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Items: 14

1.

Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout.

Tatani K, Hiratochi M, Kikuchi N, Kuramochi Y, Watanabe S, Yamauchi Y, Itoh F, Isaji M, Shuto S.

J Med Chem. 2016 Apr 28;59(8):3719-31. doi: 10.1021/acs.jmedchem.5b01884. Epub 2016 Apr 11.

PMID:
27007871
2.

Duration of drug action of dopamine D2 agonists in mice with 6-hydroxydopamine-induced lesions.

Tsuchioka A, Oana F, Suzuki T, Yamauchi Y, Ijiro T, Kaidoh K, Hiratochi M.

Neuroreport. 2015 Dec 16;26(18):1126-32. doi: 10.1097/WNR.0000000000000484.

PMID:
26559726
3.

Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors.

Tatani K, Hiratochi M, Nonaka Y, Isaji M, Shuto S.

ACS Med Chem Lett. 2015 Jan 28;6(3):244-8. doi: 10.1021/ml500343r. eCollection 2015 Mar 12.

4.

Function and expression differences between ergot and non-ergot dopamine D2 agonists on heart valve interstitial cells.

Oana F, Onozuka H, Tsuchioka A, Suzuki T, Tanaka N, Kaidoh K, Hoyano Y, Hiratochi M, Kikuchi S, Takehana Y, Shibata N.

J Heart Valve Dis. 2014 Mar;23(2):246-52.

PMID:
25076559
5.

Hypouricemic effects of novel concentrative nucleoside transporter 2 inhibitors through suppressing intestinal absorption of purine nucleosides.

Hiratochi M, Tatani K, Shimizu K, Kuramochi Y, Kikuchi N, Kamada N, Itoh F, Isaji M.

Eur J Pharmacol. 2012 Sep 5;690(1-3):183-91. doi: 10.1016/j.ejphar.2012.06.015. Epub 2012 Jun 16.

PMID:
22709993
7.

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis.

Nakayama K, Ohkawara T, Hiratochi M, Koh CS, Nagase H.

Neurosci Lett. 2008 Oct 24;444(2):127-31. doi: 10.1016/j.neulet.2008.08.034. Epub 2008 Aug 15.

PMID:
18722509
8.

The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway.

Hiratochi M, Nagase H, Kuramochi Y, Koh CS, Ohkawara T, Nakayama K.

Nucleic Acids Res. 2007;35(3):912-22. Epub 2007 Jan 23.

9.

Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level.

Katsuno K, Fujimori Y, Takemura Y, Hiratochi M, Itoh F, Komatsu Y, Fujikura H, Isaji M.

J Pharmacol Exp Ther. 2007 Jan;320(1):323-30. Epub 2006 Oct 18.

PMID:
17050778
10.

SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.

Tazawa S, Yamato T, Fujikura H, Hiratochi M, Itoh F, Tomae M, Takemura Y, Maruyama H, Sugiyama T, Wakamatsu A, Isogai T, Isaji M.

Life Sci. 2005 Jan 14;76(9):1039-50. Erratum in: Life Sci. 2010 Oct 9;87(15-16):514.

PMID:
15607332
11.

Multiple POU-binding motifs, recognized by tissue-specific nuclear factors, are important for Dll1 gene expression in neural stem cells.

Nakayama K, Nagase K, Tokutake Y, Koh CS, Hiratochi M, Ohkawara T, Nakayama N.

Biochem Biophys Res Commun. 2004 Dec 17;325(3):991-6.

PMID:
15541387
12.

Participation of thromboxane A(2) in the cough response in guinea-pigs: antitussive effect of ozagrel.

Shinagawa K, Kojima M, Ichikawa K, Hiratochi M, Aoyagi S, Akahane M.

Br J Pharmacol. 2000 Sep;131(2):266-70.

13.
14.

Morphogenic activity of fibroblast growth factor-2 on primary neural precursor cells in three-dimensional culture.

Hiratochi M, Fujiwara A, Kitani H, Iguchi T, Sakakura T, Tomooka Y.

Dev Growth Differ. 1998 Feb;40(1):59-65.

PMID:
9563911

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