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Items: 36

1.

Targeting anti-fibrotic pathways in Crohn's disease - The final frontier?

Ma C, Jairath V, Click B, Hirota SA, Lu C, Parker CE, Rieder F; Stenosis Therapy and Anti-Fibrotic Research (STAR) Consortium.

Best Pract Res Clin Gastroenterol. 2019 Feb - Apr;38-39:101603. doi: 10.1016/j.bpg.2019.02.005. Epub 2019 Feb 16. Review.

PMID:
31327400
2.

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation.

Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E350-E361. doi: 10.1152/ajpendo.00572.2018. Epub 2019 Jun 18.

PMID:
31211619
3.

Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.

Hudson G, Flannigan KL, Venu VKP, Alston L, Sandall CF, MacDonald JA, Muruve DA, Chang TKH, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2019 Jul;370(1):44-53. doi: 10.1124/jpet.118.255679. Epub 2019 Apr 19.

4.

Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes.

Pulakazhi Venu VK, El-Daly M, Saifeddine M, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Can J Diabetes. 2019 Jan 23. pii: S1499-2671(18)30879-7. doi: 10.1016/j.jcjd.2019.01.005. [Epub ahead of print]

PMID:
30930073
5.

Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice.

Miller KA, Vicentini FA, Hirota SA, Sharkey KA, Wieser ME.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):5955-5960. doi: 10.1073/pnas.1814047116. Epub 2019 Mar 8.

6.

Effects of Azithromycin on Behavior, Pathologic Signs, and Changes in Cytokines, Chemokines, and Neutrophil Migration in C57BL/6 Mice Exposed to Dextran Sulfate Sodium.

Anderson SJ, Lockhart JS, Estaki M, Quin C, Hirota SA, Alston L, Buret AG, Hancock TM, Petri B, Gibson DL, Morck DW.

Comp Med. 2019 Feb 1;69(1):4-15. doi: 10.30802/AALAS-CM-18-000001. Epub 2018 Dec 13.

7.

An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil.

Flannigan KL, Taylor MR, Pereira SK, Rodriguez-Arguello J, Moffat AW, Alston L, Wang X, Poon KK, Beck PL, Rioux KP, Jonnalagadda M, Chelikani PK, Galipeau HJ, Lewis IA, Workentine ML, Greenway SC, Hirota SA.

J Heart Lung Transplant. 2018 Sep;37(9):1047-1059. doi: 10.1016/j.healun.2018.05.002. Epub 2018 May 23.

PMID:
30173823
8.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.

El-Daly M, Pulakazhi Venu VK, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Vascul Pharmacol. 2018 Oct;109:56-71. doi: 10.1016/j.vph.2018.06.006. Epub 2018 Jun 13.

PMID:
29908295
9.

TRPing Up Fibrosis: A Novel Role for TRPA1 in Intestinal Myofibroblasts.

Hirota SA.

Cell Mol Gastroenterol Hepatol. 2018 Jan 20;5(3):365. doi: 10.1016/j.jcmgh.2018.01.002. eCollection 2018 Mar. No abstract available.

10.

Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.

Pulakazhi Venu VK, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD.

Br J Pharmacol. 2018 Jun;175(11):2063-2076. doi: 10.1111/bph.14200. Epub 2018 Apr 25.

11.

Changes in Composition of the Gut Bacterial Microbiome after Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in a Pediatric Heart Transplant Patient.

Flannigan KL, Rajbar T, Moffat A, McKenzie LS, Dicke F, Rioux K, Workentine ML, Louie TJ, Hirota SA, Greenway SC.

Front Cardiovasc Med. 2017 Apr 4;4:17. doi: 10.3389/fcvm.2017.00017. eCollection 2017.

12.

Constitutive androstane receptor regulates the intestinal mucosal response to injury.

Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA.

Br J Pharmacol. 2017 Jun;174(12):1857-1871. doi: 10.1111/bph.13787. Epub 2017 Apr 19.

13.

Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.

Ranhotra HS, Flannigan KL, Brave M, Mukherjee S, Lukin DJ, Hirota SA, Mani S.

Nucl Receptor Res. 2016;3. pii: 101199.

14.

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL.

Mucosal Immunol. 2017 May;10(3):673-684. doi: 10.1038/mi.2016.80. Epub 2016 Sep 14.

15.

Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3-/- Mice.

Hirota SA, Ueno A, Tulk SE, Becker HM, Schenck LP, Potentier MS, Li Y, Ghosh S, Muruve DA, MacDonald JA, Beck PL.

Mediators Inflamm. 2016;2016:5637685. doi: 10.1155/2016/5637685. Epub 2016 Aug 17.

16.

Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.

Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2016 Oct;359(1):91-101. doi: 10.1124/jpet.116.234096. Epub 2016 Jul 20.

18.

Airway diseases and inflammatory bowel diseases: is it something in the air (pollution)?

Hirota JA, Carlsten C, Sadatsafavi M, Kaplan G, Hirota SA.

Eur Respir J. 2015 Jul;46(1):287-8. doi: 10.1183/09031936.00003815. No abstract available.

19.

Giardia duodenalis infection reduces granulocyte infiltration in an in vivo model of bacterial toxin-induced colitis and attenuates inflammation in human intestinal tissue.

Cotton JA, Motta JP, Schenck LP, Hirota SA, Beck PL, Buret AG.

PLoS One. 2014 Oct 7;9(10):e109087. doi: 10.1371/journal.pone.0109087. eCollection 2014.

20.

The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection.

Sun X, Hirota SA.

Mol Immunol. 2015 Feb;63(2):193-202. doi: 10.1016/j.molimm.2014.09.005. Epub 2014 Sep 18. Review.

21.

Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis.

Terc J, Hansen A, Alston L, Hirota SA.

Eur J Pharm Sci. 2014 May 13;55:12-9. doi: 10.1016/j.ejps.2014.01.007. Epub 2014 Jan 29.

PMID:
24486481
22.

The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.

Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA.

PLoS One. 2013 Nov 22;8(11):e81491. doi: 10.1371/journal.pone.0081491. eCollection 2013.

23.

Effects of nitric oxide and reactive oxygen species on HIF-1α stabilization following clostridium difficile toxin exposure of the Caco-2 epithelial cell line.

Lee JY, Hirota SA, Glover LE, Armstrong GD, Beck PL, MacDonald JA.

Cell Physiol Biochem. 2013;32(2):417-30. doi: 10.1159/000354448. Epub 2013 Aug 27.

24.

Attenuation of Clostridium difficile toxin-induced damage to epithelial barrier by ecto-5'-nucleotidase (CD73) and adenosine receptor signaling.

Schenck LP, Hirota SA, Hirota CL, Boasquevisque P, Tulk SE, Li Y, Wadhwani A, Doktorchik CT, Macnaughton WK, Beck PL, MacDonald JA.

Neurogastroenterol Motil. 2013 Jun;25(6):e441-53. doi: 10.1111/nmo.12139. Epub 2013 Apr 21. Erratum in: Neurogastroenterol Motil. 2014 Mar;26(3):445. Schenck, L Patrick [corrected to Schenck, L P].

PMID:
23600886
25.

Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure.

Hirota SA, Iablokov V, Tulk SE, Schenck LP, Becker H, Nguyen J, Al Bashir S, Dingle TC, Laing A, Liu J, Li Y, Bolstad J, Mulvey GL, Armstrong GD, MacNaughton WK, Muruve DA, MacDonald JA, Beck PL.

Infect Immun. 2012 Dec;80(12):4474-84. doi: 10.1128/IAI.00933-12. Epub 2012 Oct 8.

26.

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

Bracey NA, Beck PL, Muruve DA, Hirota SA, Guo J, Jabagi H, Wright JR Jr, Macdonald JA, Lees-Miller JP, Roach D, Semeniuk LM, Duff HJ.

Exp Physiol. 2013 Feb;98(2):462-72. doi: 10.1113/expphysiol.2012.068338. Epub 2012 Jul 30.

27.

Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.

Gulbransen BD, Bashashati M, Hirota SA, Gui X, Roberts JA, MacDonald JA, Muruve DA, McKay DM, Beck PL, Mawe GM, Thompson RJ, Sharkey KA.

Nat Med. 2012 Mar 18;18(4):600-4. doi: 10.1038/nm.2679.

28.

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter.

Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, Macdonald JA, Hackett TL, Sin DD, Van Eeden S, Knight DA.

J Allergy Clin Immunol. 2012 Apr;129(4):1116-25.e6. doi: 10.1016/j.jaci.2011.11.033. Epub 2012 Jan 9.

PMID:
22227418
29.

Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum.

Fichna J, Dicay M, Hirota SA, Traboulsi D, Macdonald JA, Janecka A, Beck PL, Zjawiony JK, Macnaughton WK, Storr MA.

Neurogastroenterol Motil. 2011 Jun;23(6):583-e212. doi: 10.1111/j.1365-2982.2011.01699.x. Epub 2011 Mar 17.

PMID:
21414104
30.

Intravascular danger signals guide neutrophils to sites of sterile inflammation.

McDonald B, Pittman K, Menezes GB, Hirota SA, Slaba I, Waterhouse CC, Beck PL, Muruve DA, Kubes P.

Science. 2010 Oct 15;330(6002):362-6. doi: 10.1126/science.1195491. Erratum in: Science. 2011 Mar 25;331(6024):1517.

31.

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.

Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL.

Inflamm Bowel Dis. 2011 Jun;17(6):1359-72. doi: 10.1002/ibd.21478. Epub 2010 Sep 24.

32.

Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome.

Ng J, Hirota SA, Gross O, Li Y, Ulke-Lemee A, Potentier MS, Schenck LP, Vilaysane A, Seamone ME, Feng H, Armstrong GD, Tschopp J, Macdonald JA, Muruve DA, Beck PL.

Gastroenterology. 2010 Aug;139(2):542-52, 552.e1-3. doi: 10.1053/j.gastro.2010.04.005. Epub 2010 Apr 13.

PMID:
20398664
33.

Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.

Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL.

Gastroenterology. 2010 Jul;139(1):259-69.e3. doi: 10.1053/j.gastro.2010.03.045. Epub 2010 Mar 27.

34.

Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.

Beck PL, Ihara E, Hirota SA, MacDonald JA, Meng D, Nanthakumar NN, Podolsky DK, Xavier RJ.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G43-53. doi: 10.1152/ajpgi.00228.2009. Epub 2010 Mar 18.

35.

Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: implications for the treatment of inflammatory bowel disease.

Hirota SA, Beck PL, MacDonald JA.

Recent Pat Inflamm Allergy Drug Discov. 2009 Jan;3(1):1-16. Review.

PMID:
19149741
36.

Sodium and asthma: something borrowed, something new?

Hirota SA, Janssen LJ.

Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1369-73. Epub 2007 Sep 28.

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