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Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52.

D'Amore A, Tessa A, Naef V, Bassi MT, Citterio A, Romaniello R, Fichi G, Galatolo D, Mero S, Battini R, Bertocci G, Baldacci J, Sicca F, Gemignani F, Ricca I, Rubegni A, Hirst J, Marchese M, Sahin M, Ebrahimi-Fakhari D, Santorelli FM.

Ann Clin Transl Neurol. 2020 Mar 25. doi: 10.1002/acn3.51018. [Epub ahead of print]


Late stage functionalization via Chan-Lam amination: rapid access to potent and selective integrin inhibitors.

Robinson H, Oatley S, Rowedder J, Slade P, Macdonald S, Argent S, Hirst J, McInally T, Moody CJ.

Chemistry. 2020 Mar 4. doi: 10.1002/chem.202001059. [Epub ahead of print]


CCNE1 and BRD4 co-amplification in high-grade serous ovarian cancer is associated with poor clinical outcomes.

Petersen S, Wilson AJ, Hirst J, Roby KF, Fadare O, Crispens MA, Beeghly-Fadiel A, Khabele D.

Gynecol Oncol. 2020 Feb 7. pii: S0090-8258(20)30091-3. doi: 10.1016/j.ygyno.2020.01.038. [Epub ahead of print]


Prevalence of chronic kidney disease in the community using data from OxRen: a UK population-based cohort study.

Hirst JA, Hill N, O'Callaghan CA, Lasserson D, McManus RJ, Ogburn E, Mena JMO, Shine B, Taylor CJ, Vazquez-Montes MD, Yang Y, Hobbs FR.

Br J Gen Pract. 2020 Mar 26;70(693):e285-e293. doi: 10.3399/bjgp20X708245. Print 2020 Apr.


Prophylactic antibiotics after operative vaginal delivery.

Thompson KJ, Hirst JE.

Lancet. 2020 Jan 18;395(10219):187-188. doi: 10.1016/S0140-6736(19)32471-7. No abstract available.


Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.

Behne R, Teinert J, Wimmer M, D'Amore A, Davies AK, Scarrott JM, Eberhardt K, Brechmann B, Chen IP, Buttermore ED, Barrett L, Dwyer S, Chen T, Hirst J, Wiesener A, Segal D, Martinuzzi A, Duarte ST, Bennett JT, Bourinaris T, Houlden H, Roubertie A, Santorelli FM, Robinson M, Azzouz M, Lipton JO, Borner GHH, Sahin M, Ebrahimi-Fakhari D.

Hum Mol Genet. 2020 Jan 15;29(2):320-334. doi: 10.1093/hmg/ddz310.


How point-of-care HbA1c testing changes the behaviour of people with diabetes and clinicians - a qualitative study.

Hirst JA, Farmer AJ, Williams V.

Diabet Med. 2019 Dec 25. doi: 10.1111/dme.14219. [Epub ahead of print]


Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysis.

He JR, Ramakrishnan R, Hirst JE, Bonaventure A, Francis SS, Paltiel O, Håberg SE, Lemeshow S, Olsen S, Tikellis G, Magnus P, Murphy MFG, Wiemels JL, Linet MS, Dwyer T.

J Pediatr. 2020 Feb;217:98-109.e8. doi: 10.1016/j.jpeds.2019.10.046. Epub 2019 Dec 4.


Increasing insulin resistance predicts adverse pregnancy outcomes in women with gestational diabetes mellitus.

Sun YY, Juan J, Xu QQ, Su RN, Hirst JE, Yang HX.

J Diabetes. 2019 Dec 6. doi: 10.1111/1753-0407.13013. [Epub ahead of print]


Indonesian adolescents' experiences during pregnancy and early parenthood: a qualitative study.

Astuti AW, Hirst J, Bharj KK.

J Psychosom Obstet Gynaecol. 2019 Nov 25:1-10. doi: 10.1080/0167482X.2019.1693538. [Epub ahead of print]


Perinatal compromise contributes to programming of GABAergic and glutamatergic systems leading to long-term effects on offspring behaviour.

Shaw JC, Crombie GK, Zakar T, Palliser HK, Hirst JJ.

J Neuroendocrinol. 2020 Jan;32(1):e12814. doi: 10.1111/jne.12814. Epub 2019 Dec 9. Review.


Time resolved transient circular dichroism spectroscopy using synchrotron natural polarization.

Auvray F, Dennetiere D, Giuliani A, Jamme F, Wien F, Nay B, Zirah S, Polack F, Menneglier C, Lagarde B, Hirst JD, Réfrégiers M.

Struct Dyn. 2019 Oct 31;6(5):054307. doi: 10.1063/1.5120346. eCollection 2019 Sep.


Comment on "Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry".

Hirst J, Kunji ERS, Walker JE.

Science. 2019 Nov 8;366(6466). pii: eaaw9830. doi: 10.1126/science.aaw9830. Epub 2019 Nov 7.


Ketamine: When Delirium and Desperation Call for a Hero.

Moazam C, Hirst J, Mesarwi P, Atayee RS.

J Pain Palliat Care Pharmacother. 2019 Sep - Dec;33(3-4):120-124. doi: 10.1080/15360288.2019.1686099. Epub 2019 Nov 5.


Reversible and Selective Interconversion of Hydrogen and Carbon Dioxide into Formate by a Semiartificial Formate Hydrogenlyase Mimic.

Sokol KP, Robinson WE, Oliveira AR, Zacarias S, Lee CY, Madden C, Bassegoda A, Hirst J, Pereira IAC, Reisner E.

J Am Chem Soc. 2019 Nov 6;141(44):17498-17502. doi: 10.1021/jacs.9b09575. Epub 2019 Oct 28.


Adaptor protein complexes and disease at a glance.

Sanger A, Hirst J, Davies AK, Robinson MS.

J Cell Sci. 2019 Oct 21;132(20). pii: jcs222992. doi: 10.1242/jcs.222992. Review.


Single-particle measurements of filamentous influenza virions reveal damage induced by freezing.

Hirst JC, Hutchinson EC.

J Gen Virol. 2019 Dec;100(12):1631-1640. doi: 10.1099/jgv.0.001330.


Characteristics of Hospitalized Patients Screening Positive for Delirium.

Nguyen TH, Atayee RS, Derry KL, Hirst J, Biondo A, Edmonds KP.

Am J Hosp Palliat Care. 2020 Feb;37(2):142-148. doi: 10.1177/1049909119867046. Epub 2019 Jul 30.


Clarity, conviction and coherence supports buy-in to positive youth sexual health services: focused results from a realist evaluation.

Shearn K, Piercy H, Allmark P, Hirst J.

BMC Health Serv Res. 2019 Jul 19;19(1):503. doi: 10.1186/s12913-019-4298-4.


Impact of the Conformational Variability of Oligopeptides on the Computational Prediction of Their CD Spectra.

Michaelis M, Hildebrand N, Meißner RH, Wurzler N, Li Z, Hirst JD, Micsonai A, Kardos J, Delle Piane M, Colombi Ciacchi L.

J Phys Chem B. 2019 Aug 8;123(31):6694-6704. doi: 10.1021/acs.jpcb.9b03932. Epub 2019 Jul 25.


Thresholds for Ambulatory Blood Pressure Monitoring Based on Maternal and Neonatal Outcomes in Late Pregnancy in a Southern Chinese Population.

Lv LJ, Ji WJ, Wu LL, Miao J, Wen JY, Lei Q, Duan DM, Chen H, Hirst JE, Henry A, Zhou X, Niu JM.

J Am Heart Assoc. 2019 Jul 16;8(14):e012027. doi: 10.1161/JAHA.119.012027. Epub 2019 Jul 3.


Women's and healthcare providers' perceptions of long-term complications associated with hypertension and diabetes in pregnancy: a qualitative study.

Nagraj S, Hinton L, Praveen D, Kennedy S, Norton R, Hirst J.

BJOG. 2019 Aug;126 Suppl 4:34-42. doi: 10.1111/1471-0528.15847. Epub 2019 Aug 16.


HIV Silencing and Inducibility Are Heterogeneous and Are Affected by Factors Intrinsic to the Virus.

Norton NJ, Mok HP, Sharif F, Hirst JC, Lever AML.

mBio. 2019 Jun 25;10(3). pii: e00188-19. doi: 10.1128/mBio.00188-19.


Reduced Neurosteroid Exposure Following Preterm Birth and Its' Contribution to Neurological Impairment: A Novel Avenue for Preventative Therapies.

Shaw JC, Berry MJ, Dyson RM, Crombie GK, Hirst JJ, Palliser HK.

Front Physiol. 2019 May 15;10:599. doi: 10.3389/fphys.2019.00599. eCollection 2019. Review.


Prediction models for preeclampsia: A systematic review.

De Kat AC, Hirst J, Woodward M, Kennedy S, Peters SA.

Pregnancy Hypertens. 2019 Apr;16:48-66. doi: 10.1016/j.preghy.2019.03.005. Epub 2019 Mar 11.


Efficacy of population-wide diabetes and obesity prevention programs: An overview of systematic reviews on proximal, intermediate, and distal outcomes and a meta-analysis of impact on BMI.

Roberts S, Pilard L, Chen J, Hirst J, Rutter H, Greenhalgh T.

Obes Rev. 2019 Jul;20(7):947-963. doi: 10.1111/obr.12821. Epub 2019 Apr 30. Review.


Mammalian Respiratory Complex I Through the Lens of Cryo-EM.

Agip AA, Blaza JN, Fedor JG, Hirst J.

Annu Rev Biophys. 2019 May 6;48:165-184. doi: 10.1146/annurev-biophys-052118-115704. Epub 2019 Feb 20. Review.


Genes upregulated in the amnion at labour are bivalently marked by activating and repressive histone modifications.

Mitchell CM, Hirst JJ, Mitchell MD, Murray HG, Zakar T.

Mol Hum Reprod. 2019 Apr 1;25(4):228-240. doi: 10.1093/molehr/gaz007.


Birth and Neonatal Transition in the Guinea Pig: Experimental Approaches to Prevent Preterm Birth and Protect the Premature Fetus.

Hirst JJ, Palliser HK, Shaw JC, Crombie G, Walker DW, Zakar T.

Front Physiol. 2018 Dec 11;9:1802. doi: 10.3389/fphys.2018.01802. eCollection 2018. Review.


Development, implementation, and initial results of the UC San Diego Health Moores Cancer Center Wellbeing Screening Tool.

Cardenas V, Abbott Y, Hirst JM, Mausbach BT, Agarwal S, Collier G, Tran L, Tamayo G, Downey A, Herring M, Irwin SA.

Palliat Support Care. 2019 Aug;17(4):431-435. doi: 10.1017/S1478951518000810.


A tale of two steroids: The importance of the androgens DHEA and DHEAS for early neurodevelopment.

Greaves RF, Wudy SA, Badoer E, Zacharin M, Hirst JJ, Quinn T, Walker DW.

J Steroid Biochem Mol Biol. 2019 Apr;188:77-85. doi: 10.1016/j.jsbmb.2018.12.007. Epub 2018 Dec 15. Review.


AP-4-Associated Hereditary Spastic Paraplegia.

Ebrahimi-Fakhari D, Behne R, Davies AK, Hirst J.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020.
2018 Dec 13.


Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis.

Crocker JC, Ricci-Cabello I, Parker A, Hirst JA, Chant A, Petit-Zeman S, Evans D, Rees S.

BMJ. 2018 Nov 28;363:k4738. doi: 10.1136/bmj.k4738.


Social gradient of birthweight in England assessed using the INTERGROWTH-21st gestational age-specific standard.

Hirst JE, Knight HE, Ohuma EO, Dwyer T, Hennig BD, Papageorghiou AT, Cheikh Ismail L, Villar J, Kennedy SH.

Arch Dis Child Fetal Neonatal Ed. 2019 Sep;104(5):F486-F492. doi: 10.1136/archdischild-2018-315295. Epub 2018 Nov 21.


Open questions: respiratory chain supercomplexes-why are they there and what do they do?

Hirst J.

BMC Biol. 2018 Nov 1;16(1):111. doi: 10.1186/s12915-018-0577-5.


Clinical Implications of the NICE 2015 Criteria for Gestational Diabetes Mellitus.

Bhatia M, Mackillop LH, Bartlett K, Loerup L, Kenworthy Y, Levy JC, Farmer AJ, Velardo C, Tarassenko L, Hirst JE.

J Clin Med. 2018 Oct 22;7(10). pii: E376. doi: 10.3390/jcm7100376.


Reply to: Comment on: Olanzapine for chemotherapy-induced nausea: Lessons learned from child and adolescent psychiatry.

Samsel C, Kearney J, Meadows AL, Abrams A, Hirst JM, Muriel AC.

Pediatr Blood Cancer. 2019 Jan;66(1):e27490. doi: 10.1002/pbc.27490. Epub 2018 Sep 30. No abstract available.


AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.

Davies AK, Itzhak DN, Edgar JR, Archuleta TL, Hirst J, Jackson LP, Robinson MS, Borner GHH.

Nat Commun. 2018 Sep 27;9(1):3958. doi: 10.1038/s41467-018-06172-7.


Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs.

Shaw JC, Dyson RM, Palliser HK, Gray C, Berry MJ, Hirst JJ.

Pediatr Res. 2019 Jan;85(1):86-96. doi: 10.1038/s41390-018-0185-7. Epub 2018 Sep 20.


TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination.

Bottermann M, Foss S, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Hirst JC, McAdam MB, Slodkowicz G, Hutchinson E, Kozik P, Andersen JT, James LC.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10440-10445. doi: 10.1073/pnas.1806314115. Epub 2018 Sep 12.


Timings for HbA1c testing in people with diabetes are associated with incentive payments: an analysis of UK primary care data.

Hirst JA, Farmer AJ, Smith MC, Stevens RJ.

Diabet Med. 2019 Jan;36(1):36-43. doi: 10.1111/dme.13810. Epub 2018 Sep 21.


The association between birth order and childhood leukemia may be modified by paternal age and birth weight. Pooled results from the International Childhood Cancer Cohort Consortium (I4C).

Paltiel O, Lemeshow S, Phillips GS, Tikellis G, Linet MS, Ponsonby AL, Magnus P, Håberg SE, Olsen SF, Granström C, Klebanoff M, Golding J, Herceg Z, Ghantous A, Hirst JE, Borkhardt A, Ward MH, Holst Søegaard S, Dwyer T.

Int J Cancer. 2019 Jan 1;144(1):26-33. doi: 10.1002/ijc.31635. Epub 2018 Oct 26.


Prediction of gestational diabetes mellitus in the Born in Guangzhou Cohort Study, China.

Schaefer KK, Xiao W, Chen Q, He J, Lu J, Chan F, Chen N, Yuan M, Xia H, Lam KBH, Hirst JE, Qiu X.

Int J Gynaecol Obstet. 2018 Nov;143(2):164-171. doi: 10.1002/ijgo.12627. Epub 2018 Aug 6.


Hydromorphone-induced chorea as an atypical presentation of opioid neurotoxicity: A case report and review of the literature.

Martin EJ, Vaughan CL, Atayee R, Hirst JM, O'Donnell K, Edmonds KP.

Palliat Med. 2018 Oct;32(9):1529-1532. doi: 10.1177/0269216318786861. Epub 2018 Jul 13.


Impact of a single eGFR and eGFR-estimating equation on chronic kidney disease reclassification: a cohort study in primary care.

Hirst JA, Montes MDV, Taylor CJ, Ordóñez-Mena JM, Ogburn E, Sharma V, Shine B, James T, Hobbs FR.

Br J Gen Pract. 2018 Aug;68(673):e524-e530. doi: 10.3399/bjgp18X697937. Epub 2018 Jul 2.


Large bladder stone as a complication of AUS insertion and bladder augmentation.

Saadat S, Winkle D, Hirst J.

Urol Case Rep. 2018 May 26;20:15-16. doi: 10.1016/j.eucr.2018.05.016. eCollection 2018 Sep. No abstract available.


Mitochondrial Supercomplexes Do Not Enhance Catalysis by Quinone Channeling.

Fedor JG, Hirst J.

Cell Metab. 2018 Sep 4;28(3):525-531.e4. doi: 10.1016/j.cmet.2018.05.024. Epub 2018 Jun 21.


Olanzapine for chemotherapy-induced nausea: Lessons learned from child and adolescent psychiatry.

Samsel C, Kearney J, Meadows AL, Abrams A, Hirst JM, Muriel AC.

Pediatr Blood Cancer. 2018 Oct;65(10):e27289. doi: 10.1002/pbc.27289. Epub 2018 Jun 22. No abstract available.


Antenatal prevention of cerebral palsy and childhood disability: is the impossible possible?

Ellery SJ, Kelleher M, Grigsby P, Burd I, Derks JB, Hirst J, Miller SL, Sherman LS, Tolcos M, Walker DW.

J Physiol. 2018 Dec;596(23):5593-5609. doi: 10.1113/JP275595. Epub 2018 Jul 21. Review.


Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.

Agip AA, Blaza JN, Bridges HR, Viscomi C, Rawson S, Muench SP, Hirst J.

Nat Struct Mol Biol. 2018 Jul;25(7):548-556. doi: 10.1038/s41594-018-0073-1. Epub 2018 Jun 18.

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