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Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.

Alsabban AH, Morikawa M, Tanaka Y, Takei Y, Hirokawa N.

EMBO J. 2019 Nov 20:e101090. doi: 10.15252/embj.2018101090. [Epub ahead of print]


Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.

Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R.

Cell Rep. 2019 Oct 29;29(5):1261-1273.e6. doi: 10.1016/j.celrep.2019.09.050.


Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.

Ide M, Ohnishi T, Toyoshima M, Balan S, Maekawa M, Shimamoto-Mitsuyama C, Iwayama Y, Ohba H, Watanabe A, Ishii T, Shibuya N, Kimura Y, Hisano Y, Murata Y, Hara T, Morikawa M, Hashimoto K, Nozaki Y, Toyota T, Wada Y, Tanaka Y, Kato T, Nishi A, Fujisawa S, Okano H, Itokawa M, Hirokawa N, Kunii Y, Kakita A, Yabe H, Iwamoto K, Meno K, Katagiri T, Dean B, Uchida K, Kimura H, Yoshikawa T.

EMBO Mol Med. 2019 Dec;11(12):e10695. doi: 10.15252/emmm.201910695. Epub 2019 Oct 28.


Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.

Toyoshima M, Jiang X, Ogawa T, Ohnishi T, Yoshihara S, Balan S, Yoshikawa T, Hirokawa N.

Life Sci Alliance. 2019 Oct 7;2(5). pii: e201900478. doi: 10.26508/lsa.201900478. Print 2019 Oct.


The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling.

Ichinose S, Ogawa T, Jiang X, Hirokawa N.

Cell Rep. 2019 Aug 27;28(9):2413-2426.e7. doi: 10.1016/j.celrep.2019.07.093.


Rare case of occult testosterone-producing ovarian tumor that was diagnosed by selective venous hormone sampling.

Kuno Y, Baba T, Kuroda T, Teramoto M, Hirokawa N, Endo T, Saito T.

Reprod Med Biol. 2018 Jun 21;17(4):504-508. doi: 10.1002/rmb2.12213. eCollection 2018 Oct.


Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport.

Shima T, Morikawa M, Kaneshiro J, Kambara T, Kamimura S, Yagi T, Iwamoto H, Uemura S, Shigematsu H, Shirouzu M, Ichimura T, Watanabe TM, Nitta R, Okada Y, Hirokawa N.

J Cell Biol. 2018 Dec 3;217(12):4164-4183. doi: 10.1083/jcb.201711178. Epub 2018 Oct 8.


The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase.

Wang L, Tanaka Y, Wang D, Morikawa M, Zhou R, Homma N, Miyamoto Y, Hirokawa N.

Cell Rep. 2018 Sep 11;24(11):2894-2907. doi: 10.1016/j.celrep.2018.05.075.


Erratum to 'Ultrasonography Improves Glycemic Control by Detecting Insulin-Derived Localized Amyloidosis' [Ultrasound Med Biol 43 (2017) 2284-2294].

Kikuchi M, Hirokawa N, Hagiwara S, Nakayama H, Taneda S, Manda N, Sakata K.

Ultrasound Med Biol. 2018 Dec;44(12):2840. doi: 10.1016/j.ultrasmedbio.2018.08.010. Epub 2018 Sep 3. No abstract available.


KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth.

Xu F, Takahashi H, Tanaka Y, Ichinose S, Niwa S, Wicklund MP, Hirokawa N.

J Cell Biol. 2018 Oct 1;217(10):3480-3496. doi: 10.1083/jcb.201801085. Epub 2018 Aug 20.


Histopathological differences of experimental aneurysms treated with bare platinum, fibered, and bioactive coils.

Usami Y, Hirokawa N, Saitoh M, Okuda H, Someya M, Hasegawa T, Takakuwa Y, Sakata KI.

Minim Invasive Ther Allied Technol. 2019 Jun;28(3):172-177. doi: 10.1080/13645706.2018.1499532. Epub 2018 Aug 16.


A new ENG mutation in a Japanese family with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations.

Yokoo K, Yamada G, Chiba H, Ishikawa A, Morisaki H, Saijo H, Kudoh S, Kitamura Y, Hirokawa N, Miyajima M, Watanabe A, Takahashi H.

Respir Med Case Rep. 2018 Jul 2;25:73-77. doi: 10.1016/j.rmcr.2018.07.001. eCollection 2018.


The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation.

Morikawa M, Tanaka Y, Cho HS, Yoshihara M, Hirokawa N.

Cell Rep. 2018 Jun 26;23(13):3864-3877. doi: 10.1016/j.celrep.2018.05.089.


KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring.

Homma N, Zhou R, Naseer MI, Chaudhary AG, Al-Qahtani MH, Hirokawa N.

Elife. 2018 Jan 9;7. pii: e30935. doi: 10.7554/eLife.30935.


Multiple analyses of protein dynamics in solution.

Ogawa T, Hirokawa N.

Biophys Rev. 2018 Apr;10(2):299-306. doi: 10.1007/s12551-017-0354-7. Epub 2017 Dec 4. Review.


Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation.

Ogawa T, Saijo S, Shimizu N, Jiang X, Hirokawa N.

Cell Rep. 2017 Sep 12;20(11):2626-2638. doi: 10.1016/j.celrep.2017.08.067.


Structural basis for CRMP2-induced axonal microtubule formation.

Niwa S, Nakamura F, Tomabechi Y, Aoki M, Shigematsu H, Matsumoto T, Yamagata A, Fukai S, Hirokawa N, Goshima Y, Shirouzu M, Nitta R.

Sci Rep. 2017 Sep 6;7(1):10681. doi: 10.1038/s41598-017-11031-4.


Ultrasonography Improves Glycemic Control by Detecting Insulin-Derived Localized Amyloidosis.

Kikuchi M, Hirokawa N, Hagiwara S, Nakayama H, Taneda S, Manda N, Sakata K.

Ultrasound Med Biol. 2017 Oct;43(10):2284-2294. doi: 10.1016/j.ultrasmedbio.2017.06.011. Epub 2017 Jul 25. Erratum in: Ultrasound Med Biol. 2018 Dec;44(12):2840.


Components of RNA granules affect their localization and dynamics in neuronal dendrites.

Mitsumori K, Takei Y, Hirokawa N.

Mol Biol Cell. 2017 Jun 1;28(11):1412-1417. doi: 10.1091/mbc.E16-07-0497. Epub 2017 Apr 12.


Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A.

Wang D, Nitta R, Morikawa M, Yajima H, Inoue S, Shigematsu H, Kikkawa M, Hirokawa N.

Elife. 2016 Sep 30;5. pii: e18101. doi: 10.7554/eLife.18101.


Autoinhibition of a Neuronal Kinesin UNC-104/KIF1A Regulates the Size and Density of Synapses.

Niwa S, Lipton DM, Morikawa M, Zhao C, Hirokawa N, Lu H, Shen K.

Cell Rep. 2016 Aug 23;16(8):2129-2141. doi: 10.1016/j.celrep.2016.07.043. Epub 2016 Aug 11.


The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function.

Tanaka Y, Niwa S, Dong M, Farkhondeh A, Wang L, Zhou R, Hirokawa N.

Neuron. 2016 Jun 15;90(6):1215-1229. doi: 10.1016/j.neuron.2016.05.002. Epub 2016 Jun 2.


Influence of Ku86 and XRCC4 expression in uterine cervical cancer on the response to preoperative radiotherapy.

Takada Y, Someya M, Matsumoto Y, Satoh M, Nakata K, Hori M, Saito M, Hirokawa N, Tateoka K, Teramoto M, Saito T, Hasegawa T, Sakata KI.

Med Mol Morphol. 2016 Dec;49(4):210-216. Epub 2016 Feb 11.


Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.

Takei Y, Kikkawa YS, Atapour N, Hensch TK, Hirokawa N.

J Neurosci. 2015 Nov 25;35(47):15539-54. doi: 10.1523/JNEUROSCI.2671-15.2015.


Microtubule Destabilizer KIF2A Undergoes Distinct Site-Specific Phosphorylation Cascades that Differentially Affect Neuronal Morphogenesis.

Ogawa T, Hirokawa N.

Cell Rep. 2015 Sep 22;12(11):1774-88. doi: 10.1016/j.celrep.2015.08.018. Epub 2015 Sep 3.


Mechanism of Activity-Dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa.

Ichinose S, Ogawa T, Hirokawa N.

Neuron. 2015 Sep 2;87(5):1022-35. doi: 10.1016/j.neuron.2015.08.008.


Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy for prostate cancer.

Someya M, Yamamoto H, Nojima M, Hori M, Tateoka K, Nakata K, Takagi M, Saito M, Hirokawa N, Tokino T, Sakata K.

Radiother Oncol. 2015 May;115(2):235-9. doi: 10.1016/j.radonc.2015.04.008. Epub 2015 Apr 30.


Introduction to the ECR Special Issue on Molecular Motors.

Hirokawa N.

Exp Cell Res. 2015 May 15;334(1):1. doi: 10.1016/j.yexcr.2015.03.013. Epub 2015 Mar 24. No abstract available.


X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding.

Morikawa M, Yajima H, Nitta R, Inoue S, Ogura T, Sato C, Hirokawa N.

EMBO J. 2015 May 5;34(9):1270-86. doi: 10.15252/embj.201490588. Epub 2015 Mar 16.


Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases.

Hirokawa N, Tanaka Y.

Exp Cell Res. 2015 May 15;334(1):16-25. doi: 10.1016/j.yexcr.2015.02.016. Epub 2015 Feb 24. Review.


Message from the International Federation of Cell Biology.

Hirokawa N, Carvalho HF.

Cell Biol Int. 2015 Jan;39(1):1. doi: 10.1002/cbin.10418. No abstract available.


Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.

Yang W, Tanaka Y, Bundo M, Hirokawa N.

Dev Cell. 2014 Oct 27;31(2):202-14. doi: 10.1016/j.devcel.2014.08.028.


Results and DVH analysis of late rectal bleeding in patients treated with 3D-CRT or IMRT for localized prostate cancer.

Someya M, Hori M, Tateoka K, Nakata K, Takagi M, Saito M, Hirokawa N, Hareyama M, Sakata K.

J Radiat Res. 2015 Jan;56(1):122-7. doi: 10.1093/jrr/rru080. Epub 2014 Sep 11.


New simulated annealing approach considering helix bending applied to determine the 8.8Å structure of 15-protofilament microtubules.

Ogura T, Yajima H, Nitta R, Hirokawa N, Sato C.

J Struct Biol. 2014 Nov;188(2):165-76. doi: 10.1016/j.jsb.2014.08.009. Epub 2014 Sep 1.


KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae.

Kanai Y, Wang D, Hirokawa N.

J Cell Biol. 2014 Feb 3;204(3):395-408. doi: 10.1083/jcb.201309066. Epub 2014 Jan 27.


Axonal pruning is actively regulated by the microtubule-destabilizing protein kinesin superfamily protein 2A.

Maor-Nof M, Homma N, Raanan C, Nof A, Hirokawa N, Yaron A.

Cell Rep. 2013 Apr 25;3(4):971-7. doi: 10.1016/j.celrep.2013.03.005. Epub 2013 Apr 4.


β-Tubulin mutations that cause severe neuropathies disrupt axonal transport.

Niwa S, Takahashi H, Hirokawa N.

EMBO J. 2013 May 15;32(10):1352-64. doi: 10.1038/emboj.2013.59. Epub 2013 Mar 15.


Structural basis for the ATP-induced isomerization of kinesin.

Chang Q, Nitta R, Inoue S, Hirokawa N.

J Mol Biol. 2013 Jun 12;425(11):1869-1880. doi: 10.1016/j.jmb.2013.03.004. Epub 2013 Mar 7.


Systemic lymph node tuberculosis presenting with an aseptic psoas abscess caused by a paradoxical reaction after nine months of antituberculosis treatment: a case report.

Yamada G, Nishikiori H, Fujii M, Inomata S, Chiba H, Hirokawa N, Takahashi H.

J Med Case Rep. 2013 Mar 14;7:72. doi: 10.1186/1752-1947-7-72.


A molecular motor, KIF13A, controls anxiety by transporting the serotonin type 1A receptor.

Zhou R, Niwa S, Guillaud L, Tong Y, Hirokawa N.

Cell Rep. 2013 Feb 21;3(2):509-19. doi: 10.1016/j.celrep.2013.01.014. Epub 2013 Feb 8.


Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy.

Nakajima K, Yin X, Takei Y, Seog DH, Homma N, Hirokawa N.

Neuron. 2012 Dec 6;76(5):945-61. doi: 10.1016/j.neuron.2012.10.012.


KIF19A is a microtubule-depolymerizing kinesin for ciliary length control.

Niwa S, Nakajima K, Miki H, Minato Y, Wang D, Hirokawa N.

Dev Cell. 2012 Dec 11;23(6):1167-75. doi: 10.1016/j.devcel.2012.10.016. Epub 2012 Nov 15.


Antihypertensive effect of boysenberry seed polyphenols on spontaneously hypertensive rats and identification of orally absorbable proanthocyanidins with vasorelaxant activity.

Furuuchi R, Sakai H, Hirokawa N, Watanabe Y, Yokoyama T, Hirayama M.

Biosci Biotechnol Biochem. 2012;76(9):1694-701. Epub 2012 Sep 7.


Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy.

Yajima H, Ogura T, Nitta R, Okada Y, Sato C, Hirokawa N.

J Cell Biol. 2012 Aug 6;198(3):315-22. doi: 10.1083/jcb.201201161. Epub 2012 Jul 30.


Regulation of NMDA receptor transport: a KIF17-cargo binding/releasing underlies synaptic plasticity and memory in vivo.

Yin X, Feng X, Takei Y, Hirokawa N.

J Neurosci. 2012 Apr 18;32(16):5486-99. doi: 10.1523/JNEUROSCI.0718-12.2012.


Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment.

Kondo M, Takei Y, Hirokawa N.

Neuron. 2012 Feb 23;73(4):743-57. doi: 10.1016/j.neuron.2011.12.020.


Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches.

Noda Y, Niwa S, Homma N, Fukuda H, Imajo-Ohmi S, Hirokawa N.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1725-30. doi: 10.1073/pnas.1107808109. Epub 2012 Jan 17.


Cilia, KIF3 molecular motor and nodal flow.

Hirokawa N, Tanaka Y, Okada Y.

Curr Opin Cell Biol. 2012 Feb;24(1):31-9. doi: 10.1016/ Epub 2012 Jan 28. Review.


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