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Items: 1 to 50 of 1311

1.

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity.

Maatouk L, Yi C, Carrillo-de Sauvage MA, Compagnion AC, Hunot S, Ezan P, Hirsch EC, Koulakoff A, Pfrieger FW, Tronche F, Leybaert L, Giaume C, Vyas S.

Cell Death Differ. 2018 Jul 13. doi: 10.1038/s41418-018-0150-3. [Epub ahead of print]

PMID:
30006609
2.

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.

Zamboni V, Jones R, Umbach A, Ammoni A, Passafaro M, Hirsch E, Merlo GR.

Int J Mol Sci. 2018 Jun 20;19(6). pii: E1821. doi: 10.3390/ijms19061821. Review.

3.

Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.

Campa CC, Margaria JP, Derle A, Del Giudice M, De Santis MC, Gozzelino L, Copperi F, Bosia C, Hirsch E.

Nat Chem Biol. 2018 Jun 18. doi: 10.1038/s41589-018-0086-4. [Epub ahead of print]

PMID:
29915378
4.

Application of hydroxypropyl methylcellulose as a protective agent against magnesium stearate induced crystallization of amorphous itraconazole.

Démuth B, Galata DL, Balogh A, Szabó E, Nagy B, Farkas A, Hirsch E, Pataki H, Vigh T, Mensch J, Verreck G, Nagy ZK, Marosi G.

Eur J Pharm Sci. 2018 Jun 15;121:301-308. doi: 10.1016/j.ejps.2018.06.008. [Epub ahead of print]

PMID:
29902510
5.

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR.

Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3.

6.

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

Wyart E, Reano S, Hsu MY, Longo DL, Li M, Hirsch E, Filigheddu N, Ghigo A, Riganti C, Porporato PE.

Oxid Med Cell Longev. 2018 Feb 26;2018:6419805. doi: 10.1155/2018/6419805. eCollection 2018.

7.

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.

Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM.

Nat Commun. 2018 Apr 17;9(1):1513. doi: 10.1038/s41467-018-03986-3.

8.

Surfactant Protein (SP)-A Suppresses Preterm Delivery Induced by Live E. coli in Mice.

Agrawal V, Jaiswal MK, Beaman KD, Hirsch E.

Biol Reprod. 2018 Mar 24. doi: 10.1093/biolre/ioy074. [Epub ahead of print]

PMID:
29590302
9.

Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression.

Porta C, Ippolito A, Consonni FM, Carraro L, Celesti G, Correale C, Grizzi F, Pasqualini F, Tartari S, Rinaldi M, Bianchi P, Balzac F, Vetrano S, Turco E, Hirsch E, Laghi L, Sica A.

Cancer Immunol Res. 2018 May;6(5):578-593. doi: 10.1158/2326-6066.CIR-17-0036. Epub 2018 Mar 27.

PMID:
29588321
10.

Elucidation of the pharmacokinetic/pharmacodynamic determinants of fosfomycin activity against Pseudomonas aeruginosa using a dynamic in vitro model.

Bilal H, Peleg AY, McIntosh MP, Styles IK, Hirsch EB, Landersdorfer CB, Bergen PJ.

J Antimicrob Chemother. 2018 Jun 1;73(6):1570-1578. doi: 10.1093/jac/dky045.

PMID:
29506207
11.

Evolution of pyrrolizidine alkaloid biosynthesis in Apocynaceae: revisiting the defence de-escalation hypothesis.

Livshultz T, Kaltenegger E, Straub SCK, Weitemier K, Hirsch E, Koval K, Mema L, Liston A.

New Phytol. 2018 Apr;218(2):762-773. doi: 10.1111/nph.15061. Epub 2018 Feb 26.

12.

Functions of PDE3 Isoforms in Cardiac Muscle.

Movsesian M, Ahmad F, Hirsch E.

J Cardiovasc Dev Dis. 2018 Feb 6;5(1). pii: E10. doi: 10.3390/jcdd5010010. Review.

13.

The turtle and the rabbit story in a modern (PI3)key.

Martini M, De Santis MC, Hirsch E.

Mol Cell Oncol. 2017 Dec 7;5(1):e1405141. doi: 10.1080/23723556.2017.1405141. eCollection 2018.

PMID:
29404399
14.

Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth.

Li M, Sala V, De Santis MC, Cimino J, Cappello P, Pianca N, Di Bona A, Margaria JP, Martini M, Lazzarini E, Pirozzi F, Rossi L, Franco I, Bornbaum J, Heger J, Rohrbach S, Perino A, Tocchetti CG, Lima BHF, Teixeira MM, Porporato PE, Schulz R, Angelini A, Sandri M, Ameri P, Sciarretta S, Lima-Júnior RCP, Mongillo M, Zaglia T, Morello F, Novelli F, Hirsch E, Ghigo A.

Circulation. 2018 Jan 18. pii: CIRCULATIONAHA.117.030352. doi: 10.1161/CIRCULATIONAHA.117.030352. [Epub ahead of print]

PMID:
29348263
15.

Metabolomic characterization of human hippocampus from drug-resistant epilepsy with mesial temporal seizure.

Detour J, Bund C, Behr C, Cebula H, Cicek EA, Valenti-Hirsch MP, Lannes B, Lhermitte B, Nehlig A, Kehrli P, Proust F, Hirsch E, Namer IJ.

Epilepsia. 2018 Mar;59(3):607-616. doi: 10.1111/epi.14000. Epub 2018 Jan 17.

PMID:
29341105
16.

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.

Frantz S, Falcao-Pires I, Balligand JL, Bauersachs J, Brutsaert D, Ciccarelli M, Dawson D, de Windt LJ, Giacca M, Hamdani N, Hilfiker-Kleiner D, Hirsch E, Leite-Moreira A, Mayr M, Thum T, Tocchetti CG, van der Velden J, Varricchi G, Heymans S.

Eur J Heart Fail. 2018 Mar;20(3):445-459. doi: 10.1002/ejhf.1138. Epub 2018 Jan 15. Review.

17.

Interleukin 22 prevents lipopolysaccharide- induced preterm labor in mice.

Dambaeva S, Schneiderman S, Jaiswal MK, Agrawal V, Katara GK, Gilman-Sachs A, Hirsch E, Beaman KD.

Biol Reprod. 2018 Mar 1;98(3):299-308. doi: 10.1093/biolre/iox182.

PMID:
29315356
18.

The most important quality of a physician.

Hirsch E.

Am J Obstet Gynecol. 2018 Apr;218(4):459. doi: 10.1016/j.ajog.2017.12.237. Epub 2018 Jan 3. No abstract available.

PMID:
29305830
19.

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

Duarte LJ, Chaves VC, Nascimento MVPDS, Calvete E, Li M, Ciraolo E, Ghigo A, Hirsch E, Simões CMO, Reginatto FH, Dalmarco EM.

Food Chem. 2018 May 1;247:56-65. doi: 10.1016/j.foodchem.2017.12.015. Epub 2017 Dec 7.

PMID:
29277228
20.

The Oxygen Paradox, the French Paradox, and age-related diseases.

Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA.

Geroscience. 2017 Dec;39(5-6):499-550. doi: 10.1007/s11357-017-0002-y. Epub 2017 Dec 21. Review.

21.

An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology.

Lourenço AP, Leite-Moreira AF, Balligand JL, Bauersachs J, Dawson D, de Boer RA, de Windt LJ, Falcão-Pires I, Fontes-Carvalho R, Franz S, Giacca M, Hilfiker-Kleiner D, Hirsch E, Maack C, Mayr M, Pieske B, Thum T, Tocchetti CG, Brutsaert DL, Heymans S.

Eur J Heart Fail. 2018 Feb;20(2):216-227. doi: 10.1002/ejhf.1059. Epub 2017 Nov 16. Review.

PMID:
29148148
22.

Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity.

Spaulding A, Takrouri K, Mahalingam P, Cleary DC, Cooper HD, Zucchi P, Tear W, Koleva B, Beuning PJ, Hirsch EB, Aggen JB.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5310-5321. doi: 10.1016/j.bmcl.2017.10.018. Epub 2017 Oct 16.

PMID:
29102393
23.

Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy.

Azevedo AMM, Brites-Anselmi G, Pinheiro LC, de Almeida Belo V, Coeli-Lacchini FB, Molina CAF, de Andrade MF, Tucci S Jr, Hirsch E, Tanus-Santos JE, Lacchini R.

Nitric Oxide. 2017 Dec 1;71:44-51. doi: 10.1016/j.niox.2017.10.006. Epub 2017 Oct 23.

PMID:
29074293
24.

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.

Gulluni F, Martini M, De Santis MC, Campa CC, Ghigo A, Margaria JP, Ciraolo E, Franco I, Ala U, Annaratone L, Disalvatore D, Bertalot G, Viale G, Noatynska A, Compagno M, Sigismund S, Montemurro F, Thelen M, Fan F, Meraldi P, Marchiò C, Pece S, Sapino A, Chiarle R, Di Fiore PP, Hirsch E.

Cancer Cell. 2017 Oct 9;32(4):444-459.e7. doi: 10.1016/j.ccell.2017.09.002.

PMID:
29017056
25.

Epileptogenic networks in nodular heterotopia: A stereoelectroencephalography study.

Pizzo F, Roehri N, Catenoix H, Medina S, McGonigal A, Giusiano B, Carron R, Scavarda D, Ostrowsky K, Lepine A, Boulogne S, Scholly J, Hirsch E, Rheims S, Bénar CG, Bartolomei F.

Epilepsia. 2017 Dec;58(12):2112-2123. doi: 10.1111/epi.13919. Epub 2017 Oct 6.

PMID:
28983921
26.

Investigation of Deteriorated Dissolution of Amorphous Itraconazole: Description of Incompatibility with Magnesium Stearate and Possible Solutions.

Démuth B, Galata DL, Szabó E, Nagy B, Farkas A, Balogh A, Hirsch E, Pataki H, Rapi Z, Bezúr L, Vigh T, Verreck G, Szalay Z, Demeter Á, Marosi G, Nagy ZK.

Mol Pharm. 2017 Nov 6;14(11):3927-3934. doi: 10.1021/acs.molpharmaceut.7b00629. Epub 2017 Oct 16.

PMID:
28972782
27.

An open circuit voltage decay system for performing injection dependent lifetime spectroscopy.

Lacouture S, Schrock J, Hirsch E, Bayne S, O'Brien H, Ogunniyi AA.

Rev Sci Instrum. 2017 Sep;88(9):095105. doi: 10.1063/1.5001732.

PMID:
28964219
28.

Fetal Growth Restriction Induced by Transient Uterine Ischemia-Reperfusion: Differential Responses in Different Mouse Strains.

Thaete LG, Qu XW, Neerhof MG, Hirsch E, Jilling T.

Reprod Sci. 2018 Jul;25(7):1083-1092. doi: 10.1177/1933719117732160. Epub 2017 Sep 25.

PMID:
28946817
29.

Efficacy and safety in frameless robot-assisted stereo-electroencephalography (SEEG) for drug-resistant epilepsy.

Ollivier I, Behr C, Cebula H, Timofeev A, Benmekhbi M, Valenti MP, Staack AM, Scholly J, Kehrli P, Hirsch E, Proust F.

Neurochirurgie. 2017 Sep;63(4):286-290. doi: 10.1016/j.neuchi.2017.03.002. Epub 2017 Sep 4.

PMID:
28882607
30.

Pulmonary Adenocarcinoma, Intra-alveolar Variant: A Rare Entity Mimicking Desquamative Interstitial Pneumonia.

Hirsch E, Jagirdar J, Nazarullah A.

Int J Surg Pathol. 2018 Apr;26(2):185-189. doi: 10.1177/1066896917729436. Epub 2017 Sep 1.

PMID:
28862049
31.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC.

ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31.

32.

Nasal methicillin-resistant Staphylococcus aureus screening in patients with pneumonia: A powerful antimicrobial stewardship tool.

Smith EA, Gold HS, Mahoney MV, Hirsch EB, Giancola SE, Snyder GM, Marks G, Tran H, Hirai-Yang A, McCoy C.

Am J Infect Control. 2017 Nov 1;45(11):1295-1296. doi: 10.1016/j.ajic.2017.06.032. Epub 2017 Aug 24. No abstract available.

PMID:
28844378
33.

Atonic seizures in children with surgically remediable epilepsy: a motor system seizure phenotype?

Scholly J, Bartolomei F, Valenti-Hirsch MP, Boulay C, De Saint Martin A, Timofeev A, Kehrli P, Hirsch E.

Epileptic Disord. 2017 Sep 1;19(3):315-326. doi: 10.1684/epd.2017.0930.

PMID:
28832003
34.

PI3K and Calcium Signaling in Cardiovascular Disease.

Ghigo A, Laffargue M, Li M, Hirsch E.

Circ Res. 2017 Jul 21;121(3):282-292. doi: 10.1161/CIRCRESAHA.117.310183. Review.

PMID:
28729453
35.

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia.

Bucher K, Schmitt F, Mothes B, Blumendeller C, Schäll D, Piekorz R, Hirsch E, Nürnberg B, Beer-Hammer S.

Cell Commun Signal. 2017 Jul 19;15(1):28. doi: 10.1186/s12964-017-0185-y.

36.

On-line prediction of the glucose concentration of CHO cell cultivations by NIR and Raman spectroscopy: Comparative scalability test with a shake flask model system.

Kozma B, Hirsch E, Gergely S, Párta L, Pataki H, Salgó A.

J Pharm Biomed Anal. 2017 Oct 25;145:346-355. doi: 10.1016/j.jpba.2017.06.070. Epub 2017 Jul 6.

PMID:
28711673
37.

Randomized Comparison of 3 High-Level Disinfection and Sterilization Procedures for Duodenoscopes.

Snyder GM, Wright SB, Smithey A, Mizrahi M, Sheppard M, Hirsch EB, Chuttani R, Heroux R, Yassa DS, Olafsdottir LB, Davis RB, Anastasiou J, Bapat V, Bidari K, Pleskow DK, Leffler D, Lane B, Chen A, Gold HS, Bartley A, King AD, Sawhney MS.

Gastroenterology. 2017 Oct;153(4):1018-1025. doi: 10.1053/j.gastro.2017.06.052. Epub 2017 Jul 13.

PMID:
28711629
38.

Response to the numbering of seizure types.

Fisher RS, Helen Cross J, D'Souza C, French JA, Haut S, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshe SL, Korey SR, Purpura DP, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM.

Epilepsia. 2017 Jul;58(7):1300-1301. doi: 10.1111/epi.13800. No abstract available.

39.

PI3Ks in Diabetic Cardiomyopathy.

Li M, Murabito A, Ghigo A, Hirsch E.

J Cardiovasc Pharmacol. 2017 Dec;70(6):422-429. doi: 10.1097/FJC.0000000000000511.

PMID:
28654509
40.

Angiogenesis in metabolic-vascular disease.

Breier G, Chavakis T, Hirsch E.

Thromb Haemost. 2017 Jun 27;117(7):1289-1295. doi: 10.1160/TH17-05-0325. Epub 2017 Jun 8. Review.

PMID:
28594427
41.

Hypothalamic hamartoma: Epileptogenesis beyond the lesion?

Scholly J, Staack AM, Kahane P, Scavarda D, Régis J, Hirsch E, Bartolomei F.

Epilepsia. 2017 Jun;58 Suppl 2:32-40. doi: 10.1111/epi.13755. Review.

42.

Data demonstrating the anti-oxidant role of hemopexin in the heart.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Data Brief. 2017 May 13;13:69-76. doi: 10.1016/j.dib.2017.05.026. eCollection 2017 Aug.

43.

Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline.

Chen A, Smith KP, Whitfield BA, Zucchi PC, Lasco TM, Bias TE, Kirby JE, Hirsch EB.

Diagn Microbiol Infect Dis. 2017 Aug;88(4):365-367. doi: 10.1016/j.diagmicrobio.2017.05.004. Epub 2017 May 11.

PMID:
28535946
44.

Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).

Sala V, Margaria JP, Murabito A, Morello F, Ghigo A, Hirsch E.

Curr Heart Fail Rep. 2017 Jun;14(3):187-196. doi: 10.1007/s11897-017-0331-2. Review.

PMID:
28451983
45.

Cytokinetic Abscission: Phosphoinositides and ESCRTs Direct the Final Cut.

Gulluni F, Martini M, Hirsch E.

J Cell Biochem. 2017 Nov;118(11):3561-3568. doi: 10.1002/jcb.26066. Epub 2017 May 30. Review.

46.

Adenosine Triphosphate Quantification Correlates Poorly with Microbial Contamination of Duodenoscopes.

Olafsdottir LB, Wright SB, Smithey A, Heroux R, Hirsch EB, Chen A, Lane B, Sawhney MS, Snyder GM.

Infect Control Hosp Epidemiol. 2017 Jun;38(6):678-684. doi: 10.1017/ice.2017.58. Epub 2017 Apr 17.

PMID:
28414009
47.

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Free Radic Biol Med. 2017 Jul;108:452-464. doi: 10.1016/j.freeradbiomed.2017.04.003. Epub 2017 Apr 8.

48.

The noble gas xenon provides protection and trophic stimulation to midbrain dopamine neurons.

Lavaur J, Le Nogue D, Lemaire M, Pype J, Farjot G, Hirsch EC, Michel PP.

J Neurochem. 2017 Jul;142(1):14-28. doi: 10.1111/jnc.14041. Epub 2017 May 16.

49.

Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease.

Bulteau AL, Mena NP, Auchère F, Lee I, Prigent A, Lobsiger CS, Camadro JM, Hirsch EC.

Free Radic Biol Med. 2017 Jul;108:236-246. doi: 10.1016/j.freeradbiomed.2017.03.036. Epub 2017 Mar 30.

PMID:
28365360
50.

PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts.

De Santis MC, Sala V, Martini M, Ferrero GB, Hirsch E.

Cancers (Basel). 2017 Mar 29;9(4). pii: E30. doi: 10.3390/cancers9040030. Review.

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