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Intratumoral delivery of an adenoviral vector carrying the SOCS-1 gene enhances T cell-mediated anti-tumor immunity by suppressing PD-L1.

Nakagawa S, Serada S, Kakubari R, Hiramatsu K, Sugase T, Matsuzaki S, Matsuzaki S, Ueda Y, Yoshino K, Ohkawara T, Fujimoto M, Kishimoto T, Kimura T, Naka T.

Mol Cancer Ther. 2018 Jun 11. pii: molcanther.0822.2017. doi: 10.1158/1535-7163.MCT-17-0822. [Epub ahead of print]


Laparoscopic treatment of rectal cancer and lateral pelvic lymph node dissection. Are they obsolete?

Toda S, Kuroyanagi H, Matoba S, Hiramatsu K, Okazaki N, Tate T, Tomizawa K, Hanaoka Y, Moriyama J.

Minerva Chir. 2018 May 24. doi: 10.23736/S0026-4733.18.07704-0. [Epub ahead of print]


Risk factors of fecal colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae in special nursing homes in Japan.

Yokoyama K, Uehara Y, Sasaki T, Hiramatsu K.

J Gen Fam Med. 2018 Mar 23;19(3):90-96. doi: 10.1002/jgf2.161. eCollection 2018 May.


Anterior laxity of the knee assessed with gravity stress radiograph.

Mae T, Shino K, Hiramatsu K, Tachibana Y, Nakagawa S, Yoshikawa H.

Skeletal Radiol. 2018 Apr 14. doi: 10.1007/s00256-018-2941-5. [Epub ahead of print]


[The Actual State of Treatment of Gastrointestinal Cancer with Abdominal Aortic Aneurysm in Our Department over the Past Five Years].

Yubakami M, Hiramatsu K, Yamazaki T, Matsuzaki Y, Houri Y, Watanabe N, Kondo Y, Ujiie K, Nishimura Y, Todo M, Nakamura Y, Atsuji K, Yamaguchi A, Taniguchi H.

Gan To Kagaku Ryoho. 2018 Mar;45(3):477-479. Japanese.


Development of new application for comprehensive viability analysis based on microbiome analysis by next-generation sequencing: insights into staphylococcal carriage in human nasal cavities.

Lu YJ, Sasaki T, Kuwahara-Arai K, Uehara Y, Hiramatsu K.

Appl Environ Microbiol. 2018 Apr 6. pii: AEM.00517-18. doi: 10.1128/AEM.00517-18. [Epub ahead of print]


SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling.

Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Nishida T, Hirota S, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanasaki K, Kishimoto T, Mori M, Doki Y, Naka T.

Gastric Cancer. 2018 Apr 5. doi: 10.1007/s10120-018-0822-1. [Epub ahead of print]


Duplication cyst of the ileum presenting with severe anemia detected by double-balloon endoscopy.

Takegawa Y, Hiramatsu K, Murata Y, Akazawa Y, Saito Y, Ozaki Y, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Nemoto T, Suto H, Goi T, Imamura Y, Nakamoto Y.

Endosc Int Open. 2018 Apr;6(4):E395-E398. doi: 10.1055/s-0043-125142. Epub 2018 Mar 29.


Long-term results of autologous bone marrow mesenchymal stem cell transplantation for cartilage defects in the patella: Two case reports with more than 18 years of follow-up.

Tsujii A, Hiramatsu K, Shimomura K, Kobayashi M, Mera H, Wakitani S, Nakamura N, Horibe S, Mitsuoka T.

J Orthop Sci. 2018 Feb 14. pii: S0949-2658(18)30036-8. doi: 10.1016/j.jos.2018.01.011. [Epub ahead of print] No abstract available.


Sub-minimum inhibitory concentrations of ceftazidime inhibit Pseudomonas aeruginosa biofilm formation.

Otani S, Hiramatsu K, Hashinaga K, Komiya K, Umeki K, Kishi K, Kadota JI.

J Infect Chemother. 2018 Jun;24(6):428-433. doi: 10.1016/j.jiac.2018.01.007. Epub 2018 Feb 12.


Viral shedding and clinical status of feline-norovirus-infected cats after reinfection with the same strain.

Takano T, Hiramatsu K, Matsuyama M, Mutoh K, Matsumoto Y, Fukushima T, Doki T, Kusuhara H, Hohdatsu T.

Arch Virol. 2018 Jun;163(6):1503-1510. doi: 10.1007/s00705-018-3770-5. Epub 2018 Feb 14.


Genetic polymorphism and decreased expression of HLA class II DP genes are associated with HBV reactivation in patients treated with immunomodulatory agents.

Matsuda H, Hiramatsu K, Akazawa Y, Nosaka T, Saito Y, Ozaki Y, Hayama R, Takahashi K, Naito T, Ofuji K, Ohtani M, Nemoto T, Hida Y, Kimura H, Soya Y, Nakamoto Y.

J Med Virol. 2018 Apr;90(4):712-720. doi: 10.1002/jmv.25011. Epub 2018 Jan 24.


A case of gastric glomus tumor resection using laparoscopy endoscopy cooperative surgery (LECS).

Aoba T, Kato T, Hiramatsu K, Shibata Y, Yoshihara M, Yamaguchi N, Kamiya T.

Int J Surg Case Rep. 2018;42:204-207. doi: 10.1016/j.ijscr.2017.12.023. Epub 2017 Dec 16.


LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.

Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T.

Cancer Res. 2018 Jan 15;78(2):516-527. doi: 10.1158/0008-5472.CAN-17-0910. Epub 2017 Nov 29.


Optimal Trough Concentration of Teicoplanin in Febrile Neutropenic Patients with Hematological Malignancy.

Sato Y, Hiramatsu K, Suzuki Y, Tanaka R, Kaneko T, Nonoshita K, Ogata M, Kadota JI, Itoh H.

Chemotherapy. 2018;63(1):29-34. doi: 10.1159/000481725. Epub 2017 Nov 24.


Modular representation of layered neural networks.

Watanabe C, Hiramatsu K, Kashino K.

Neural Netw. 2018 Jan;97:62-73. doi: 10.1016/j.neunet.2017.09.017. Epub 2017 Oct 12.


Rapid-scan Fourier-transform coherent anti-Stokes Raman scattering spectroscopy with heterodyne detection.

Hiramatsu K, Luo Y, Ideguchi T, Goda K.

Opt Lett. 2017 Nov 1;42(21):4335-4338. doi: 10.1364/OL.42.004335.


Contact area between femoral tunnel and interference screw in anatomic rectangular tunnel ACL reconstruction: a comparison of outside-in and trans-portal inside-out techniques.

Hiramatsu K, Mae T, Tachibana Y, Nakagawa S, Shino K.

Knee Surg Sports Traumatol Arthrosc. 2018 Feb;26(2):519-525. doi: 10.1007/s00167-017-4732-2. Epub 2017 Oct 20.


Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer.

Matsuzaki S, Serada S, Hiramatsu K, Nojima S, Matsuzaki S, Ueda Y, Ohkawara T, Mabuchi S, Fujimoto M, Morii E, Yoshino K, Kimura T, Naka T.

Int J Cancer. 2018 Mar 1;142(5):1056-1066. doi: 10.1002/ijc.31124. Epub 2017 Oct 31.


SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma.

Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T.

Cancer Res. 2017 Dec 15;77(24):6975-6986. doi: 10.1158/0008-5472.CAN-17-1525. Epub 2017 Oct 17.


Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.

Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S.

J Immunol. 2017 Nov 15;199(10):3516-3524. doi: 10.4049/jimmunol.1700248. Epub 2017 Oct 11.


CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells.

Uno N, Hiramatsu K, Uno K, Komoto S, Kazuki Y, Oshimura M.

Sci Rep. 2017 Oct 6;7(1):12739. doi: 10.1038/s41598-017-10418-7.


Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.

Nosaka T, Naito T, Hiramatsu K, Ohtani M, Nemoto T, Marusawa H, Ma N, Hiraku Y, Kawanishi S, Yamashita T, Kaneko S, Nakamoto Y.

PLoS One. 2017 Oct 2;12(10):e0185442. doi: 10.1371/journal.pone.0185442. eCollection 2017.


Comparison between dexmedetomidine and midazolam as a sedation agent with local anesthesia in inguinal hernia repair: randomized controlled trial.

Mishina T, Aiba T, Hiramatsu K, Shibata Y, Yoshihara M, Aoba T, Yamaguchi N, Kato T.

Hernia. 2018 Jun;22(3):471-478. doi: 10.1007/s10029-017-1680-1. Epub 2017 Sep 30.


Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice.

Shinohara T, Kazuki K, Ogonuki N, Morimoto H, Matoba S, Hiramatsu K, Honma K, Suzuki T, Hara T, Ogura A, Oshimura M, Kanatsu-Shinohara M, Kazuki Y.

Stem Cell Reports. 2017 Oct 10;9(4):1180-1191. doi: 10.1016/j.stemcr.2017.08.012. Epub 2017 Sep 21.


Sensitive and selective quantification of total and free itraconazole and hydroxyitraconazole in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry.

Suzuki Y, Tanaka R, Oyama N, Nonoshita K, Hashinaga K, Umeki K, Sato Y, Hiramatsu K, Kadota JI, Itoh H.

Clin Biochem. 2017 Dec;50(18):1228-1236. doi: 10.1016/j.clinbiochem.2017.09.011. Epub 2017 Sep 18.


Long-term survival of a patient with advanced gastric cancer with paraaortic lymph node metastasis who attained pathological complete response after S-1/CDDP chemotherapy: A case report.

Ushida Y, Hiramatsu K, Saeki S, Amemiya T, Goto H, Arai T.

Int J Surg Case Rep. 2017;39:260-263. doi: 10.1016/j.ijscr.2017.08.016. Epub 2017 Aug 18.


First report of sasX-positive methicillin-resistant Staphylococcus aureus in Japan.

Nakaminami H, Ito T, Han X, Ito A, Matsuo M, Uehara Y, Baba T, Hiramatsu K, Noguchi N.

FEMS Microbiol Lett. 2017 Sep 1;364(16). doi: 10.1093/femsle/fnx171.


Identification and structural characterization of LytU, a unique peptidoglycan endopeptidase from the lysostaphin family.

Raulinaitis V, Tossavainen H, Aitio O, Juuti JT, Hiramatsu K, Kontinen V, Permi P.

Sci Rep. 2017 Jul 20;7(1):6020. doi: 10.1038/s41598-017-06135-w.


Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility.

Yanagihara K, Watanabe A, Aoki N, Matsumoto T, Yoshida M, Sato J, Wakamura T, Sunakawa K, Kadota J, Kiyota H, Iwata S, Kaku M, Hanaki H, Ohsaki Y, Fujiuchi S, Takahashi M, Takeuchi K, Takeda H, Ikeda H, Miki M, Nakanowatari S, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Morino E, Takasaki J, Mezaki K, Chonabayashi N, Tanaka C, Sugiura H, Goto H, Saraya T, Kurai D, Katono Y, Inose R, Niki Y, Takuma T, Kudo M, Ehara S, Sato Y, Tsukada H, Watabe N, Honma Y, Mikamo H, Yamagishi Y, Nakamura A, Ohashi M, Seki M, Hamaguchi S, Toyokawa M, Fujikawa Y, Mitsuno N, Ukimura A, Miyara T, Nakamura T, Mikasa K, Kasahara K, Ui K, Fukuda S, Nakamura A, Morimura M, Yamashita M, Takesue Y, Wada Y, Sugimoto K, Kusano N, Nose M, Mihara E, Kuwabara M, Doi M, Watanabe Y, Tokuyasu H, Hino S, Negayama K, Mukae H, Kawanami T, Ota T, Fujita M, Honda J, Hiramatsu K, Aoki Y, Fukuoka M, Magarifuchi H, Nagasawa Z, Kaku N, Fujita J, Higa F, Tateyama M.

J Infect Chemother. 2017 Sep;23(9):587-597. doi: 10.1016/j.jiac.2017.05.010. Epub 2017 Jun 29.


A case of protein-losing enteropathy caused by sclerosing mesenteritis diagnosed with capsule endoscopy and double-balloon endoscopy.

Saito Y, Hiramatsu K, Nosaka T, Ozaki Y, Takahashi K, Naito T, Ofuji K, Matsuda H, Ohtani M, Nemoto T, Imamura Y, Nakamoto Y.

Clin J Gastroenterol. 2017 Aug;10(4):351-356. doi: 10.1007/s12328-017-0755-y. Epub 2017 Jun 29.


Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma.

Harada E, Serada S, Fujimoto M, Takahashi Y, Takahashi T, Hara H, Nakatsuka R, Sugase T, Nishigaki T, Saito Y, Hiramatsu K, Nojima S, Mitsuo R, Ohkawara T, Morii E, Mori M, Doki Y, Kaneda Y, Naka T.

Oncotarget. 2017 Apr 11;8(15):24741-24752. doi: 10.18632/oncotarget.15799.


Phase II trial of neoadjuvant chemotherapy with S-1 and oxaliplatin plus bevacizumab for colorectal liver metastasis (N-SOG 05 trial).

Mukai T, Uehara K, Goto H, Hiramatsu K, Kobayashi S, Sakamoto E, Maeda A, Takeuchi E, Okada Y, Ebata T, Nagino M; Nagoya Surgical Oncology Group.

Jpn J Clin Oncol. 2017 Jul 1;47(7):597-603. doi: 10.1093/jjco/hyx048.


Sewing needles in the abdominal cavity assumed to have been ingested and to have penetrated the GI tract 40 years ago: A case report.

Yamaguchi N, Hiramatsu K, Shibata Y, Yoshihara M, Aoba T, Kamiya T, Koike Y, Fujita T, Maeda C, Ito K, Kanbara Y, Nishimura M, Kobayashi R, Dei H, Takimoto A, Nonaka Y, Kato T.

Asian J Endosc Surg. 2017 Nov;10(4):446-449. doi: 10.1111/ases.12375. Epub 2017 Mar 28.


Identification of novel variants in HLA class II region related to HLA DPB1 expression and disease progression in patients with chronic hepatitis C.

Hiramatsu K, Matsuda H, Nemoto T, Nosaka T, Saito Y, Naito T, Takahashi K, Ofuji K, Ohtani M, Suto H, Yasuda T, Hida Y, Kimura H, Soya Y, Nakamoto Y.

J Med Virol. 2017 Sep;89(9):1574-1583. doi: 10.1002/jmv.24814. Epub 2017 May 2.


Potential Impact of Rapid Blood Culture Testing for Gram-Positive Bacteremia in Japan with the Verigene Gram-Positive Blood Culture Test.

Kikuchi K, Matsuda M, Iguchi S, Mizutani T, Hiramatsu K, Tega-Ishii M, Sansaka K, Negishi K, Shimada K, Umemura J, Notake S, Yanagisawa H, Takahashi H, Yabusaki R, Araoka H, Yoneyama A.

Can J Infect Dis Med Microbiol. 2017;2017:4896791. doi: 10.1155/2017/4896791. Epub 2017 Feb 20.


Can laparoscopic appendectomy be safely performed by surgical residents without prior experience of open appendectomy?

Hiramatsu K, Toda S, Tate T, Fukui Y, Tomizawa K, Hanaoka Y, Moriyama J, Matoba S, Kuroyanagi H.

Asian J Surg. 2018 May;41(3):270-273. doi: 10.1016/j.asjsur.2016.12.003. Epub 2017 Jan 27.


Glucagon-like peptide-1 is co-localized with neurotensin in the chicken ileum.

Nishimura K, Hiramatsu K, Watanabe T, Kita K.

Cell Tissue Res. 2017 May;368(2):277-286. doi: 10.1007/s00441-016-2561-0. Epub 2017 Jan 20.


Poorly differentiated adenocarcinoma with signet-ring cells in duodenal papilla: a case report.

Ushida Y, Hiramatsu K, Saeki S, Amemiya T, Goto H, Arai T.

Surg Case Rep. 2017 Dec;3(1):14. doi: 10.1186/s40792-017-0287-1. Epub 2017 Jan 17.


In vitro antibacterial activity of α-methoxyimino acylide derivatives against macrolide-resistant pathogens and mutation analysis in 23S rRNA.

Sugiyama H, Yoshida I, Ueki M, Tanabe K, Manaka A, Hiramatsu K.

J Antibiot (Tokyo). 2017 Mar;70(3):264-271. doi: 10.1038/ja.2016.148. Epub 2017 Jan 11.


Activated ADI pathway: the initiator of intermediate vancomycin resistance in Staphylococcus aureus.

Tan XE, Neoh HM, Looi ML, Chin SF, Cui L, Hiramatsu K, Hussin S, Jamal R.

Can J Microbiol. 2017 Mar;63(3):260-264. doi: 10.1139/cjm-2016-0439. Epub 2016 Oct 19.


A Retrospective Analysis of Risk Factors for Linezolid-Associated Hyponatremia in Japanese Patients.

Tanaka R, Suzuki Y, Takumi Y, Iwao M, Sato Y, Hashinaga K, Hiramatsu K, Kadota JI, Itoh H.

Biol Pharm Bull. 2016;39(12):1968-1973.


Changes in Intestinal Microbiota Following Combination Therapy with Fecal Microbial Transplantation and Antibiotics for Ulcerative Colitis.

Ishikawa D, Sasaki T, Osada T, Kuwahara-Arai K, Haga K, Shibuya T, Hiramatsu K, Watanabe S.

Inflamm Bowel Dis. 2017 Jan;23(1):116-125. doi: 10.1097/MIB.0000000000000975.


In Vitro Tolerance of Drug-Naive Staphylococcus aureus Strain FDA209P to Vancomycin.

Singh M, Matsuo M, Sasaki T, Morimoto Y, Hishinuma T, Hiramatsu K.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01154-16. doi: 10.1128/AAC.01154-16. Print 2017 Feb.


Effects of suture site or penetration depth on anchor location in all-inside meniscal repair.

Uchida R, Mae T, Hiramatsu K, Iuchi R, Kinugasa K, Shino K, Yoshikawa H, Nakata K.

Knee. 2016 Dec;23(6):1024-1028. doi: 10.1016/j.knee.2016.06.012. Epub 2016 Oct 29.


A case of cutaneous tuberculosis: a clue to diagnosing miliary tuberculosis.

Shimada H, Nakamura Y, Saito-Shono T, Ishikawa K, Nishida H, Yokoyama S, Hiramatsu K, Nakanaga K, Ishii N, Takikawa S, Sakai T, Takeo N, Fujiwara S, Hatano Y.

Eur J Dermatol. 2016 Oct 1;26(5):510-511. No abstract available.


Relation between premenstrual syndrome and equol-production status.

Takeda T, Ueno T, Uchiyama S, Hiramatsu K, Shiina M.

J Obstet Gynaecol Res. 2016 Nov;42(11):1575-1580. doi: 10.1111/jog.13073. Epub 2016 Jun 29.


Effect of Methotrexate Plus Adalimumab on the Achievement of Rheumatoid Arthritis Therapeutic Goals: Post Hoc Analysis of Japanese Patients (MELODY Study).

Koike T, Harigai M, Ishiguro N, Inokuma S, Takei S, Takeuchi T, Yamanaka H, Takasaki Y, Mimori T, Hiramatsu K, Komatsu S, Tanaka Y.

Rheumatol Ther. 2016 Jun;3(1):129-141. doi: 10.1007/s40744-015-0023-x. Epub 2015 Dec 22.


Ring-Mesh Model of Proteoglycan Glycosaminoglycan Chains in Tendon based on Three-dimensional Reconstruction by Focused Ion Beam Scanning Electron Microscopy.

Watanabe T, Kametani K, Koyama YI, Suzuki D, Imamura Y, Takehana K, Hiramatsu K.

J Biol Chem. 2016 Nov 4;291(45):23704-23708. Epub 2016 Sep 13.


Activity of tick antimicrobial peptide from Ixodes persulcatus (persulcatusin) against cell membranes of drug-resistant Staphylococcus aureus.

Miyoshi N, Isogai E, Hiramatsu K, Sasaki T.

J Antibiot (Tokyo). 2017 Feb;70(2):142-146. doi: 10.1038/ja.2016.101. Epub 2016 Aug 17.


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