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Items: 1 to 50 of 219

1.

Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.

Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A.

Life Sci Alliance. 2019 Jul 22;2(4). pii: e201900425. doi: 10.26508/lsa.201900425. Print 2019 Aug.

2.

Parathyroid Hormone Shifts Cell Fate of a Leptin Receptor-Marked Stromal Population from Adipogenic to Osteoblastic Lineage.

Yang M, Arai A, Udagawa N, Zhao L, Nishida D, Murakami K, Hiraga T, Takao-Kawabata R, Matsuo K, Komori T, Kobayashi Y, Takahashi N, Isogai Y, Ishizuya T, Yamaguchi A, Mizoguchi T.

J Bone Miner Res. 2019 Jun 7. doi: 10.1002/jbmr.3811. [Epub ahead of print]

PMID:
31173642
3.

Bone metastasis: Interaction between cancer cells and bone microenvironment.

Hiraga T.

J Oral Biosci. 2019 Jun;61(2):95-98. doi: 10.1016/j.job.2019.02.002. Epub 2019 Mar 5. Review.

PMID:
31109867
4.

Hypoxic Microenvironment and Metastatic Bone Disease.

Hiraga T.

Int J Mol Sci. 2018 Nov 9;19(11). pii: E3523. doi: 10.3390/ijms19113523. Review.

5.

The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio).

Chen X, Fang M, Chernick M, Wang F, Yang J, Yu Y, Zheng N, Teraoka H, Nanba S, Hiraga T, Hinton DE, Dong W.

Gen Comp Endocrinol. 2019 Jan 15;271:73-81. doi: 10.1016/j.ygcen.2018.11.003. Epub 2018 Nov 5.

PMID:
30408483
6.

Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring.

Matsumoto S, Hiraga T, Hayashi Y, Yoshikawa Y, Tsuda C, Araki M, Neya M, Shima F, Kataoka T.

Biochemistry. 2018 Sep 11;57(36):5350-5358. doi: 10.1021/acs.biochem.8b00680. Epub 2018 Aug 30.

PMID:
30141910
7.

Establishment and characterization of a C57BL/6 mouse model of bone metastasis of breast cancer.

Hiraga T, Ninomiya T.

J Bone Miner Metab. 2019 Mar;37(2):235-242. doi: 10.1007/s00774-018-0927-y. Epub 2018 Apr 17.

PMID:
29667006
8.

Steroid pulse therapy in patients with encephalopathy associated with severe fever with thrombocytopenia syndrome.

Nakamura S, Azuma M, Maruhashi T, Sogabe K, Sumitani R, Uemura M, Iwasa M, Fujii S, Miki H, Kagawa K, Hiraga T, Kondo N, Fujita H, Mahara F, Abe M.

J Infect Chemother. 2018 May;24(5):389-392. doi: 10.1016/j.jiac.2017.11.004. Epub 2018 Feb 7.

PMID:
29428565
9.

Expression and localization of CRAMP in rat tooth germ and during reparative dentin formation.

Horibe K, Hosoya A, Hiraga T, Nakamura H.

Clin Oral Investig. 2018 Sep;22(7):2559-2566. doi: 10.1007/s00784-018-2353-x. Epub 2018 Feb 2.

PMID:
29396644
10.

Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy.

Yang M, Arai A, Udagawa N, Hiraga T, Lijuan Z, Ito S, Komori T, Moriishi T, Matsuo K, Shimoda K, Zahalka AH, Kobayashi Y, Takahashi N, Mizoguchi T.

Sci Rep. 2017 Jul 10;7(1):4928. doi: 10.1038/s41598-017-05401-1.

11.

Comparison of Different Disease-Specific Health-Related Quality of Life Measurements in Patients with Long-Term Noninvasive Ventilation.

Oga T, Taniguchi H, Kita H, Tsuboi T, Tomii K, Ando M, Kojima E, Tomioka H, Taguchi Y, Kaji Y, Maekura R, Hiraga T, Sakai N, Kimura T, Mishima M, Windisch W, Chin K.

Can Respir J. 2017;2017:8295079. doi: 10.1155/2017/8295079. Epub 2017 May 15.

12.

Decreased sensory nerve excitation and bone pain associated with mouse Lewis lung cancer in TRPV1-deficient mice.

Wakabayashi H, Wakisaka S, Hiraga T, Hata K, Nishimura R, Tominaga M, Yoneda T.

J Bone Miner Metab. 2018 May;36(3):274-285. doi: 10.1007/s00774-017-0842-7. Epub 2017 May 17.

13.

Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs.

Kozlowska AK, Topchyan P, Kaur K, Tseng HC, Teruel A, Hiraga T, Jewett A.

J Cancer. 2017 Feb 11;8(4):537-554. doi: 10.7150/jca.15989. eCollection 2017.

14.

Validation of the Japanese Severe Respiratory Insufficiency Questionnaire in hypercapnic patients with noninvasive ventilation.

Oga T, Taniguchi H, Kita H, Tsuboi T, Tomii K, Ando M, Kojima E, Tomioka H, Taguchi Y, Kaji Y, Maekura R, Hiraga T, Sakai N, Kimura T, Mishima M, Windisch W, Chin K.

Respir Investig. 2017 Mar;55(2):166-172. doi: 10.1016/j.resinv.2016.12.003. Epub 2017 Feb 6.

PMID:
28274533
15.

Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model.

Hiraga T, Nakamura H.

Oncol Lett. 2016 Oct;12(4):2962-2969. Epub 2016 Aug 10.

16.

Characterization of feline cytochrome P450 2B6.

Okamatsu G, Komatsu T, Ono Y, Inoue H, Uchide T, Onaga T, Endoh D, Kitazawa T, Hiraga T, Uno Y, Teraoka H.

Xenobiotica. 2017 Feb;47(2):93-102. doi: 10.3109/00498254.2016.1145754. Epub 2016 Mar 9.

PMID:
26956662
17.

Targeted Agents in Preclinical and Early Clinical Development for the Treatment of Cancer Bone Metastases.

Hiraga T.

Expert Opin Investig Drugs. 2016;25(3):319-34. doi: 10.1517/13543784.2016.1142972. Epub 2016 Feb 6. Review.

PMID:
26778342
18.

Analysis of the relationship between health status and mortality in hypercapnic patients with noninvasive ventilation.

Oga T, Taniguchi H, Kita H, Tsuboi T, Tomii K, Ando M, Kojima E, Tomioka H, Taguchi Y, Kaji Y, Maekura R, Hiraga T, Sakai N, Kimura T, Mishima M, Chin K.

Clin Respir J. 2017 Nov;11(6):772-780. doi: 10.1111/crj.12415. Epub 2015 Dec 28.

PMID:
26605994
19.

EpCAM expression in breast cancer cells is associated with enhanced bone metastasis formation.

Hiraga T, Ito S, Nakamura H.

Int J Cancer. 2016 Apr 1;138(7):1698-708. doi: 10.1002/ijc.29921. Epub 2015 Nov 23.

20.

Accumulation properties of inorganic mercury and organic mercury in the red-crowned crane Grus japonensis in east Hokkaido, Japan.

Teraoka H, Okamoto E, Kudo M, Nakayama SM, Ikenaka Y, Ishizuka M, Endo T, Kitazawa T, Hiraga T.

Ecotoxicol Environ Saf. 2015 Dec;122:557-64. doi: 10.1016/j.ecoenv.2015.09.025. Epub 2015 Sep 30.

PMID:
26432029
21.

Personalized pulmonary rehabilitation and occupational therapy based on cardiopulmonary exercise testing for patients with advanced chronic obstructive pulmonary disease.

Maekura R, Hiraga T, Miki K, Kitada S, Miki M, Yoshimura K, Yamamoto H, Kawabe T, Mori M.

Int J Chron Obstruct Pulmon Dis. 2015 Sep 3;10:1787-800. doi: 10.2147/COPD.S86455. eCollection 2015.

22.

Correlation of ghrelin concentration and ghrelin, ghrelin-O-acetyltransferase (GOAT) and growth hormone secretagogue receptor 1a mRNAs expression in the proventriculus and brain of the growing chicken.

Kitazawa T, Hiraga T, Teraoka H, Yaosaka N, Kaiya H.

Peptides. 2015 Jan;63:134-42. doi: 10.1016/j.peptides.2014.11.006. Epub 2014 Nov 27.

PMID:
25435492
23.

[Molecular mechanisms of bone cancer pain].

Hiraga T.

Clin Calcium. 2014 Aug;24(8):1185-91. doi: CliCa140811851191. Review. Japanese.

PMID:
25065870
24.

Identification of three exercise-induced mortality risk factors in patients with COPD.

Yoshimura K, Maekura R, Hiraga T, Miki K, Kitada S, Miki M, Tateishi Y, Mori M.

COPD. 2014 Dec;11(6):615-26. doi: 10.3109/15412555.2014.898038. Epub 2014 Jun 10.

PMID:
24914923
25.

Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish.

Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson RE, Stegeman JJ, Kitazawa T, Hiraga T, Kubota A.

Aquat Toxicol. 2014 Sep;154:19-26. doi: 10.1016/j.aquatox.2014.04.025. Epub 2014 May 2.

26.

Vertebral formula in red-crowned crane (Grus japonensis) and hooded crane (Grus monacha).

Hiraga T, Sakamoto H, Nishikawa S, Muneuchi I, Ueda H, Inoue M, Shimura R, Uebayashi A, Yasuda N, Momose K, Masatomi H, Teraoka H.

J Vet Med Sci. 2014 Apr;76(4):503-8. Epub 2013 Dec 11.

27.

Olivine crystals align during diffusion creep of Earth's upper mantle.

Miyazaki T, Sueyoshi K, Hiraga T.

Nature. 2013 Oct 17;502(7471):321-6. doi: 10.1038/nature12570.

PMID:
24132289
28.

Differences in physiological response to exercise in patients with different COPD severity.

Maekura R, Hiraga T, Miki K, Kitada S, Yoshimura K, Miki M, Tateishi Y.

Respir Care. 2014 Feb;59(2):252-62. doi: 10.4187/respcare.02201. Epub 2013 Jul 2.

29.

Effects of ghrelin treatment on exercise capacity in underweight COPD patients: a substudy of a multicenter, randomized, double-blind, placebo-controlled trial of ghrelin treatment.

Miki K, Maekura R, Nagaya N, Kitada S, Miki M, Yoshimura K, Tateishi Y, Motone M, Hiraga T, Mori M, Kangawa K.

BMC Pulm Med. 2013 Jun 10;13:37. doi: 10.1186/1471-2466-13-37.

30.

Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production.

Hiraga T, Ito S, Nakamura H.

Cancer Res. 2013 Jul 1;73(13):4112-22. doi: 10.1158/0008-5472.CAN-12-3801. Epub 2013 Apr 30.

31.

Origin of three Red-crowned Cranes Grus japonensis found in northeast Honshu and west Hokkaido, Japan, from 2008 to 2012.

Miura Y, Shiraishi J, Shiomi A, Kitazawa T, Hiraga T, Matsumoto F, Teraoka H, Masatomi H.

J Vet Med Sci. 2013;75(9):1241-4. Epub 2013 Apr 26.

32.

Physical body parameters of red-crowned cranes Grus japonensis by sex and life stage in eastern Hokkaido, Japan.

Inoue M, Shimura R, Uebayashi A, Ikoma S, Iima H, Sumiyoshi T, Teraoka H, Makita K, Hiraga T, Momose K, Masatomi H.

J Vet Med Sci. 2013;75(8):1055-60. Epub 2013 Apr 15.

33.

Enhanced bone-forming activity of side population cells in the periodontal ligament.

Ninomiya T, Hiraga T, Hosoya A, Ohnuma K, Ito Y, Takahashi M, Ito S, Asashima M, Nakamura H.

Cell Transplant. 2014 Apr;23(6):691-701. doi: 10.3727/096368913X663587. Epub 2013 Feb 5.

PMID:
23394738
34.

Localization of SUMOylation factors and Osterix in odontoblast lineage cells during dentin formation and regeneration.

Hosoya A, Yukita A, Ninomiya T, Hiraga T, Yoshiba K, Yoshiba N, Kasahara E, Nakamura H.

Histochem Cell Biol. 2013 Aug;140(2):201-11. doi: 10.1007/s00418-013-1076-y. Epub 2013 Jan 25.

PMID:
23354182
35.

Large-scale survey of mitochondrial D-loop of the red-crowned crane Grus japonensis in Hokkaido, Japan by convenient genotyping method.

Miura Y, Shiomi A, Shiraishi J, Makita K, Asakawa M, Kitazawa T, Hiraga T, Momose Y, Momose K, Masatomi H, Teraoka H.

J Vet Med Sci. 2013 Jan 31;75(1):43-7. Epub 2012 Aug 28.

36.

Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases.

Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y, Yoshikawa H, Rosen CJ, Mundy GR, Yoneda T.

Cancer Res. 2012 Aug 15;72(16):4238-49. Epub 2012 Jun 27.

37.

Immunohistochemical and functional studies for M₃ muscarinic receptors and cyclo-oxygenase-2 expressed in the mouse atrium.

Harada N, Ochi K, Yaosaka N, Teraoka H, Hiraga T, Iwanaga T, Unno T, Komori S, Yamada M, Kitazawa T.

Auton Autacoid Pharmacol. 2012 Oct;32(3 Pt 4):41-52. doi: 10.1111/j.1474-8673.2012.00472.x. Epub 2012 Jun 22.

PMID:
22726658
38.

Effects of tiotropium on sympathetic activation during exercise in stable chronic obstructive pulmonary disease patients.

Yoshimura K, Maekura R, Hiraga T, Kitada S, Miki K, Miki M, Tateishi Y.

Int J Chron Obstruct Pulmon Dis. 2012;7:109-17. doi: 10.2147/COPD.S28677. Epub 2012 May 2.

39.

Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial.

Miki K, Maekura R, Nagaya N, Nakazato M, Kimura H, Murakami S, Ohnishi S, Hiraga T, Miki M, Kitada S, Yoshimura K, Tateishi Y, Arimura Y, Matsumoto N, Yoshikawa M, Yamahara K, Kangawa K.

PLoS One. 2012;7(5):e35708. doi: 10.1371/journal.pone.0035708. Epub 2012 May 1.

40.

Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells.

Hosoya A, Hiraga T, Ninomiya T, Yukita A, Yoshiba K, Yoshiba N, Takahashi M, Ito S, Nakamura H.

Histochem Cell Biol. 2012 Jun;137(6):733-42. doi: 10.1007/s00418-012-0928-1. Epub 2012 Feb 12.

PMID:
22327831
41.

Changes of mercury contamination in red-crowned cranes, Grus japonensis, in East Hokkaido, Japan.

Teraoka H, Tagami Y, Kudo M, Miura Y, Okamoto E, Matsumoto F, Koga K, Uebayashi A, Shimura R, Inoue M, Momose K, Masatomi H, Kitazawa T, Hiraga T, Subramanian A.

Arch Environ Contam Toxicol. 2012 Jul;63(1):153-60. doi: 10.1007/s00244-011-9742-3. Epub 2011 Dec 23.

PMID:
22193864
42.

1α,25-Dihydroxyvitamin D3 inhibits osteoblastic differentiation of mouse periodontal fibroblasts.

Chen YC, Ninomiya T, Hosoya A, Hiraga T, Miyazawa H, Nakamura H.

Arch Oral Biol. 2012 May;57(5):453-9. doi: 10.1016/j.archoralbio.2011.10.005. Epub 2011 Oct 29.

PMID:
22041016
43.

Effects of oxygen on exertional dyspnoea and exercise performance in patients with chronic obstructive pulmonary disease.

Miki K, Maekura R, Hiraga T, Kitada S, Miki M, Yoshimura K, Tateishi Y.

Respirology. 2012 Jan;17(1):149-54. doi: 10.1111/j.1440-1843.2011.02086.x.

PMID:
22008208
44.

Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig.

Kitazawa T, Nakamura T, Saeki A, Teraoka H, Hiraga T, Kaiya H.

Peptides. 2011 Sep;32(9):1876-86. doi: 10.1016/j.peptides.2011.07.026. Epub 2011 Aug 6.

PMID:
21843569
45.

Expression of two novel cytochrome P450 3A131 and 3A132 in liver and small intestine of domestic cats.

Honda K, Komatsu T, Koyama F, Kubota A, Kawakami K, Asakura H, Uno Y, Kitazawa T, Hiraga T, Teraoka H.

J Vet Med Sci. 2011 Nov;73(11):1489-92. Epub 2011 Jun 28.

46.

Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2.

Kubota A, Stegeman JJ, Woodin BR, Iwanaga T, Harano R, Peterson RE, Hiraga T, Teraoka H.

Toxicol Appl Pharmacol. 2011 Jun 15;253(3):244-52. doi: 10.1016/j.taap.2011.03.025. Epub 2011 Apr 12.

47.

Mantle superplasticity and its self-made demise.

Hiraga T, Miyazaki T, Tasaka M, Yoshida H.

Nature. 2010 Dec 23;468(7327):1091-4. doi: 10.1038/nature09685.

PMID:
21179165
48.

[Susceptibility to rifabutin and novel fluoroquinolones in Mycobacterium avium complex isolates from patients with sputum culture-positive pulmonary disease who are undergoing standard chemotherapy].

Tateishi Y, Motone M, Yoshimura K, Miki M, Miki K, Kitada S, Hashimoto H, Hiraga T, Maekura R.

Nihon Kokyuki Gakkai Zasshi. 2010 Nov;48(11):797-802. Japanese.

PMID:
21141056
50.

Prostaglandin E(2) receptor EP(4)-selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation.

Ninomiya T, Hosoya A, Hiraga T, Koide M, Yamaguchi K, Oida H, Arai Y, Sahara N, Nakamura H, Ozawa H.

Eur J Pharmacol. 2011 Jan 10;650(1):396-402. doi: 10.1016/j.ejphar.2010.10.021. Epub 2010 Oct 20.

PMID:
20969852

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