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Items: 1 to 50 of 133

1.

Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting.

Alves CRR, MacDonald TL, Nigro P, Pathak P, Hirshman MF, Goodyear LJ, Lessard SJ.

Biomed Pharmacother. 2019 Sep;117:109197. doi: 10.1016/j.biopha.2019.109197. Epub 2019 Jul 6.

2.

Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.

Li ME, Lauritzen HPMM, O'Neill BT, Wang CH, Cai W, Brandao BB, Sakaguchi M, Tao R, Hirshman MF, Softic S, Kahn CR.

Nat Commun. 2019 Jul 30;10(1):3412. doi: 10.1038/s41467-019-11265-y.

3.

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.

Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH.

Cell Metab. 2019 Oct 1;30(4):768-783.e7. doi: 10.1016/j.cmet.2019.07.001. Epub 2019 Jul 25.

PMID:
31353262
4.

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism.

Takahashi H, Alves CRR, Stanford KI, Middelbeek RJW, Pasquale Nigro, Ryan RE, Xue R, Sakaguchi M, Lynes MD, So K, Mul JD, Lee MY, Balan E, Pan H, Dreyfuss JM, Hirshman MF, Azhar M, Hannukainen JC, Nuutila P, Kalliokoski KK, Nielsen S, Pedersen BK, Kahn CR, Tseng YH, Goodyear LJ.

Nat Metab. 2019 Feb;1(2):291-303. doi: 10.1038/s42255-018-0030-7. Epub 2019 Feb 11.

5.

Paternal Exercise Improves Glucose Metabolism in Adult Offspring.

Stanford KI, Rasmussen M, Baer LA, Lehnig AC, Rowland LA, White JD, So K, De Sousa-Coelho AL, Hirshman MF, Patti ME, Rando OJ, Goodyear LJ.

Diabetes. 2018 Dec;67(12):2530-2540. doi: 10.2337/db18-0667. Epub 2018 Oct 21.

6.

Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart.

Sun XL, Lessard SJ, An D, Koh HJ, Esumi H, Hirshman MF, Goodyear LJ.

J Cell Biochem. 2019 Jan;120(1):685-696. doi: 10.1002/jcb.27425. Epub 2018 Sep 7.

PMID:
30256437
7.

JNK regulates muscle remodeling via myostatin/SMAD inhibition.

Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ.

Nat Commun. 2018 Aug 2;9(1):3030. doi: 10.1038/s41467-018-05439-3.

8.

Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB.

Mul JD, Soto M, Cahill ME, Ryan RE, Takahashi H, So K, Zheng J, Croote DE, Hirshman MF, la Fleur SE, Nestler EJ, Goodyear LJ.

Neuropsychopharmacology. 2018 Aug;43(9):1934-1942. doi: 10.1038/s41386-018-0103-z. Epub 2018 May 24.

9.

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake.

Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ.

Cell Metab. 2018 Jun 5;27(6):1357. doi: 10.1016/j.cmet.2018.04.023. No abstract available.

10.

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake.

Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ.

Cell Metab. 2018 May 1;27(5):1111-1120.e3. doi: 10.1016/j.cmet.2018.03.020. Erratum in: Cell Metab. 2018 Jun 5;27(6):1357.

11.

Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384b.

12.

Tribbles 3 regulates protein turnover in mouse skeletal muscle.

Choi RH, McConahay A, Jeong HW, McClellan JL, Hardee JP, Carson JA, Hirshman MF, Goodyear LJ, Koh HJ.

Biochem Biophys Res Commun. 2017 Nov 25;493(3):1236-1242. doi: 10.1016/j.bbrc.2017.09.134. Epub 2017 Sep 27.

13.

Maternal Exercise Improves Glucose Tolerance in Female Offspring.

Stanford KI, Takahashi H, So K, Alves-Wagner AB, Prince NB, Lehnig AC, Getchell KM, Lee MY, Hirshman MF, Goodyear LJ.

Diabetes. 2017 Aug;66(8):2124-2136. doi: 10.2337/db17-0098. Epub 2017 Jun 1.

14.

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.

Nat Med. 2017 May;23(5):631-637. doi: 10.1038/nm.4297. Epub 2017 Mar 27. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

15.

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR.

J Clin Invest. 2016 Sep 1;126(9):3433-46. doi: 10.1172/JCI86522. Epub 2016 Aug 15.

16.

Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.

Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O'Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y, Tseng YH.

Diabetologia. 2016 Aug;59(8):1769-77. doi: 10.1007/s00125-016-3990-8. Epub 2016 May 21.

17.

Relationship of brown adipose tissue perfusion and function: a study through β2-adrenoreceptor stimulation.

Ernande L, Stanford KI, Thoonen R, Zhang H, Clerte M, Hirshman MF, Goodyear LJ, Bloch KD, Buys ES, Scherrer-Crosbie M.

J Appl Physiol (1985). 2016 Apr 15;120(8):825-32. doi: 10.1152/japplphysiol.00634.2015. Epub 2016 Jan 28.

18.

The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.

Lessard SJ, Rivas DA, So K, Koh HJ, Queiroz AL, Hirshman MF, Fielding RA, Goodyear LJ.

J Clin Invest. 2016 Feb;126(2):560-70.

19.

Contraction stimulates muscle glucose uptake independent of atypical PKC.

Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ.

Physiol Rep. 2015 Nov;3(11). pii: e12565. doi: 10.14814/phy2.12565.

20.

Exercise and Regulation of Carbohydrate Metabolism.

Mul JD, Stanford KI, Hirshman MF, Goodyear LJ.

Prog Mol Biol Transl Sci. 2015;135:17-37. doi: 10.1016/bs.pmbts.2015.07.020. Epub 2015 Aug 20. Review.

21.

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

Zhang H, Guan M, Townsend KL, Huang TL, An D, Yan X, Xue R, Schulz TJ, Winnay J, Mori M, Hirshman MF, Kristiansen K, Tsang JS, White AP, Cypess AM, Goodyear LJ, Tseng YH.

EMBO Rep. 2015 Oct;16(10):1378-93. doi: 10.15252/embr.201540837. Epub 2015 Aug 24.

22.

Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.

Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR.

Nat Commun. 2015 Aug 24;6:8054. doi: 10.1038/ncomms9054.

23.

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.

O'Neill BT, Lauritzen HP, Hirshman MF, Smyth G, Goodyear LJ, Kahn CR.

Cell Rep. 2015 May 26;11(8):1220-35. doi: 10.1016/j.celrep.2015.04.037. Epub 2015 May 14.

24.

A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis.

Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH, Goodyear LJ.

Diabetes. 2015 Jun;64(6):2002-14. doi: 10.2337/db14-0704. Epub 2015 Jan 20.

25.

Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring.

Stanford KI, Lee MY, Getchell KM, So K, Hirshman MF, Goodyear LJ.

Diabetes. 2015 Feb;64(2):427-33. doi: 10.2337/db13-1848. Epub 2014 Sep 9.

26.

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.

Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ.

Science. 2014 May 9;344(6184):649-52. doi: 10.1126/science.1251152. Epub 2014 May 5.

27.

Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice.

An D, Lessard SJ, Toyoda T, Lee MY, Koh HJ, Qi L, Hirshman MF, Goodyear LJ.

Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15;306(12):R925-33. doi: 10.1152/ajpregu.00027.2014. Epub 2014 Apr 16.

28.

Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo.

Lauritzen HP, Brandauer J, Schjerling P, Koh HJ, Treebak JT, Hirshman MF, Galbo H, Goodyear LJ.

Diabetes. 2013 Sep;62(9):3081-92. doi: 10.2337/db12-1261. Epub 2013 Jun 12.

29.

Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle.

Middelbeek RJ, Chambers MA, Tantiwong P, Treebak JT, An D, Hirshman MF, Musi N, Goodyear LJ.

Nutr Diabetes. 2013 Jun 10;3:e74. doi: 10.1038/nutd.2013.13.

30.

Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle.

Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z.

Cell Rep. 2013 May 30;3(5):1449-56. doi: 10.1016/j.celrep.2013.04.023. Epub 2013 May 23.

31.

Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.

Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ.

Nat Commun. 2013;4:1871. doi: 10.1038/ncomms2851.

32.

Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks.

Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG, Goodyear LJ.

Diabetes. 2013 Aug;62(8):2717-27. doi: 10.2337/db13-0062. Epub 2013 Apr 22.

33.

Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation.

Friedrichsen M, Birk JB, Richter EA, Ribel-Madsen R, Pehmøller C, Hansen BF, Beck-Nielsen H, Hirshman MF, Goodyear LJ, Vaag A, Poulsen P, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2013 Mar 15;304(6):E631-9. doi: 10.1152/ajpendo.00494.2012. Epub 2013 Jan 15.

34.

Characterization of an acute muscle contraction model using cultured C2C12 myotubes.

Manabe Y, Miyatake S, Takagi M, Nakamura M, Okeda A, Nakano T, Hirshman MF, Goodyear LJ, Fujii NL.

PLoS One. 2012;7(12):e52592. doi: 10.1371/journal.pone.0052592. Epub 2012 Dec 31.

35.

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.

Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, Hitchcox KM, Markan KR, Nakano K, Hirshman MF, Tseng YH, Goodyear LJ.

J Clin Invest. 2013 Jan;123(1):215-23. doi: 10.1172/JCI62308. Epub 2012 Dec 10.

36.

Exercise training-induced adaptations associated with increases in skeletal muscle glycogen content.

Manabe Y, Gollisch KS, Holton L, Kim YB, Brandauer J, Fujii NL, Hirshman MF, Goodyear LJ.

FEBS J. 2013 Feb;280(3):916-26. doi: 10.1111/febs.12085. Epub 2013 Jan 7.

37.

Exercise increases TBC1D1 phosphorylation in human skeletal muscle.

Jessen N, An D, Lihn AS, Nygren J, Hirshman MF, Thorell A, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E164-71. doi: 10.1152/ajpendo.00042.2011. Epub 2011 Apr 19.

38.

Myo1c regulates glucose uptake in mouse skeletal muscle.

Toyoda T, An D, Witczak CA, Koh HJ, Hirshman MF, Fujii N, Goodyear LJ.

J Biol Chem. 2011 Feb 11;286(6):4133-40. doi: 10.1074/jbc.M110.174938. Epub 2010 Dec 2.

39.

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.

Koh HJ, Toyoda T, Fujii N, Jung MM, Rathod A, Middelbeek RJ, Lessard SJ, Treebak JT, Tsuchihara K, Esumi H, Richter EA, Wojtaszewski JF, Hirshman MF, Goodyear LJ.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15541-6. doi: 10.1073/pnas.1008131107. Epub 2010 Aug 16.

40.

Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.

Vichaiwong K, Purohit S, An D, Toyoda T, Jessen N, Hirshman MF, Goodyear LJ.

Biochem J. 2010 Oct 15;431(2):311-20. doi: 10.1042/BJ20101100.

41.

Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.

Jessen N, Koh HJ, Folmes CD, Wagg C, Fujii N, Løfgren B, Wolf CM, Berul CI, Hirshman MF, Lopaschuk GD, Goodyear LJ.

Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):593-600. doi: 10.1016/j.bbadis.2010.04.008. Epub 2010 May 2.

42.

TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle.

An D, Toyoda T, Taylor EB, Yu H, Fujii N, Hirshman MF, Goodyear LJ.

Diabetes. 2010 Jun;59(6):1358-65. doi: 10.2337/db09-1266. Epub 2010 Mar 18.

43.

CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle.

Witczak CA, Jessen N, Warro DM, Toyoda T, Fujii N, Anderson ME, Hirshman MF, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1150-60. doi: 10.1152/ajpendo.00659.2009. Epub 2010 Mar 9.

44.

Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals.

Sharoff CG, Hagobian TA, Malin SK, Chipkin SR, Yu H, Hirshman MF, Goodyear LJ, Braun B.

Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E815-23. doi: 10.1152/ajpendo.00517.2009. Epub 2010 Jan 13.

45.

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.

Treebak JT, Taylor EB, Witczak CA, An D, Toyoda T, Koh HJ, Xie J, Feener EP, Wojtaszewski JF, Hirshman MF, Goodyear LJ.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C377-85. doi: 10.1152/ajpcell.00297.2009. Epub 2009 Nov 18.

46.

Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats.

Gollisch KS, Brandauer J, Jessen N, Toyoda T, Nayer A, Hirshman MF, Goodyear LJ.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E495-504. doi: 10.1152/ajpendo.90424.2008. Epub 2009 Jun 2.

47.

Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus.

Rogers NH, Witczak CA, Hirshman MF, Goodyear LJ, Greenberg AS.

Biochem Biophys Res Commun. 2009 May 15;382(4):646-50. doi: 10.1016/j.bbrc.2009.02.154. Epub 2009 Mar 3.

48.

Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.

Fujii N, Ho RC, Manabe Y, Jessen N, Toyoda T, Holland WL, Summers SA, Hirshman MF, Goodyear LJ.

Diabetes. 2008 Nov;57(11):2958-66. doi: 10.2337/db07-1187. Epub 2008 Aug 26.

49.

Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.

Norris AW, Hirshman MF, Yao J, Jessen N, Musi N, Chen L, Sivitz WI, Goodyear LJ, Kahn CR.

Endocrinology. 2008 Nov;149(11):5374-83. doi: 10.1210/en.2008-0100. Epub 2008 Jul 24.

50.

Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles.

Cerletti M, Jurga S, Witczak CA, Hirshman MF, Shadrach JL, Goodyear LJ, Wagers AJ.

Cell. 2008 Jul 11;134(1):37-47. doi: 10.1016/j.cell.2008.05.049.

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