Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 51

1.

Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558.

Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Hirouchi M, Kimura T, Toda N.

Bioorg Med Chem. 2015 Sep 1;23(17):5546-65. doi: 10.1016/j.bmc.2015.07.028. Epub 2015 Jul 23.

PMID:
26234904
2.

Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.

Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Hirouchi M, Yoneyama T, Ito S, Toda N.

ACS Med Chem Lett. 2015 Jan 13;6(3):266-70. doi: 10.1021/ml500391n. eCollection 2015 Mar 12.

3.

Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.

Karibe T, Hagihara-Nakagomi R, Abe K, Imaoka T, Mikkaichi T, Yasuda S, Hirouchi M, Watanabe N, Okudaira N, Izumi T.

Pharm Res. 2015 May;32(5):1634-47. doi: 10.1007/s11095-014-1563-4. Epub 2014 Nov 8.

PMID:
25380981
4.

[Pharmacological profiles and clinical roles of acamprosate (Regtect(®) tablets 333 mg) for the maintenance of abstinence in alcohol-dependent patients].

Ohhara T, Hirouchi M, Oka M.

Nihon Yakurigaku Zasshi. 2014 Jul;144(1):34-41. Japanese. No abstract available.

PMID:
25007810
5.

Acamprosate {monocalcium bis(3-acetamidopropane-1-sulfonate)} reduces ethanol-drinking behavior in rats and glutamate-induced toxicity in ethanol-exposed primary rat cortical neuronal cultures.

Oka M, Hirouchi M, Tamura M, Sugahara S, Oyama T.

Eur J Pharmacol. 2013 Oct 15;718(1-3):323-31. doi: 10.1016/j.ejphar.2013.08.014. Epub 2013 Sep 4.

PMID:
24012782
6.

Acamprosate suppresses ethanol-induced place preference in mice with ethanol physical dependence.

Kurokawa K, Mizuno K, Shibasaki M, Higashioka M, Oka M, Hirouchi M, Ohkuma S.

J Pharmacol Sci. 2013;122(4):289-98. Epub 2013 Aug 1.

7.

Integrated approach of in vivo and in vitro evaluation of the involvement of hepatic uptake organic anion transporters in the drug disposition in rats using rifampicin as an inhibitor.

Imaoka T, Mikkaichi T, Abe K, Hirouchi M, Okudaira N, Izumi T.

Drug Metab Dispos. 2013 Jul;41(7):1442-9. doi: 10.1124/dmd.113.051052. Epub 2013 May 2.

PMID:
23640987
8.

Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties.

Matsufuji T, Ikeda M, Naito A, Hirouchi M, Kanda S, Izumi M, Harada J, Shinozuka T.

Bioorg Med Chem Lett. 2013 May 1;23(9):2560-5. doi: 10.1016/j.bmcl.2013.02.116. Epub 2013 Mar 7.

PMID:
23528296
9.

Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors.

Matsufuji T, Ikeda M, Naito A, Hirouchi M, Takakusa H, Kanda S, Izumi M, Harada J, Shinozuka T.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5067-70. doi: 10.1016/j.bmcl.2012.05.130. Epub 2012 Jun 19.

PMID:
22749869
10.

Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4.

Hayashi H, Naoi S, Nakagawa T, Nishikawa T, Fukuda H, Imajoh-Ohmi S, Kondo A, Kubo K, Yabuki T, Hattori A, Hirouchi M, Sugiyama Y.

J Biol Chem. 2012 Apr 27;287(18):15054-65. doi: 10.1074/jbc.M111.337931. Epub 2012 Mar 12.

11.

[Pharmacological profiles and clinical roles of tramadol hydrochloride (Tramal(®) capsules 25 mg·50 mg) in the treatment of cancer pain].

Hirouchi M, Tanaka M, Nishimura T.

Nihon Yakurigaku Zasshi. 2011 Apr;137(4):189-97. Review. Japanese. No abstract available.

PMID:
21478640
12.

Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach.

Deguchi T, Watanabe N, Kurihara A, Igeta K, Ikenaga H, Fusegawa K, Suzuki N, Murata S, Hirouchi M, Furuta Y, Iwasaki M, Okazaki O, Izumi T.

Drug Metab Dispos. 2011 May;39(5):820-9. doi: 10.1124/dmd.110.037457. Epub 2011 Jan 31.

PMID:
21282406
13.

Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.

Hirouchi M, Kusuhara H, Onuki R, Ogilvie BW, Parkinson A, Sugiyama Y.

Drug Metab Dispos. 2009 Oct;37(10):2103-11. doi: 10.1124/dmd.109.027193. Epub 2009 Jul 23.

PMID:
19628752
14.

Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3).

Kitamura Y, Hirouchi M, Kusuhara H, Schuetz JD, Sugiyama Y.

J Pharmacol Exp Ther. 2008 Nov;327(2):465-73. doi: 10.1124/jpet.108.140475. Epub 2008 Aug 21.

PMID:
18719291
15.

Expression of beta-adrenergic receptor up-regulation is mediated by two different processes.

Ohkuma S, Katsura M, Shibasaki M, Tsujimura A, Hirouchi M.

Brain Res. 2006 Sep 27;1112(1):114-25. Epub 2006 Aug 22.

PMID:
16920085
16.

Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans.

Yamashiro W, Maeda K, Hirouchi M, Adachi Y, Hu Z, Sugiyama Y.

Drug Metab Dispos. 2006 Jul;34(7):1247-54. Epub 2006 Apr 19.

PMID:
16624871
17.

Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.

Hirouchi M, Suzuki H, Sugiyama Y.

Pharm Res. 2005 Apr;22(4):661-6. Epub 2005 Apr 7.

PMID:
15846474
18.

Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2.

Hirouchi M, Suzuki H, Itoda M, Ozawa S, Sawada J, Ieiri I, Ohtsubo K, Sugiyama Y.

Pharm Res. 2004 May;21(5):742-8.

PMID:
15180328
19.

[Current status and perspectives on the development of therapeutic agents for Alzheimer's disease].

Hirouchi M.

Nihon Yakurigaku Zasshi. 2004 Jun;123(6):421-7. Review. Japanese.

PMID:
15170082
20.

Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome.

Shoda J, Suzuki H, Suzuki H, Sugiyama Y, Hirouchi M, Utsunomiya H, Oda K, Kawamoto T, Matsuzaki Y, Tanaka N.

Hepatol Res. 2003 Dec;27(4):323-326.

PMID:
14662121
21.

Functional role of inhibitory and excitatory nerves in the porcine lower urinary tract.

Noda K, Takebe M, Oka M, Hirouchi M, Ukai Y, Toda N.

Eur J Pharmacol. 2002 Dec 5;456(1-3):81-90.

PMID:
12450573
22.

[Current state on development of neuroprotective agents for cerebral ischemia].

Hirouchi M, Ukai Y.

Nihon Yakurigaku Zasshi. 2002 Aug;120(2):107-13. Review. Japanese.

PMID:
12187623
24.

Neurochemical and molecular pharmacological aspects of the GABA(B) receptor.

Kuriyama K, Hirouchi M, Kimura H.

Neurochem Res. 2000 Oct;25(9-10):1233-9. Review.

PMID:
11059797
25.
26.

Role of metabotropic glutamate receptor subclasses in modulation of adenylyl cyclase activity by a nootropic NS-105.

Hirouchi M, Oka M, Itoh Y, Ukai Y, Kimura K.

Eur J Pharmacol. 2000 Jan 3;387(1):9-17.

PMID:
10633154
28.

[GABA receptors].

Kuriyama K, Hirouchi M.

Tanpakushitsu Kakusan Koso. 1997 Feb;42(3 Suppl):302-7. Review. Japanese. No abstract available.

PMID:
9162964
29.

[Recent advances in studies of GABA receptors: neurochemical aspects].

Kuriyama K, Hirouchi M, Ohkuma S.

Yakugaku Zasshi. 1995 Feb;115(2):101-13. Review. Japanese.

PMID:
7536844
30.
31.

[Molecular pharmacology of GABAA and GABAB receptors].

Hirouchi M, Kuriyama K.

Nihon Yakurigaku Zasshi. 1994 Sep;104(3):199-206. Review. Japanese.

PMID:
7959412
32.

Association and agonistic action of DN-2327, a novel isoindoline derivative, GABAB receptor in brain.

Ichida T, Hirouchi M, Mizutani H, Narihara R, Kuriyama K.

Eur J Pharmacol. 1994 Mar 15;267(1):43-7.

PMID:
7911433
33.

Alteration in cerebral GABAB receptor functions during formation of alcohol dependence.

Kuriyama K, Mizutani H, Hirouchi M, Ichida T, Hashimoto T.

Alcohol Alcohol Suppl. 1994;2:193-7.

PMID:
8974335
34.

Alteration of GABAA receptor alpha 1-subunit mRNA in mouse brain following continuous ethanol inhalation.

Hirouchi M, Hashimoto T, Kuriyama K.

Eur J Pharmacol. 1993 Oct 15;247(2):127-30.

PMID:
8282001
35.

Structure and function of cerebral GABAA and GABAB receptors.

Kuriyama K, Hirouchi M, Nakayasu H.

Neurosci Res. 1993 Jul;17(2):91-9. Review.

PMID:
8233122
36.

Functional alterations in GABAA receptor complex induced by ethanol.

Kuriyama K, Ueha T, Hirouchi M, Hashimoto T, Ohkuma S.

Alcohol Alcohol Suppl. 1993;2:321-5.

PMID:
7748318
37.

Muscimol-induced reduction of GABAA receptor alpha 1-subunit mRNA in primary cultured cerebral cortical neurons.

Hirouchi M, Ohkuma S, Kuriyama K.

Brain Res Mol Brain Res. 1992 Oct;15(3-4):327-31.

PMID:
1331688
39.

Expression of mRNA for Gs alpha and Gi2 alpha in primary cultured mouse cerebral cortical neurons.

Hirouchi M, Ohkuma S, Kuriyama K.

Neuroreport. 1991 Dec;2(12):766-8.

PMID:
1724387
40.

[Expression and regulation of GABA receptors in the brain].

Kuriyama K, Hirouchi M.

Nihon Yakurigaku Zasshi. 1991 Sep;98(3):161-8. Review. Japanese.

PMID:
1660441
41.

[Structure and function of GABA receptor in the brain].

Kuriyama K, Hirouchi M.

Tanpakushitsu Kakusan Koso. 1990 Jun;35(8):1455-64. Review. Japanese. No abstract available.

PMID:
1695758
42.

[GABA receptor and benzodiazepine receptor].

Kuriyama K, Hirouchi M.

Tanpakushitsu Kakusan Koso. 1990 Mar;35(4 Suppl):743-50. Japanese. No abstract available.

PMID:
1692146
44.

[Structure and function of gamma-aminobutyric acid (GABA) receptor: current state and prospectives].

Kuriyama K, Hirouchi M.

Nihon Yakurigaku Zasshi. 1989 Jul;94(1):7-15. Review. Japanese.

PMID:
2551802
45.

Nucleotide and deduced amino acid sequences of the GABA(A) receptor ?-subunit from human brain.

Hirouchi M, Kuwano R, Takashi K, Yasuo T, Kuriyama K.

Neurochem Int. 1989;15(1):33-8.

PMID:
20504462
46.

[Effect of buflomedil on cerebral acetylcholine, neuroactive amino acids contents and energy metabolism: analysis using spontaneously hypertensive rat (SHR)].

Koda H, Hashimoto T, Kimori M, Hirouchi M, Kuriyama K.

Nihon Yakurigaku Zasshi. 1988 Jun;91(6):351-8. Japanese.

PMID:
3417208
47.

Inactivation of peroxidases of rat bone marrow by repeated administration of propylthiouracil is accompanied by a change in the heme structure.

Lee E, Hirouchi M, Hosokawa M, Sayo H, Kohno M, Kariya K.

Biochem Pharmacol. 1988 Jun 1;37(11):2151-3.

PMID:
2837228
48.

GABA-stimulated 36Cl- influx into reconstituted vesicles with purified GABAA/benzodiazepine receptor complex.

Hirouchi M, Taguchi J, Ueha T, Kuriyama K.

Biochem Biophys Res Commun. 1987 Aug 14;146(3):1471-7.

PMID:
3040004
49.

Purification and some properties of peroxidases of rat bone marrow.

Kariya K, Lee E, Hirouchi M, Hosokawa M, Sayo H.

Biochim Biophys Acta. 1987 Jan 5;911(1):95-101.

PMID:
3024734
50.

Supplemental Content

Loading ...
Support Center