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Items: 1 to 50 of 173

1.

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.

Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, Méndez-Solís O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM.

Cell Rep. 2019 Jun 11;27(11):3269-3283.e6. doi: 10.1016/j.celrep.2019.05.040.

2.

Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.

Singh S, Ramírez-Salazar EG, Doueiri R, Valentin A, Rosati M, Hu X, Keele BF, Shen X, Tomaras GD, Ferrari G, LaBranche C, Montefiori DC, Das J, Alter G, Trinh HV, Hamlin C, Rao M, Dayton F, Bear J, Chowdhury B, Alicea C, Lifson JD, Broderick KE, Sardesai NY, Sivananthan SJ, Fox CB, Reed SG, Venzon DJ, Hirsch VM, Pavlakis GN, Felber BK.

J Virol. 2018 Jul 17;92(15). pii: e00281-18. doi: 10.1128/JVI.00281-18. Print 2018 Aug 1.

3.

Truncating the gp41 Cytoplasmic Tail of Simian Immunodeficiency Virus Decreases Sensitivity to Neutralizing Antibodies without Increasing the Envelope Content of Virions.

White E, Wu F, Chertova E, Bess J, Roser JD, Lifson JD, Hirsch VM.

J Virol. 2018 Jan 17;92(3). pii: e01688-17. doi: 10.1128/JVI.01688-17. Print 2018 Feb 1.

4.

A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques.

Matsuda K, Riddick NE, Lee CA, Puryear SB, Wu F, Lafont BAP, Whitted S, Hirsch VM.

PLoS Pathog. 2017 Aug 7;13(8):e1006538. doi: 10.1371/journal.ppat.1006538. eCollection 2017 Aug.

5.

Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4+ T Cells in African Green Monkeys.

Vinton CL, Ortiz AM, Calantone N, Mudd JC, Deleage C, Morcock DR, Whitted S, Estes JD, Hirsch VM, Brenchley JM.

J Immunol. 2017 Jun 1;198(11):4403-4412. doi: 10.4049/jimmunol.1700136. Epub 2017 Apr 24.

6.

Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques.

DiNapoli SR, Ortiz AM, Wu F, Matsuda K, Twigg HL 3rd, Hirsch VM, Knox K, Brenchley JM.

JCI Insight. 2017 Feb 23;2(4):e91214. doi: 10.1172/jci.insight.91214.

7.

TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains.

Wu F, Kirmaier A, White E, Ourmanov I, Whitted S, Matsuda K, Riddick N, Hall LR, Morgan JS, Plishka RJ, Buckler-White A, Johnson WE, Hirsch VM.

J Virol. 2016 Nov 28;90(24):11087-11095. Print 2016 Dec 15.

8.

Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections.

DiNapoli SR, Hirsch VM, Brenchley JM.

J Virol. 2016 Aug 12;90(17):7596-606. doi: 10.1128/JVI.00672-16. Print 2016 Sep 1. Review.

9.

Enhanced antagonism of BST-2 by a neurovirulent SIV envelope.

Matsuda K, Chen CY, Whitted S, Chertova E, Roser DJ, Wu F, Plishka RJ, Ourmanov I, Buckler-White A, Lifson JD, Strebel K, Hirsch VM.

J Clin Invest. 2016 Jun 1;126(6):2295-307. doi: 10.1172/JCI83725. Epub 2016 May 9.

10.

Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys.

Mudd JC, Perkins MR, DiNapoli SR, Hirsch VM, Brenchley JM.

J Virol. 2016 May 27;90(12):5750-5758. doi: 10.1128/JVI.00057-16. Print 2016 Jun 15.

11.

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.

Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL.

Nat Med. 2016 Apr;22(4):362-8. doi: 10.1038/nm.4063. Epub 2016 Mar 21.

12.

Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors.

Riddick NE, Wu F, Matsuda K, Whitted S, Ourmanov I, Goldstein S, Goeken RM, Plishka RJ, Buckler-White A, Brenchley JM, Hirsch VM.

J Virol. 2015 Dec 9;90(5):2316-31. doi: 10.1128/JVI.02529-15.

13.

Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses.

Takeuchi JS, Ren F, Yoshikawa R, Yamada E, Nakano Y, Kobayashi T, Matsuda K, Izumi T, Misawa N, Shintaku Y, Wetzel KS, Collman RG, Tanaka H, Hirsch VM, Koyanagi Y, Sato K.

Sci Rep. 2015 Nov 4;5:16021. doi: 10.1038/srep16021.

14.

Down-modulation of primate lentiviral receptors by Nef proteins of simian immunodeficiency virus (SIV) of chimpanzees (SIVcpz) and related SIVs: implication for the evolutionary event at the emergence of SIVcpz.

Nakano Y, Matsuda K, Yoshikawa R, Yamada E, Misawa N, Hirsch VM, Koyanagi Y, Sato K.

J Gen Virol. 2015 Sep;96(9):2867-77. doi: 10.1099/vir.0.000207. Epub 2015 Jun 3.

15.

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.

Fukazawa Y, Lum R, Okoye AA, Park H, Matsuda K, Bae JY, Hagen SI, Shoemaker R, Deleage C, Lucero C, Morcock D, Swanson T, Legasse AW, Axthelm MK, Hesselgesser J, Geleziunas R, Hirsch VM, Edlefsen PT, Piatak M Jr, Estes JD, Lifson JD, Picker LJ.

Nat Med. 2015 Feb;21(2):132-9. doi: 10.1038/nm.3781. Epub 2015 Jan 19.

16.

TRIM5α restriction affects clinical outcome and disease progression in simian immunodeficiency virus-infected rhesus macaques.

Wu F, Ourmanov I, Riddick N, Matsuda K, Whitted S, Plishka RJ, Buckler-White A, Starost MF, Hirsch VM.

J Virol. 2015 Feb;89(4):2233-40. doi: 10.1128/JVI.02978-14. Epub 2014 Dec 3.

17.

Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.

Calantone N, Wu F, Klase Z, Deleage C, Perkins M, Matsuda K, Thompson EA, Ortiz AM, Vinton CL, Ourmanov I, Loré K, Douek DC, Estes JD, Hirsch VM, Brenchley JM.

Immunity. 2014 Sep 18;41(3):493-502. doi: 10.1016/j.immuni.2014.08.014.

18.

Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.

Matsuda K, Dang Q, Brown CR, Keele BF, Wu F, Ourmanov I, Goeken R, Whitted S, Riddick NE, Buckler-White A, Hirsch VM.

J Virol. 2014 Nov;88(22):13201-11. doi: 10.1128/JVI.01996-14. Epub 2014 Sep 3.

19.

Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells.

Perkins MR, Briant JA, Calantone N, Whitted S, Vinton CL, Klatt NR, Ourmanov I, Ortiz AM, Hirsch VM, Brenchley JM.

J Virol. 2014 Sep;88(18):10714-24. doi: 10.1128/JVI.01331-14. Epub 2014 Jul 2.

20.

Characterization of red-capped mangabey tetherin: implication for the co-evolution of primates and their lentiviruses.

Kobayashi T, Takeuchi JS, Ren F, Matsuda K, Sato K, Kimura Y, Misawa N, Yoshikawa R, Nakano Y, Yamada E, Tanaka H, Hirsch VM, Koyanagi Y.

Sci Rep. 2014 Jul 2;4:5529. doi: 10.1038/srep05529.

21.

The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys.

Teigler JE, Phogat S, Franchini G, Hirsch VM, Michael NL, Barouch DH.

J Virol. 2014 Feb;88(3):1809-14. doi: 10.1128/JVI.02386-13. Epub 2013 Nov 20.

22.

TRIM5 alpha drives SIVsmm evolution in rhesus macaques.

Wu F, Kirmaier A, Goeken R, Ourmanov I, Hall L, Morgan JS, Matsuda K, Buckler-White A, Tomioka K, Plishka R, Whitted S, Johnson W, Hirsch VM.

PLoS Pathog. 2013;9(8):e1003577. doi: 10.1371/journal.ppat.1003577. Epub 2013 Aug 22.

23.

Laser capture microdissection assessment of virus compartmentalization in the central nervous systems of macaques infected with neurovirulent simian immunodeficiency virus.

Matsuda K, Brown CR, Foley B, Goeken R, Whitted S, Dang Q, Wu F, Plishka R, Buckler-White A, Hirsch VM.

J Virol. 2013 Aug;87(16):8896-908. doi: 10.1128/JVI.00874-13. Epub 2013 May 29.

24.

Conformational epitope consisting of the V3 and V4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses.

Kuwata T, Takaki K, Yoshimura K, Enomoto I, Wu F, Ourmanov I, Hirsch VM, Yokoyama M, Sato H, Matsushita S.

J Virol. 2013 May;87(10):5424-36. doi: 10.1128/JVI.00201-13. Epub 2013 Mar 6.

25.

DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge.

Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, von Gegerfelt A, Huang W, Guan Y, Keele BF, Bess JW Jr, Piatak M Jr, Lifson JD, Williams WT, Shen X, Tomaras GD, Amara RR, Robinson HL, Johnson W, Broderick KE, Sardesai NY, Venzon DJ, Hirsch VM, Felber BK, Pavlakis GN.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2975-80. doi: 10.1073/pnas.1215393110. Epub 2013 Jan 28.

26.

Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.

Dang Q, Whitted S, Goeken RM, Brenchley JM, Matsuda K, Brown CR, Lafont BA, Starost MF, Iyengar R, Plishka RJ, Buckler-White A, Hirsch VM.

J Virol. 2012 Dec;86(24):13795-9. doi: 10.1128/JVI.02174-12. Epub 2012 Oct 3.

27.

Sequential evolution and escape from neutralization of simian immunodeficiency virus SIVsmE660 clones in rhesus macaques.

Wu F, Ourmanov I, Kuwata T, Goeken R, Brown CR, Buckler-White A, Iyengar R, Plishka R, Aoki ST, Hirsch VM.

J Virol. 2012 Aug;86(16):8835-47. doi: 10.1128/JVI.00923-12. Epub 2012 Jun 13.

28.

Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection.

Klatt NR, Estes JD, Sun X, Ortiz AM, Barber JS, Harris LD, Cervasi B, Yokomizo LK, Pan L, Vinton CL, Tabb B, Canary LA, Dang Q, Hirsch VM, Alter G, Belkaid Y, Lifson JD, Silvestri G, Milner JD, Paiardini M, Haddad EK, Brenchley JM.

Mucosal Immunol. 2012 Nov;5(6):646-57. doi: 10.1038/mi.2012.38. Epub 2012 May 30.

29.

Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques.

Vassena L, Miao H, Cimbro R, Malnati MS, Cassina G, Proschan MA, Hirsch VM, Lafont BA, Morre M, Fauci AS, Lusso P.

PLoS Pathog. 2012;8(4):e1002636. doi: 10.1371/journal.ppat.1002636. Epub 2012 Apr 12.

30.

The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.

Compton AA, Hirsch VM, Emerman M.

Cell Host Microbe. 2012 Jan 19;11(1):91-8. doi: 10.1016/j.chom.2011.11.010.

31.

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys.

Barouch DH, Liu J, Li H, Maxfield LF, Abbink P, Lynch DM, Iampietro MJ, SanMiguel A, Seaman MS, Ferrari G, Forthal DN, Ourmanov I, Hirsch VM, Carville A, Mansfield KG, Stablein D, Pau MG, Schuitemaker H, Sadoff JC, Billings EA, Rao M, Robb ML, Kim JH, Marovich MA, Goudsmit J, Michael NL.

Nature. 2012 Jan 4;482(7383):89-93. doi: 10.1038/nature10766.

32.

SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses.

Lai L, Kwa SF, Kozlowski PA, Montefiori DC, Nolen TL, Hudgens MG, Johnson WE, Ferrari G, Hirsch VM, Felber BK, Pavlakis GN, Earl PL, Moss B, Amara RR, Robinson HL.

Vaccine. 2012 Feb 21;30(9):1737-45. doi: 10.1016/j.vaccine.2011.12.026. Epub 2011 Dec 15.

33.

Characterization of a monoclonal anti-capsid antibody that cross-reacts with three major primate lentivirus lineages.

Sanders-Beer BE, Eschricht M, Seifried J, Hirsch VM, Allan JS, Norley S.

Virology. 2012 Jan 20;422(2):402-12. doi: 10.1016/j.virol.2011.11.003. Epub 2011 Dec 5.

34.

Distal leucines are key functional determinants of Alix-binding simian immunodeficiency virus SIV(smE543) and SIV(mac239) type 3 L domains.

Bello NF, Wu F, Sette P, Dussupt V, Hirsch VM, Bouamr F.

J Virol. 2011 Nov;85(21):11532-7. doi: 10.1128/JVI.05284-11. Epub 2011 Aug 17.

35.

CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.

Vinton C, Klatt NR, Harris LD, Briant JA, Sanders-Beer BE, Herbert R, Woodward R, Silvestri G, Pandrea I, Apetrei C, Hirsch VM, Brenchley JM.

J Virol. 2011 Sep;85(17):8702-8. doi: 10.1128/JVI.00332-11. Epub 2011 Jun 29.

36.

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections.

Estes JD, Harris LD, Klatt NR, Tabb B, Pittaluga S, Paiardini M, Barclay GR, Smedley J, Pung R, Oliveira KM, Hirsch VM, Silvestri G, Douek DC, Miller CJ, Haase AT, Lifson J, Brenchley JM.

PLoS Pathog. 2010 Aug 19;6(8):e1001052. doi: 10.1371/journal.ppat.1001052.

37.

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.

Kirmaier A, Wu F, Newman RM, Hall LR, Morgan JS, O'Connor S, Marx PA, Meythaler M, Goldstein S, Buckler-White A, Kaur A, Hirsch VM, Johnson WE.

PLoS Biol. 2010 Aug 24;8(8). pii: e1000462. doi: 10.1371/journal.pbio.1000462.

38.

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.

Harris LD, Klatt NR, Vinton C, Briant JA, Tabb B, Ladell K, Lifson J, Estes JD, Price DA, Hirsch VM, Brenchley JM.

Blood. 2010 Nov 18;116(20):4148-57. doi: 10.1182/blood-2010-05-283549. Epub 2010 Jul 26.

39.

Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques.

Zheng Y, Ourmanov I, Goeken RM, Whitted S, Brown CR, Buckler-White A, Iyengar R, Plishka RJ, Hirsch VM.

Virology. 2010 Jun 5;401(2):207-14. doi: 10.1016/j.virol.2010.02.026. Epub 2010 Mar 19.

40.

Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.

Zahn RC, Rett MD, Li M, Tang H, Korioth-Schmitz B, Balachandran H, White R, Pryputniewicz S, Letvin NL, Kaur A, Montefiori DC, Carville A, Hirsch VM, Allan JS, Schmitz JE.

Blood. 2010 Apr 15;115(15):3070-8. doi: 10.1182/blood-2009-10-245225. Epub 2010 Feb 10.

41.

Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.

Schmitz JE, Zahn RC, Brown CR, Rett MD, Li M, Tang H, Pryputniewicz S, Byrum RA, Kaur A, Montefiori DC, Allan JS, Goldstein S, Hirsch VM.

PLoS Pathog. 2009 Dec;5(12):e1000691. doi: 10.1371/journal.ppat.1000691. Epub 2009 Dec 11.

42.

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.

Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G.

Nat Med. 2009 Aug;15(8):861-5. doi: 10.1038/nm.2013. Review.

43.

Blocking and tackling HIV.

Haigwood NL, Hirsch VM.

Nat Med. 2009 Aug;15(8):841-2. doi: 10.1038/nm0809-841. No abstract available.

PMID:
19661984
44.

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection.

Beaumier CM, Harris LD, Goldstein S, Klatt NR, Whitted S, McGinty J, Apetrei C, Pandrea I, Hirsch VM, Brenchley JM.

Nat Med. 2009 Aug;15(8):879-85. doi: 10.1038/nm.1970. Epub 2009 Jun 14.

45.

Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies.

Kuwata T, Nishimura Y, Whitted S, Ourmanov I, Brown CR, Dang Q, Buckler-White A, Iyengar R, Brenchley JM, Hirsch VM.

PLoS Pathog. 2009 Apr;5(4):e1000372. doi: 10.1371/journal.ppat.1000372. Epub 2009 Apr 10.

46.

Improved survival in rhesus macaques immunized with modified vaccinia virus Ankara recombinants expressing simian immunodeficiency virus envelope correlates with reduction in memory CD4+ T-cell loss and higher titers of neutralizing antibody.

Ourmanov I, Kuwata T, Goeken R, Goldstein S, Iyengar R, Buckler-White A, Lafont B, Hirsch VM.

J Virol. 2009 Jun;83(11):5388-400. doi: 10.1128/JVI.02598-08. Epub 2009 Mar 25.

47.

Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.

Zahn RC, Rett MD, Korioth-Schmitz B, Sun Y, Buzby AP, Goldstein S, Brown CR, Byrum RA, Freeman GJ, Letvin NL, Hirsch VM, Schmitz JE.

J Virol. 2008 Dec;82(23):11577-88. doi: 10.1128/JVI.01779-08. Epub 2008 Oct 1.

48.

Adaptive evolution of simian immunodeficiency viruses isolated from 2 conventional-progressor macaques with encephalitis.

Dang Q, Goeken RM, Brown CR, Plishka RJ, Buckler-White A, Byrum R, Foley BT, Hirsch VM.

J Infect Dis. 2008 Jun 15;197(12):1695-700. doi: 10.1086/588671.

49.

Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys.

Veazey RS, Acierno PM, McEvers KJ, Baumeister SH, Foster GJ, Rett MD, Newberg MH, Kuroda MJ, Williams K, Kim EY, Wolinsky SM, Rieber EP, Piatak M Jr, Lifson JD, Montefiori DC, Brown CR, Hirsch VM, Schmitz JE.

J Virol. 2008 Jun;82(11):5618-30. doi: 10.1128/JVI.02748-07. Epub 2008 Mar 26.

50.

Rapid disease progression to AIDS due to Simian immunodeficiency virus infection of macaques: host and viral factors.

Dang Q, Hirsch VM.

Adv Pharmacol. 2008;56:369-98. Review. No abstract available.

PMID:
18086418

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