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Items: 1 to 50 of 138

1.

Predicting the future direction of cell movement with convolutional neural networks.

Nishimoto S, Tokuoka Y, Yamada TG, Hiroi NF, Funahashi A.

PLoS One. 2019 Sep 4;14(9):e0221245. doi: 10.1371/journal.pone.0221245. eCollection 2019.

2.

Neurobiological perspective of 22q11.2 deletion syndrome.

Zinkstok JR, Boot E, Bassett AS, Hiroi N, Butcher NJ, Vingerhoets C, Vorstman JAS, van Amelsvoort TAMJ.

Lancet Psychiatry. 2019 Nov;6(11):951-960. doi: 10.1016/S2215-0366(19)30076-8. Epub 2019 Aug 5. Review.

PMID:
31395526
3.

Modeling and Predicting Developmental Trajectories of Neuropsychiatric Dimensions Associated With Copy Number Variations.

Hiroi N, Yamauchi T.

Int J Neuropsychopharmacol. 2019 Aug 1;22(8):488-500. doi: 10.1093/ijnp/pyz026.

4.

Activation of cell migration via morphological changes in focal adhesions depends on shear stress in MYCN-amplified neuroblastoma cells.

Hiraiwa T, Yamada TG, Miki N, Funahashi A, Hiroi N.

J R Soc Interface. 2019 Mar 29;16(152):20180934. doi: 10.1098/rsif.2018.0934.

5.

Inhibitory effects of methimazole and propylthiouracil on iodotyrosine deiodinase 1 in thyrocytes.

Yoshihara A, Luo Y, Ishido Y, Usukura K, Oda K, Sue M, Kawashima A, Hiroi N, Suzuki K.

Endocr J. 2019 Apr 25;66(4):349-357. doi: 10.1507/endocrj.EJ18-0380. Epub 2019 Feb 27.

6.

Transcriptome analysis of the anhydrobiotic cell line Pv11 infers the mechanism of desiccation tolerance and recovery.

Yamada TG, Suetsugu Y, Deviatiiarov R, Gusev O, Cornette R, Nesmelov A, Hiroi N, Kikawada T, Funahashi A.

Sci Rep. 2018 Dec 18;8(1):17941. doi: 10.1038/s41598-018-36124-6.

7.

Quantitative analysis of sensitivity to a Wnt3a gradient in determination of the pole-to-pole axis of mitotic cells by using a microfluidic device.

Hiraiwa T, Nakai Y, Yamada TG, Tanimoto R, Kimura H, Matsumoto Y, Miki N, Hiroi N, Funahashi A.

FEBS Open Bio. 2018 Nov 9;8(12):1920-1935. doi: 10.1002/2211-5463.12525. eCollection 2018 Dec.

8.

Computational Analysis of Neonatal Mouse Ultrasonic Vocalization.

Ó Broin P, Beckert MV, Takahashi T, Izumi T, Ye K, Kang G, Pouso P, Topolski M, Pena JL, Hiroi N.

Curr Protoc Mouse Biol. 2018 Jun;8(2):e46. doi: 10.1002/cpmo.46. Epub 2018 May 21.

9.

Critical reappraisal of mechanistic links of copy number variants to dimensional constructs of neuropsychiatric disorders in mouse models.

Hiroi N.

Psychiatry Clin Neurosci. 2018 May;72(5):301-321. doi: 10.1111/pcn.12641. Epub 2018 Mar 1. Review.

10.

Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis.

Boku S, Izumi T, Abe S, Takahashi T, Nishi A, Nomaru H, Naka Y, Kang G, Nagashima M, Hishimoto A, Enomoto S, Duran-Torres G, Tanigaki K, Zhang J, Ye K, Kato S, Männistö PT, Kobayashi K, Hiroi N.

Mol Psychiatry. 2018 Apr;23(4):985-992. doi: 10.1038/mp.2017.158. Epub 2017 Aug 22.

11.

Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice.

Solís O, García-Montes JR, Garcia-Sanz P, Herranz AS, Asensio MJ, Kang G, Hiroi N, Moratalla R.

Neurobiol Dis. 2017 Jun;102:133-139. doi: 10.1016/j.nbd.2017.03.006. Epub 2017 Mar 16.

12.

Cry, baby, cry: Expression of Distress as a Biomarker and Modulator in Autism Spectrum Disorder.

Esposito G, Hiroi N, Scattoni ML.

Int J Neuropsychopharmacol. 2017 Feb 15. doi: 10.1093/ijnp/pyx014. [Epub ahead of print] No abstract available.

13.

Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.

Oda K, Luo Y, Yoshihara A, Ishido Y, Sekihata K, Usukura K, Sue M, Hiroi N, Hirose T, Suzuki K.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):541-546. doi: 10.1016/j.bbrc.2016.12.109. Epub 2016 Dec 18.

PMID:
27998776
14.

A Self-Generated Environmental Factor as a Potential Contributor to Atypical Early Social Communication in Autism.

Kikusui T, Hiroi N.

Neuropsychopharmacology. 2017 Jan;42(1):378. doi: 10.1038/npp.2016.225. No abstract available.

15.

A Novel Role for Flotillin-Containing Lipid Rafts in Negative-Feedback Regulation of Thyroid-Specific Gene Expression by Thyroglobulin.

Luo Y, Akama T, Okayama A, Yoshihara A, Sue M, Oda K, Hayashi M, Ishido Y, Hirano H, Hiroi N, Katoh R, Suzuki K.

Thyroid. 2016 Nov;26(11):1630-1639.

PMID:
27676653
16.

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK.

Biol Psychiatry. 2016 Jul 15;80(2):84-86. doi: 10.1016/j.biopsych.2016.05.004. No abstract available.

17.

Editorial: Quantitative Biology: Dynamics of Living Systems.

Hiroi N, Draviam VM, Funahashi A.

Front Physiol. 2016 Jun 2;7:196. doi: 10.3389/fphys.2016.00196. eCollection 2016. No abstract available.

18.

Detection of Temperature Difference in Neuronal Cells.

Tanimoto R, Hiraiwa T, Nakai Y, Shindo Y, Oka K, Hiroi N, Funahashi A.

Sci Rep. 2016 Mar 1;6:22071. doi: 10.1038/srep22071.

19.

Simulation technology and its application in Systems Biology.

Funahashi A, Hiroi N.

Nihon Yakurigaku Zasshi. 2016 Feb;147(2):101-6. doi: 10.1254/fpj.147.101. Review. Japanese. No abstract available.

PMID:
26860650
20.

Structure and function of neonatal social communication in a genetic mouse model of autism.

Takahashi T, Okabe S, Broin PÓ, Nishi A, Ye K, Beckert MV, Izumi T, Machida A, Kang G, Abe S, Pena JL, Golden A, Kikusui T, Hiroi N.

Mol Psychiatry. 2016 Sep;21(9):1208-14. doi: 10.1038/mp.2015.190. Epub 2015 Dec 15.

21.

Molecular Histochemistry Identifies Peptidomic Organization and Reorganization Along Striatal Projection Units.

Hishimoto A, Nomaru H, Ye K, Nishi A, Lim J, Aguilan JT, Nieves E, Kang G, Angeletti RH, Hiroi N.

Biol Psychiatry. 2016 Mar 1;79(5):415-420. doi: 10.1016/j.biopsych.2015.09.012. Epub 2015 Sep 28.

22.

Acceleration of discrete stochastic biochemical simulation using GPGPU.

Sumiyoshi K, Hirata K, Hiroi N, Funahashi A.

Front Physiol. 2015 Feb 13;6:42. doi: 10.3389/fphys.2015.00042. eCollection 2015.

23.

High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexes.

Nakai Y, Ozeki M, Hiraiwa T, Tanimoto R, Funahashi A, Hiroi N, Taniguchi A, Nonaka S, Boilot V, Shrestha R, Clark J, Tamura N, Draviam VM, Oku H.

Rev Sci Instrum. 2015 Jan;86(1):013707. doi: 10.1063/1.4905330.

PMID:
25638090
24.

A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset.

Tamura N, Simon JE, Nayak A, Shenoy R, Hiroi N, Boilot V, Funahashi A, Draviam VM.

Biol Open. 2015 Jan 16;4(2):155-69. doi: 10.1242/bio.201410413.

25.

Rapid preparation of high-purity nuclear proteins from a small number of cultured cells for use in electrophoretic mobility shift assays.

Luo Y, Hara T, Ishido Y, Yoshihara A, Oda K, Makino M, Ishii N, Hiroi N, Suzuki K.

BMC Immunol. 2014 Dec 20;15:586. doi: 10.1186/s12865-014-0062-z.

26.

Neonatal maternal separation alters the capacity of adult neural precursor cells to differentiate into neurons via methylation of retinoic acid receptor gene promoter.

Boku S, Toda H, Nakagawa S, Kato A, Inoue T, Koyama T, Hiroi N, Kusumi I.

Biol Psychiatry. 2015 Feb 15;77(4):335-44. doi: 10.1016/j.biopsych.2014.07.008. Epub 2014 Jul 15.

27.

Iodine excess as an environmental risk factor for autoimmune thyroid disease.

Luo Y, Kawashima A, Ishido Y, Yoshihara A, Oda K, Hiroi N, Ito T, Ishii N, Suzuki K.

Int J Mol Sci. 2014 Jul 21;15(7):12895-912. doi: 10.3390/ijms150712895. Review.

28.

Small cracks in the dam: rare genetic variants provide opportunities to delve into mechanisms of neuropsychiatric disorders.

Hiroi N.

Biol Psychiatry. 2014 Jul 15;76(2):91-2. doi: 10.1016/j.biopsych.2014.05.002. No abstract available.

29.

Assessing uncertainty in model parameters based on sparse and noisy experimental data.

Hiroi N, Swat M, Funahashi A.

Front Physiol. 2014 Apr 4;5:128. doi: 10.3389/fphys.2014.00128. eCollection 2014.

30.

In vivo oriented modeling with consideration of intracellular crowding.

Hiroi N, Iba K, Tabira A, Okuhara T, Kubojima T, Hiraiwa T, Kobayashi TJ, Oka K, Funahashi A.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:2716-9. doi: 10.1109/EMBC.2013.6610101.

PMID:
24110288
31.

Copy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders.

Hiroi N, Takahashi T, Hishimoto A, Izumi T, Boku S, Hiramoto T.

Mol Psychiatry. 2013 Nov;18(11):1153-65. doi: 10.1038/mp.2013.92. Epub 2013 Aug 6. Review.

32.

Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance.

Corrigan AM, Shrestha RL, Zulkipli I, Hiroi N, Liu Y, Tamura N, Yang B, Patel J, Funahashi A, Donald A, Draviam VM.

Cell Cycle. 2013 Aug 15;12(16):2643-55. doi: 10.4161/cc.25671. Epub 2013 Jul 16.

33.

The systems biology simulation core algorithm.

Keller R, Dörr A, Tabira A, Funahashi A, Ziller MJ, Adams R, Rodriguez N, Le Novère N, Hiroi N, Planatscher H, Zell A, Dräger A.

BMC Syst Biol. 2013 Jul 5;7:55. doi: 10.1186/1752-0509-7-55.

34.

LibSBMLSim: a reference implementation of fully functional SBML simulator.

Takizawa H, Nakamura K, Tabira A, Chikahara Y, Matsui T, Hiroi N, Funahashi A.

Bioinformatics. 2013 Jun 1;29(11):1474-6. doi: 10.1093/bioinformatics/btt157. Epub 2013 Apr 5.

35.

A case of severe acute necrotizing pancreatitis after administration of sitagliptin.

Sue M, Yoshihara A, Kuboki K, Hiroi N, Yoshino G.

Clin Med Insights Case Rep. 2013;6:23-7. doi: 10.4137/CCRep.S10856. Epub 2013 Feb 13.

36.

Meeting report of the International Workshop on Quantitative Biology 2012: mesoscopic and microscopic worlds meet.

Draviam VM, Funahashi A, Hiroi N, Kimura A, Kobayashi TJ.

Front Physiol. 2013 Jan 11;3:479. doi: 10.3389/fphys.2012.00479. eCollection 2012. No abstract available.

37.

Mathematical modeling of sustainable synaptogenesis by repetitive stimuli suggests signaling mechanisms in vivo.

Takizawa H, Hiroi N, Funahashi A.

PLoS One. 2012;7(12):e51000. doi: 10.1371/journal.pone.0051000. Epub 2012 Dec 20.

38.

Physiological Intracellular Crowdedness is Defined by the Perimeter-to-Area Ratio of Sub-Cellular Compartments.

Hiroi N, Okuhara T, Kubojima T, Iba K, Tabira A, Yamashita S, Okada Y, Kobayashi TJ, Funahashi A.

Front Physiol. 2012 Jul 23;3:293. doi: 10.3389/fphys.2012.00293. eCollection 2012.

39.

Regulation of dual oxidase expression and H2O2 production by thyroglobulin.

Yoshihara A, Hara T, Kawashima A, Akama T, Tanigawa K, Wu H, Sue M, Ishido Y, Hiroi N, Ishii N, Yoshino G, Suzuki K.

Thyroid. 2012 Oct;22(10):1054-62. doi: 10.1089/thy.2012.0003. Epub 2012 Aug 8.

40.

Propylthiouracil increases sodium/iodide symporter gene expression and iodide uptake in rat thyroid cells in the absence of TSH.

Sue M, Akama T, Kawashima A, Nakamura H, Hara T, Tanigawa K, Wu H, Yoshihara A, Ishido Y, Hiroi N, Yoshino G, Kohn LD, Ishii N, Suzuki K.

Thyroid. 2012 Aug;22(8):844-52. doi: 10.1089/thy.2011.0290.

41.

Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain.

Harper KM, Hiramoto T, Tanigaki K, Kang G, Suzuki G, Trimble W, Hiroi N.

Hum Mol Genet. 2012 Aug 1;21(15):3489-99. doi: 10.1093/hmg/dds180. Epub 2012 May 15.

42.

Localization of septin proteins in the mouse cochlea.

Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G, Trimble WS, Tanigaki K, Nakagawa T, Ito J.

Hear Res. 2012 Jul;289(1-2):40-51. doi: 10.1016/j.heares.2012.04.015. Epub 2012 Apr 30.

43.

Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning.

Lapidus KA, Nwokafor C, Scott D, Baroni TE, Tenenbaum SA, Hiroi N, Singer RH, Czaplinski K.

Learn Mem. 2012 Jan 12;19(2):35-42. doi: 10.1101/lm.024471.111. Print 2012 Feb.

44.

Mouse Models of 22q11.2-Associated Autism Spectrum Disorder.

Hiroi N, Hiramoto T, Harper KM, Suzuki G, Boku S.

Autism Open Access. 2012;Suppl 1:001.

45.

Physiological environment induces quick response - slow exhaustion reactions.

Hiroi N, Lu J, Iba K, Tabira A, Yamashita S, Okada Y, Flamm C, Oka K, Köhler G, Funahashi A.

Front Physiol. 2011 Sep 21;2:50. doi: 10.3389/fphys.2011.00050. eCollection 2011.

46.

Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model.

Hiramoto T, Kang G, Suzuki G, Satoh Y, Kucherlapati R, Watanabe Y, Hiroi N.

Hum Mol Genet. 2011 Dec 15;20(24):4775-85. doi: 10.1093/hmg/ddr404. Epub 2011 Sep 9.

47.

First case report of acquired pure red cell aplasia associated with micafungin.

Yoshida-Hiroi M, Koizumi M, Oka R, Mitsuda A, Hiroi N.

Intern Med. 2011;50(9):1051-4. Epub 2011 May 1.

48.

Thyroid storm associated with Graves' disease covered by diabetic ketoacidosis: A case report.

Osada E, Hiroi N, Sue M, Masai N, Iga R, Shigemitsu R, Oka R, Miyagi M, Iso K, Kuboki K, Yoshino G.

Thyroid Res. 2011 Apr 14;4(1):8. doi: 10.1186/1756-6614-4-8.

49.

Deconstructing craving: dissociable cortical control of cue reactivity in nicotine addiction.

Scott D, Hiroi N.

Biol Psychiatry. 2011 Jun 1;69(11):1052-9. doi: 10.1016/j.biopsych.2011.01.023. Epub 2011 Mar 23.

50.

Malignant adrenal rest tumor of the retroperitoneum producing adrenocortical steroids.

Akishima-Fukasawa Y, Yoshihara A, Ishikawa Y, Watanabe N, Hiroi N, Akasaka Y, Sasano H, Ishii T, Yoshino G.

Endocr Pathol. 2011 Jun;22(2):112-7. doi: 10.1007/s12022-011-9152-0.

PMID:
21374072

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