, Lee YB, Smith B, Bridi JC, Spinelli G, Dearlove J, Humphrey DM, Gallo JM, Troakes C, Fanto M, Soller M, Rogelj B, Parsons RB, Shaw CE, Hortobágyi T, Hirth F.

Brain. 2018 Oct 1;141(10):2908-2924. doi: 10.1093/brain/awy241.


In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors.

Shaw RE, Kottler B, Ludlow ZN, Buhl E, Kim D, Morais da Silva S, Miedzik A, Coum A, Hodge JJ, Hirth F, Sousa-Nunes R.

EMBO J. 2018 Jul 2;37(13). pii: e98163. doi: 10.15252/embj.201798163. Epub 2018 May 4.


Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease.

Bridi JC, Hirth F.

Front Neurosci. 2018 Feb 19;12:80. doi: 10.3389/fnins.2018.00080. eCollection 2018. Review.


C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

Lee YB, Baskaran P, Gomez-Deza J, Chen HJ, Nishimura AL, Smith BN, Troakes C, Adachi Y, Stepto A, Petrucelli L, Gallo JM, Hirth F, Rogelj B, Guthrie S, Shaw CE.

Hum Mol Genet. 2017 Dec 15;26(24):4765-4777. doi: 10.1093/hmg/ddx350.


In silico Interrogation of Insect Central Complex Suggests Computational Roles for the Ellipsoid Body in Spatial Navigation.

Fiore VG, Kottler B, Gu X, Hirth F.

Front Behav Neurosci. 2017 Aug 3;11:142. doi: 10.3389/fnbeh.2017.00142. eCollection 2017.


Corrigendum: Changing pattern in the basal ganglia: motor switching under reduced dopaminergic drive.

Fiore VG, Rigoli F, Stenner MP, Zaehle T, Hirth F, Heinze HJ, Dolan RJ.

Sci Rep. 2016 Aug 19;6:30841. doi: 10.1038/srep30841. No abstract available.


Changing pattern in the basal ganglia: motor switching under reduced dopaminergic drive.

Fiore VG, Rigoli F, Stenner MP, Zaehle T, Hirth F, Heinze HJ, Dolan RJ.

Sci Rep. 2016 Mar 23;6:23327. doi: 10.1038/srep23327. Erratum in: Sci Rep. 2016 Aug 19;6:30841.


Introduction to 'Homology and convergence in nervous system evolution'.

Strausfeld NJ, Hirth F.

Philos Trans R Soc Lond B Biol Sci. 2016 Jan 5;371(1685):20150034. doi: 10.1098/rstb.2015.0034.


Evolutionarily conserved mechanisms for the selection and maintenance of behavioural activity.

Fiore VG, Dolan RJ, Strausfeld NJ, Hirth F.

Philos Trans R Soc Lond B Biol Sci. 2015 Dec 19;370(1684). pii: 20150053. doi: 10.1098/rstb.2015.0053.


Introduction to 'Origin and evolution of the nervous system'.

Strausfeld NJ, Hirth F.

Philos Trans R Soc Lond B Biol Sci. 2015 Dec 19;370(1684). pii: 20150033. doi: 10.1098/rstb.2015.0033.


Modelling C9ORF72 hexanucleotide repeat expansion in amyotrophic lateral sclerosis and frontotemporal dementia.

Stepto A, Gallo JM, Shaw CE, Hirth F.

Acta Neuropathol. 2014 Mar;127(3):377-89. doi: 10.1007/s00401-013-1235-1. Epub 2013 Dec 24. Review.


Homology versus convergence in resolving transphyletic correspondences of brain organization.

Strausfeld NJ, Hirth F.

Brain Behav Evol. 2013;82(4):215-9. doi: 10.1159/000356102. Epub 2013 Nov 26.


Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic.

Lee YB, Chen HJ, Peres JN, Gomez-Deza J, Attig J, Stalekar M, Troakes C, Nishimura AL, Scotter EL, Vance C, Adachi Y, Sardone V, Miller JW, Smith BN, Gallo JM, Ule J, Hirth F, Rogelj B, Houart C, Shaw CE.

Cell Rep. 2013 Dec 12;5(5):1178-86. doi: 10.1016/j.celrep.2013.10.049. Epub 2013 Nov 27.


Immunostaining of the developing embryonic and larval Drosophila brain.

Diaper DC, Hirth F.

Methods Mol Biol. 2014;1082:3-17. doi: 10.1007/978-1-62703-655-9_1.


Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD.

Diaper DC, Adachi Y, Lazarou L, Greenstein M, Simoes FA, Di Domenico A, Solomon DA, Lowe S, Alsubaie R, Cheng D, Buckley S, Humphrey DM, Shaw CE, Hirth F.

Hum Mol Genet. 2013 Oct 1;22(19):3883-93. doi: 10.1093/hmg/ddt243. Epub 2013 May 31.


Deep homology of arthropod central complex and vertebrate basal ganglia.

Strausfeld NJ, Hirth F.

Science. 2013 Apr 12;340(6129):157-61. doi: 10.1126/science.1231828. Review.


TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila.

Vanden Broeck L, Naval-Sánchez M, Adachi Y, Diaper D, Dourlen P, Chapuis J, Kleinberger G, Gistelinck M, Van Broeckhoven C, Lambert JC, Hirth F, Aerts S, Callaerts P, Dermaut B.

Cell Rep. 2013 Jan 31;3(1):160-72. doi: 10.1016/j.celrep.2012.12.014. Epub 2013 Jan 17.


Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.

Diaper DC, Adachi Y, Sutcliffe B, Humphrey DM, Elliott CJ, Stepto A, Ludlow ZN, Vanden Broeck L, Callaerts P, Dermaut B, Al-Chalabi A, Shaw CE, Robinson IM, Hirth F.

Hum Mol Genet. 2013 Apr 15;22(8):1539-57. doi: 10.1093/hmg/ddt005. Epub 2013 Jan 10.


Thin film measurement system for moving objects based on a laterally distributed linear variable filter spectrometer.

Murr PJ, Wiesent BR, Hirth F, Koch AW.

Rev Sci Instrum. 2012 Mar;83(3):035110. doi: 10.1063/1.3697750.


Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila.

Humphrey DM, Parsons RB, Ludlow ZN, Riemensperger T, Esposito G, Verstreken P, Jacobs HT, Birman S, Hirth F.

Hum Mol Genet. 2012 Jun 15;21(12):2698-712. doi: 10.1093/hmg/dds096. Epub 2012 Mar 7.


The dopaminergic system in the aging brain of Drosophila.

White KE, Humphrey DM, Hirth F.

Front Neurosci. 2010 Dec 8;4:205. doi: 10.3389/fnins.2010.00205. eCollection 2010.


On the origin and evolution of the tripartite brain.

Hirth F.

Brain Behav Evol. 2010;76(1):3-10. doi: 10.1159/000320218. Epub 2010 Sep 30. Review.


Drosophila melanogaster in the study of human neurodegeneration.

Hirth F.

CNS Neurol Disord Drug Targets. 2010 Aug;9(4):504-23. Review.


Loss of heterozygosity of TRIM3 in malignant gliomas.

Boulay JL, Stiefel U, Taylor E, Dolder B, Merlo A, Hirth F.

BMC Cancer. 2009 Feb 27;9:71. doi: 10.1186/1471-2407-9-71.


Commissure formation in the embryonic insect brain.

Boyan G, Reichert H, Hirth F.

Arthropod Struct Dev. 2003 Aug;32(1):61-77.


Asymmetric stem cell division in development and cancer.

Caussinus E, Hirth F.

Prog Mol Subcell Biol. 2007;45:205-25. Review.


The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila.

Sprecher SG, Urbach R, Technau GM, Rijli FM, Reichert H, Hirth F.

Development. 2006 Nov;133(21):4331-9.


The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.

Bello B, Reichert H, Hirth F.

Development. 2006 Jul;133(14):2639-48. Epub 2006 Jun 14.


ventral veins lacking is required for specification of the tritocerebrum in embryonic brain development of Drosophila.

Meier S, Sprecher SG, Reichert H, Hirth F.

Mech Dev. 2006 Jan;123(1):76-83. Epub 2005 Dec 2.


Hox gene cross-regulatory interactions in the embryonic brain of Drosophila.

Sprecher SG, Müller M, Kammermeier L, Miller DF, Kaufman TC, Reichert H, Hirth F.

Mech Dev. 2004 Jun;121(6):527-36.


Transcriptional signature of an adult brain tumor in Drosophila.

Loop T, Leemans R, Stiefel U, Hermida L, Egger B, Xie F, Primig M, Certa U, Fischbach KF, Reichert H, Hirth F.

BMC Genomics. 2004 Apr 16;5(1):24.


An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila.

Hirth F, Kammermeier L, Frei E, Walldorf U, Noll M, Reichert H.

Development. 2003 Jun;130(11):2365-73.


Expression and function of the LIM homeodomain protein Apterous during embryonic brain development of Drosophila.

Herzig MC, Thor S, Thomas JB, Reichert H, Hirth F.

Dev Genes Evol. 2001 Dec;211(11):545-54. Epub 2001 Nov 20.


Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila.

Hirth F, Loop T, Egger B, Miller DF, Kaufman TC, Reichert H.

Development. 2001 Dec;128(23):4781-8.


Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging.

Leemans R, Loop T, Egger B, He H, Kammermeier L, Hartmann B, Certa U, Reichert H, Hirth F.

Genome Biol. 2001;2(5):RESEARCH0015. Epub 2001 Apr 24.


Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development.

Kammermeier L, Leemans R, Hirth F, Flister S, Wenger U, Walldorf U, Gehring WJ, Reichert H.

Mech Dev. 2001 May;103(1-2):71-8.


Drosophila transcription factor AP-2 in proboscis, leg and brain central complex development.

Monge I, Krishnamurthy R, Sims D, Hirth F, Spengler M, Kammermeier L, Reichert H, Mitchell PJ.

Development. 2001 Apr;128(8):1239-52.


Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays.

Leemans R, Egger B, Loop T, Kammermeier L, He H, Hartmann B, Certa U, Hirth F, Reichert H.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12138-43.


Conserved genetic programs in insect and mammalian brain development.

Hirth F, Reichert H.

Bioessays. 1999 Aug;21(8):677-84. Review.


Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.

Leuzinger S, Hirth F, Gerlich D, Acampora D, Simeone A, Gehring WJ, Finkelstein R, Furukubo-Tokunaga K, Reichert H.

Development. 1998 May;125(9):1703-10.


Homeotic gene action in embryonic brain development of Drosophila.

Hirth F, Hartmann B, Reichert H.

Development. 1998 May;125(9):1579-89.


Embryonic development of the Drosophila brain: formation of commissural and descending pathways.

Therianos S, Leuzinger S, Hirth F, Goodman CS, Reichert H.

Development. 1995 Nov;121(11):3849-60.


Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila.

Hirth F, Therianos S, Loop T, Gehring WJ, Reichert H, Furukubo-Tokunaga K.

Neuron. 1995 Oct;15(4):769-78.

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