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Items: 1 to 50 of 1980

1.

New paradigm for expediting drug development in Asia.

Rajman I, Hirano M, Honma W, Zhao S.

Drug Discov Today. 2020 Jan 8. pii: S1359-6446(20)30004-0. doi: 10.1016/j.drudis.2019.12.013. [Epub ahead of print]

2.

Plastid-targeted forms of restriction endonucleases enhance the plastid genome rearrangement rate and trigger the reorganization of its genomic architecture.

Sugimoto H, Hirano M, Tanaka H, Tanaka T, Kitagawa-Yogo R, Muramoto N, Mitsukawa N.

Plant J. 2020 Jan 11. doi: 10.1111/tpj.14687. [Epub ahead of print]

PMID:
31925982
3.

Enzyme-free release of adhered cells from standard culture dishes using intermittent ultrasonic traveling waves.

Kurashina Y, Imashiro C, Hirano M, Kuribara T, Totani K, Ohnuma K, Friend J, Takemura K.

Commun Biol. 2019 Oct 29;2(1):393. doi: 10.1038/s42003-019-0638-5.

PMID:
31925249
4.

The C-terminal region affects the activity of photoactivated adenylyl cyclase from Oscillatoria acuminata.

Hirano M, Takebe M, Ishido T, Ide T, Matsunaga S.

Sci Rep. 2019 Dec 30;9(1):20262. doi: 10.1038/s41598-019-56721-3.

5.
6.

Naquotinib exerts antitumor activity in activated B-cell-like diffuse large B-cell lymphoma.

Tanaka H, Kaneko N, Sakagami H, Matsuya T, Hiramoto M, Yamanaka Y, Mori M, Koshio H, Hirano M, Takeuchi M.

Leuk Res. 2020 Jan;88:106286. doi: 10.1016/j.leukres.2019.106286. Epub 2019 Dec 10.

PMID:
31865062
7.

Novel Mitochondrial Translation Optimizer-1 Mutations as a Cause of Hereditary Optic Neuropathy.

Li E, Emmanuele V, Testa F, Moreno CAM, Hirano M, Lesser RL.

J Neuroophthalmol. 2019 Dec 13. doi: 10.1097/WNO.0000000000000858. [Epub ahead of print] No abstract available.

PMID:
31842146
8.

Effects of Lyophilization of Arginine-rich Cell-penetrating Peptide-modified Extracellular Vesicles on Intracellular Delivery.

Noguchi K, Hirano M, Hashimoto T, Yuba E, Takatani-Nakase T, Nakase I.

Anticancer Res. 2019 Dec;39(12):6701-6709. doi: 10.21873/anticanres.13885.

PMID:
31810935
9.

Leber hereditary optic neuropathy plus dystonia, and transverse myelitis due to double mutations in MT-ND4 and MT-ND6.

Berardo A, Emmanuele V, Vargas W, Tanji K, Naini A, Hirano M.

J Neurol. 2019 Nov 27. doi: 10.1007/s00415-019-09619-z. [Epub ahead of print]

PMID:
31776719
10.

A rare case of peliosis hepatis in a patient with chronic renal failure and renal cell carcinoma.

Maruyama H, Takahashi K, Ishikawa N, Hosaka K, Kumaki D, Aruga Y, Yamakawa M, Hirano M, Funakoshi K, Terai S.

Clin J Gastroenterol. 2019 Nov 11. doi: 10.1007/s12328-019-01068-5. [Epub ahead of print]

PMID:
31713159
11.

Potential mechanisms underlying embryonic developmental toxicity caused by benzo[a]pyrene in Japanese medaka (Oryzias latipes).

Yamaguchi A, Uchida M, Ishibashi H, Hirano M, Ichikawa N, Arizono K, Koyama J, Tominaga N.

Chemosphere. 2020 Mar;242:125243. doi: 10.1016/j.chemosphere.2019.125243. Epub 2019 Oct 31.

PMID:
31704526
12.

Enzyme-free release of adhered cells from standard culture dishes using intermittent ultrasonic traveling waves.

Kurashina Y, Imashiro C, Hirano M, Kuribara T, Totani K, Ohnuma K, Friend J, Takemura K.

Commun Biol. 2019 Oct 29;2:393. doi: 10.1038/s42003-019-0638-5. eCollection 2019.

13.

Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence.

Goto C, Hirano M, Hayashi K, Kikuchi Y, Hara-Kudo Y, Misawa T, Demizu Y.

ChemMedChem. 2019 Nov 20;14(22):1911-1916. doi: 10.1002/cmdc.201900460. Epub 2019 Nov 6.

PMID:
31667994
14.

Ancient BCMA-like Genes Herald B Cell Regulation in Lampreys.

Das S, Sutoh Y, Cancro MP, Rast JP, Han Q, Bommakanti G, Cooper MD, Hirano M.

J Immunol. 2019 Dec 1;203(11):2909-2916. doi: 10.4049/jimmunol.1900026. Epub 2019 Oct 30.

PMID:
31666307
15.

Reorganization of finger covariation patterns represented in the corticospinal system by learning of a novel movement irrelevant to common daily movements.

Hirano M, Funase K.

J Neurophysiol. 2019 Dec 1;122(6):2458-2467. doi: 10.1152/jn.00514.2019. Epub 2019 Oct 30.

PMID:
31664876
16.

Correction: A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer: "eCura system".

Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Yamanouchi K, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Nakamura T, Shimosegawa T.

Am J Gastroenterol. 2019 Dec;114(12):1925-1926. doi: 10.14309/ajg.0000000000000432. No abstract available.

PMID:
31658102
17.

Fatigue in primary genetic mitochondrial disease: No rest for the weary.

Parikh S, Galioto R, Lapin B, Haas R, Hirano M, Koenig MK, Saneto RP, Zolkipli-Cunningham Z, Goldstein A, Karaa A.

Neuromuscul Disord. 2019 Nov;29(11):895-902. doi: 10.1016/j.nmd.2019.09.012. Epub 2019 Sep 25.

PMID:
31653361
18.

Dystonia-Ataxia with early handwriting deterioration in COQ8A mutation carriers: A case series and literature review.

Galosi S, Barca E, Carrozzo R, Schirinzi T, Quinzii CM, Lieto M, Vasco G, Zanni G, Di Nottia M, Galatolo D, Filla A, Bertini E, Santorelli FM, Leuzzi V, Haas R, Hirano M, Friedman J.

Parkinsonism Relat Disord. 2019 Nov;68:8-16. doi: 10.1016/j.parkreldis.2019.09.015. Epub 2019 Sep 28. Review.

PMID:
31621627
19.

Developing a comprehensive career development scale for public health nurses in Japan.

Saeki K, Hirano M, Honda H, Asahara K.

Public Health Nurs. 2020 Jan;37(1):135-143. doi: 10.1111/phn.12673. Epub 2019 Oct 16.

PMID:
31617246
20.

Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells.

Takenaka T, Nakai S, Katayama M, Hirano M, Ueno N, Noguchi K, Takatani-Nakase T, Fujii I, Kobayashi SS, Nakase I.

Int J Pharm. 2019 Dec 15;572:118762. doi: 10.1016/j.ijpharm.2019.118762. Epub 2019 Oct 11.

PMID:
31610280
21.

Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine.

Takano Y, Hirano M, Machida T, Obara Y, Hamaue N, Fujita K, Taniguchi M, Endo T, Shiga S, Machida M, Iizuka K, Hirafuji M.

J Pharmacol Sci. 2019 Sep;141(1):32-40. doi: 10.1016/j.jphs.2019.09.001. Epub 2019 Sep 10.

22.

Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure.

Rosenberg BJ, Hirano M, Quinzii CM, Colantuoni E, Needham DM, Lederer DJ, Baldwin MR.

Thorax. 2019 Nov;74(11):1099-1101. doi: 10.1136/thoraxjnl-2019-213621. Epub 2019 Sep 18.

PMID:
31534031
23.

Redefining the Etiologic Landscape of Cerebellar Malformations.

Aldinger KA, Timms AE, Thomson Z, Mirzaa GM, Bennett JT, Rosenberg AB, Roco CM, Hirano M, Abidi F, Haldipur P, Cheng CV, Collins S, Park K, Zeiger J, Overmann LM, Alkuraya FS, Biesecker LG, Braddock SR, Cathey S, Cho MT, Chung BHY, Everman DB, Zarate YA, Jones JR, Schwartz CE, Goldstein A, Hopkin RJ, Krantz ID, Ladda RL, Leppig KA, McGillivray BC, Sell S, Wusik K, Gleeson JG, Nickerson DA, Bamshad MJ, Gerrelli D, Lisgo SN, Seelig G, Ishak GE, Barkovich AJ, Curry CJ, Glass IA, Millen KJ, Doherty D, Dobyns WB.

Am J Hum Genet. 2019 Sep 5;105(3):606-615. doi: 10.1016/j.ajhg.2019.07.019. Epub 2019 Aug 29.

PMID:
31474318
24.

Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma.

Adilijiang A, Hirano M, Okuno Y, Aoki K, Ohka F, Maeda S, Tanahashi K, Motomura K, Shimizu H, Yamaguchi J, Wakabayashi T, Natsume A.

Molecules. 2019 Aug 22;24(17). pii: E3046. doi: 10.3390/molecules24173046.

25.

Catalytic cross-dimerisation giving reactive borylated polyenes toward cross-coupling.

Hirano M, Kuramochi A, Shimada K, Komine N, Kiyota S, Westcott SA.

Chem Commun (Camb). 2019 Aug 29;55(71):10527-10530. doi: 10.1039/c9cc05930j.

PMID:
31418006
26.

Advances in primary mitochondrial myopathies.

de Barcelos IP, Emmanuele V, Hirano M.

Curr Opin Neurol. 2019 Oct;32(5):715-721. doi: 10.1097/WCO.0000000000000743.

PMID:
31408013
27.

Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G.

Saito M, Cui L, Hirano M, Li G, Yanagisawa T, Sato T, Sukegawa J.

Mol Pharmacol. 2019 Oct;96(4):441-451. doi: 10.1124/mol.119.116426. Epub 2019 Aug 5.

PMID:
31383768
28.

Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency.

Lopez-Gomez C, Hewan H, Sierra C, Akman HO, Sanchez-Quintero MJ, Juanola-Falgarona M, Tadesse S, Tanji K, Konofagou EE, Hirano M.

EBioMedicine. 2019 Aug;46:356-367. doi: 10.1016/j.ebiom.2019.07.037. Epub 2019 Aug 2.

29.

Predominant surface property of an anodized titanium that enhances the cell response.

Ohtsu N, Kuji T, Hirano M, Yamasaki K.

Biointerphases. 2019 Jul 29;14(4):041002. doi: 10.1116/1.5108542.

PMID:
31357867
30.

Is Additional Surgery Always Sufficient for Preventing Recurrence After Endoscopic Submucosal Dissection with Curability C-2 for Early Gastric Cancer?

Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Oka S, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Shimoda R, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Aoyagi H, Nakamura T, Nakaya N, Shimosegawa T, Masamune A.

Ann Surg Oncol. 2019 Oct;26(11):3636-3643. doi: 10.1245/s10434-019-07579-2. Epub 2019 Jul 24.

PMID:
31342376
31.

Specialized Somatosensory-Motor Integration Functions in Musicians.

Hirano M, Kimoto Y, Furuya S.

Cereb Cortex. 2019 Jul 25. pii: bhz154. doi: 10.1093/cercor/bhz154. [Epub ahead of print]

PMID:
31342056
32.

Spontaneous Tumor Regression of Intracranial Solitary Fibrous Tumor Originating From the Medulla Oblongata: A Case Report and Literature Review.

Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Shimizu H, Wakabayashi T, Natsume A.

World Neurosurg. 2019 Oct;130:400-404. doi: 10.1016/j.wneu.2019.07.052. Epub 2019 Jul 18.

PMID:
31326640
33.

Effects of the rotigotine transdermal patch versus oral levodopa on swallowing in patients with Parkinson's disease.

Hirano M, Isono C, Fukuda K, Ueno S, Nakamura Y, Kusunoki S.

J Neurol Sci. 2019 Sep 15;404:5-10. doi: 10.1016/j.jns.2019.07.003. Epub 2019 Jul 9.

PMID:
31323520
34.

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues.

Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y.

Medchemcomm. 2019 Apr 4;10(6):896-900. doi: 10.1039/c9md00166b. eCollection 2019 Jun 1.

PMID:
31303986
35.

Pathological Findings in Male Patients With Anti-N-methyl-d-Aspartate Receptor Encephalitis.

Hirano M, Itoh T, Fujimura H, Inoue K, Samukawa M, Nose K, Sakamoto H, Maekura S, Ueno S, Satou T, Nishioka T, Kusunoki S, Nakamura Y.

J Neuropathol Exp Neurol. 2019 May 31. pii: nlz052. doi: 10.1093/jnen/nlz052. [Epub ahead of print]

PMID:
31282957
36.

Clinicopathological differences between the motor onset and psychiatric onset of Huntington's disease, focusing on the nucleus accumbens.

Hirano M, Iritani S, Fujishiro H, Torii Y, Habuchi C, Sekiguchi H, Yoshida M, Ozaki N.

Neuropathology. 2019 Oct;39(5):331-341. doi: 10.1111/neup.12578. Epub 2019 Jul 2.

PMID:
31264738
37.

Synthesis and Pharmacological Evaluation of 3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile Derivatives as Orally Active AMPA Receptor Antagonists.

Inami H, Shishikura JI, Yasunaga T, Hirano M, Kimura T, Yamashita H, Ohno K, Sakamoto S.

Chem Pharm Bull (Tokyo). 2019;67(7):699-706. doi: 10.1248/cpb.c18-00977.

38.

In vitro assessment of effects of persistent organic pollutants on the transactivation of estrogen receptor α and β (ERα and ERβ) from the Baikal seal (Pusa sibirica).

Yoshinouchi Y, Shimizu S, Lee JS, Hirano M, Suzuki KT, Kim EY, Iwata H.

Ecotoxicol Environ Saf. 2019 Oct 15;181:463-471. doi: 10.1016/j.ecoenv.2019.06.033. Epub 2019 Jun 19.

PMID:
31228822
39.

Different characteristics of postoperative atrial tachyarrhythmias between congenital and non-congenital heart disease.

Kondo M, Fukuda K, Wakayama Y, Nakano M, Hasebe Y, Satake H, Segawa M, Hirano M, Shimokawa H.

J Interv Card Electrophysiol. 2019 Jun 13. doi: 10.1007/s10840-019-00575-2. [Epub ahead of print]

PMID:
31197584
40.

Aberrant Transcriptional Regulation of Super-enhancers by RET Finger Protein-histone Deacetylase 1 Complex in Glioblastoma: Chemoresistance to Temozolomide.

Natsume A, Hirano M, Ranjit M, Aoki K, Wakabayashi T.

Neurol Med Chir (Tokyo). 2019 Aug 15;59(8):293-298. doi: 10.2176/nmc.ra.2019-0049. Epub 2019 Jun 7.

41.

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts.

Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hägg S, Hirano M, Picard M.

Epigenetics. 2019 Oct;14(10):961-976. doi: 10.1080/15592294.2019.1626651. Epub 2019 Jun 12.

PMID:
31156022
42.

EN FACE IMAGE-BASED ANALYSIS OF RETINAL TRACTION CAUSED BY EPIRETINAL MEMBRANE AND ITS RELATIONSHIP WITH VISUAL FUNCTIONS.

Hirano M, Morizane Y, Kanzaki Y, Kimura S, Hosokawa M, Shiode Y, Doi S, Toshima S, Takahashi K, Hosogi M, Fujiwara A, Takasu I, Shiraga F.

Retina. 2019 May 23. doi: 10.1097/IAE.0000000000002569. [Epub ahead of print]

PMID:
31136461
43.

Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body.

Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y.

Eur J Pharmacol. 2019 Aug 15;857:172405. doi: 10.1016/j.ejphar.2019.172405. Epub 2019 May 22.

PMID:
31128092
44.

Deoxynucleoside Therapy for Thymidine Kinase 2-Deficient Myopathy.

Domínguez-González C, Madruga-Garrido M, Mavillard F, Garone C, Aguirre-Rodríguez FJ, Donati MA, Kleinsteuber K, Martí I, Martín-Hernández E, Morealejo-Aycinena JP, Munell F, Nascimento A, Kalko SG, Sardina MD, Álvarez Del Vayo C, Serrano O, Long Y, Tu Y, Levin B, Thompson JLP, Engelstad K, Uddin J, Torres-Torronteras J, Jimenez-Mallebrera C, Martí R, Paradas C, Hirano M.

Ann Neurol. 2019 Aug;86(2):293-303. doi: 10.1002/ana.25506. Epub 2019 Jun 17.

PMID:
31125140
45.

Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping.

Motomura K, Chalise L, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Yamaguchi J, Shimizu H, Wakabayashi T, Natsume A.

J Neurosurg. 2019 May 17:1-9. doi: 10.3171/2019.3.JNS19211. [Epub ahead of print]

PMID:
31100731
46.

Age Affects Clinical Management after Noncurative Endoscopic Submucosal Dissection for Early Gastric Cancer.

Esaki M, Hatta W, Shimosegawa T, Oyama T, Kawata N, Takahashi A, Oka S, Hoteya S, Nakagawa M, Hirano M, Matsuda M, Ohnita K, Shimoda R, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Aoyagi H, Gotoda T.

Dig Dis. 2019;37(6):423-433. doi: 10.1159/000499538. Epub 2019 May 16.

PMID:
31096243
47.

Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression.

Tanaka H, Sakagami H, Kaneko N, Konagai S, Yamamoto H, Matsuya T, Yuri M, Yamanaka Y, Mori M, Takeuchi M, Koshio H, Hirano M, Kuromitsu S.

Mol Cancer Ther. 2019 Aug;18(8):1366-1373. doi: 10.1158/1535-7163.MCT-18-0976. Epub 2019 May 15.

PMID:
31092564
48.

The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations.

Rodríguez Cruz PM, Cossins J, Estephan EP, Munell F, Selby K, Hirano M, Maroofin R, Mehrjardi MYV, Chow G, Carr A, Manzur A, Robb S, Munot P, Wei Liu W, Banka S, Fraser H, De Goede C, Zanoteli E, Conti Reed U, Sage A, Gratacos M, Macaya A, Dusl M, Senderek J, Töpf A, Hofer M, Knight R, Ramdas S, Jayawant S, Lochmüller H, Palace J, Beeson D.

Brain. 2019 Jun 1;142(6):1547-1560. doi: 10.1093/brain/awz107.

49.

Late-onset thymidine kinase 2 deficiency: a review of 18 cases.

Domínguez-González C, Hernández-Laín A, Rivas E, Hernández-Voth A, Sayas Catalán J, Fernández-Torrón R, Fuiza-Luces C, García García J, Morís G, Olivé M, Miralles F, Díaz-Manera J, Caballero C, Méndez-Ferrer B, Martí R, García Arumi E, Badosa MC, Esteban J, Jimenez-Mallebrera C, Encinar AB, Arenas J, Hirano M, Martin MÁ, Paradas C.

Orphanet J Rare Dis. 2019 May 6;14(1):100. doi: 10.1186/s13023-019-1071-z.

50.

A case of pancreatic pseudocysts accompanied by infection, pseudoaneurysm ruptures, and pseudocystocolonic fistulae.

Sato K, Takahashi K, Aruga Y, Yamazaki F, Kumaki D, Yamakawa M, Hirano M, Funakoshi K, Terai S.

Clin J Gastroenterol. 2019 Dec;12(6):615-620. doi: 10.1007/s12328-019-00986-8. Epub 2019 Apr 23.

PMID:
31016682

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