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Items: 1 to 50 of 224

1.

Atom Efficient Synthesis of Selectively Difluorinated Carbocycles through a Gold(I)-Catalyzed Cyclization.

McCarter AW, Sommer M, Percy JM, Jamieson C, Kennedy AR, Hirst DJ.

J Org Chem. 2018 Jul 30. doi: 10.1021/acs.joc.8b01121. [Epub ahead of print]

PMID:
29978696
2.

Exploring Molecular-Biomembrane Interactions with Surface Plasmon Resonance and Dual Polarization Interferometry Technology: Expanding the Spotlight onto Biomembrane Structure.

Lee TH, Hirst DJ, Kulkarni K, Del Borgo MP, Aguilar MI.

Chem Rev. 2018 Jun 13;118(11):5392-5487. doi: 10.1021/acs.chemrev.7b00729. Epub 2018 May 25.

PMID:
29793341
3.

Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain.

Law RP, Atkinson SJ, Bamborough P, Chung CW, Demont EH, Gordon LJ, Lindon M, Prinjha RK, Watson AJB, Hirst DJ.

J Med Chem. 2018 May 24;61(10):4317-4334. doi: 10.1021/acs.jmedchem.7b01666. Epub 2018 May 3.

PMID:
29656650
4.

Persistence of Bowl Water Contamination during Sequential Flushes of Contaminated Toilets.

Johnson DL, Lynch RA, Villanella SM, Jones JF, Fang H, Mead KR, Hirst DVL.

J Environ Health. 2017 Oct;80(3):34-49.

PMID:
29651169
5.

Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor.

Measom ND, Down KD, Hirst DJ, Jamieson C, Manas ES, Patel VK, Somers DO.

ACS Med Chem Lett. 2016 Nov 15;8(1):43-48. doi: 10.1021/acsmedchemlett.6b00281. eCollection 2017 Jan 12.

6.

The impact of cell-penetrating peptides on membrane bilayer structure during binding and insertion.

Hirst DJ, Lee TH, Kulkarni K, Wilce JA, Aguilar MI.

Biochim Biophys Acta. 2016 Aug;1858(8):1841-9. doi: 10.1016/j.bbamem.2016.05.004. Epub 2016 May 7.

7.

Imaging and radiation effects of gold nanoparticles in tumour cells.

McQuaid HN, Muir MF, Taggart LE, McMahon SJ, Coulter JA, Hyland WB, Jain S, Butterworth KT, Schettino G, Prise KM, Hirst DG, Botchway SW, Currell FJ.

Sci Rep. 2016 Jan 20;6:19442. doi: 10.1038/srep19442.

8.

Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.

Demont EH, Bailey JM, Bit RA, Brown JA, Campbell CA, Deeks N, Dowell SJ, Eldred C, Gaskin P, Gray JR, Haynes A, Hirst DJ, Holmes DS, Kumar U, Morse MA, Osborne GJ, Renaux JF, Seal GA, Smethurst CA, Taylor S, Watson R, Willis R, Witherington J.

J Med Chem. 2016 Feb 11;59(3):1003-20. doi: 10.1021/acs.jmedchem.5b01512. Epub 2016 Jan 22.

PMID:
26751273
9.

Developing the Saegusa-Ito Cyclisation for the Synthesis of Difluorinated Cyclohexenones.

Percy JM, McCarter AW, Sewell AL, Sloan N, Kennedy AR, Hirst DJ.

Chemistry. 2015 Dec 21;21(52):19119-27. doi: 10.1002/chem.201503653. Epub 2015 Nov 13.

PMID:
26564395
10.

Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion.

Hirst DJ, Lee TH, Pattenden LK, Thomas WG, Aguilar MI.

Sci Rep. 2015 Jun 30;5:9972. doi: 10.1038/srep09972.

11.

New insights into the molecular mechanisms of biomembrane structural changes and interactions by optical biosensor technology.

Lee TH, Hirst DJ, Aguilar MI.

Biochim Biophys Acta. 2015 Sep;1848(9):1868-85. doi: 10.1016/j.bbamem.2015.05.012. Epub 2015 May 22. Review.

12.

Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself.

McCrudden CM, O'Rourke MG, Cherry KE, Yuen HF, O'Rourke D, Babur M, Telfer BA, Thomas HD, Keane P, Nambirajan T, Hagan C, O'Sullivan JM, Shaw C, Williams KJ, Curtin NJ, Hirst DG, Robson T.

PLoS One. 2015 Feb 17;10(2):e0118187. doi: 10.1371/journal.pone.0118187. eCollection 2015.

13.

A modular synthesis of functionalised phenols enabled by controlled boron speciation.

Molloy JJ, Law RP, Fyfe JW, Seath CP, Hirst DJ, Watson AJ.

Org Biomol Chem. 2015 Mar 14;13(10):3093-102. doi: 10.1039/c5ob00078e.

PMID:
25628154
14.

Highly selective allylborations of aldehydes using α,α-disubstituted allylic pinacol boronic esters.

Hesse MJ, Essafi S, Watson CG, Harvey JN, Hirst D, Willis CL, Aggarwal VK.

Angew Chem Int Ed Engl. 2014 Jun 10;53(24):6145-9. doi: 10.1002/anie.201402995. Epub 2014 May 5.

PMID:
24799283
15.

Evaluation of engineering controls for the mixing of flavorings containing diacetyl and other volatile ingredients.

Hirst DV, Dunn KH, Shulman SA, Hammond DR, Sestito N.

J Occup Environ Hyg. 2014;11(10):680-7. doi: 10.1080/15459624.2014.904517.

16.

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions.

Jain S, Coulter JA, Butterworth KT, Hounsell AR, McMahon SJ, Hyland WB, Muir MF, Dickson GR, Prise KM, Currell FJ, Hirst DG, O'Sullivan JM.

Radiother Oncol. 2014 Feb;110(2):342-7. doi: 10.1016/j.radonc.2013.12.013. Epub 2014 Jan 17.

PMID:
24444528
17.

Combined mass and structural kinetic analysis of multistate antimicrobial peptide-membrane interactions.

Hirst DJ, Lee TH, Swann MJ, Aguilar MI.

Anal Chem. 2013 Oct 1;85(19):9296-304. doi: 10.1021/ac402148v. Epub 2013 Sep 20.

PMID:
23998643
18.

The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway.

Yakkundi A, McCallum L, O'Kane A, Dyer H, Worthington J, McKeen HD, McClements L, Elliott C, McCarthy HO, Hirst DG, Robson T.

PLoS One. 2013;8(2):e55075. doi: 10.1371/journal.pone.0055075. Epub 2013 Feb 15.

19.

The contribution of N₂O₃ to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation.

Ali AA, Coulter JA, Ogle CH, Migaud MM, Hirst DG, Robson T, McCarthy HO.

Biosci Rep. 2013 Mar 28;33(2). pii: e00031. doi: 10.1042/BSR20120120.

20.

Aerosol Generation by Modern Flush Toilets.

Johnson D, Lynch R, Marshall C, Mead K, Hirst D.

Aerosol Sci Technol. 2013;47(9):1047-1057.

21.

Lifting the lid on toilet plume aerosol: a literature review with suggestions for future research.

Johnson DL, Mead KR, Lynch RA, Hirst DV.

Am J Infect Control. 2013 Mar;41(3):254-8. doi: 10.1016/j.ajic.2012.04.330. Epub 2012 Oct 5. Review.

22.

Recording the many face of death at the Denbigh Asylum, 1848-1938.

Michael P, Hirst D.

Hist Psychiatry. 2012 Mar;23(89 Pt 1):40-51.

PMID:
22701926
23.

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles.

Coulter JA, Jain S, Butterworth KT, Taggart LE, Dickson GR, McMahon SJ, Hyland WB, Muir MF, Trainor C, Hounsell AR, O'Sullivan JM, Schettino G, Currell FJ, Hirst DG, Prise KM.

Int J Nanomedicine. 2012;7:2673-85. doi: 10.2147/IJN.S31751. Epub 2012 Jun 1.

24.

Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor.

Xu H, Zhang H, Luan L, Xu Y, Li C, Wang Y, Han F, Yang T, Ren F, Xiang JN, Elliott JD, Zhao Y, Guo TB, Lu H, Zhang W, Hirst D, Lindon M, Lin X.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2456-9. doi: 10.1016/j.bmcl.2012.02.016. Epub 2012 Feb 15.

PMID:
22386243
25.

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles.

McMahon SJ, Hyland WB, Muir MF, Coulter JA, Jain S, Butterworth KT, Schettino G, Dickson GR, Hounsell AR, O'Sullivan JM, Prise KM, Hirst DG, Currell FJ.

Sci Rep. 2011;1:18. doi: 10.1038/srep00018. Epub 2011 Jun 20. Erratum in: Sci Rep. 2013;3:1725.

26.

Gold nanoparticles as novel agents for cancer therapy.

Jain S, Hirst DG, O'Sullivan JM.

Br J Radiol. 2012 Feb;85(1010):101-13. doi: 10.1259/bjr/59448833. Epub 2011 Oct 18. Review.

27.

Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.

Senra JM, Telfer BA, Cherry KE, McCrudden CM, Hirst DG, O'Connor MJ, Wedge SR, Stratford IJ.

Mol Cancer Ther. 2011 Oct;10(10):1949-58. doi: 10.1158/1535-7163.MCT-11-0278. Epub 2011 Aug 8.

28.

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy.

McMahon SJ, Hyland WB, Muir MF, Coulter JA, Jain S, Butterworth KT, Schettino G, Dickson GR, Hounsell AR, O'Sullivan JM, Prise KM, Hirst DG, Currell FJ.

Radiother Oncol. 2011 Sep;100(3):412-6. doi: 10.1016/j.radonc.2011.08.026. Epub 2011 Sep 15.

PMID:
21924786
29.

Antitumor actions of ruthenium(III)-based nitric oxide scavengers and nitric oxide synthase inhibitors.

Flitney FW, Pritchard RJ, Kennovin GD, Bisland SK, Hirst DG, Fricker SP.

Mol Cancer Ther. 2011 Sep;10(9):1571-80. doi: 10.1158/1535-7163.MCT-10-0840. Epub 2011 Jun 28.

30.

Short-term monitoring of formaldehyde: comparison of two direct-reading instruments to a laboratory-based method.

Hirst DV, Gressel MG, Flanders WD.

J Occup Environ Hyg. 2011 Jun;8(6):357-63. doi: 10.1080/15459624.2011.578499.

PMID:
21557128
31.

FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism.

Valentine A, O'Rourke M, Yakkundi A, Worthington J, Hookham M, Bicknell R, McCarthy HO, McClelland K, McCallum L, Dyer H, McKeen H, Waugh DJ, Roberts J, McGregor J, Cotton G, James I, Harrison T, Hirst DG, Robson T.

Clin Cancer Res. 2011 Mar 1;17(5):1044-56. doi: 10.1158/1078-0432.CCR-10-2241. Epub 2011 Mar 1.

32.

Effect of acyl chain structure and bilayer phase state on binding and penetration of a supported lipid bilayer by HPA3.

Hirst DJ, Lee TH, Swann MJ, Unabia S, Park Y, Hahm KS, Aguilar MI.

Eur Biophys J. 2011 Apr;40(4):503-14. doi: 10.1007/s00249-010-0664-1. Epub 2011 Jan 11.

PMID:
21222117
33.

Nitric oxide physiology and pathology.

Hirst DG, Robson T.

Methods Mol Biol. 2011;704:1-13. doi: 10.1007/978-1-61737-964-2_1. Review.

PMID:
21161625
34.

Evaluation of a multi-functional nanocarrier for targeted breast cancer iNOS gene therapy.

McCarthy HO, Zholobenko AV, Wang Y, Canine B, Robson T, Hirst DG, Hatefi A.

Int J Pharm. 2011 Feb 28;405(1-2):196-202. doi: 10.1016/j.ijpharm.2010.11.051. Epub 2010 Dec 4.

PMID:
21134429
35.

Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies.

Jain S, Coulter JA, Hounsell AR, Butterworth KT, McMahon SJ, Hyland WB, Muir MF, Dickson GR, Prise KM, Currell FJ, O'Sullivan JM, Hirst DG.

Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):531-9. doi: 10.1016/j.ijrobp.2010.08.044. Epub 2010 Nov 20.

36.

Thymidine kinase gene modified bone marrow mesenchymal stem cells as vehicles for antitumor therapy.

Song C, Xiang J, Tang J, Hirst DG, Zhou J, Chan KM, Li G.

Hum Gene Ther. 2011 Apr;22(4):439-49. doi: 10.1089/hum.2010.116. Epub 2011 Feb 2.

PMID:
20925460
37.

Transcriptional regulation of inducible nitric oxide synthase gene therapy: targeting early stage and advanced prostate cancer.

Coulter JA, Page NL, Worthington J, Robson T, Hirst DG, McCarthy HO.

J Gene Med. 2010 Sep;12(9):755-65. doi: 10.1002/jgm.1495.

PMID:
20821746
38.

A multicenter trial of aviation-style training for surgical teams.

Catchpole KR, Dale TJ, Hirst DG, Smith JP, Giddings TA.

J Patient Saf. 2010 Sep;6(3):180-6. doi: 10.1097/PTS.0b013e3181f100ea.

PMID:
20802280
39.

Molecular biology: the key to personalised treatment in radiation oncology?

Hirst DG, Robson T.

Br J Radiol. 2010 Sep;83(993):723-8. doi: 10.1259/bjr/91488645.

40.

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy.

Butterworth KT, Coulter JA, Jain S, Forker J, McMahon SJ, Schettino G, Prise KM, Currell FJ, Hirst DG.

Nanotechnology. 2010 Jul 23;21(29):295101. doi: 10.1088/0957-4484/21/29/295101. Epub 2010 Jul 5.

41.

Nitric oxide in cancer therapeutics: interaction with cytotoxic chemotherapy.

Hirst D, Robson T.

Curr Pharm Des. 2010;16(4):411-20. Review.

PMID:
20236069
42.

Nitrosative stress as a mediator of apoptosis: implications for cancer therapy.

Hirst DG, Robson T.

Curr Pharm Des. 2010 Jan;16(1):45-55. Review.

PMID:
20214617
43.

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.

Sunnotel O, Hiripi L, Lagan K, McDaid JR, De León JM, Miyagawa Y, Crowe H, Kaluskar S, Ward M, Scullion C, Campbell A, Downes CS, Hirst D, Barton D, Mocanu E, Tsujimura A, Cox MB, Robson T, Walsh CP.

Reprod Biol Endocrinol. 2010 Mar 8;8:22. doi: 10.1186/1477-7827-8-22.

44.

Total synthesis of (+/-)-powelline and (+/-)-buphanidrine.

Bogle KM, Hirst DJ, Dixon DJ.

Org Lett. 2010 Mar 19;12(6):1252-4. doi: 10.1021/ol1000654.

PMID:
20175516
45.

FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy.

McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T.

Cancer Res. 2010 Feb 1;70(3):1090-100. doi: 10.1158/0008-5472.CAN-09-2515. Epub 2010 Jan 26.

46.

Assessing quality and safety competencies of graduating prelicensure nursing students.

Sullivan DT, Hirst D, Cronenwett L.

Nurs Outlook. 2009 Nov-Dec;57(6):323-31. doi: 10.1016/j.outlook.2009.08.004.

PMID:
19942033
47.

Info-jection: dispelling myths and overcoming fears.

Thomson S, Burrow E, Walker D, Turner M, Gobbie A, Unger F, Hirst D.

Aust Nurs J. 2009 Sep;17(3):27. No abstract available.

PMID:
19860050
48.

Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

Ali M, Telfer BA, McCrudden C, O'Rourke M, Thomas HD, Kamjoo M, Kyle S, Robson T, Shaw C, Hirst DG, Curtin NJ, Williams KJ.

Clin Cancer Res. 2009 Oct 1;15(19):6106-12. doi: 10.1158/1078-0432.CCR-09-0398. Epub 2009 Sep 29.

49.

Fragmentation and plasmid strand breaks in pure and gold-doped DNA irradiated by beams of fast hydrogen atoms.

Wyer JA, Butterworth KT, Hirst DG, Latimer CJ, Montenegro EC, Shah MB, Currell FJ.

Phys Med Biol. 2009 Aug 7;54(15):4705-21. doi: 10.1088/0031-9155/54/15/005. Epub 2009 Jul 10.

PMID:
19590119
50.

Mesenchymal stem cells as a gene therapy carrier for treatment of fibrosarcoma.

Xiang J, Tang J, Song C, Yang Z, Hirst DG, Zheng QJ, Li G.

Cytotherapy. 2009;11(5):516-26. doi: 10.1080/14653240902960429.

PMID:
19562576

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