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Items: 12

1.

INTESTINAL TOXICITY IN RATS FOLLOWING ADMINISTRATION OF CDK4/6 INHIBITORS IS INDEPENDENT OF PRIMARY PHARMACOLOGY.

Thibault S, Hu W, Hirakawa B, Kalabat D, Franks T, Sung T, Khoh-Reiter S, Lu S, Finkelstein M, Jessen B, Sacaan AI.

Mol Cancer Ther. 2018 Nov 6. pii: molcanther.0734.2018. doi: 10.1158/1535-7163.MCT-18-0734. [Epub ahead of print]

PMID:
30401694
2.

miR-208a as a biomarker of isoproterenol-induced cardiac injury in Sod2+/- and C57BL/6J wild-type mice.

Liu L, Aguirre SA, Evering WE, Hirakawa BP, May JR, Palacio K, Wang J, Zhang Y, Stevens GJ.

Toxicol Pathol. 2014 Oct;42(7):1117-29. doi: 10.1177/0192623314525684. Epub 2014 Apr 8.

PMID:
24713317
3.

Responses of the steroidogenic pathway from exposure to methyl-tert-butyl ether and tert-butanol.

de Peyster A, Mihaich E, Kim DH, Elyea WA, Nemec MJ, Hirakawa BP, Leggieri SE.

Toxicology. 2014 May 7;319:23-37. doi: 10.1016/j.tox.2014.01.015. Epub 2014 Feb 19.

4.

RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801.

Rittenhouse KD, Johnson TR, Vicini P, Hirakawa B, Kalabat D, Yang AH, Huang W, Basile AS.

Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1232-40. doi: 10.1167/iovs.13-13449.

PMID:
24458146
5.

Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction.

Yanochko GM, Vitsky A, Heyen JR, Hirakawa B, Lam JL, May J, Nichols T, Sace F, Trajkovic D, Blasi E.

Toxicol Sci. 2013 Oct;135(2):451-64. doi: 10.1093/toxsci/kft161. Epub 2013 Jul 20.

PMID:
23872713
6.

A tyrosine kinase inhibitor-induced myocardial degeneration in rats through off-target phosphodiesterase inhibition.

Hu W, Hirakawa B, Jessen B, Lee M, Aguirre S.

J Appl Toxicol. 2012 Dec;32(12):1008-20. doi: 10.1002/jat.2801. Epub 2012 Aug 31.

PMID:
22936366
7.

Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.

Taub ME, Mease K, Sane RS, Watson CA, Chen L, Ellens H, Hirakawa B, Reyner EL, Jani M, Lee CA.

Drug Metab Dispos. 2011 Nov;39(11):2093-102. doi: 10.1124/dmd.111.040816. Epub 2011 Aug 17.

8.

Antisense inhibition of S6 kinase 1 produces improved glucose tolerance and is well tolerated for 4 weeks of treatment in rats.

Younis HS, Hirakawa B, Scott W, Tran P, Bhat G, Affolter T, Chapman J, Heyen J, Chakravarty K, Alton G.

Pharmacology. 2011;87(1-2):11-23. doi: 10.1159/000322526. Epub 2010 Dec 20.

PMID:
21178385
9.

Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells.

Will Y, Dykens JA, Nadanaciva S, Hirakawa B, Jamieson J, Marroquin LD, Hynes J, Patyna S, Jessen BA.

Toxicol Sci. 2008 Nov;106(1):153-61. doi: 10.1093/toxsci/kfn157. Epub 2008 Jul 29.

PMID:
18664550
10.

First-in-class pan caspase inhibitor developed for the treatment of liver disease.

Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD, Fritz LC, Gladstone P, Groessl T, Gu X, Herrmann J, Hirakawa BP, Hoglen NC, Jahangiri KG, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs J, McQuiston J, Meduna SP, Nalley K, Robinson ED, Sayers RO, Sebring K, Spada AP, Ternansky RJ, Tomaselli KJ, Ullman BR, Valentino KL, Weeks S, Winn D, Wu JC, Yeo P, Zhang CZ.

J Med Chem. 2005 Nov 3;48(22):6779-82.

PMID:
16250635
11.

Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor.

Hoglen NC, Chen LS, Fisher CD, Hirakawa BP, Groessl T, Contreras PC.

J Pharmacol Exp Ther. 2004 May;309(2):634-40. Epub 2004 Jan 23.

12.

Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.

Hoglen NC, Hirakawa BP, Fisher CD, Weeks S, Srinivasan A, Wong AM, Valentino KL, Tomaselli KJ, Bai X, Karanewsky DS, Contreras PC.

J Pharmacol Exp Ther. 2001 May;297(2):811-8.

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