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Items: 1 to 50 of 818

1.

Enrichment of CLDN18-ARHGAP fusion gene in gastric cancers in young adults.

Nakayama I, Shinozaki E, Sakata S, Yamamoto N, Fujisaki J, Muramatsu Y, Hirota T, Takeuchi K, Takahashi S, Yamaguchi K, Noda T.

Cancer Sci. 2019 Feb 16. doi: 10.1111/cas.13967. [Epub ahead of print]

PMID:
30771244
2.

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.

Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.

Sci Adv. 2019 Jan 23;5(1):eaau9060. doi: 10.1126/sciadv.aau9060. eCollection 2019 Jan.

3.

Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ.

Lee JW, Hirota T, Ono D, Honma S, Honma KI, Park K, Kay SA.

J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.8b01541. [Epub ahead of print]

PMID:
30707835
4.

Improvement of glycemic control by treatment for insomnia with suvorexant in type 2 diabetes mellitus.

Toi N, Inaba M, Kurajoh M, Morioka T, Hayashi N, Hirota T, Miyaoka D, Emoto M, Yamada S.

J Clin Transl Endocrinol. 2018 Dec 18;15:37-44. doi: 10.1016/j.jcte.2018.12.006. eCollection 2019 Mar.

5.

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.

Qu M, Duffy T, Hirota T, Kay SA.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12305-E12312. doi: 10.1073/pnas.1816411115. Epub 2018 Dec 10.

6.

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.

Mori D, Kashihara Y, Yoshikado T, Kimura M, Hirota T, Matsuki S, Maeda K, Irie S, Ieiri I, Sugiyama Y, Kusuhara H.

Drug Metab Pharmacokinet. 2018 Sep 20. pii: S1347-4367(18)30077-6. doi: 10.1016/j.dmpk.2018.09.003. [Epub ahead of print]

PMID:
30528195
7.

Child and adolescent psychiatry in the Far East: A 5-year follow up on the Consortium on Academic Child and Adolescent Psychiatry in the Far East (CACAP-FE) study.

Hirota T, Guerrero A, Sartorius N, Fung D, Leventhal B, Ong SH, Kaneko H, Apinuntavech S, Bennett A, Bhoomikumar J, Cheon KA, Davaasuren O, Gau S, Hall B, Koren E, van Nguyen T, Oo T, Tan S, Tateno M, Thikeo M, Wiguna T, Wong M, Zheng Y, Skokauskas N.

Psychiatry Clin Neurosci. 2019 Feb;73(2):84-89. doi: 10.1111/pcn.12800. Epub 2018 Dec 24.

PMID:
30471156
8.

Endotoxemia by Porphyromonas gingivalis Injection Aggravates Non-alcoholic Fatty Liver Disease, Disrupts Glucose/Lipid Metabolism, and Alters Gut Microbiota in Mice.

Sasaki N, Katagiri S, Komazaki R, Watanabe K, Maekawa S, Shiba T, Udagawa S, Takeuchi Y, Ohtsu A, Kohda T, Tohara H, Miyasaka N, Hirota T, Tamari M, Izumi Y.

Front Microbiol. 2018 Oct 24;9:2470. doi: 10.3389/fmicb.2018.02470. eCollection 2018.

9.

Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis.

Inoue H, Tamaki Y, Kashihara Y, Muraki S, Kakara M, Hirota T, Ieiri I.

Br J Clin Pharmacol. 2019 Feb;85(2):393-402. doi: 10.1111/bcp.13807. Epub 2018 Dec 6.

PMID:
30394576
10.

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.

Hirota T, Blakeley P, Sangrithi MN, Mahadevaiah SK, Encheva V, Snijders AP, ElInati E, Ojarikre OA, de Rooij DG, Niakan KK, Turner JMA.

Dev Cell. 2018 Dec 3;47(5):645-659.e6. doi: 10.1016/j.devcel.2018.10.004. Epub 2018 Nov 1.

11.

Ice Ball Crack During CT-Guided Renal Cryoablation Using 1.5-mm-Diameter Cryoprobes.

Ichijo Y, Miura H, Hirota T, Tanaka T, Yoshikawa T, Asai S, Hongo F, Ukimura O, Yamada K.

Cardiovasc Intervent Radiol. 2019 Mar;42(3):475-477. doi: 10.1007/s00270-018-2104-z. Epub 2018 Nov 1.

PMID:
30386882
12.

Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation.

Kashihara Y, Terao Y, Yoda K, Hirota T, Kubota T, Kimura M, Matsuki S, Hirakawa M, Irie S, Ieiri I.

Eur J Clin Pharmacol. 2018 Oct 31. doi: 10.1007/s00228-018-2568-4. [Epub ahead of print]

PMID:
30382297
13.

[Epigenetic Regulation of Pharmacokinetic-related Genes in Human Tissues].

Hirota T.

Yakugaku Zasshi. 2018;138(11):1391-1396. doi: 10.1248/yakushi.18-00145. Review. Japanese.

14.

Characterization of changes in HbA1c in patients with and without secondary failure after metformin treatments by a population pharmacodynamic analysis using mixture models.

Tamaki Y, Maema K, Kakara M, Fukae M, Kinoshita R, Kashihara Y, Muraki S, Hirota T, Ieiri I.

Drug Metab Pharmacokinet. 2018 Dec;33(6):264-269. doi: 10.1016/j.dmpk.2018.08.002. Epub 2018 Aug 16.

PMID:
30360949
15.

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy.

Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I.

J Neurochem. 2019 Feb;148(3):373-385. doi: 10.1111/jnc.14607. Epub 2018 Dec 3.

PMID:
30295925
16.

Prevalence of pathological and maladaptive Internet use and the association with depression and health-related quality of life in Japanese elementary and junior high school-aged children.

Takahashi M, Adachi M, Nishimura T, Hirota T, Yasuda S, Kuribayashi M, Nakamura K.

Soc Psychiatry Psychiatr Epidemiol. 2018 Dec;53(12):1349-1359. doi: 10.1007/s00127-018-1605-z. Epub 2018 Sep 25.

PMID:
30255383
17.

[GENETIC FACTORS FOR THE DEVELOPMENT OF ALLERGIC DISORDERS].

Tamari M, Hirota T.

Arerugi. 2018;67(8):1006-1010. doi: 10.15036/arerugi.67.1006. Japanese. No abstract available.

PMID:
30249949
18.

Protection of the endothelial glycocalyx by antithrombin in an endotoxin-induced rat model of sepsis.

Iba T, Levy JH, Hirota T, Hiki M, Sato K, Murakami T, Nagaoka I.

Thromb Res. 2018 Nov;171:1-6. doi: 10.1016/j.thromres.2018.09.042. Epub 2018 Sep 6.

PMID:
30216821
19.

Association analyses of eQTLs of the TYRO3 gene and allergic diseases in Japanese populations.

Kanazawa J, Masuko H, Yatagai Y, Sakamoto T, Yamada H, Kitazawa H, Iijima H, Naito T, Saito T, Noguchi E, Hirota T, Tamari M, Hizawa N.

Allergol Int. 2019 Jan;68(1):77-81. doi: 10.1016/j.alit.2018.07.004. Epub 2018 Aug 3.

20.

ATR is a multifunctional regulator of male mouse meiosis.

Widger A, Mahadevaiah SK, Lange J, ElInati E, Zohren J, Hirota T, Pacheco S, Maldonado-Linares A, Stanzione M, Ojarikre O, Maciulyte V, de Rooij DG, Tóth A, Roig I, Keeney S, Turner JMA.

Nat Commun. 2018 Jul 5;9(1):2621. doi: 10.1038/s41467-018-04850-0.

21.

Nucleosome Positioning and Gene Regulation of the SGLT2 Gene in the Renal Proximal Tubular Epithelial Cells.

Takesue H, Hirota T, Tachimura M, Tokashiki A, Ieiri I.

Mol Pharmacol. 2018 Sep;94(3):953-962. doi: 10.1124/mol.118.111807. Epub 2018 Jun 29.

PMID:
29959222
22.

Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer.

Hirota T, Muraki S, Ieiri I.

Clin Pharmacokinet. 2018 Jun 19. doi: 10.1007/s40262-018-0689-7. [Epub ahead of print] Review.

PMID:
29915924
23.

Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry.

Hayashi Y, Fujimura A, Kato K, Udagawa R, Hirota T, Kimura K.

Sci Adv. 2018 Jun 6;4(6):eaap7777. doi: 10.1126/sciadv.aap7777. eCollection 2018 Jun.

24.

A systematic review of screening tools in non-young children and adults for autism spectrum disorder.

Hirota T, So R, Kim YS, Leventhal B, Epstein RA.

Res Dev Disabil. 2018 Sep;80:1-12. doi: 10.1016/j.ridd.2018.05.017. Epub 2018 Jun 4.

PMID:
29879612
25.

Intractable Hemophagocytic Syndrome Associated with Systemic Lupus Erythematosus Resistant to Corticosteroids and Intravenous Cyclophosphamide That Was Successfully Treated with Cyclosporine A.

Toko H, Tsuboi H, Umeda N, Honda F, Ohyama A, Takahashi H, Abe S, Yokosawa M, Asashima H, Hagiwara S, Hirota T, Kondo Y, Matsumoto I, Sumida T.

Intern Med. 2018 Sep 15;57(18):2747-2752. doi: 10.2169/internalmedicine.0571-17. Epub 2018 May 18.

26.

Dynamics of sister chromatids through the cell cycle: Together and apart.

Takahashi M, Hirota T.

J Cell Biol. 2018 Jun 4;217(6):1887-1889. doi: 10.1083/jcb.201804091. Epub 2018 May 15.

27.

Quantitative analyses of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1.

Konishi M, Shindo N, Komiya M, Tanaka K, Itoh T, Hirota T.

Biomed Res. 2018;39(2):75-85. doi: 10.2220/biomedres.39.75.

28.

Positive association of plasma leptin with sleep quality in obese type 2 diabetes patients.

Hirota T, Morioka T, Yoda K, Toi N, Hayashi N, Maruo S, Yamazaki Y, Kurajoh M, Motoyama K, Yamada S, Shoji T, Emoto M, Inaba M.

J Diabetes Investig. 2018 Sep;9(5):1100-1105. doi: 10.1111/jdi.12826. Epub 2018 Mar 26.

29.

Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene.

Takechi T, Hirota T, Sakai T, Maeda N, Kobayashi D, Ieiri I.

Drug Metab Dispos. 2018 May;46(5):628-635. doi: 10.1124/dmd.117.079061. Epub 2018 Feb 2.

PMID:
29437875
30.

Author Correction: Sister chromatid resolution is an intrinsic part of chromosome organization in prophase.

Nagasaka K, Hossain MJ, Roberti MJ, Ellenberg J, Hirota T.

Nat Cell Biol. 2018 Apr;20(4):503. doi: 10.1038/s41556-018-0044-0.

PMID:
29434373
31.

Clinical practice guideline for Sjögren's syndrome 2017.

Sumida T, Azuma N, Moriyama M, Takahashi H, Asashima H, Honda F, Abe S, Ono Y, Hirota T, Hirata S, Tanaka Y, Shimizu T, Nakamura H, Kawakami A, Sano H, Ogawa Y, Tsubota K, Ryo K, Saito I, Tanaka A, Nakamura S, Takamura E, Tanaka M, Suzuki K, Takeuchi T, Yamakawa N, Mimori T, Ohta A, Nishiyama S, Yoshihara T, Suzuki Y, Kawano M, Tomiita M, Tsuboi H.

Mod Rheumatol. 2018 May;28(3):383-408. doi: 10.1080/14397595.2018.1438093. Epub 2018 Mar 13. Review.

PMID:
29409370
32.

Vacuolar Protein Degradation via Autophagy Provides Substrates to Amino Acid Catabolic Pathways as an Adaptive Response to Sugar Starvation in Arabidopsis thaliana.

Hirota T, Izumi M, Wada S, Makino A, Ishida H.

Plant Cell Physiol. 2018 Jul 1;59(7):1363-1376. doi: 10.1093/pcp/pcy005.

PMID:
29390157
33.

Protective effect of a newly developed fucose-deficient recombinant antithrombin against histone-induced endothelial damage.

Iba T, Hirota T, Sato K, Nagaoka I.

Int J Hematol. 2018 May;107(5):528-534. doi: 10.1007/s12185-018-2402-x. Epub 2018 Jan 20.

PMID:
29353463
34.

Patients' Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort - Results From Kochi RYOMA Study.

Kubo T, Hirota T, Baba Y, Ochi Y, Takahashi A, Yamasaki N, Hamashige N, Yamamoto K, Kondo F, Bando K, Yamada E, Furuno T, Yabe T, Doi YL, Kitaoka H.

Circ J. 2018 Feb 23;82(3):824-830. doi: 10.1253/circj.CJ-17-0845. Epub 2018 Jan 13.

35.

Conformational dynamics of human protein kinase CK2α and its effect on function and inhibition.

Srivastava A, Hirota T, Irle S, Tama F.

Proteins. 2018 Mar;86(3):344-353. doi: 10.1002/prot.25444. Epub 2017 Dec 25.

PMID:
29243286
36.

Boron and nitrogen co-doped ordered microporous carbons with high surface areas.

Castro-Muñiz A, Nishihara H, Hirota T, Ohwada M, Li LX, Tsuda T, Kuwabata S, Maruyama J, Kyotani T.

Chem Commun (Camb). 2017 Dec 14;53(100):13348-13351. doi: 10.1039/c7cc08390d.

PMID:
29192698
37.

Association of interleukin 1 receptor-like 1 gene polymorphisms with eosinophilic phenotype in Japanese adults with asthma.

Inoue H, Ito I, Niimi A, Matsumoto H, Oguma T, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Morishima T, Hirota T, Tamari M, Wenzel SE, Mishima M.

Respir Investig. 2017 Nov;55(6):338-347. doi: 10.1016/j.resinv.2017.08.006. Epub 2017 Sep 22.

PMID:
29153414
38.

DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line.

ElInati E, Russell HR, Ojarikre OA, Sangrithi M, Hirota T, de Rooij DG, McKinnon PJ, Turner JMA.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12536-12541. doi: 10.1073/pnas.1712530114. Epub 2017 Nov 7.

39.

How important is allergic sensitization as a cause of atopic asthma?

Kanazawa J, Masuko H, Yamada H, Yatagai Y, Sakamoto T, Kitazawa H, Iijima H, Naito T, Hirota T, Tamari M, Hizawa N.

Allergol Int. 2018 Apr;67(2):292-294. doi: 10.1016/j.alit.2017.10.005. Epub 2017 Nov 2. No abstract available.

40.
41.

Population Pharmacodynamic Analysis of Uric Acid-Lowering Effects of Febuxostat Based on Electronic Medical Records in Two Hospitals.

Muraki S, Moriki K, Shigematsu S, Fukae M, Kakara M, Yamashita D, Hirota T, Takane H, Shimada M, Hirakawa M, Ieiri I.

J Clin Pharmacol. 2017 Oct 18. doi: 10.1002/jcph.1023. [Epub ahead of print]

PMID:
29045766
42.

Variants at HLA-A, HLA-C, and HLA-DQB1 Confer Risk of Psoriasis Vulgaris in Japanese.

Hirata J, Hirota T, Ozeki T, Kanai M, Sudo T, Tanaka T, Hizawa N, Nakagawa H, Sato S, Mushiroda T, Saeki H, Tamari M, Okada Y.

J Invest Dermatol. 2018 Mar;138(3):542-548. doi: 10.1016/j.jid.2017.10.001. Epub 2017 Oct 12.

43.

Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids.

Honda F, Tsuboi H, Toko H, Ohyama A, Takahashi H, Abe S, Yokosawa M, Asashima H, Hagiwara S, Hirota T, Kondo Y, Matsumoto I, Sumida T.

Intern Med. 2017 Dec 15;56(24):3373-3377. doi: 10.2169/internalmedicine.9205-17. Epub 2017 Oct 11.

44.

Fertile offspring from sterile sex chromosome trisomic mice.

Hirota T, Ohta H, Powell BE, Mahadevaiah SK, Ojarikre OA, Saitou M, Turner JMA.

Science. 2017 Sep 1;357(6354):932-935. doi: 10.1126/science.aam9046. Epub 2017 Aug 17.

45.

Synthesis of ordered carbonaceous frameworks from organic crystals.

Nishihara H, Hirota T, Matsuura K, Ohwada M, Hoshino N, Akutagawa T, Higuchi T, Jinnai H, Koseki Y, Kasai H, Matsuo Y, Maruyama J, Hayasaka Y, Konaka H, Yamada Y, Yamaguchi S, Kamiya K, Kamimura T, Nobukuni H, Tani F.

Nat Commun. 2017 Jul 24;8(1):109. doi: 10.1038/s41467-017-00152-z.

46.

Diffusion-weighted magnetic resonance imaging of parotid glands before and after abatacept therapy in patients with Sjögren's syndrome associated with rheumatoid arthritis: Utility to evaluate and predict response to treatment.

Takahashi H, Tsuboi H, Yokosawa M, Asashima H, Hirota T, Kondo Y, Matsumoto I, Sumida T.

Mod Rheumatol. 2018 Mar;28(2):300-307. doi: 10.1080/14397595.2017.1349234. Epub 2017 Jul 19.

PMID:
28722506
47.

Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies.

Hatori M, Gronfier C, Van Gelder RN, Bernstein PS, Carreras J, Panda S, Marks F, Sliney D, Hunt CE, Hirota T, Furukawa T, Tsubota K.

NPJ Aging Mech Dis. 2017 Jun 16;3:9. doi: 10.1038/s41514-017-0010-2. eCollection 2017. Review.

48.

Association study of childhood food allergy with genome-wide association studies-discovered loci of atopic dermatitis and eosinophilic esophagitis.

Hirota T, Nakayama T, Sato S, Yanagida N, Matsui T, Sugiura S, Takaoka Y, Hizawa N, Fujieda S, Miyatake A, Sasaki T, Amagai M, Doi S, Ito K, Ebisawa M, Tamari M.

J Allergy Clin Immunol. 2017 Dec;140(6):1713-1716. doi: 10.1016/j.jaci.2017.05.034. Epub 2017 Jun 16. No abstract available.

PMID:
28629743
49.

cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren's syndrome.

Takahashi H, Tsuboi H, Asashima H, Hirota T, Kondo Y, Moriyama M, Matsumoto I, Nakamura S, Sumida T.

Clin Exp Immunol. 2017 Oct;190(1):96-109. doi: 10.1111/cei.13000. Epub 2017 Jul 21.

50.

Suppression of GPI-induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands.

Hirota T, Tsuboi H, Takahashi H, Asashima H, Ohta M, Wakasa Y, Matsumoto I, Takaiwa F, Sumida T.

Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(1):28-34. doi: 10.2177/jsci.40.28. Review. Japanese.

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