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Items: 25


Zika virus causes acute and chronic prostatitis in mice and macaques.

Halabi J, Jagger BW, Salazar V, Winkler ES, White JP, Humphrey PA, Hirsch AJ, Streblow DN, Diamond MS, Moley K.

J Infect Dis. 2019 Oct 16. pii: jiz533. doi: 10.1093/infdis/jiz533. [Epub ahead of print]


Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Martín CS, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale M Jr, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano SV 3rd, Simmons HA, Mejia A, Friedrich TC, Golos TG, O'Connor DH.

Nat Med. 2018 Aug;24(8):1104-1107. doi: 10.1038/s41591-018-0088-5. Epub 2018 Jul 2.


Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions.

Smith JL, Sheridan K, Parkins CJ, Frueh L, Jemison AL, Strode K, Dow G, Nilsen A, Hirsch AJ.

Antiviral Res. 2018 Jul;155:12-19. doi: 10.1016/j.antiviral.2018.04.019. Epub 2018 Apr 27.


Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.

Hirsch AJ, Roberts VHJ, Grigsby PL, Haese N, Schabel MC, Wang X, Lo JO, Liu Z, Kroenke CD, Smith JL, Kelleher M, Broeckel R, Kreklywich CN, Parkins CJ, Denton M, Smith P, DeFilippis V, Messer W, Nelson JA, Hennebold JD, Grafe M, Colgin L, Lewis A, Ducore R, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Moses AV, Morgan TK, Frias AE, Streblow DN.

Nat Commun. 2018 Jan 17;9(1):263. doi: 10.1038/s41467-017-02499-9.


A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.

Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR.

MBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17.


Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN.

PLoS Pathog. 2017 Apr 5;13(4):e1006317. doi: 10.1371/journal.ppat.1006317. eCollection 2017 Apr.


Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN.

PLoS Pathog. 2017 Mar 9;13(3):e1006219. doi: 10.1371/journal.ppat.1006219. eCollection 2017 Mar. Erratum in: PLoS Pathog. 2017 Apr 5;13(4):e1006317.


A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection.

Smith JL, Jeng S, McWeeney SK, Hirsch AJ.

J Virol. 2017 Mar 29;91(8). pii: e02388-16. doi: 10.1128/JVI.02388-16. Print 2017 Apr 15.


Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling.

Smith JL, Stein DA, Shum D, Fischer MA, Radu C, Bhinder B, Djaballah H, Nelson JA, Früh K, Hirsch AJ.

J Virol. 2014 May;88(10):5533-42. doi: 10.1128/JVI.00365-14. Epub 2014 Mar 5.


Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.

Fischer MA, Smith JL, Shum D, Stein DA, Parkins C, Bhinder B, Radu C, Hirsch AJ, Djaballah H, Nelson JA, Früh K.

J Virol. 2013 Sep;87(17):9411-9. doi: 10.1128/JVI.00101-13. Epub 2013 Jul 3.


Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors.

Smith JL, Grey FE, Uhrlaub JL, Nikolich-Zugich J, Hirsch AJ.

J Virol. 2012 May;86(9):5278-87. doi: 10.1128/JVI.06883-11. Epub 2012 Feb 15.


Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence.

Stein DA, Perry ST, Buck MD, Oehmen CS, Fischer MA, Poore E, Smith JL, Lancaster AM, Hirsch AJ, Slifka MK, Nelson JA, Shresta S, Früh K.

J Virol. 2011 Oct;85(19):10154-66. doi: 10.1128/JVI.05298-11. Epub 2011 Jul 27.


High-content assay to identify inhibitors of dengue virus infection.

Shum D, Smith JL, Hirsch AJ, Bhinder B, Radu C, Stein DA, Nelson JA, Früh K, Djaballah H.

Assay Drug Dev Technol. 2010 Oct;8(5):553-70. doi: 10.1089/adt.2010.0321.


The use of RNAi-based screens to identify host proteins involved in viral replication.

Hirsch AJ.

Future Microbiol. 2010 Feb;5(2):303-11. doi: 10.2217/fmb.09.121. Review.


Promoting positive developmental outcomes in sexual minority youth through best practices in clinic-school consultation.

Hirsch AJ, Carlson JS, Crowl AL.

J Child Adolesc Psychiatr Nurs. 2010 Feb;23(1):17-22. doi: 10.1111/j.1744-6171.2009.00212.x.


West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function.

Medigeshi GR, Hirsch AJ, Brien JD, Uhrlaub JL, Mason PW, Wiley C, Nikolich-Zugich J, Nelson JA.

J Virol. 2009 Jun;83(12):6125-34. doi: 10.1128/JVI.02617-08. Epub 2009 Apr 15.


West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin.

Medigeshi GR, Hirsch AJ, Streblow DN, Nikolich-Zugich J, Nelson JA.

J Virol. 2008 Jun;82(11):5212-9. doi: 10.1128/JVI.00008-08. Epub 2008 Apr 2.


Prescription practices and empirical efficacy of psychopharmacologic treatments for pediatric major depressive disorder.

Hirsch AJ, Carlson JS.

J Child Adolesc Psychiatr Nurs. 2007 Nov;20(4):222-33.


West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis.

Medigeshi GR, Lancaster AM, Hirsch AJ, Briese T, Lipkin WI, Defilippis V, Früh K, Mason PW, Nikolich-Zugich J, Nelson JA.

J Virol. 2007 Oct;81(20):10849-60. Epub 2007 Aug 8.


Sultam thiourea inhibition of West Nile virus.

Barklis E, Still A, Sabri MI, Hirsch AJ, Nikolich-Zugich J, Brien J, Dhenub TC, Scholz I, Alfadhli A.

Antimicrob Agents Chemother. 2007 Jul;51(7):2642-5. Epub 2007 Apr 23.


The Src family kinase c-Yes is required for maturation of West Nile virus particles.

Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Früh K, Briese T, Lipkin WI, Nelson JA.

J Virol. 2005 Sep;79(18):11943-51.


Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12.

Melnychuk RM, Streblow DN, Smith PP, Hirsch AJ, Pancheva D, Nelson JA.

J Virol. 2004 Aug;78(15):8382-91.


A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis.

Armand P, Knapp AC, Hirsch AJ, Wieschaus EF, Cole MD.

Mol Cell Biol. 1994 Jun;14(6):4145-54.

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