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Items: 1 to 50 of 66

1.

Sensing Mitochondrial Acetyl-CoA to Tune Respiration.

Mills CA, Trub AG, Hirschey MD.

Trends Endocrinol Metab. 2018 Nov 12. pii: S1043-2760(18)30189-9. doi: 10.1016/j.tem.2018.10.003. [Epub ahead of print]

PMID:
30442533
2.

Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.

Peterson BS, Campbell JE, Ilkayeva O, Grimsrud PA, Hirschey MD, Newgard CB.

Cell Rep. 2018 Jul 3;24(1):209-223.e6. doi: 10.1016/j.celrep.2018.05.088.

3.

Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.

Hershberger KA, Abraham DM, Liu J, Locasale JW, Grimsrud PA, Hirschey MD.

J Biol Chem. 2018 Jul 6;293(27):10630-10645. doi: 10.1074/jbc.RA118.002187. Epub 2018 May 16.

PMID:
29769314
4.

Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress.

Trub AG, Hirschey MD.

Trends Biochem Sci. 2018 May;43(5):369-379. doi: 10.1016/j.tibs.2018.02.002. Epub 2018 Feb 22. Review.

PMID:
29478872
5.

Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.

Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB.

J Biol Chem. 2018 Feb 9;293(6):2006-2014. doi: 10.1074/jbc.M117.782557. Epub 2017 Dec 8.

PMID:
29222328
6.

Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.

Weir HJ, Yao P, Huynh FK, Escoubas CC, Goncalves RL, Burkewitz K, Laboy R, Hirschey MD, Mair WB.

Cell Metab. 2017 Dec 5;26(6):884-896.e5. doi: 10.1016/j.cmet.2017.09.024. Epub 2017 Oct 26.

PMID:
29107506
7.

daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival.

Hibshman JD, Doan AE, Moore BT, Kaplan RE, Hung A, Webster AK, Bhatt DP, Chitrakar R, Hirschey MD, Baugh LR.

Elife. 2017 Oct 24;6. pii: e30057. doi: 10.7554/eLife.30057.

8.

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.

Rajabi N, Auth M, Troelsen KR, Pannek M, Bhatt DP, Fontenas M, Hirschey MD, Steegborn C, Madsen AS, Olsen CA.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841. doi: 10.1002/anie.201709050. Epub 2017 Nov 2.

9.

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.

Hershberger KA, Abraham DM, Martin AS, Mao L, Liu J, Gu H, Locasale JW, Hirschey MD.

J Biol Chem. 2017 Dec 1;292(48):19767-19781. doi: 10.1074/jbc.M117.809897. Epub 2017 Oct 2.

PMID:
28972174
10.

Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio.

Anderson KA, Madsen AS, Olsen CA, Hirschey MD.

Biochim Biophys Acta Bioenerg. 2017 Dec;1858(12):991-998. doi: 10.1016/j.bbabio.2017.09.005. Epub 2017 Sep 22. Review.

PMID:
28947253
11.

Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.

Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS.

Alcohol Clin Exp Res. 2017 Oct;41(10):1705-1714. doi: 10.1111/acer.13473. Epub 2017 Sep 14.

12.

Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.

Huynh FK, Hu X, Lin Z, Johnson JD, Hirschey MD.

J Inherit Metab Dis. 2018 Jan;41(1):59-72. doi: 10.1007/s10545-017-0069-8. Epub 2017 Jul 19.

PMID:
28726069
13.

Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.

Martin AS, Abraham DM, Hershberger KA, Bhatt DP, Mao L, Cui H, Liu J, Liu X, Muehlbauer MJ, Grimsrud PA, Locasale JW, Payne RM, Hirschey MD.

JCI Insight. 2017 Jul 20;2(14). pii: 93885. doi: 10.1172/jci.insight.93885. [Epub ahead of print]

14.

Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.

Stram AR, Wagner GR, Fogler BD, Pride PM, Hirschey MD, Payne RM.

PLoS One. 2017 May 25;12(5):e0178354. doi: 10.1371/journal.pone.0178354. eCollection 2017.

15.

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.

Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD.

Cell Metab. 2017 Apr 4;25(4):838-855.e15. doi: 10.1016/j.cmet.2017.03.003.

16.

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.

Wagner GR, Bhatt DP, O'Connell TM, Thompson JW, Dubois LG, Backos DS, Yang H, Mitchell GA, Ilkayeva OR, Stevens RD, Grimsrud PA, Hirschey MD.

Cell Metab. 2017 Apr 4;25(4):823-837.e8. doi: 10.1016/j.cmet.2017.03.006.

17.

A Prob(e)able Route to Lysine Acylation.

Wagner GR, Hirschey MD.

Cell Chem Biol. 2017 Feb 16;24(2):126-128. doi: 10.1016/j.chembiol.2017.01.011.

18.

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases.

Hershberger KA, Martin AS, Hirschey MD.

Nat Rev Nephrol. 2017 Apr;13(4):213-225. doi: 10.1038/nrneph.2017.5. Epub 2017 Feb 6. Review.

19.

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.

McDonnell E, Crown SB, Fox DB, Kitir B, Ilkayeva OR, Olsen CA, Grimsrud PA, Hirschey MD.

Cell Rep. 2016 Nov 1;17(6):1463-1472. doi: 10.1016/j.celrep.2016.10.012.

20.

Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans.

Luz AT, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN.

Toxicol Sci. 2016 Nov;154(1):195. No abstract available.

PMID:
27794142
22.

From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans.

Luz AL, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN.

Toxicol Sci. 2016 Aug;152(2):349-62. doi: 10.1093/toxsci/kfw093. Epub 2016 May 20. Erratum in: Toxicol Sci. 2016 Nov;154(1):195.

23.

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.

Madsen AS, Andersen C, Daoud M, Anderson KA, Laursen JS, Chakladar S, Huynh FK, Colaço AR, Backos DS, Fristrup P, Hirschey MD, Olsen CA.

J Biol Chem. 2016 Mar 25;291(13):7128-41. doi: 10.1074/jbc.M115.668699. Epub 2016 Feb 9.

24.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

25.

Dysregulated metabolism contributes to oncogenesis.

Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE; Target Validation Team.

Semin Cancer Biol. 2015 Dec;35 Suppl:S129-S150. doi: 10.1016/j.semcancer.2015.10.002. Epub 2015 Oct 8. Review.

26.

SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control.

Huynh FK, Muoio DM, Hirschey MD.

Diabetes. 2015 Sep;64(9):3058-60. doi: 10.2337/db15-0709. No abstract available.

27.

Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.

Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES.

J Biol Chem. 2015 Sep 25;290(39):23897-904. doi: 10.1074/jbc.M115.655837. Epub 2015 Aug 3.

28.

SIRT3 regulates progression and development of diseases of aging.

McDonnell E, Peterson BS, Bomze HM, Hirschey MD.

Trends Endocrinol Metab. 2015 Sep;26(9):486-492. doi: 10.1016/j.tem.2015.06.001. Epub 2015 Jun 29. Review.

29.

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet.

Liu X, Sadhukhan S, Sun S, Wagner GR, Hirschey MD, Qi L, Lin H, Locasale JW.

Mol Cell Proteomics. 2015 Jun;14(6):1489-500. doi: 10.1074/mcp.M114.044859. Epub 2015 Mar 20.

30.

Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.

Burkewitz K, Morantte I, Weir HJM, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB.

Cell. 2015 Feb 26;160(5):842-855. doi: 10.1016/j.cell.2015.02.004.

31.

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.

Hirschey MD, Zhao Y.

Mol Cell Proteomics. 2015 Sep;14(9):2308-15. doi: 10.1074/mcp.R114.046664. Epub 2015 Feb 25. Review.

32.

Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.

Glass OK, Inman BA, Broadwater G, Courneya KS, Mackey JR, Goruk S, Nelson ER, Jasper J, Field CJ, Bain JR, Muehlbauer M, Stevens RD, Hirschey MD, Jones LW.

Br J Cancer. 2015 Mar 3;112(5):825-31. doi: 10.1038/bjc.2014.662. Epub 2015 Jan 13.

33.

SnapShot: Mammalian Sirtuins.

Anderson KA, Green MF, Huynh FK, Wagner GR, Hirschey MD.

Cell. 2014 Nov 6;159(4):956-956.e1. doi: 10.1016/j.cell.2014.10.045.

34.

Mitochondria, energetics, epigenetics, and cellular responses to stress.

Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL.

Environ Health Perspect. 2014 Dec;122(12):1271-8. doi: 10.1289/ehp.1408418. Epub 2014 Aug 15. Review.

35.

Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.

Schechter MA, Hsieh MK, Njoroge LW, Thompson JW, Soderblom EJ, Feger BJ, Troupes CD, Hershberger KA, Ilkayeva OR, Nagel WL, Landinez GP, Shah KM, Burns VA, Santacruz L, Hirschey MD, Foster MW, Milano CA, Moseley MA, Piacentino V 3rd, Bowles DE.

PLoS One. 2014 Aug 12;9(8):e104157. doi: 10.1371/journal.pone.0104157. eCollection 2014.

36.

Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.

Moffat C, Bhatia L, Nguyen T, Lynch P, Wang M, Wang D, Ilkayeva OR, Han X, Hirschey MD, Claypool SM, Seifert EL.

J Lipid Res. 2014 Dec;55(12):2458-70. doi: 10.1194/jlr.M046961. Epub 2014 Aug 11.

37.

Measurement of fatty acid oxidation rates in animal tissues and cell lines.

Huynh FK, Green MF, Koves TR, Hirschey MD.

Methods Enzymol. 2014;542:391-405. doi: 10.1016/B978-0-12-416618-9.00020-0.

38.

Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.

Wagner GR, Hirschey MD.

Mol Cell. 2014 Apr 10;54(1):5-16. doi: 10.1016/j.molcel.2014.03.027. Review.

39.

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y.

Cell Metab. 2014 Apr 1;19(4):605-17. doi: 10.1016/j.cmet.2014.03.014.

40.

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.

Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES.

J Biol Chem. 2013 Nov 22;288(47):33837-47. doi: 10.1074/jbc.M113.510354. Epub 2013 Oct 11.

41.

Ethanol metabolism modifies hepatic protein acylation in mice.

Fritz KS, Green MF, Petersen DR, Hirschey MD.

PLoS One. 2013 Sep 20;8(9):e75868. doi: 10.1371/journal.pone.0075868. eCollection 2013.

42.

Oxygen flux analysis to understand the biological function of sirtuins.

Wang D, Green MF, McDonnell E, Hirschey MD.

Methods Mol Biol. 2013;1077:241-58. doi: 10.1007/978-1-62703-637-5_16.

43.

Generating mammalian sirtuin tools for protein-interaction analysis.

Hershberger KA, Motley J, Hirschey MD, Anderson KA.

Methods Mol Biol. 2013;1077:69-78. doi: 10.1007/978-1-62703-637-5_5.

44.

Targeting sirtuins for the treatment of diabetes.

Huynh FK, Hershberger KA, Hirschey MD.

Diabetes Manag (Lond). 2013 May 1;3(3):245-257.

45.

The sirtuins, oxidative stress and aging: an emerging link.

Merksamer PI, Liu Y, He W, Hirschey MD, Chen D, Verdin E.

Aging (Albany NY). 2013 Mar;5(3):144-50. Review.

46.

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.

Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV Jr, de Cabo R, Ulrich S, Akassoglou K, Verdin E.

Science. 2013 Jan 11;339(6116):211-4. doi: 10.1126/science.1227166. Epub 2012 Dec 6.

47.

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.

Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY.

Nat Chem Biol. 2013 Feb;9(2):97-104. doi: 10.1038/nchembio.1136. Epub 2012 Dec 2.

48.

HINT2 and fatty liver disease: mitochondrial protein hyperacetylation gives a hint?

Anderson KA, Wang D, Hirschey MD.

Hepatology. 2013 May;57(5):1681-3. doi: 10.1002/hep.26085. No abstract available.

49.

Mitochondrial protein acetylation regulates metabolism.

Anderson KA, Hirschey MD.

Essays Biochem. 2012;52:23-35. doi: 10.1042/bse0520023. Review.

50.

SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome.

Green MF, Hirschey MD.

J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):105-7. doi: 10.1093/gerona/gls132. Epub 2012 May 4.

PMID:
22562958

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