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Items: 1 to 50 of 231

1.

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.

Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, Méndez-Solís O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM.

Cell Rep. 2019 Jun 11;27(11):3269-3283.e6. doi: 10.1016/j.celrep.2019.05.040.

2.

Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET.

Shah S, Sinharay S, Matsuda K, Schreiber-Stainthorp W, Muthusamy S, Lee D, Wakim P, Hirsch V, Nath A, Mascio MD, Hammoud DA.

Front Psychiatry. 2019 May 23;10:362. doi: 10.3389/fpsyt.2019.00362. eCollection 2019.

3.

Neuroinflammatory Changes in Relation to Cerebrospinal Fluid Viral Load in Simian Immunodeficiency Virus Encephalitis.

Hammoud DA, Sinharay S, Shah S, Schreiber-Stainthorp W, Maric D, Muthusamy S, Lee DE, Lee CA, Basuli F, Reid WC, Wakim P, Matsuda K, Hirsch V, Nath A, Di Mascio M.

MBio. 2019 May 28;10(3). pii: e00970-19. doi: 10.1128/mBio.00970-19.

5.

Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.

Singh S, Ramírez-Salazar EG, Doueiri R, Valentin A, Rosati M, Hu X, Keele BF, Shen X, Tomaras GD, Ferrari G, LaBranche C, Montefiori DC, Das J, Alter G, Trinh HV, Hamlin C, Rao M, Dayton F, Bear J, Chowdhury B, Alicea C, Lifson JD, Broderick KE, Sardesai NY, Sivananthan SJ, Fox CB, Reed SG, Venzon DJ, Hirsch VM, Pavlakis GN, Felber BK.

J Virol. 2018 Jul 17;92(15). pii: e00281-18. doi: 10.1128/JVI.00281-18. Print 2018 Aug 1.

6.

Comparative Population Genomics Analysis of the Mammalian Fungal Pathogen Pneumocystis.

Cissé OH, Ma L, Wei Huang D, Khil PP, Dekker JP, Kutty G, Bishop L, Liu Y, Deng X, Hauser PM, Pagni M, Hirsch V, Lempicki RA, Stajich JE, Cuomo CA, Kovacs JA.

MBio. 2018 May 8;9(3). pii: e00381-18. doi: 10.1128/mBio.00381-18.

7.

Truncating the gp41 Cytoplasmic Tail of Simian Immunodeficiency Virus Decreases Sensitivity to Neutralizing Antibodies without Increasing the Envelope Content of Virions.

White E, Wu F, Chertova E, Bess J, Roser JD, Lifson JD, Hirsch VM.

J Virol. 2018 Jan 17;92(3). pii: e01688-17. doi: 10.1128/JVI.01688-17. Print 2018 Feb 1.

8.

A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques.

Matsuda K, Riddick NE, Lee CA, Puryear SB, Wu F, Lafont BAP, Whitted S, Hirsch VM.

PLoS Pathog. 2017 Aug 7;13(8):e1006538. doi: 10.1371/journal.ppat.1006538. eCollection 2017 Aug.

9.

Inflammatory cytokines in normal and irreversibly inflamed pulps: A systematic review.

Hirsch V, Wolgin M, Mitronin AV, Kielbassa AM.

Arch Oral Biol. 2017 Oct;82:38-46. doi: 10.1016/j.archoralbio.2017.05.008. Epub 2017 Jun 1. Review.

PMID:
28600966
10.

Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4+ T Cells in African Green Monkeys.

Vinton CL, Ortiz AM, Calantone N, Mudd JC, Deleage C, Morcock DR, Whitted S, Estes JD, Hirsch VM, Brenchley JM.

J Immunol. 2017 Jun 1;198(11):4403-4412. doi: 10.4049/jimmunol.1700136. Epub 2017 Apr 24.

11.

Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques.

DiNapoli SR, Ortiz AM, Wu F, Matsuda K, Twigg HL 3rd, Hirsch VM, Knox K, Brenchley JM.

JCI Insight. 2017 Feb 23;2(4):e91214. doi: 10.1172/jci.insight.91214.

12.

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

Huang J, Kang BH, Ishida E, Zhou T, Griesman T, Sheng Z, Wu F, Doria-Rose NA, Zhang B, McKee K, O'Dell S, Chuang GY, Druz A, Georgiev IS, Schramm CA, Zheng A, Joyce MG, Asokan M, Ransier A, Darko S, Migueles SA, Bailer RT, Louder MK, Alam SM, Parks R, Kelsoe G, Von Holle T, Haynes BF, Douek DC, Hirsch V, Seaman MS, Shapiro L, Mascola JR, Kwong PD, Connors M.

Immunity. 2016 Nov 15;45(5):1108-1121. doi: 10.1016/j.immuni.2016.10.027.

14.

TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains.

Wu F, Kirmaier A, White E, Ourmanov I, Whitted S, Matsuda K, Riddick N, Hall LR, Morgan JS, Plishka RJ, Buckler-White A, Johnson WE, Hirsch VM.

J Virol. 2016 Nov 28;90(24):11087-11095. Print 2016 Dec 15.

15.

Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure.

Haddad S, Wang Y, Galy B, Korf-Klingebiel M, Hirsch V, Baru AM, Rostami F, Reboll MR, Heineke J, Flögel U, Groos S, Renner A, Toischer K, Zimmermann F, Engeli S, Jordan J, Bauersachs J, Hentze MW, Wollert KC, Kempf T.

Eur Heart J. 2017 Feb 1;38(5):362-372. doi: 10.1093/eurheartj/ehw333.

PMID:
27545647
16.

Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections.

DiNapoli SR, Hirsch VM, Brenchley JM.

J Virol. 2016 Aug 12;90(17):7596-606. doi: 10.1128/JVI.00672-16. Print 2016 Sep 1. Review.

17.

Enhanced antagonism of BST-2 by a neurovirulent SIV envelope.

Matsuda K, Chen CY, Whitted S, Chertova E, Roser DJ, Wu F, Plishka RJ, Ourmanov I, Buckler-White A, Lifson JD, Strebel K, Hirsch VM.

J Clin Invest. 2016 Jun 1;126(6):2295-307. doi: 10.1172/JCI83725. Epub 2016 May 9.

18.

Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys.

Mudd JC, Perkins MR, DiNapoli SR, Hirsch VM, Brenchley JM.

J Virol. 2016 May 27;90(12):5750-5758. doi: 10.1128/JVI.00057-16. Print 2016 Jun 15.

19.

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.

Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL.

Nat Med. 2016 Apr;22(4):362-8. doi: 10.1038/nm.4063. Epub 2016 Mar 21.

20.

Mucosa-Associated Invariant T Cells Are Systemically Depleted in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

Vinton C, Wu F, Rossjohn J, Matsuda K, McCluskey J, Hirsch V, Price DA, Brenchley JM.

J Virol. 2016 Apr 14;90(9):4520-4529. doi: 10.1128/JVI.02876-15. Print 2016 May.

21.

TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.

Campbell EM, Weingart J, Sette P, Opp S, Sastri J, O'Connor SK, Talley S, Diaz-Griffero F, Hirsch V, Bouamr F.

J Virol. 2015 Dec 16;90(4):1849-57. doi: 10.1128/JVI.01948-15. Print 2016 Feb 15.

22.

Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors.

Riddick NE, Wu F, Matsuda K, Whitted S, Ourmanov I, Goldstein S, Goeken RM, Plishka RJ, Buckler-White A, Brenchley JM, Hirsch VM.

J Virol. 2015 Dec 9;90(5):2316-31. doi: 10.1128/JVI.02529-15.

23.

Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses.

Takeuchi JS, Ren F, Yoshikawa R, Yamada E, Nakano Y, Kobayashi T, Matsuda K, Izumi T, Misawa N, Shintaku Y, Wetzel KS, Collman RG, Tanaka H, Hirsch VM, Koyanagi Y, Sato K.

Sci Rep. 2015 Nov 4;5:16021. doi: 10.1038/srep16021.

24.

Nanoparticle colloidal stability in cell culture media and impact on cellular interactions.

Moore TL, Rodriguez-Lorenzo L, Hirsch V, Balog S, Urban D, Jud C, Rothen-Rutishauser B, Lattuada M, Petri-Fink A.

Chem Soc Rev. 2015 Oct 7;44(17):6287-305. doi: 10.1039/c4cs00487f. Epub 2015 Jun 9. Review.

PMID:
26056687
25.

Down-modulation of primate lentiviral receptors by Nef proteins of simian immunodeficiency virus (SIV) of chimpanzees (SIVcpz) and related SIVs: implication for the evolutionary event at the emergence of SIVcpz.

Nakano Y, Matsuda K, Yoshikawa R, Yamada E, Misawa N, Hirsch VM, Koyanagi Y, Sato K.

J Gen Virol. 2015 Sep;96(9):2867-77. doi: 10.1099/vir.0.000207. Epub 2015 Jun 3.

26.

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.

Fukazawa Y, Lum R, Okoye AA, Park H, Matsuda K, Bae JY, Hagen SI, Shoemaker R, Deleage C, Lucero C, Morcock D, Swanson T, Legasse AW, Axthelm MK, Hesselgesser J, Geleziunas R, Hirsch VM, Edlefsen PT, Piatak M Jr, Estes JD, Lifson JD, Picker LJ.

Nat Med. 2015 Feb;21(2):132-9. doi: 10.1038/nm.3781. Epub 2015 Jan 19.

27.

TRIM5α restriction affects clinical outcome and disease progression in simian immunodeficiency virus-infected rhesus macaques.

Wu F, Ourmanov I, Riddick N, Matsuda K, Whitted S, Plishka RJ, Buckler-White A, Starost MF, Hirsch VM.

J Virol. 2015 Feb;89(4):2233-40. doi: 10.1128/JVI.02978-14. Epub 2014 Dec 3.

28.

Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.

Calantone N, Wu F, Klase Z, Deleage C, Perkins M, Matsuda K, Thompson EA, Ortiz AM, Vinton CL, Ourmanov I, Loré K, Douek DC, Estes JD, Hirsch VM, Brenchley JM.

Immunity. 2014 Sep 18;41(3):493-502. doi: 10.1016/j.immuni.2014.08.014.

29.

Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.

Matsuda K, Dang Q, Brown CR, Keele BF, Wu F, Ourmanov I, Goeken R, Whitted S, Riddick NE, Buckler-White A, Hirsch VM.

J Virol. 2014 Nov;88(22):13201-11. doi: 10.1128/JVI.01996-14. Epub 2014 Sep 3.

30.

Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells.

Perkins MR, Briant JA, Calantone N, Whitted S, Vinton CL, Klatt NR, Ourmanov I, Ortiz AM, Hirsch VM, Brenchley JM.

J Virol. 2014 Sep;88(18):10714-24. doi: 10.1128/JVI.01331-14. Epub 2014 Jul 2.

31.

Characterization of red-capped mangabey tetherin: implication for the co-evolution of primates and their lentiviruses.

Kobayashi T, Takeuchi JS, Ren F, Matsuda K, Sato K, Kimura Y, Misawa N, Yoshikawa R, Nakano Y, Yamada E, Tanaka H, Hirsch VM, Koyanagi Y.

Sci Rep. 2014 Jul 2;4:5529. doi: 10.1038/srep05529.

32.

In vitro dosimetry of agglomerates.

Hirsch V, Kinnear C, Rodriguez-Lorenzo L, Monnier CA, Rothen-Rutishauser B, Balog S, Petri-Fink A.

Nanoscale. 2014 Jul 7;6(13):7325-31. doi: 10.1039/c4nr00460d.

PMID:
24853436
33.

Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir.

Moniuszko M, Liyanage NP, Doster MN, Parks RW, Grubczak K, Lipinska D, McKinnon K, Brown C, Hirsch V, Vaccari M, Gordon S, Pegu P, Fenizia C, Flisiak R, Grzeszczuk A, Dabrowska M, Robert-Guroff M, Silvestri G, Stevenson M, McCune J, Franchini G.

AIDS Res Hum Retroviruses. 2015 Jan;31(1):115-26. doi: 10.1089/AID.2013.0220.

34.

The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys.

Teigler JE, Phogat S, Franchini G, Hirsch VM, Michael NL, Barouch DH.

J Virol. 2014 Feb;88(3):1809-14. doi: 10.1128/JVI.02386-13. Epub 2013 Nov 20.

35.

TRIM5 alpha drives SIVsmm evolution in rhesus macaques.

Wu F, Kirmaier A, Goeken R, Ourmanov I, Hall L, Morgan JS, Matsuda K, Buckler-White A, Tomioka K, Plishka R, Whitted S, Johnson W, Hirsch VM.

PLoS Pathog. 2013;9(8):e1003577. doi: 10.1371/journal.ppat.1003577. Epub 2013 Aug 22.

36.

Laser capture microdissection assessment of virus compartmentalization in the central nervous systems of macaques infected with neurovirulent simian immunodeficiency virus.

Matsuda K, Brown CR, Foley B, Goeken R, Whitted S, Dang Q, Wu F, Plishka R, Buckler-White A, Hirsch VM.

J Virol. 2013 Aug;87(16):8896-908. doi: 10.1128/JVI.00874-13. Epub 2013 May 29.

37.

Conformational epitope consisting of the V3 and V4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses.

Kuwata T, Takaki K, Yoshimura K, Enomoto I, Wu F, Ourmanov I, Hirsch VM, Yokoyama M, Sato H, Matsushita S.

J Virol. 2013 May;87(10):5424-36. doi: 10.1128/JVI.00201-13. Epub 2013 Mar 6.

38.

DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge.

Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, von Gegerfelt A, Huang W, Guan Y, Keele BF, Bess JW Jr, Piatak M Jr, Lifson JD, Williams WT, Shen X, Tomaras GD, Amara RR, Robinson HL, Johnson W, Broderick KE, Sardesai NY, Venzon DJ, Hirsch VM, Felber BK, Pavlakis GN.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2975-80. doi: 10.1073/pnas.1215393110. Epub 2013 Jan 28.

39.

Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro.

Hirsch V, Kinnear C, Moniatte M, Rothen-Rutishauser B, Clift MJ, Fink A.

Nanoscale. 2013 May 7;5(9):3723-32. doi: 10.1039/c2nr33134a. Epub 2013 Jan 18.

PMID:
23334060
40.

Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.

Dang Q, Whitted S, Goeken RM, Brenchley JM, Matsuda K, Brown CR, Lafont BA, Starost MF, Iyengar R, Plishka RJ, Buckler-White A, Hirsch VM.

J Virol. 2012 Dec;86(24):13795-9. doi: 10.1128/JVI.02174-12. Epub 2012 Oct 3.

41.

Sequential evolution and escape from neutralization of simian immunodeficiency virus SIVsmE660 clones in rhesus macaques.

Wu F, Ourmanov I, Kuwata T, Goeken R, Brown CR, Buckler-White A, Iyengar R, Plishka R, Aoki ST, Hirsch VM.

J Virol. 2012 Aug;86(16):8835-47. doi: 10.1128/JVI.00923-12. Epub 2012 Jun 13.

42.

Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection.

Klatt NR, Estes JD, Sun X, Ortiz AM, Barber JS, Harris LD, Cervasi B, Yokomizo LK, Pan L, Vinton CL, Tabb B, Canary LA, Dang Q, Hirsch VM, Alter G, Belkaid Y, Lifson JD, Silvestri G, Milner JD, Paiardini M, Haddad EK, Brenchley JM.

Mucosal Immunol. 2012 Nov;5(6):646-57. doi: 10.1038/mi.2012.38. Epub 2012 May 30.

43.

Vpx is critical for SIVmne infection of pigtail macaques.

Belshan M, Kimata JT, Brown C, Cheng X, McCulley A, Larsen A, Thippeshappa R, Hodara V, Giavedoni L, Hirsch V, Ratner L.

Retrovirology. 2012 Apr 24;9:32. doi: 10.1186/1742-4690-9-32.

44.

Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques.

Vassena L, Miao H, Cimbro R, Malnati MS, Cassina G, Proschan MA, Hirsch VM, Lafont BA, Morre M, Fauci AS, Lusso P.

PLoS Pathog. 2012;8(4):e1002636. doi: 10.1371/journal.ppat.1002636. Epub 2012 Apr 12.

45.

Nonpathogenic simian immunodeficiency virus infections.

Klatt NR, Silvestri G, Hirsch V.

Cold Spring Harb Perspect Med. 2012 Jan;2(1):a007153. doi: 10.1101/cshperspect.a007153. Review.

46.

The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.

Compton AA, Hirsch VM, Emerman M.

Cell Host Microbe. 2012 Jan 19;11(1):91-8. doi: 10.1016/j.chom.2011.11.010.

47.

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys.

Barouch DH, Liu J, Li H, Maxfield LF, Abbink P, Lynch DM, Iampietro MJ, SanMiguel A, Seaman MS, Ferrari G, Forthal DN, Ourmanov I, Hirsch VM, Carville A, Mansfield KG, Stablein D, Pau MG, Schuitemaker H, Sadoff JC, Billings EA, Rao M, Robb ML, Kim JH, Marovich MA, Goudsmit J, Michael NL.

Nature. 2012 Jan 4;482(7383):89-93. doi: 10.1038/nature10766.

48.

SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses.

Lai L, Kwa SF, Kozlowski PA, Montefiori DC, Nolen TL, Hudgens MG, Johnson WE, Ferrari G, Hirsch VM, Felber BK, Pavlakis GN, Earl PL, Moss B, Amara RR, Robinson HL.

Vaccine. 2012 Feb 21;30(9):1737-45. doi: 10.1016/j.vaccine.2011.12.026. Epub 2011 Dec 15.

49.

Characterization of a monoclonal anti-capsid antibody that cross-reacts with three major primate lentivirus lineages.

Sanders-Beer BE, Eschricht M, Seifried J, Hirsch VM, Allan JS, Norley S.

Virology. 2012 Jan 20;422(2):402-12. doi: 10.1016/j.virol.2011.11.003. Epub 2011 Dec 5.

50.

TRIM5α does not affect simian immunodeficiency virus SIV(mac251) replication in vaccinated or unvaccinated Indian rhesus macaques following intrarectal challenge exposure.

Fenizia C, Keele BF, Nichols D, Cornara S, Binello N, Vaccari M, Pegu P, Robert-Guroff M, Ma ZM, Miller CJ, Venzon D, Hirsch V, Franchini G.

J Virol. 2011 Dec;85(23):12399-409. doi: 10.1128/JVI.05707-11. Epub 2011 Sep 14.

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