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Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1.

Hasegawa T, Kikuta J, Sudo T, Matsuura Y, Matsui T, Simmons S, Ebina K, Hirao M, Okuzaki D, Yoshida Y, Hirao A, Kalinichenko VV, Yamaoka K, Takeuchi T, Ishii M.

Nat Immunol. 2019 Dec;20(12):1631-1643. doi: 10.1038/s41590-019-0526-7. Epub 2019 Nov 18.


Draft Genome Sequence of Novel Metschnikowia sp. Strain JCM 33374, a Nectar Yeast Isolated from a Bumblebee.

Hirao AS, Imai R, Endoh R, Ohkuma M, Degawa Y.

Microbiol Resour Announc. 2019 Sep 12;8(37). pii: e00704-19. doi: 10.1128/MRA.00704-19.


Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma.

Kitabayashi T, Dong Y, Furuta T, Sabit H, Jiapaer S, Zhang J, Zhang G, Hayashi Y, Kobayashi M, Domoto T, Minamoto T, Hirao A, Nakada M.

Sci Rep. 2019 Jul 11;9(1):10049. doi: 10.1038/s41598-019-46454-8.


Ecotypic divergences of the alpine herb Potentilla matsumurae adapted to fellfield-snowbed habitats across a series of mountain sky islands.

Hirao AS, Shimono Y, Narita K, Wada N, Kudo G.

Am J Bot. 2019 Jun;106(6):772-787. doi: 10.1002/ajb2.1290. Epub 2019 May 23.


Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.

Imanishi T, Unno M, Kobayashi W, Yoneda N, Matsuda S, Ikeda K, Hoshii T, Hirao A, Miyake K, Barber GN, Arita M, Ishii KJ, Akira S, Saito T.

Life Sci Alliance. 2019 Jan 25;2(1). pii: e201800282. doi: 10.26508/lsa.201800282. Print 2019 Feb.


[Regulation of hematopoietic stem cell homeostasis by Spred1].

Tadokoro Y, Hirao A.

Rinsho Ketsueki. 2018;59(11):2441-2448. doi: 10.11406/rinketsu.59.2441. Japanese.


Engineering movement into automotive seating: Does the driver feel more comfortable and refreshed?

Varela M, Gyi D, Mansfield N, Picton R, Hirao A, Furuya T.

Appl Ergon. 2019 Jan;74:214-220. doi: 10.1016/j.apergo.2018.08.024. Epub 2018 Sep 11.


The influence of various distractions prior to upper gastrointestinal endoscopy: a prospective randomized controlled study.

Sogabe M, Okahisa T, Adachi Y, Takehara M, Hamada S, Okazaki J, Fujino Y, Fukuya A, Kagemoto K, Hirao A, Okamoto K, Nakasono M, Takayama T.

BMC Gastroenterol. 2018 Aug 29;18(1):132. doi: 10.1186/s12876-018-0859-y.


Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.

Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.

Cancer Sci. 2018 Aug;109(8):2497-2508. doi: 10.1111/cas.13695. Epub 2018 Jul 26.


JLP-JNK signaling protects cancer cells from reactive oxygen species-induced cell death.

Li R, Gunarta IK, Suzuki R, Boldbaatar J, Nakazato R, Yuliana D, Davaakhuu G, Oyunsuren T, Takamatsu N, Kobayashi M, Hirao A, Yoshioka K.

Biochem Biophys Res Commun. 2018 Jun 27;501(3):724-730. doi: 10.1016/j.bbrc.2018.05.055.


Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A.

Cell Stem Cell. 2018 May 3;22(5):713-725.e8. doi: 10.1016/j.stem.2018.04.002. Epub 2018 Apr 26.


Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug.

Dong Y, Furuta T, Sabit H, Kitabayashi T, Jiapaer S, Kobayashi M, Ino Y, Todo T, Teng L, Hirao A, Zhao SG, Nakada M.

Oncotarget. 2017 Dec 4;8(67):111728-111741. doi: 10.18632/oncotarget.22904. eCollection 2017 Dec 19.


Histochemical properties of bovine and ovine mammary glands during fetal development.

Hara A, Abe T, Hirao A, Sanbe K, Ayakawa H, Sarantonglaga B, Yamaguchi M, Sato A, Khurchabilig A, Ogata K, Fukumori R, Sugita S, Nagao Y.

J Vet Med Sci. 2018 Feb 20;80(2):263-271. doi: 10.1292/jvms.17-0584. Epub 2017 Dec 15.


Survival times with and without tube feeding in patients with dementia or psychiatric diseases in Japan.

Takayama K, Hirayama K, Hirao A, Kondo K, Hayashi H, Kadota K, Asaba H, Ishizu H, Nakata K, Kurisu K, Oshima E, Yokota O, Yamada N, Terada S.

Psychogeriatrics. 2017 Nov;17(6):453-459. doi: 10.1111/psyg.12274.


Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells.

Peng H, Kasada A, Ueno M, Hoshii T, Tadokoro Y, Nomura N, Ito C, Takase Y, Vu HT, Kobayashi M, Xiao B, Worley PF, Hirao A.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):1129-1135. doi: 10.1016/j.bbrc.2017.11.140. Epub 2017 Nov 22.


Tube feeding decreases pneumonia rate in patients with severe dementia: comparison between pre- and post-intervention.

Takenoshita S, Kondo K, Okazaki K, Hirao A, Takayama K, Hirayama K, Asaba H, Nakata K, Ishizu H, Takahashi H, Nakashima-Yasuda H, Sakurada Y, Fujikawa K, Yokota O, Yamada N, Terada S; Middle Western Japan-Dementia Study (mid-Dem study).

BMC Geriatr. 2017 Nov 21;17(1):267. doi: 10.1186/s12877-017-0662-6.


Effects of growth hormone on uncoupling protein 1 in white adipose tissues in obese mice.

Hayashi M, Futawaka K, Koyama R, Fan Y, Matsushita M, Hirao A, Fukuda Y, Nushida A, Nezu S, Tagami T, Moriyama K.

Growth Horm IGF Res. 2017 Dec;37:31-39. doi: 10.1016/j.ghir.2017.10.006. Epub 2017 Oct 24.


Precise Synthesis of Macromolecular Architectures by Novel Iterative Methodology Combining Living Anionic Polymerization with Specially Designed Linking Chemistry.

Goseki R, Ito S, Matsuo Y, Higashihara T, Hirao A.

Polymers (Basel). 2017 Sep 25;9(10). pii: E470. doi: 10.3390/polym9100470. Review.


Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.

Ali MAE, Fuse K, Tadokoro Y, Hoshii T, Ueno M, Kobayashi M, Nomura N, Vu HT, Peng H, Hegazy AM, Masuko M, Sone H, Arai F, Tajima A, Hirao A.

Sci Rep. 2017 Sep 12;7(1):11442. doi: 10.1038/s41598-017-11909-3.


Regulation of Hematopoiesis and Hematological Disease by TGF-β Family Signaling Molecules.

Naka K, Hirao A.

Cold Spring Harb Perspect Biol. 2017 Sep 1;9(9). pii: a027987. doi: 10.1101/cshperspect.a027987. Review.


Simultaneous Determination of Seven Kinds of Fungicides in Citrus Fruits by Gas Chromatograghy/Mass Spectrometry.

Nagashima H, Hirao A, Tokuda Y, Uruta K.

Shokuhin Eiseigaku Zasshi. 2016;57(4):101-6. doi: 10.3358/shokueishi.57.101.


Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.

Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A.

J Biol Chem. 2016 Oct 7;291(41):21496-21509. Epub 2016 Aug 12.


Guest editorial: Cooperative networks for stem cell homeostasis in normal and malignant hematopoiesis: from metabolism to epigenetics.

Hirao A.

Int J Hematol. 2016 Jun;103(6):605-6. doi: 10.1007/s12185-016-2012-4. Epub 2016 Apr 19. No abstract available.


MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.

Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N.

Blood. 2016 May 26;127(21):2607-17. doi: 10.1182/blood-2015-10-673087. Epub 2016 Mar 22.


A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol 3-kinase-Akt pathway activation.

Matsushita T, Le Huu D, Kobayashi T, Hamaguchi Y, Hasegawa M, Naka K, Hirao A, Muramatsu M, Takehara K, Fujimoto M.

J Allergy Clin Immunol. 2016 Oct;138(4):1170-1182.e9. doi: 10.1016/j.jaci.2015.12.1319. Epub 2016 Mar 2.


Association between occlusal force and physical functions in preschool children: a comparison of males and females.

Hirao A, Murata S, Kubo A, Hachiya M, Mitsumaru N, Asami T.

J Phys Ther Sci. 2015 Dec;27(12):3729-32. doi: 10.1589/jpts.27.3729. Epub 2015 Dec 28.


Heterogeneity of patients receiving artificial nutrition in Japanese psychiatric hospitals: a cross-sectional study.

Hirao A, Abe K, Takayama K, Kondo K, Yokota O, Sato Y, Norikiyo T, Sato S, Nakashima T, Hayashi H, Nakata K, Asaba H, Tanaka K, Tanaka R, Morisada Y, Itakura H, Honda H, Okabe N, Oshima E, Terada S; Middle Western Japan-Dementia Study (mid-Dem study).

Psychogeriatrics. 2016 Nov;16(6):341-348. doi: 10.1111/psyg.12173. Epub 2016 Jan 12.


Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells.

Naka K, Ishihara K, Jomen Y, Jin CH, Kim DH, Gu YK, Jeong ES, Li S, Krause DS, Kim DW, Bae E, Takihara Y, Hirao A, Oshima H, Oshima M, Ooshima A, Sheen YY, Kim SJ, Kim DK.

Cancer Sci. 2016 Feb;107(2):140-8. doi: 10.1111/cas.12849. Epub 2016 Jan 26.


Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142.

Kawahara T, Kagaya N, Masuda Y, Doi T, Izumikawa M, Ohta K, Hirao A, Shin-ya K.

Org Lett. 2015 Nov 6;17(21):5476-9. doi: 10.1021/acs.orglett.5b02842. Epub 2015 Oct 23.


[Targeted molecular therapy based on advanced cancer stem cell model].

Hirao A.

Nihon Rinsho. 2015 Aug;73(8):1256-62. Review. Japanese.


[Roles of mTOR signalings in hematopoiesis and leukemogenesis].

Hirao A.

Rinsho Ketsueki. 2015 Jun;56(6):601-5. doi: 10.11406/rinketsu.56.601. Japanese.


S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation.

Nakagawa T, Araki T, Nakagawa M, Hirao A, Unno M, Nakayama K.

Mol Cell Biol. 2015 Oct;35(20):3517-27. doi: 10.1128/MCB.00343-15. Epub 2015 Aug 3.


Development and evaluation of microsatellite markers for Acer miyabei (Sapindaceae), a threatened maple species in East Asia.

Saeki I, Hirao AS, Kenta T.

Appl Plant Sci. 2015 Jun 5;3(6). pii: apps.1500020. doi: 10.3732/apps.1500020. eCollection 2015 Jun.


Aging rather than sun exposure is a major determining factor for the density of miR-125b-positive epidermal stem cells in human skin.

Toyokuni S, Jiang L, Wang S, Hirao A, Wada T, Soh C, Toyama K, Kawada A.

Pathol Int. 2015 Aug;65(8):415-9. doi: 10.1111/pin.12320. Epub 2015 Jun 17.


[Regulation of cancer behavior mediated by mTOR signal].

Hirao A.

Nihon Rinsho. 2015 May;73(5):773-8. Japanese.


[Roles of mTORC1 in acute myeloid leukemia].

Hoshii T, Hirao A.

Rinsho Ketsueki. 2015 Apr;56(4):359-65. doi: 10.11406/rinketsu.56.359. Review. Japanese.


Association between intraoperative blood pressure and postoperative delirium in elderly hip fracture patients.

Wang NY, Hirao A, Sieber F.

PLoS One. 2015 Apr 10;10(4):e0123892. doi: 10.1371/journal.pone.0123892. eCollection 2015.


Verification of the Correlation between Cognitive Function and Lower Limb Muscle Strength for the Community-dwelling Elderly.

Ohsugi H, Murata S, Kubo A, Hachiya M, Hirao A, Fujiwara K, Kamijou K.

J Phys Ther Sci. 2014 Dec;26(12):1861-3. doi: 10.1589/jpts.26.1861. Epub 2014 Dec 25.


Changes in pollinator fauna affect altitudinal variation of floral size in a bumblebee-pollinated herb.

Nagano Y, Abe K, Kitazawa T, Hattori M, Hirao AS, Itino T.

Ecol Evol. 2014 Sep;4(17):3395-407. doi: 10.1002/ece3.1191. Epub 2014 Aug 18.


Development of the thalamo-dorsal ventricular ridge tract in the Chinese soft-shelled turtle, Pelodiscus sinensis.

Tosa Y, Hirao A, Matsubara I, Kawaguchi M, Fukui M, Kuratani S, Murakami Y.

Dev Growth Differ. 2015 Jan;57(1):40-57. doi: 10.1111/dgd.12186. Epub 2014 Dec 14.


Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism.

Fahkri H, Zhang B, Fajol A, Hernando N, Elvira B, Mannheim JG, Pichler BJ, Daniel C, Amann K, Hirao A, Haight J, Mak TW, Lang F, Föller M.

Pflugers Arch. 2015 Sep;467(9):1871-80. doi: 10.1007/s00424-014-1625-9. Epub 2014 Oct 17.


Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells.

Tanaka S, Nakada M, Yamada D, Nakano I, Todo T, Ino Y, Hoshii T, Tadokoro Y, Ohta K, Ali MA, Hayashi Y, Hamada J, Hirao A.

J Neurooncol. 2015 Jan;121(2):239-50. doi: 10.1007/s11060-014-1630-z. Epub 2014 Oct 8.


Hes1 suppresses acute myeloid leukemia development through FLT3 repression.

Kato T, Sakata-Yanagimoto M, Nishikii H, Ueno M, Miyake Y, Yokoyama Y, Asabe Y, Kamada Y, Muto H, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S.

Leukemia. 2015 Mar;29(3):576-85. doi: 10.1038/leu.2014.281. Epub 2014 Sep 19.


Development and evaluation of microsatellite markers for the gynodioecious shrub Daphne jezoensis (Thymelaeaceae).

Kameyama Y, Hirao AS.

Appl Plant Sci. 2014 Apr 18;2(5). pii: apps.1400001. doi: 10.3732/apps.1400001. eCollection 2014 May.


Relationships between the Occlusal Force and Physical/Cognitive Functions of Elderly Females Living in the Community.

Hirao A, Murata S, Murata J, Kubo A, Hachiya M, Asami T.

J Phys Ther Sci. 2014 Aug;26(8):1279-82. doi: 10.1589/jpts.26.1279. Epub 2014 Aug 30.


Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis.

Hoshii T, Matsuda S, Hirao A.

J Biochem. 2014 Aug;156(2):73-83. doi: 10.1093/jb/mvu037. Epub 2014 Jun 23. Review.


Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients.

Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A.

Biochem Biophys Res Commun. 2014 Jul 18;450(1):837-43. doi: 10.1016/j.bbrc.2014.06.066. Epub 2014 Jun 21.


Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch.

Imai Y, Takahashi A, Hanyu A, Hori S, Sato S, Naka K, Hirao A, Ohtani N, Hara E.

Cell Rep. 2014 Apr 10;7(1):194-207. doi: 10.1016/j.celrep.2014.03.006. Epub 2014 Apr 3.


Development of a renal subcapsular hematoma during angiography for diagnosis and subsequent treatment of hepatocellular carcinoma.

Hirao A, Tomonari T, Tanaka H, Tanaka K, Kagawa M, Tanaka T, Taniguchi T, Harada R, Sato M, Muguruma N, Takayama T.

Clin J Gastroenterol. 2014 Apr;7(2):185-8. doi: 10.1007/s12328-014-0468-4. Epub 2014 Feb 28.


Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.

Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3805-10. doi: 10.1073/pnas.1320265111. Epub 2014 Feb 24.

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