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Items: 1 to 50 of 154

1.

TREML4 mRNA Expression and Polymorphisms in Blood Leukocytes are Associated with Atherosclerotic Lesion Extension in Coronary Artery Disease.

Duarte VHR, Miranda CTOF, Cruz MS, de Araújo JNG, Duarte MKRN, Santos AMQSD, Santos ICCD, Santos JCD, da Silva AMG, de Oliveira JM, Paiva MSMO, de Oliveira Galvão MF, Rezende AA, Hirata MH, Hirata RDC, Luchessi AD, Silbiger VN.

Sci Rep. 2019 May 10;9(1):7229. doi: 10.1038/s41598-019-43745-y.

2.

Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease.

Miranda CTOF, Duarte VHR, Cruz MSM, Duarte MKRN, de Araújo JNG, Dos Santos AMQS, de Oliveira JM, Paiva MSMO, Rezende AA, Hirata MH, Hirata RDC, Ribeiro KDDS, Luchessi AD, Silbiger VN.

J Nutr Metab. 2018 Dec 11;2018:6104169. doi: 10.1155/2018/6104169. eCollection 2018.

3.

Polymorphisms in mTOR and Calcineurin Signaling Pathways Are Associated With Long-Term Clinical Outcomes in Kidney Transplant Recipients.

Campos-Salazar AB, Genvigir FDV, Felipe CR, Tedesco-Silva H, Medina-Pestana J, Monteiro GV, Basso RG, Cerda A, Hirata MH, Hirata RDC.

Front Pharmacol. 2018 Nov 14;9:1296. doi: 10.3389/fphar.2018.01296. eCollection 2018.

4.

The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus.

Souza KSC, Ururahy MAG, Oliveira YMDC, Loureiro MB, Silva HPVD, Bortolin RH, Luchessi AD, Arrais RF, Hirata RDC, Almeida MDG, Hirata MH, Rezende AA.

Arch Endocrinol Metab. 2018 Aug;62(4):480-484. doi: 10.20945/2359-3997000000057.

5.

Relationship between circulating VCAM-1, ICAM-1, E-selectin and MMP9 and the extent of coronary lesions.

Santos JCD, Cruz MS, Bortolin RH, Oliveira KM, Araújo JNG, Duarte VHR, Silva AMGD, Santos ICCD, Dantas JMO, Paiva MSMO, Rezende AA, Hirata MH, Hirata RDC, Luchessi AD, Silbiger VN.

Clinics (Sao Paulo). 2018;73:e203. doi: 10.6061/clinics/2018/e203. Epub 2018 May 28.

6.

Transport of cowpea bean derived peptides and their modulator effects on mRNA expression of cholesterol-related genes in Caco-2 and HepG2 cells.

Marques MR, Cerda A, Fontanari GG, Pimenta DC, Soares-Freitas RM, Hirata MH, Hirata RDC, Arêas JAG.

Food Res Int. 2018 May;107:165-171. doi: 10.1016/j.foodres.2018.01.031. Epub 2018 Jan 31.

PMID:
29580474
7.

Statins differentially modulate microRNAs expression in peripheral cells of hyperlipidemic subjects: A pilot study.

Zambrano T, Hirata RDC, Hirata MH, Cerda Á, Salazar LA.

Eur J Pharm Sci. 2018 May 30;117:55-61. doi: 10.1016/j.ejps.2018.02.007. Epub 2018 Feb 7.

PMID:
29427701
8.

Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells.

de Freitas RCC, Bortolin RH, Lopes MB, Tamborlin L, Meneguello L, Silbiger VN, Hirata RDC, Hirata MH, Luchessi AD, Luchessi AD.

Front Pharmacol. 2017 Dec 12;8:906. doi: 10.3389/fphar.2017.00906. eCollection 2017.

9.

Application of aqueous two-phase micellar system to improve extraction of adenoviral particles from cell lysate.

Molino JVD, Lopes AM, Viana Marques DA, Mazzola PG, da Silva JL, Hirata MH, Hirata RDC, Gatti MSV, Pessoa A.

Biotechnol Appl Biochem. 2018 May;65(3):381-389. doi: 10.1002/bab.1627. Epub 2017 Dec 22.

PMID:
29205941
10.

Polymorphisms in Genes Involved in the Leptin-Melanocortin Pathway are Associated with Obesity-Related Cardiometabolic Alterations in a Southern Chilean Population.

Manriquez V, Aviles J, Salazar L, Saavedra N, Seron P, Lanas F, Fajardo CM, Hirata MH, Hirata RDC, Cerda A.

Mol Diagn Ther. 2018 Feb;22(1):101-113. doi: 10.1007/s40291-017-0306-8.

PMID:
28975585
11.

Effects of short-term add-on ezetimibe to statin treatment on expression of adipokines and inflammatory markers in diabetic and dyslipidemic patients.

Guimarães ES, Cerda A, Dorea EL, Bernik MMS, Gusukuma MC, Pinto GA, Fajardo CM, Hirata MH, Hirata RDC.

Cardiovasc Ther. 2017 Dec;35(6). doi: 10.1111/1755-5922.12307. Epub 2017 Oct 4.

PMID:
28940978
12.

Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients.

Tamashiro EY, Felipe CR, Genvigir FDV, Rodrigues AC, Campos AB, Hirata RDC, Tedesco-Silva H, Medina-Pestana JO.

Drug Metab Pers Ther. 2017 May 24;32(2):89-95. doi: 10.1515/dmpt-2016-0036.

PMID:
28593920
13.

Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats.

Ferreira ECS, Bortolin RH, Freire-Neto FP, Souza KSC, Bezerra JF, Ururahy MAG, Ramos AMO, Himelfarb ST, Abreu BJ, Didone TVN, Pedrosa LFC, Medeiros AC, Doi SQ, Brandão-Neto J, Hirata RDC, Rezende LA, Almeida MG, Hirata MH, Rezende AA.

Nutr Res. 2017 Apr;40:48-56. doi: 10.1016/j.nutres.2017.03.004. Epub 2017 Mar 14.

PMID:
28473060
14.

Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients.

Salgado PC, Genvigir FD, Felipe CR, Tedesco-Silva H Jr, Medina-Pestana JO, Doi SQ, Hirata MH, Hirata RD.

Pharmgenomics Pers Med. 2017 Mar 31;10:101-106. doi: 10.2147/PGPM.S131390. eCollection 2017.

15.

Effects of clopidogrel on inflammatory cytokines and adhesion molecules in human endothelial cells: Role of nitric oxide mediating pleiotropic effects.

Cerda A, Pavez M, Manriquez V, Luchessi AD, Leal P, Benavente F, Fajardo CM, Salazar L, Hirata MH, Hirata RDC.

Cardiovasc Ther. 2017 Aug;35(4). doi: 10.1111/1755-5922.12261.

PMID:
28371087
16.

Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients.

Genvigir FDV, Nishikawa AM, Felipe CR, Tedesco-Silva H Jr, Oliveira N, Salazar ABC, Medina-Pestana JO, Doi SQ, Hirata MH, Hirata RDC.

Pharmacotherapy. 2017 May;37(5):535-545. doi: 10.1002/phar.1928. Epub 2017 May 9.

PMID:
28316087
17.

ABCC3 Polymorphisms and mRNA Expression Influence the Concentration of a Carboxylic Acid Metabolite in Patients on Clopidogrel and Aspirin Therapy.

Luchessi AD, Concheiro M, Germano JF, Silbiger VN, Bortolin RH, Cruz A, Quintela O, Brion M, Carracedo A, Iñiguez A, Bravo M, López-Rivadulla M, Hirata RD, Sousa AG, Hirata MH.

Basic Clin Pharmacol Toxicol. 2017 May;120(5):466-474. doi: 10.1111/bcpt.12703. Epub 2017 Jan 16.

18.

The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion.

Duarte MK, de Araújo JN, Duarte VH, de Oliveira KM, de Oliveira JM, Carioca AA, Bortolin RH, Rezende AA, Hirata MH, Hirata RD, Waitzberg DL, Lima SC, Luchessi AD, Silbiger VN.

Lipids Health Dis. 2016 Sep 1;15:144. doi: 10.1186/s12944-016-0312-6.

19.

Atorvastatin attenuation of ABCB1 expression is mediated by microRNA miR-491-3p in Caco-2 cells.

Rodrigues AC, Neri EA, Veríssimo-Filho S, Rebouças NA, Hirata RD, Yu AM.

Eur J Pharm Sci. 2016 Oct 10;93:431-6. doi: 10.1016/j.ejps.2016.08.044. Epub 2016 Aug 26.

20.

Integrated analysis of miRNA and mRNA gene expression microarrays: Influence on platelet reactivity, clopidogrel response and drug-induced toxicity.

Freitas RCC, Bortolin RH, Lopes MB, Hirata MH, Hirata RDC, Silbiger VN, Luchessi AD.

Gene. 2016 Nov 15;593(1):172-178. doi: 10.1016/j.gene.2016.08.028. Epub 2016 Aug 16.

PMID:
27543010
21.

Influence of the CYP3A4/5 genetic score and ABCB1 polymorphisms on tacrolimus exposure and renal function in Brazilian kidney transplant patients.

Genvigir FD, Salgado PC, Felipe CR, Luo EY, Alves C, Cerda A, Tedesco-Silva H Jr, Medina-Pestana JO, Oliveira N, Rodrigues AC, Doi SQ, Hirata MH, Hirata RD.

Pharmacogenet Genomics. 2016 Oct;26(10):462-72. doi: 10.1097/FPC.0000000000000237.

PMID:
27434656
22.

Low bone mineral density in patients with type 1 diabetes: association with reduced expression of IGF1, IGF1R and TGF B 1 in peripheral blood mononuclear cells.

de Souza KS, Ururahy MA, da Costa Oliveira YM, Loureiro MB, da Silva HP, Bortolin RH, Melo Dos Santos F, Luchessi AD, Neto JJ, Arrais RF, Hirata RD, das Graças Almeida M, Hirata MH, de Rezende AA.

Diabetes Metab Res Rev. 2016 Sep;32(6):589-95. doi: 10.1002/dmrr.2772. Epub 2016 Jan 26.

PMID:
26663878
23.

Altered microRNome Profiling in Statin-Induced HepG2 Cells: A Pilot Study Identifying Potential new Biomarkers Involved in Lipid-Lowering Treatment.

Zambrano T, Hirata RDC, Hirata MH, Cerda Á, Salazar LA.

Cardiovasc Drugs Ther. 2015 Dec;29(6):509-518. doi: 10.1007/s10557-015-6627-0.

PMID:
26602562
24.

The association between the HLA-G 14-bp insertion/deletion polymorphism and type 1 diabetes.

Silva HP, Ururahy MA, Souza KS, Loureiro MB, Oliveira YM, Oliveira GH, Luchessi AD, Carvalho KT, Freitas JC, Donadi EA, Hirata RD, Almeida MG, Arrais RF, Hirata MH, Rezende AA.

Genes Immun. 2016 Jan-Feb;17(1):13-8. doi: 10.1038/gene.2015.45. Epub 2015 Oct 22.

PMID:
26492519
25.

Impact of 3'UTR genetic variants in PCSK9 and LDLR genes on plasma lipid traits and response to atorvastatin in Brazilian subjects: a pilot study.

Zambrano T, Hirata MH, Cerda Á, Dorea EL, Pinto GA, Gusukuma MC, Bertolami MC, Salazar LA, Hirata RD.

Int J Clin Exp Med. 2015 Apr 15;8(4):5978-88. eCollection 2015.

26.

Modulation of adhesion molecules by cholesterol-lowering therapy in mononuclear cells from hypercholesterolemic patients.

Cerda A, Rodrigues AC, Alves C, Genvigir FD, Fajardo CM, Dorea EL, Gusukuma MC, Pinto GA, Hirata MH, Hirata RD.

Cardiovasc Ther. 2015 Aug;33(4):168-76. doi: 10.1111/1755-5922.12126.

PMID:
25903419
27.

ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction.

de Oliveira R, Moraes TI, Cerda A, Hirata MH, Fajardo CM, Sousa MC, Dorea EL, Bernik MM, Hirata RD.

Diabetol Metab Syndr. 2015 Apr 11;7:34. doi: 10.1186/s13098-015-0027-2. eCollection 2015.

28.

Influence of cardiorespiratory fitness on PPARG mRNA expression using monozygotic twin case control.

Queiroga MR, Barbieri RA, Ferreira SA, Luchessi AD, Hirata RD, Hirata MH, Kokubun E.

J Diabetes Res. 2015;2015:538732. doi: 10.1155/2015/538732. Epub 2015 Mar 24.

29.

Antimicrobial photodynamic effect to treat residual pockets in periodontal patients: a randomized controlled clinical trial.

Carvalho VF, Andrade PV, Rodrigues MF, Hirata MH, Hirata RD, Pannuti CM, De Micheli G, Conde MC.

J Clin Periodontol. 2015 May;42(5):440-7. doi: 10.1111/jcpe.12393. Epub 2015 Apr 22.

PMID:
25808980
30.

Role of microRNAs 221/222 on statin induced nitric oxide release in human endothelial cells.

Cerda A, Fajardo CM, Basso RG, Hirata MH, Hirata RD.

Arq Bras Cardiol. 2015 Mar;104(3):195-201. doi: 10.5935/abc.20140192. Epub 2014 Dec 16. English, Portuguese.

31.

Multiplex-PCR for differentiation of Mycobacterium bovis from Mycobacterium tuberculosis complex.

Spositto FL, Campanerut PA, Ghiraldi LD, Leite CQ, Hirata MH, Hirata RD, Siqueira VL, Cardoso RF.

Braz J Microbiol. 2014 Oct 9;45(3):841-3. eCollection 2014.

32.

Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio.

Ururahy MA, de Souza KS, Oliveira YM, Loureiro MB, da Silva HP, Freire-Neto FP, Bezerra JF, Luchessi AD, Doi SQ, Hirata RD, Almeida Md, Arrais RF, Hirata MH, de Rezende AA.

Diabetes Metab Res Rev. 2015 Jul;31(5):500-6. doi: 10.1002/dmrr.2621. Epub 2014 Dec 8.

PMID:
25384728
33.

Association between Pro12Ala, Pvull, Avall, Sstl and ADIPOQ single-nucleotide polymorphisms with lipid and glycemic profiles of patients with Berardinelli-Seip syndrome.

Baracho MF, Nunes AB, Hirata MH, Hirata RD, Fajardo CM, Santos MG, Wajchenberg BL, De Marco LA, Brandão-Neto J.

Ann Nutr Metab. 2014;65(4):272-9. doi: 10.1159/000366026. Epub 2014 Oct 31.

PMID:
25376908
34.

Chlamydophila pneumonia and increased TLR4 gene expression in leukocytes are associated with acute myocardial infarction.

Lima-Neto LG, Hirata RD, Luchessi AD, Silbiger VN, Cavichioli D, Dos Santos ES, Sousa AG, Sprovieri SR, De Sousa Junior EB, Dos Santos FC, Colombo S, Hirata MH.

J Biol Regul Homeost Agents. 2014 Jul-Sep;28(3):449-60.

PMID:
25316132
35.

Occurrence of Mycobacterium bovis and non-tuberculous mycobacteria (NTM) in raw and pasteurized milk in the northwestern region of Paraná, Brazil.

Sgarioni SA, Hirata RD, Hirata MH, Leite CQ, de Prince KA, de Andrade Leite SR, Filho DV, Siqueira VL, Caleffi-Ferracioli KR, Cardoso RF.

Braz J Microbiol. 2014 Aug 29;45(2):707-11. eCollection 2014.

36.

Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development.

Bezerra JF, Oliveira GH, Soares CD, Cardoso ML, Ururahy MA, Neto FP, Lima-Neto LG, Luchessi AD, Silbiger VN, Fajardo CM, Oliveira SR, Almeida Md, Hirata RD, Rezende AA, Hirata MH.

Oral Dis. 2015 Apr;21(3):393-9. doi: 10.1111/odi.12292. Epub 2014 Oct 8.

PMID:
25219684
37.

Relationship between SLCO1B3 and ABCA3 polymorphisms and imatinib response in chronic myeloid leukemia patients.

de Lima LT, Bueno CT, Vivona D, Hirata RD, Hirata MH, Hungria VT, Chiattone CS, Zanichelli MA, Chauffaille Mde L, Guerra-Shinohara EM.

Hematology. 2015 Apr;20(3):137-42. doi: 10.1179/1607845414Y.0000000181. Epub 2014 Jul 24.

PMID:
25056761
38.

Detection and quantification of periodontal pathogens in smokers and never-smokers with chronic periodontitis by real-time polymerase chain reaction.

Guglielmetti MR, Rosa EF, Lourenção DS, Inoue G, Gomes EF, De Micheli G, Mendes FM, Hirata RD, Hirata MH, Pannuti CM.

J Periodontol. 2014 Oct;85(10):1450-7. doi: 10.1902/jop.2014.140048. Epub 2014 May 2.

PMID:
24794687
39.

Influence of PCSK9 polymorphisms on plasma lipids and response to atorvastatin treatment in Brazilian subjects.

Anderson JM, Cerda A, Hirata MH, Rodrigues AC, Dorea EL, Bernik MM, Bertolami MC, Faludi AA, Hirata RD.

J Clin Lipidol. 2014 May-Jun;8(3):256-64. doi: 10.1016/j.jacl.2014.02.008. Epub 2014 Mar 5.

PMID:
24793346
40.

Pharmacogenetics of drug metabolizing enzymes in Brazilian populations.

Cerda A, Hirata MH, Hirata RD.

Drug Metabol Drug Interact. 2014;29(3):153-77. doi: 10.1515/dmdi-2013-0067. Review.

PMID:
24744305
41.

Low bone mineral density is associated to poor glycemic control and increased OPG expression in children and adolescents with type 1 diabetes.

Loureiro MB, Ururahy MA, Freire-Neto FP, Oliveira GH, Duarte VM, Luchessi AD, Brandão-Neto J, Hirata RD, Hirata MH, Maciel-Neto JJ, Arrais RF, Almeida MG, Rezende AA.

Diabetes Res Clin Pract. 2014 Mar;103(3):452-7. doi: 10.1016/j.diabres.2013.12.018. Epub 2014 Jan 17.

PMID:
24529565
42.

Reduced ABCG2 and increased SLC22A1 mRNA expression are associated with imatinib response in chronic myeloid leukemia.

de Lima LT, Vivona D, Bueno CT, Hirata RD, Hirata MH, Luchessi AD, de Castro FA, de Lourdes F Chauffaille M, Zanichelli MA, Chiattone CS, Hungria VT, Guerra-Shinohara EM.

Med Oncol. 2014 Mar;31(3):851. doi: 10.1007/s12032-014-0851-5. Epub 2014 Jan 29.

PMID:
24469953
43.

Leptin receptor gene polymorphisms are associated with adiposity and metabolic alterations in Brazilian individuals.

Oliveira Rd, Cerda A, Genvigir FD, Sampaio MF, Armaganijan D, Bernik MM, Dorea EL, Hirata MH, Hinuy HM, Hirata RD.

Arq Bras Endocrinol Metabol. 2013 Dec;57(9):677-84.

PMID:
24402012
44.

Pharmacogenetic markers for antihypertensive drug-related adverse reactions.

Cerda A, Hirata RD, Hirata MH.

Pharmacogenomics. 2013 Nov;14(15):1819-20. No abstract available.

PMID:
24386648
45.

Pharmacogenomics of antihypertensive drug response: new evidence of miRNA controlling blood pressure.

Cerda A, Hirata RD, Hirata MH.

Pharmacogenomics. 2013 Nov;14(15):1819. No abstract available.

PMID:
24386647
46.

Evaluation of hsp65 nested PCR-restriction analysis (PRA) for diagnosing tuberculosis in a high burden country.

Macente S, Fujimura Leite CQ, Santos AC, Siqueira VL, Machado LN, Marcondes NR, Hirata MH, Hirata RD, Cardoso RF.

Biomed Res Int. 2013;2013:391549. doi: 10.1155/2013/391549. Epub 2013 Oct 24.

47.

Genetic scoring to predict antihypertensive drug response using gene variants associated with hypertension.

Cerda A, Hirata RD, Hirata MH.

Pharmacogenomics. 2013 Nov;14(15):1817-18. doi: 10.2217/pgs.13.179. No abstract available.

PMID:
24236481
48.

Novel nonsynonymous variants associated with blood pressure control in response to antihypertensives and their impact on cardiovascular outcomes.

Cerda A, Hirata RD, Hirata MH.

Pharmacogenomics. 2013 Nov;14(15):1818-9. doi: 10.2217/pgs.13.208. No abstract available.

49.

Atorvastatin and hormone therapy influence expression of ABCA1, APOA1 and SCARB1 in mononuclear cells from hypercholesterolemic postmenopausal women.

Cerda A, Issa MH, Genvigir FD, Rohde CB, Cavalli SA, Bertolami MC, Faludi AA, Hirata MH, Hirata RD.

J Steroid Biochem Mol Biol. 2013 Nov;138:403-9. doi: 10.1016/j.jsbmb.2013.08.017. Epub 2013 Sep 3.

PMID:
24007717
50.

Pharmacogenomics of anti-platelet therapy focused on peripheral blood cells of coronary arterial disease patients.

Luchessi AD, Silbiger VN, Hirata RD, Lima-Neto LG, Cavichioli D, Iñiguez A, Bravo M, Bastos G, Sousa AG, Brión M, Carracedo A, Hirata MH.

Clin Chim Acta. 2013 Oct 21;425:9-17. doi: 10.1016/j.cca.2013.06.021. Epub 2013 Jul 4.

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