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Dopamine Transporter Dynamics of N-Substituted Benztropine Analogs with Atypical Behavioral Effects.

Hong WC, Wasko MJ, Wilkinson DS, Hiranita T, Li L, Hayashi S, Snell DB, Madura JD, Surratt CK, Katz JL.

J Pharmacol Exp Ther. 2018 Jun 26. pii: jpet.118.250498. doi: 10.1124/jpet.118.250498. [Epub ahead of print]


Positron emission tomography (PET) imaging of nicotine-induced dopamine release in squirrel monkeys using [18F]Fallypride.

Naylor JE, Hiranita T, Matazel KS, Zhang X, Paule MG, Goodwin AK.

Drug Alcohol Depend. 2017 Oct 1;179:254-259. doi: 10.1016/j.drugalcdep.2017.07.013. Epub 2017 Aug 8.


The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.

Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL.

J Biol Chem. 2017 Jul 7;292(27):11250-11261. doi: 10.1074/jbc.M116.774075. Epub 2017 May 11.


σ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration.

Hiranita T, Hong WC, Kopajtic T, Katz JL.

J Pharmacol Exp Ther. 2017 Jul;362(1):2-13. doi: 10.1124/jpet.117.241109. Epub 2017 Apr 25.


Importance of Substrate-Coupled Proton Antiport by the Vesicular Monoamine Transporter in the Actions of Amphetamines in Drosophila Brain.

Hiranita T, Freyberg Z.

J Alcohol Drug Depend. 2016 Dec;4(6). pii: e136. doi: 10.4172/2329-6488.1000e136. Epub 2016 Dec 16. No abstract available.


A Role for Sigma Receptors in Stimulant Self-Administration and Addiction.

Katz JL, Hiranita T, Hong WC, Job MO, McCurdy CR.

Handb Exp Pharmacol. 2017;244:177-218. doi: 10.1007/164_2016_94. Review.


Lack of Effects of Toll-Like Receptor 4 Antagonists on the Reinforcing Effects of Cocaine and Remifentanil.

Hiranita T.

J Alcohol Drug Depend. 2016 Dec;4(6). pii: 1000e135. doi: 10.4172/2329-6488. No abstract available.


DAT Conformation Does Not Predict the Ability of Atypical Dopamine Uptake Inhibitors to Substitute for Cocaine.

Hiranita T.

J Alcohol Drug Depend. 2016;4(4). pii: e132. Epub 2016 Aug 8. No abstract available.


Identification of Antagonists Selective for Sigma Receptor Subtypes that are Active In vivo.

Hiranita T.

J Alcohol Drug Depend. 2016;4(4). pii: e131. Epub 2016 Jul 11. No abstract available.


Identification of the Sigma-2 Receptor: Distinct from the Progesterone Receptor Membrane Component 1 (PGRMC1).

Hiranita T.

J Alcohol Drug Depend. 2016;4. pii: doi:10.4172/2329-6488.1000e130. Epub 2016 Apr 25. No abstract available.


(-)-Trans-Δ9-Tetrahydrocannabinol-Like Discriminative-Stimulus Effects of Gabapentin in Cannabis Users.

Hiranita T.

J Alcohol Drug Depend. 2016 Feb;4(1). pii: e129. Epub 2016 Feb 10. No abstract available.


Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids.

Tanda G, Mereu M, Hiranita T, Quarterman JC, Coggiano M, Katz JL.

Neuropsychopharmacology. 2016 Oct;41(11):2772-81. doi: 10.1038/npp.2016.91. Epub 2016 Jun 14.


Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.

Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR.

J Pharmacol Exp Ther. 2016 Jul;358(1):109-24. doi: 10.1124/jpet.116.232728. Epub 2016 Apr 21.


Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.

Freyberg Z, Sonders MS, Aguilar JI, Hiranita T, Karam CS, Flores J, Pizzo AB, Zhang Y, Farino ZJ, Chen A, Martin CA, Kopajtic TA, Fei H, Hu G, Lin YY, Mosharov EV, McCabe BD, Freyberg R, Wimalasena K, Hsin LW, Sames D, Krantz DE, Katz JL, Sulzer D, Javitch JA.

Nat Commun. 2016 Feb 16;7:10652. doi: 10.1038/ncomms10652.


A role for sigma receptors in stimulant self-administration and addiction.

Katz JL, Hong WC, Hiranita T, Su TP.

Behav Pharmacol. 2016 Apr;27(2-3 Spec Issue):100-15. doi: 10.1097/FBP.0000000000000209. Review.


Dopamine D₂-Like Receptors and Behavioral Economics of Food Reinforcement.

Soto PL, Hiranita T, Xu M, Hursh SR, Grandy DK, Katz JL.

Neuropsychopharmacology. 2016 Mar;41(4):971-8. doi: 10.1038/npp.2015.223. Epub 2015 Jul 24.


In Vivo Significance of In Vitro Studies on G-Protein-Coupled Receptor Heteromers.

Hiranita T.

J Alcohol Drug Depend. 2015 Apr;3(2). pii: e120. Epub 2015 Mar 14. No abstract available.


The Reinforcing Effects of Nicotine in Humans and Nonhuman Primates: A Review of Intravenous Self-Administration Evidence and Future Directions for Research.

Goodwin AK, Hiranita T, Paule MG.

Nicotine Tob Res. 2015 Nov;17(11):1297-310. doi: 10.1093/ntr/ntv002. Epub 2015 Feb 10. Review.


DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.

Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, Yin H, Zahniser NR, Katz JL, Rice KC, Maier SF, Bachtell RK, Watkins LR.

Mol Psychiatry. 2015 Dec;20(12):1525-37. doi: 10.1038/mp.2014.177. Epub 2015 Feb 3.


Medications Discovery: Importance of Assessment of Drug Self Administration Dose-Effect Curves.

Hiranita T.

J Alcohol Drug Depend. 2015 Jun;3(3). pii: e121. Epub 2015 Jun 12. No abstract available.


Self-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats.

Hiranita T.

J Alcohol Drug Depend. 2015 Dec;3(6). pii: e128. Epub 2015 Nov 18. No abstract available.


Cocaine Antagonists; Studies on Cocaine Self-Administration.

Hiranita T.

J Alcohol Drug Depend. 2015 Oct;3(5). pii: e125. Epub 2015 Sep 3. No abstract available.


Preclinical Efficacy of Novel Vesicular Monoamine Transporter 2 Inhibitors as Antagonists of d-Methamphetamine Self-Administration in Rats.

Hiranita T.

J Alcohol Drug Depend. 2015 Oct;3(5). pii: e127. Epub 2015 Oct 27. No abstract available.


Trace Amine-Associated Receptor Type 1 as A Target for The Development of Treatments for Stimulant Abuse.

Hiranita T, Thorn DA.

J Alcohol Drug Depend. 2015 Jun;3(3). pii: e122. Epub 2015 Jun 12. No abstract available.


Self-Administration of an Endogenous Cannabinoid 2-Arachidonoylglycerol in Experimentally Naïve Rats.

Hiranita T.

J Alcohol Drug Depend. 2015 Oct;3(5). pii: e126. Epub 2015 Oct 17. No abstract available.


Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine.

Kohut SJ, Hiranita T, Hong SK, Ebbs AL, Tronci V, Green J, Garcés-Ramírez L, Chun LE, Mereu M, Newman AH, Katz JL, Tanda G.

Biol Psychiatry. 2014 Nov 15;76(10):802-9. doi: 10.1016/j.biopsych.2014.03.031. Epub 2014 Apr 19.


Role of the σRs for Development of Medications.

Hiranita T.

J Alcohol Drug Depend. 2014 May;2(2). pii: e109. Epub 2013 Sep 12. No abstract available.


Choice for response alternatives differing in reinforcement frequency in dopamine D2 receptor mutant and Swiss-Webster mice.

Soto PL, Hiranita T, Grandy DK, Katz JL.

Psychopharmacology (Berl). 2014 Aug;231(16):3169-77. doi: 10.1007/s00213-014-3495-4. Epub 2014 Feb 28.


2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.

Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL.

J Pharmacol Exp Ther. 2014 May;349(2):297-309. doi: 10.1124/jpet.113.212738. Epub 2014 Feb 11. Erratum in: J Pharmacol Exp Ther. 2014 Jun 1;349(3):534.


Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats.

Hiranita T, Kohut SJ, Soto PL, Tanda G, Kopajtic TA, Katz JL.

J Pharmacol Exp Ther. 2014 Jan;348(1):174-91. doi: 10.1124/jpet.113.208264. Epub 2013 Nov 5.


Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats.

Hiranita T, Soto PL, Tanda G, Kopajtic TA, Katz JL.

J Pharmacol Exp Ther. 2013 Oct;347(1):20-9. doi: 10.1124/jpet.113.207522. Epub 2013 Aug 1.


Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists.

Hiranita T, Mereu M, Soto PL, Tanda G, Katz JL.

Neuropsychopharmacology. 2013 Mar;38(4):605-15. doi: 10.1038/npp.2012.224. Epub 2012 Nov 28.


The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.

Li L, Hiranita T, Hayashi S, Newman AH, Katz JL.

Psychopharmacology (Berl). 2013 Feb;225(3):733-42. doi: 10.1007/s00213-012-2862-2. Epub 2012 Sep 14.


Opioid activation of toll-like receptor 4 contributes to drug reinforcement.

Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, Maslanik T, Chapman TR, Strand KA, Fleshner M, Bachtell RK, Somogyi AA, Yin H, Katz JL, Rice KC, Maier SF, Watkins LR.

J Neurosci. 2012 Aug 15;32(33):11187-200.


A Role for Sigma Receptors in Stimulant Self Administration and Addiction.

Katz JL, Su TP, Hiranita T, Hayashi T, Tanda G, Kopajtic T, Tsai SY.

Pharmaceuticals (Basel). 2011;4(6):880-914.


Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.

Hiranita T, Soto PL, Kohut SJ, Kopajtic T, Cao J, Newman AH, Tanda G, Katz JL.

J Pharmacol Exp Ther. 2011 Nov;339(2):662-77. doi: 10.1124/jpet.111.185025. Epub 2011 Aug 22.


Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats.

Hiranita T, Soto PL, Tanda G, Katz JL.

Behav Pharmacol. 2011 Sep;22(5-6):525-30. doi: 10.1097/FBP.0b013e328349ab22.


Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.

Garcés-Ramírez L, Green JL, Hiranita T, Kopajtic TA, Mereu M, Thomas AM, Mesangeau C, Narayanan S, McCurdy CR, Katz JL, Tanda G.

Biol Psychiatry. 2011 Feb 1;69(3):208-17. doi: 10.1016/j.biopsych.2010.07.026. Epub 2010 Oct 15.


Citalopram enhances cocaine's subjective effects in rats.

Soto PL, Hiranita T, Katz JL.

Behav Pharmacol. 2009 Dec;20(8):759-62. doi: 10.1097/FBP.0b013e328333a267.


Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.

Hiranita T, Soto PL, Tanda G, Katz JL.

J Pharmacol Exp Ther. 2010 Feb;332(2):515-24. doi: 10.1124/jpet.109.159236. Epub 2009 Nov 5.


A tryptamine-derived catecholaminergic enhancer, (-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP], attenuates reinstatement of methamphetamine-seeking behavior in rats.

Hiranita T, Yamamoto T, Nawata Y.

Neuroscience. 2010 Jan 20;165(2):300-12. doi: 10.1016/j.neuroscience.2009.10.055.


A cannabinoid CB(1) receptor antagonist ameliorates impairment of recognition memory on withdrawal from MDMA (Ecstasy).

Nawata Y, Hiranita T, Yamamoto T.

Neuropsychopharmacology. 2010 Jan;35(2):515-20. doi: 10.1038/npp.2009.158.


Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors.

Hiranita T, Soto PL, Newman AH, Katz JL.

J Pharmacol Exp Ther. 2009 May;329(2):677-86. doi: 10.1124/jpet.108.145813. Epub 2009 Feb 19.


Methamphetamine-seeking behavior is due to inhibition of nicotinic cholinergic transmission by activation of cannabinoid CB1 receptors.

Hiranita T, Nawata Y, Sakimura K, Yamamoto T.

Neuropharmacology. 2008 Dec;55(8):1300-6. doi: 10.1016/j.neuropharm.2008.08.012. Epub 2008 Aug 22.


Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.

Sakae N, Yamasaki N, Kitaichi K, Fukuda T, Yamada M, Yoshikawa H, Hiranita T, Tatsumi Y, Kira J, Yamamoto T, Miyakawa T, Nakayama KI.

Hum Mol Genet. 2008 Oct 15;17(20):3191-203. doi: 10.1093/hmg/ddn215. Epub 2008 Jul 22.


Involvement of the GABA/benzodiazepine receptor in the axiolytic-like effect of nociceptin/orphanin FQ.

Uchiyama H, Yamaguchi T, Toda A, Hiranita T, Watanabe S, Eyanagi R.

Eur J Pharmacol. 2008 Aug 20;590(1-3):185-9. doi: 10.1016/j.ejphar.2008.05.031. Epub 2008 May 29.


Role of amygdaloid nuclei in the anxiolytic-like effect of nociceptin/orphanin FQ in rats.

Uchiyama H, Toda A, Hiranita T, Watanabe S, Eyanagi R.

Neurosci Lett. 2008 Jan 24;431(1):66-70. doi: 10.1016/j.neulet.2007.11.023. Epub 2007 Dec 4.


Suppression of methamphetamine-seeking behavior by nicotinic agonists.

Hiranita T, Nawata Y, Sakimura K, Anggadiredja K, Yamamoto T.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8523-7. Epub 2006 May 22.


Mode of interaction of amphiphilic alpha-helical peptide with phosphatidylcholines at the air-water interface.

Nakahara H, Nakamura S, Hiranita T, Kawasaki H, Lee S, Sugihara G, Shibata O.

Langmuir. 2006 Jan 31;22(3):1182-92.


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