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[Refractory ascites developing in late-phase of cord blood transplantation improving with CART].

Hiroi T, Mushino T, Tanaka K, Yamashita Y, Kuriyama K, Murata S, Furuya Y, Hori Y, Oiwa T, Kobata H, Hosoi H, Nishikawa A, Tamura S, Sonoki T.

Rinsho Ketsueki. 2019;60(2):130-133. doi: 10.11406/rinketsu.60.130. Japanese.


Serum Cytokine Interactions Are Implicated in the Mechanism of Action of Sublingual Immunotherapy for Japanese Cedar Pollinosis.

Shimada K, Gotoh M, Okubo K, Hiroi T, Kaminuma O, Nakaya A.

J Nippon Med Sch. 2018;85(5):250-258. doi: 10.1272/jnms.JNMS.2018_85-40.


Microarray-Based Multivariate Analysis of the Effectiveness of Sublingual Immunotherapy for Cedar Pollinosis.

Gotoh M, Kaminuma O, Hiroi T, Okubo K.

Allergy Asthma Immunol Res. 2018 Sep;10(5):562-569. doi: 10.4168/aair.2018.10.5.562.


Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis.

Nishimura T, Kaminuma O, Saeki M, Kitamura N, Gotoh M, Mori A, Hiroi T.

Allergol Int. 2018 Sep;67S:S25-S31. doi: 10.1016/j.alit.2018.05.002. Epub 2018 Jun 15.


Involvement of taste receptors in the effectiveness of sublingual immunotherapy.

Gotoh M, Kaminuma O, Nakaya A, Katayama K, Watanabe N, Saeki M, Nishimura T, Kitamura N, Okubo K, Hiroi T.

Allergol Int. 2018 Jul;67(3):421-424. doi: 10.1016/j.alit.2018.02.003. Epub 2018 Mar 6. No abstract available.


Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells.

Kaminuma O, Katoh S, Miyagi T, Watanabe N, Kitamura N, Nishimura T, Saeki M, Mori A, Hiroi T.

Genes Cells. 2018 Feb;23(2):112-116. doi: 10.1111/gtc.12553. Epub 2017 Dec 22.


Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor TBX5 Is Crucial for Cytokine Expression in T Cells.

Kaminuma O, Kitamura N, Nishito Y, Nemoto S, Tatsumi H, Mori A, Hiroi T.

J Immunol. 2018 Jan 1;200(1):92-100. doi: 10.4049/jimmunol.1602113. Epub 2017 Nov 27.


T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice.

Kaminuma O, Nishimura T, Kitamura N, Saeki M, Hiroi T, Mori A.

Allergy Asthma Immunol Res. 2018 Jan;10(1):77-82. doi: 10.4168/aair.2018.10.1.77.


Differential Contribution of Adhesion Molecules to Th1 and Th2 Cell-Mediated Lung and Bowel Inflammation.

Kaminuma O, Saeki M, Nishimura T, Kitamura N, Watanabe N, Hiroi T, Mori A.

Biol Pharm Bull. 2017;40(10):1801-1805. doi: 10.1248/bpb.b17-00279.


Oral administration of ovalbumin after sensitization attenuates symptoms in a mouse model of food allergic enteropathy.

Hiraide E, Morinaga M, Hidaka H, Yamada S, Takeyama J, Kitamura N, Kaminuma O, Hiroi T, Du W, Ohashi-Doi K, Nakajima-Adachi H, Hachimura S.

Biosci Biotechnol Biochem. 2017 Oct;81(10):1967-1972. doi: 10.1080/09168451.2017.1361806. Epub 2017 Aug 16.


Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice.

Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T.

Allergol Int. 2017 Sep;66S:S35-S40. doi: 10.1016/j.alit.2017.07.001. Epub 2017 Jul 26.


Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis.

Gotoh M, Kaminuma O, Nakaya A, Katayama K, Motoi Y, Watanabe N, Saeki M, Nishimura T, Kitamura N, Yamaoka K, Okubo K, Hiroi T.

Int Immunol. 2017 Jun 1;29(6):291-300. doi: 10.1093/intimm/dxx034.


Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4+ T cells.

Kaminuma O, Katayama K, Inoue K, Saeki M, Nishimura T, Kitamura N, Shimo Y, Tofukuji S, Ishida S, Ogonuki N, Kamimura S, Oikawa M, Katoh S, Mori A, Shichijo M, Hiroi T, Ogura A.

EMBO Rep. 2017 Jun;18(6):885-893. doi: 10.15252/embr.201643321. Epub 2017 May 2.


Functional characterization of the neuron-restrictive silencer element in the human tryptophan hydroxylase 2 gene expression.

Nawa Y, Kaneko H, Oda M, Tsubonoya M, Hiroi T, Gentile MT, Colucci-D'Amato L, Takahashi R, Matsui H.

J Neurochem. 2017 May 2. doi: 10.1111/jnc.14060. [Epub ahead of print]


Role of the local structure in superconductivity of LaO0.5F0.5BiS2-x Se x system.

Paris E, Mizuguchi Y, Hacisalihoglu MY, Hiroi T, Joseph B, Aquilanti G, Miura O, Mizokawa T, Saini NL.

J Phys Condens Matter. 2017 Apr 12;29(14):145603. doi: 10.1088/1361-648X/aa5e97. Epub 2017 Feb 6.


Th9 cells elicit eosinophil-independent bronchial hyperresponsiveness in mice.

Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T.

Allergol Int. 2016 Sep;65 Suppl:S24-9. doi: 10.1016/j.alit.2016.05.003. Epub 2016 Jun 11.


Critical role of CD44 in antigen-induced Th2- but not Th17-madiated murine airway inflammation.

Nishimura T, Katoh S, Mori A, Ohtomo T, Saeki M, Hiroi T, Kaminuma O.

Allergol Int. 2016 Sep;65 Suppl:S59-61. doi: 10.1016/j.alit.2016.04.010. Epub 2016 Jul 7. No abstract available.


Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.

Watanabe N, Kaminuma O, Kitamura N, Hiroi T.

PLoS One. 2016 Mar 7;11(3):e0150244. doi: 10.1371/journal.pone.0150244. eCollection 2016.


Effects of Dendritic Cell Subset Manipulation on Airway Allergy in a Mouse Model.

Murakami R, Nakagawa Y, Shimizu M, Wakabayashi A, Negishi Y, Hiroi T, Okubo K, Takahashi H.

Int Arch Allergy Immunol. 2015;168(4):219-32. doi: 10.1159/000443237. Epub 2016 Feb 9.


Essential Contribution of CD4+ T Cells to Antigen-Induced Nasal Hyperresponsiveness in Experimental Allergic Rhinitis.

Nishimura T, Kaminuma O, Saeki M, Kitamura N, Matsuoka K, Yonekawa H, Mori A, Hiroi T.

PLoS One. 2016 Jan 11;11(1):e0146686. doi: 10.1371/journal.pone.0146686. eCollection 2016.


[A biomarker set relation to the efficacy of allergen-specific immunotherapy].

Kaminuma O, Gotoh M, Nakaya A, Okubo K, Hiroi T.

Nihon Yakurigaku Zasshi. 2015 Nov;146(5):259-62. doi: 10.1254/fpj.146.259. Japanese. No abstract available.


Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).

Yokoyama S, Perera PY, Terawaki S, Watanabe N, Kaminuma O, Waldmann TA, Hiroi T, Perera LP.

J Clin Immunol. 2015 Oct;35(7):661-7. doi: 10.1007/s10875-015-0203-z. Epub 2015 Oct 9.


In-plane chemical pressure essential for superconductivity in BiCh2-based (Ch: S, Se) layered structure.

Mizuguchi Y, Miura A, Kajitani J, Hiroi T, Miura O, Tadanaga K, Kumada N, Magome E, Moriyoshi C, Kuroiwa Y.

Sci Rep. 2015 Oct 8;5:14968. doi: 10.1038/srep14968.


Reliable Hydrogel with Mechanical "Fuse Link" in an Aqueous Environment.

Kondo S, Hiroi T, Han YS, Kim TH, Shibayama M, Chung UI, Sakai T.

Adv Mater. 2015 Dec 2;27(45):7407-11. doi: 10.1002/adma.201503130. Epub 2015 Oct 7.


TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition.

Li HM, Hiroi T, Zhang Y, Shi A, Chen G, De S, Metter EJ, Wood WH 3rd, Sharov A, Milner JD, Becker KG, Zhan M, Weng NP.

J Leukoc Biol. 2016 Mar;99(3):505-13. doi: 10.1189/jlb.6A0215-071RR. Epub 2015 Sep 22.


Rice seed for delivery of vaccines to gut mucosal immune tissues.

Takaiwa F, Wakasa Y, Takagi H, Hiroi T.

Plant Biotechnol J. 2015 Oct;13(8):1041-55. doi: 10.1111/pbi.12423. Epub 2015 Jun 23. Review.


Analysis of the effects of dietary fat on body and skin lipids of hamsters by Raman spectroscopy.

Meksiarun P, Maeda Y, Hiroi T, Andriana BB, Sato H.

Analyst. 2015 Jun 21;140(12):4238-44. doi: 10.1039/c5an00076a. Epub 2015 Apr 29.


Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.

Nabekura T, Hiroi T, Kawasaki T, Uwai Y.

Biomed Pharmacother. 2015 Mar;70:140-5. doi: 10.1016/j.biopha.2015.01.007. Epub 2015 Jan 15.


Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy--a new mucosal vaccine formulation against Japanese cedar pollen allergy.

Wakasa Y, Takagi H, Watanabe N, Kitamura N, Fujiwara Y, Ogo Y, Hayashi S, Yang L, Ohta M, Thet Tin WW, Sekikawa K, Takano M, Ozawa K, Hiroi T, Takaiwa F.

PLoS One. 2015 Mar 16;10(3):e0120209. doi: 10.1371/journal.pone.0120209. eCollection 2015.


Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth.

Yin Y, Cai X, Chen X, Liang H, Zhang Y, Li J, Wang Z, Chen X, Zhang W, Yokoyama S, Wang C, Li L, Li L, Hou D, Dong L, Xu T, Hiroi T, Yang F, Ji H, Zhang J, Zen K, Zhang CY.

Cell Res. 2014 Oct;24(10):1164-80. doi: 10.1038/cr.2014.121. Epub 2014 Sep 16.


IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages.

Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, Hori M.

J Pharmacol Sci. 2014;125(4):394-405. Epub 2014 Jul 25.


Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake.

Shibahara K, Nakajima-Adachi H, Kaminuma O, Hiroi T, Mori A, Hachimura S.

Biosci Microbiota Food Health. 2014;33(1):41-6. doi: 10.12938/bmfh.33.41. Epub 2014 Jan 30.


Antigen-induced mixed and separated inflammation in murine upper and lower airways.

Saeki M, Nishimura T, Mori A, Kaminuma O, Hiroi T.

Allergol Int. 2014 May;63 Suppl 1:59-61. doi: 10.2332/allergolint.13-LE-0634. No abstract available.


Selective suppression of Th2 cell-mediated lung eosinophilic inflammation by anti-major facilitator super family domain containing 10 monoclonal antibody.

Nishimura T, Saeki M, Motoi Y, Kitamura N, Mori A, Kaminuma O, Hiroi T.

Allergol Int. 2014 May;63 Suppl 1:29-35. doi: 10.2332/allergolint.13-OA-0635.


A gene cluster for the synthesis of serotype g-specific polysaccharide antigen in Aggregatibacter actinomycetemcomitans.

Tsuzukibashi O, Saito M, Kobayashi T, Umezawa K, Nagahama F, Hiroi T, Hirasawa M, Takada K.

Arch Microbiol. 2014 Apr;196(4):261-5. doi: 10.1007/s00203-014-0965-3. Epub 2014 Feb 22.


Development of an immunochromatographic test strip for detection of cholera toxin.

Yamasaki E, Sakamoto R, Matsumoto T, Morimatsu F, Kurazono T, Hiroi T, Nair GB, Kurazono H.

Biomed Res Int. 2013;2013:679038. doi: 10.1155/2013/679038. Epub 2013 Nov 7.


Chelyabinsk airburst, damage assessment, meteorite recovery, and characterization.

Popova OP, Jenniskens P, Emel'yanenko V, Kartashova A, Biryukov E, Khaibrakhmanov S, Shuvalov V, Rybnov Y, Dudorov A, Grokhovsky VI, Badyukov DD, Yin QZ, Gural PS, Albers J, Granvik M, Evers LG, Kuiper J, Kharlamov V, Solovyov A, Rusakov YS, Korotkiy S, Serdyuk I, Korochantsev AV, Larionov MY, Glazachev D, Mayer AE, Gisler G, Gladkovsky SV, Wimpenny J, Sanborn ME, Yamakawa A, Verosub KL, Rowland DJ, Roeske S, Botto NW, Friedrich JM, Zolensky ME, Le L, Ross D, Ziegler K, Nakamura T, Ahn I, Lee JI, Zhou Q, Li XH, Li QL, Liu Y, Tang GQ, Hiroi T, Sears D, Weinstein IA, Vokhmintsev AS, Ishchenko AV, Schmitt-Kopplin P, Hertkorn N, Nagao K, Haba MK, Komatsu M, Mikouchi T; Chelyabinsk Airburst Consortium.

Science. 2013 Nov 29;342(6162):1069-73. doi: 10.1126/science.1242642. Epub 2013 Nov 7.


Dynamic light scattering microscope: accessing opaque samples with high spatial resolution.

Hiroi T, Shibayama M.

Opt Express. 2013 Aug 26;21(17):20260-7. doi: 10.1364/OE.21.020260.


The proteasome inhibitor bortezomib inhibits the growth of canine malignant melanoma cells in vitro and in vivo.

Ito K, Kobayashi M, Kuroki S, Sasaki Y, Iwata T, Mori K, Kuroki T, Ozawa Y, Tetsuka M, Nakagawa T, Hiroi T, Yamamoto H, Ono K, Washizu T, Bonkobara M.

Vet J. 2013 Dec;198(3):577-82. doi: 10.1016/j.tvjl.2013.08.003. Epub 2013 Aug 11.


Protective-antigen (PA) based anthrax vaccines confer protection against inhalation anthrax by precluding the establishment of a systemic infection.

Merkel TJ, Perera PY, Lee GM, Verma A, Hiroi T, Yokote H, Waldmann TA, Perera LP.

Hum Vaccin Immunother. 2013 Sep;9(9):1841-8. doi: 10.4161/hv.25337. Epub 2013 Jun 20.


Oral immunotherapy for allergic diseases using transgenic rice seeds: current state and future prospects.

Saeki M, Nishimura T, Kaminuma O, Mori A, Hiroi T.

Int Arch Allergy Immunol. 2013;161 Suppl 2:164-9. doi: 10.1159/000350402. Epub 2013 May 29.


Existence of antigen-specific immunoglobulin E is not sufficient for allergic nasal eosinophil infiltration in mice.

Nishimura T, Saeki M, Kaminuma O, Matsuoka K, Yonekawa H, Mori A, Hiroi T.

Int Arch Allergy Immunol. 2013;161 Suppl 2:125-8. doi: 10.1159/000350565. Epub 2013 May 29.



Ootaki M, Nawa Y, Hiroi T, Matsui H, Sugawara Y.

Acta Crystallogr Sect E Struct Rep Online. 2013 Apr 5;69(Pt 5):o660. doi: 10.1107/S1600536813008490. Print 2013 May 1.


Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload.

Shimizu S, Ishibashi M, Kumagai S, Wajima T, Hiroi T, Kurihara T, Ishii M, Kiuchi Y.

Int J Mol Med. 2013 Mar;31(3):589-96. doi: 10.3892/ijmm.2013.1236. Epub 2013 Jan 10.


Streptococcus orisasini sp. nov. and Streptococcus dentasini sp. nov., isolated from the oral cavity of donkeys.

Takada K, Saito M, Tsudukibashi O, Hiroi T, Hirasawa M.

Int J Syst Evol Microbiol. 2013 Aug;63(Pt 8):2782-6. doi: 10.1099/ijs.0.047142-0. Epub 2013 Jan 4.


Tofacitinib, a janus kinase inhibitor demonstrates efficacy in an IL-15 transgenic mouse model that recapitulates pathologic manifestations of celiac disease.

Yokoyama S, Perera PY, Waldmann TA, Hiroi T, Perera LP.

J Clin Immunol. 2013 Apr;33(3):586-94. doi: 10.1007/s10875-012-9849-y. Epub 2012 Dec 28.


Radar-enabled recovery of the Sutter's Mill meteorite, a carbonaceous chondrite regolith breccia.

Jenniskens P, Fries MD, Yin QZ, Zolensky M, Krot AN, Sandford SA, Sears D, Beauford R, Ebel DS, Friedrich JM, Nagashima K, Wimpenny J, Yamakawa A, Nishiizumi K, Hamajima Y, Caffee MW, Welten KC, Laubenstein M, Davis AM, Simon SB, Heck PR, Young ED, Kohl IE, Thiemens MH, Nunn MH, Mikouchi T, Hagiya K, Ohsumi K, Cahill TA, Lawton JA, Barnes D, Steele A, Rochette P, Verosub KL, Gattacceca J, Cooper G, Glavin DP, Burton AS, Dworkin JP, Elsila JE, Pizzarello S, Ogliore R, Schmitt-Kopplin P, Harir M, Hertkorn N, Verchovsky A, Grady M, Nagao K, Okazaki R, Takechi H, Hiroi T, Smith K, Silber EA, Brown PG, Albers J, Klotz D, Hankey M, Matson R, Fries JA, Walker RJ, Puchtel I, Lee CT, Erdman ME, Eppich GR, Roeske S, Gabelica Z, Lerche M, Nuevo M, Girten B, Worden SP; Sutter’s Mill Meteorite Consortium.

Science. 2012 Dec 21;338(6114):1583-7. doi: 10.1126/science.1227163.


Quadruplet pregnancy complicated by ovarian hyperstimulation syndrome with spontaneous ovulation.

Sugaya S, Hiroi T.

Clin Exp Obstet Gynecol. 2012;39(3):402-4.


Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury.

Hiroi T, Wajima T, Negoro T, Ishii M, Nakano Y, Kiuchi Y, Mori Y, Shimizu S.

Cardiovasc Res. 2013 Feb 1;97(2):271-81. doi: 10.1093/cvr/cvs332. Epub 2012 Nov 5.


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