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Items: 1 to 50 of 343

1.

Disseminated cutaneous Mycobacterium avium complex infection invading the sternum and cervical vertebra.

Sakakibara M, Takehana A, Nakashima C, Shimoyama H, Hirabayashi M, Kuwano Y.

Eur J Dermatol. 2020 Feb 6. doi: 10.1684/ejd.2019.3686. [Epub ahead of print] No abstract available.

PMID:
32031534
2.

Silk fibroin sheet multilayer suitable for vitrification of in vitro-matured bovine oocytes.

Nakayama K, Chinen S, Teshima J, Tamada Y, Hirabayashi M, Hochi S.

Theriogenology. 2020 Mar 15;145:109-114. doi: 10.1016/j.theriogenology.2020.01.052. Epub 2020 Jan 27.

PMID:
32014616
3.

Germline development in rat revealed by visualization and deletion of Prdm14.

Kobayashi T, Kobayashi H, Goto T, Takashima T, Oikawa M, Ikeda H, Terada R, Yoshida F, Sanbo M, Nakauchi H, Kurimoto K, Hirabayashi M.

Development. 2020 Feb 21;147(4). pii: dev183798. doi: 10.1242/dev.183798.

PMID:
32001439
4.

Serum delta-like 4 levels: A possible association with interstitial lung disease in systemic sclerosis.

Fukui Y, Miyagawa T, Toyama S, Omatsu J, Hirabayashi M, Nakamura K, Yoshizaki A, Sato S, Asano Y.

J Dermatol. 2020 Jan 26. doi: 10.1111/1346-8138.15245. [Epub ahead of print] No abstract available.

PMID:
31984546
5.

A retrospective survey on canine intracranial tumors between 2007 and 2017.

Kishimoto TE, Uchida K, Chambers JK, Kok MK, Son NV, Shiga T, Hirabayashi M, Ushio N, Nakayama H.

J Vet Med Sci. 2020 Jan 17;82(1):77-83. doi: 10.1292/jvms.19-0486. Epub 2019 Dec 4.

6.

Fli1 deficiency induces endothelial adipsin expression, contributing to the onset of pulmonary arterial hypertension in systemic sclerosis.

Miyagawa T, Taniguchi T, Saigusa R, Fukayama M, Takahashi T, Yamashita T, Hirabayashi M, Miura S, Nakamura K, Yoshizaki A, Sato S, Asano Y.

Rheumatology (Oxford). 2019 Nov 29. pii: kez517. doi: 10.1093/rheumatology/kez517. [Epub ahead of print]

PMID:
31782787
7.

Comparison Of Surgical Outcomes Between Excisional Goniotomy Using The Kahook Dual Blade And iStent Trabecular Micro-Bypass Stent In Combination With Phacoemulsification.

Lee D, King J, Thomsen S, Hirabayashi M, An J.

Clin Ophthalmol. 2019 Oct 25;13:2097-2102. doi: 10.2147/OPTH.S224109. eCollection 2019.

8.

Comparison Of Surgical Outcomes Of 360° Circumferential Trabeculotomy Versus Sectoral Excisional Goniotomy With The Kahook Dual Blade At 6 Months.

Hirabayashi MT, Lee D, King JT, Thomsen S, An JA.

Clin Ophthalmol. 2019 Oct 15;13:2017-2024. doi: 10.2147/OPTH.S208468. eCollection 2019.

9.

Corrigendum to "External validation of prognostic indices for overall survival of malignant pleural mesothelioma" [Lung Cancer 113 (November) (2017) 88-92].

Kataoka Y, Yamamoto Y, Otsuki T, Kaku S, Maehashi-Wada N, Fukuma S, Hirabayashi M, Nakano T, Fukuhara S.

Lung Cancer. 2020 Jan;139:225. doi: 10.1016/j.lungcan.2019.10.008. Epub 2019 Oct 23. No abstract available.

PMID:
31668525
10.

Effect of body-mass index on the risk of gastric cancer: A population-based cohort study in A Japanese population.

Hirabayashi M, Inoue M, Sawada N, Saito E, Abe SK, Hidaka A, Iwasaki M, Yamaji T, Shimazu T, Shibuya K, Tsugane S; JPHC Study Group.

Cancer Epidemiol. 2019 Dec;63:101622. doi: 10.1016/j.canep.2019.101622. Epub 2019 Oct 22.

PMID:
31654882
11.

Efficacy of the phosphodiesterase-4 inhibitor, apremilast, in a patient with severe alopecia areata.

Sakakibara M, Shimoyama H, Nomura M, Nakashima C, Hirabayashi M, Sei Y, Kuwano Y.

Eur J Dermatol. 2019 Aug 1;29(4):436-437. doi: 10.1684/ejd.2019.3576. No abstract available.

PMID:
31625923
12.

Nylon mesh cryodevice for bovine mature oocytes, easily removable excess vitrification solution.

Chinen S, Yamanaka T, Nakayama K, Watanabe H, Akiyama Y, Hirabayashi M, Hochi S.

Cryobiology. 2019 Oct;90:96-99. doi: 10.1016/j.cryobiol.2019.09.010. Epub 2019 Sep 21.

PMID:
31550455
13.

Reversal of Toric Intraocular Lens-corrected Corneal Astigmatism after Kahook Dual Blade Goniotomy.

Hirabayashi MT, McDaniel LM, An JA.

J Curr Glaucoma Pract. 2019 Jan-Apr;13(1):42-44. doi: 10.5005/jp-journals-10078-1243.

14.

A phase II study of low starting dose of afatinib as first-line treatment in patients with EGFR mutation-positive non-small-cell lung cancer (KTORG1402).

Yokoyama T, Yoshioka H, Fujimoto D, Demura Y, Hirano K, Kawai T, Kagami R, Washio Y, Ishida T, Kogo M, Tomii K, Okuno T, Akai M, Hirabayashi M, Nishimura T, Nakahara Y, Kim YH, Miyakoshi C, Yoshimura K, Hirai T; Kyoto Thoracic Oncology Research Group (KTORG).

Lung Cancer. 2019 Sep;135:175-180. doi: 10.1016/j.lungcan.2019.03.030. Epub 2019 Mar 28.

PMID:
31446992
15.

A Phase II Study of Cisplatin Plus Gemcitabine followed by Maintenance Gemcitabine for Advanced Squamous Non-Small-Cell Lung Cancer: Kyoto Thoracic Oncology Research Group 1302.

Ikeda S, Yoshioka H, Kaneda T, Yokoyama T, Niwa T, Sone N, Ishida T, Morita M, Tomioka H, Komaki C, Hirabayashi M, Hasegawa Y, Noguchi T, Nakano Y, Sakaguchi C, Yoshimura K, Hirai T.

Oncology. 2019;97(6):327-333. doi: 10.1159/000501967. Epub 2019 Aug 14.

PMID:
31412347
16.

Comparison of successful outcome predictors for MicroPulse® laser trabeculoplasty and selective laser trabeculoplasty at 6 months.

Hirabayashi MT, Rosenlof TL, An JA.

Clin Ophthalmol. 2019 Jun 14;13:1001-1009. doi: 10.2147/OPTH.S205977. eCollection 2019.

17.

Reduced marine phytoplankton sulphur emissions in the Southern Ocean during the past seven glacials.

Goto-Azuma K, Hirabayashi M, Motoyama H, Miyake T, Kuramoto T, Uemura R, Igarashi M, Iizuka Y, Sakurai T, Horikawa S, Suzuki K, Suzuki T, Fujita K, Kondo Y, Hattori S, Fujii Y.

Nat Commun. 2019 Jul 19;10(1):3247. doi: 10.1038/s41467-019-11128-6.

18.

Blastic natural killer cell lymphoma/leukaemia in a cat.

Hirabayashi M, Chambers JK, Sugawara M, Ohmi A, Tsujimoto H, Nakayama H, Uchida K.

JFMS Open Rep. 2019 Jul 11;5(2):2055116919863080. doi: 10.1177/2055116919863080. eCollection 2019 Jul-Dec.

19.

Pluripotent stem cell-derived organogenesis in the rat model system.

Hirabayashi M, Goto T, Hochi S.

Transgenic Res. 2019 Aug;28(3-4):287-297. doi: 10.1007/s11248-019-00161-2. Epub 2019 Jun 28. Review.

PMID:
31254209
20.

Anatomical and Surgical Evaluation of the Common Marmoset as an Animal Model in Hearing Research.

Kurihara S, Fujioka M, Hata J, Yoshida T, Hirabayashi M, Yamamoto Y, Ogawa K, Kojima H, Okano HJ.

Front Neuroanat. 2019 Jun 6;13:60. doi: 10.3389/fnana.2019.00060. eCollection 2019.

21.

Embryonic Stem Cells and Gene Manipulation in Rat.

Hirabayashi M, Takizawa A, Hochi S.

Methods Mol Biol. 2019;2018:115-130. doi: 10.1007/978-1-4939-9581-3_5.

PMID:
31228154
22.

β2 microglobulin and lactate dehydrogenase are indices of different features of Mycoplasma pneumoniae-associated community-acquired lower respiratory tract infection for severity evaluation in children.

Kusubae R, Nomura Y, Hirabayashi M, Sameshima K.

J Infect Chemother. 2019 Dec;25(12):1007-1011. doi: 10.1016/j.jiac.2019.05.029. Epub 2019 Jun 18.

PMID:
31227380
23.

Outcome of phacoemulsification combined with excisional goniotomy using the Kahook Dual Blade in severe glaucoma patients at 6 months.

Hirabayashi MT, King JT, Lee D, An JA.

Clin Ophthalmol. 2019 Apr 24;13:715-721. doi: 10.2147/OPTH.S196105. eCollection 2019.

24.

Possible association of decreased serum CXCL14 levels with digital ulcers in patients with systemic sclerosis.

Fukui Y, Miyagawa T, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Nakamura K, Yoshizaki A, Sato S, Asano Y.

J Dermatol. 2019 Jul;46(7):584-589. doi: 10.1111/1346-8138.14914. Epub 2019 May 14.

PMID:
31087594
25.

Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: A population-based cohort study in a large Japanese population: the JPHC Study.

Hirabayashi M, Inoue M, Sawada N, Saito E, Abe SK, Hidaka A, Iwasaki M, Yamaji T, Shimazu T, Tsugane S.

Sci Rep. 2019 Apr 15;9(1):6099. doi: 10.1038/s41598-019-42365-w.

26.

Supplementary cryoprotective effect of carboxylated ε-poly-l-lysine during vitrification of rat pancreatic islets.

Nakayama K, Yamanaka T, Tamada Y, Hirabayashi M, Hochi S.

Cryobiology. 2019 Jun;88:70-74. doi: 10.1016/j.cryobiol.2019.03.009. Epub 2019 Mar 25.

PMID:
30922739
27.

Hayabusa2 arrives at the carbonaceous asteroid 162173 Ryugu-A spinning top-shaped rubble pile.

Watanabe S, Hirabayashi M, Hirata N, Hirata N, Noguchi R, Shimaki Y, Ikeda H, Tatsumi E, Yoshikawa M, Kikuchi S, Yabuta H, Nakamura T, Tachibana S, Ishihara Y, Morota T, Kitazato K, Sakatani N, Matsumoto K, Wada K, Senshu H, Honda C, Michikami T, Takeuchi H, Kouyama T, Honda R, Kameda S, Fuse T, Miyamoto H, Komatsu G, Sugita S, Okada T, Namiki N, Arakawa M, Ishiguro M, Abe M, Gaskell R, Palmer E, Barnouin OS, Michel P, French AS, McMahon JW, Scheeres DJ, Abell PA, Yamamoto Y, Tanaka S, Shirai K, Matsuoka M, Yamada M, Yokota Y, Suzuki H, Yoshioka K, Cho Y, Tanaka S, Nishikawa N, Sugiyama T, Kikuchi H, Hemmi R, Yamaguchi T, Ogawa N, Ono G, Mimasu Y, Yoshikawa K, Takahashi T, Takei Y, Fujii A, Hirose C, Iwata T, Hayakawa M, Hosoda S, Mori O, Sawada H, Shimada T, Soldini S, Yano H, Tsukizaki R, Ozaki M, Iijima Y, Ogawa K, Fujimoto M, Ho TM, Moussi A, Jaumann R, Bibring JP, Krause C, Terui F, Saiki T, Nakazawa S, Tsuda Y.

Science. 2019 Apr 19;364(6437):268-272. doi: 10.1126/science.aav8032. Epub 2019 Mar 19.

PMID:
30890588
28.

The geomorphology, color, and thermal properties of Ryugu: Implications for parent-body processes.

Sugita S, Honda R, Morota T, Kameda S, Sawada H, Tatsumi E, Yamada M, Honda C, Yokota Y, Kouyama T, Sakatani N, Ogawa K, Suzuki H, Okada T, Namiki N, Tanaka S, Iijima Y, Yoshioka K, Hayakawa M, Cho Y, Matsuoka M, Hirata N, Hirata N, Miyamoto H, Domingue D, Hirabayashi M, Nakamura T, Hiroi T, Michikami T, Michel P, Ballouz RL, Barnouin OS, Ernst CM, Schröder SE, Kikuchi H, Hemmi R, Komatsu G, Fukuhara T, Taguchi M, Arai T, Senshu H, Demura H, Ogawa Y, Shimaki Y, Sekiguchi T, Müller TG, Hagermann A, Mizuno T, Noda H, Matsumoto K, Yamada R, Ishihara Y, Ikeda H, Araki H, Yamamoto K, Abe S, Yoshida F, Higuchi A, Sasaki S, Oshigami S, Tsuruta S, Asari K, Tazawa S, Shizugami M, Kimura J, Otsubo T, Yabuta H, Hasegawa S, Ishiguro M, Tachibana S, Palmer E, Gaskell R, Le Corre L, Jaumann R, Otto K, Schmitz N, Abell PA, Barucci MA, Zolensky ME, Vilas F, Thuillet F, Sugimoto C, Takaki N, Suzuki Y, Kamiyoshihara H, Okada M, Nagata K, Fujimoto M, Yoshikawa M, Yamamoto Y, Shirai K, Noguchi R, Ogawa N, Terui F, Kikuchi S, Yamaguchi T, Oki Y, Takao Y, Takeuchi H, Ono G, Mimasu Y, Yoshikawa K, Takahashi T, Takei Y, Fujii A, Hirose C, Nakazawa S, Hosoda S, Mori O, Shimada T, Soldini S, Iwata T, Abe M, Yano H, Tsukizaki R, Ozaki M, Nishiyama K, Saiki T, Watanabe S, Tsuda Y.

Science. 2019 Apr 19;364(6437):252. doi: 10.1126/science.aaw0422. Epub 2019 Mar 19.

PMID:
30890587
29.

A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis.

Saigusa R, Yamashita T, Miura S, Hirabayashi M, Nakamura K, Miyagawa T, Fukui Y, Yoshizaki A, Sato S, Asano Y.

Exp Dermatol. 2019 May;28(5):536-542. doi: 10.1111/exd.13900.

PMID:
30739341
30.

Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.

Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi S, Kobayashi T, Nakauchi H, Hirabayashi M.

Nat Commun. 2019 Feb 5;10(1):451. doi: 10.1038/s41467-019-08394-9.

31.

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4.

32.

Neonatal meningoencephalitis caused by human adenovirus species F infection.

Tamiya M, Komatsu H, Hirabayashi M, Imura M, Hoshino H.

Pediatr Int. 2019 Jan;61(1):99-101. doi: 10.1111/ped.13722. Epub 2019 Jan 10. No abstract available.

PMID:
30632227
33.

A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.

Miyagawa T, Asano Y, Saigusa R, Hirabayashi M, Yamashita T, Taniguchi T, Takahashi T, Nakamura K, Miura S, Yoshizaki A, Miyagaki T, Sato S.

J Eur Acad Dermatol Venereol. 2019 Apr;33(4):753-760. doi: 10.1111/jdv.15387. Epub 2019 Jan 1.

PMID:
30520152
34.

Thromboembolic Complications Following Tissue Plasminogen Activator Therapy in Patients of Acute Ischemic Stroke - Case Report and Possibility for Detection of Cardiac Thrombi.

Yamaguchi J, Kinoshita K, Hirabayashi M, Hori S, Furukawa M, Sakurai A.

Open Med (Wars). 2018 Nov 19;13:551-555. doi: 10.1515/med-2018-0081. eCollection 2018.

35.

Cyclophosphamide Pulse Therapy Normalizes Vascular Abnormalities in a Mouse Model of Systemic Sclerosis Vasculopathy.

Yamashita T, Asano Y, Saigusa R, Taniguchi T, Hirabayashi M, Miyagawa T, Nakamura K, Miura S, Yoshizaki A, Trojanowska M, Sato S.

J Invest Dermatol. 2019 May;139(5):1150-1160. doi: 10.1016/j.jid.2018.11.016. Epub 2018 Nov 30.

PMID:
30508546
36.

Abrupt ice-age shifts in southern westerly winds and Antarctic climate forced from the north.

Buizert C, Sigl M, Severi M, Markle BR, Wettstein JJ, McConnell JR, Pedro JB, Sodemann H, Goto-Azuma K, Kawamura K, Fujita S, Motoyama H, Hirabayashi M, Uemura R, Stenni B, Parrenin F, He F, Fudge TJ, Steig EJ.

Nature. 2018 Nov;563(7733):681-685. doi: 10.1038/s41586-018-0727-5. Epub 2018 Nov 28.

PMID:
30487614
37.

Pseudoprogression in Previously Treated Patients with Non-Small Cell Lung Cancer Who Received Nivolumab Monotherapy.

Fujimoto D, Yoshioka H, Kataoka Y, Morimoto T, Hata T, Kim YH, Tomii K, Ishida T, Hirabayashi M, Hara S, Ishitoko M, Fukuda Y, Hwang MH, Sakai N, Fukui M, Nakaji H, Morita M, Mio T, Yasuda T, Sugita T, Hirai T.

J Thorac Oncol. 2019 Mar;14(3):468-474. doi: 10.1016/j.jtho.2018.10.167. Epub 2018 Nov 20.

PMID:
30468872
38.

Contribution of rat embryonic stem cells to xenogeneic chimeras in blastocyst or 8-cell embryo injection and aggregation.

Okumura H, Nakanishi A, Toyama S, Yamanoue M, Yamada K, Ukai A, Hashita T, Iwao T, Miyamoto T, Tagawa YI, Hirabayashi M, Miyoshi I, Matsunaga T.

Xenotransplantation. 2019 Jan;26(1):e12468. doi: 10.1111/xen.12468. Epub 2018 Oct 30.

PMID:
30375053
39.

Neck carbuncle associated with methicillin-susceptible Staphylococcus aureus bacteraemia.

Hirabayashi M, Takedomi H, Ando Y, Omura K.

BMJ Case Rep. 2018 Oct 25;2018. pii: bcr-2018-226935. doi: 10.1136/bcr-2018-226935. No abstract available.

40.

Organ Generation from Knockedout Rat Blastocysts Complemented with Pluripotent Stem Cells.

Hirabayashi M, Hochi S.

Methods Mol Biol. 2019;1874:313-326. doi: 10.1007/978-1-4939-8831-0_18.

PMID:
30353522
41.

Immunohistochemical studies on meningoencephalitis in feline infectious peritonitis (FIP).

Wang H, Hirabayashi M, Chambers JK, Uchida K, Nakayama H.

J Vet Med Sci. 2018 Dec 11;80(12):1813-1817. doi: 10.1292/jvms.18-0406. Epub 2018 Oct 17.

42.

An interspecies barrier to tetraploid complementation and chimera formation.

Yamaguchi T, Sato H, Kobayashi T, Kato-Itoh M, Goto T, Hara H, Mizuno N, Yanagida A, Umino A, Hamanaka S, Suchy F, Masaki H, Ota Y, Hirabayashi M, Nakauchi H.

Sci Rep. 2018 Oct 16;8(1):15289. doi: 10.1038/s41598-018-33690-7.

43.

Thrombin-antithrombin complex measurement using a point-of-care testing device for diagnosis of disseminated intravascular coagulation in dogs.

Rimpo K, Tanaka A, Ukai M, Ishikawa Y, Hirabayashi M, Shoyama T.

PLoS One. 2018 Oct 10;13(10):e0205511. doi: 10.1371/journal.pone.0205511. eCollection 2018.

44.

Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis.

Yamashita T, Asano Y, Saigusa R, Taniguchi T, Nakamura K, Miura S, Toyama T, Takahashi T, Ichimura Y, Hirabayashi M, Yoshizaki A, Miyagaki T, Sugaya M, Sato S.

J Dermatol Sci. 2019 Jan;93(1):24-32. doi: 10.1016/j.jdermsci.2018.09.007. Epub 2018 Sep 21.

PMID:
30270117
45.

Progranulin overproduction due to constitutively activated c-Abl/PKC-δ/Fli1 pathway contributes to the resistance of dermal fibroblasts to the anti-fibrotic effect of tumor necrosis factor-α in localized scleroderma.

Miyagawa T, Ichimura Y, Nakamura K, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Takahashi T, Toyama T, Taniguchi T, Akamata K, Yoshizaki A, Sato S, Asano Y.

J Dermatol Sci. 2018 Nov;92(2):207-214. doi: 10.1016/j.jdermsci.2018.09.005. Epub 2018 Sep 19.

PMID:
30268392
46.

Rapid alteration of serum interleukin-6 levels may predict the reactivity of i.v. cyclophosphamide pulse therapy in systemic sclerosis-associated interstitial lung disease.

Numajiri H, Yoshizaki A, Fukasawa T, Ebata S, Nakamura K, Yamashita T, Saigusa R, Miura S, Hirabayashi M, Yoshizaki A, Sumida H, Asano Y, Kazoe Y, Mawatari K, Kitamori T, Sato S.

J Dermatol. 2018 Oct;45(10):1221-1224. doi: 10.1111/1346-8138.14580. Epub 2018 Jul 27.

PMID:
30051925
47.

Serum interleukin-34 levels in patients with systemic sclerosis: Clinical association with interstitial lung disease.

Kuzumi A, Yoshizaki A, Toyama S, Fukasawa T, Ebata S, Nakamura K, Yamashita T, Saigusa R, Miura S, Hirabayashi M, Yoshizaki A, Asano Y, Sato S.

J Dermatol. 2018 Oct;45(10):1216-1220. doi: 10.1111/1346-8138.14538. Epub 2018 Jul 13.

PMID:
30004593
48.

Combination therapy of electroconvulsive therapy and aripiprazole for dopamine supersensitivity psychosis.

Kanahara N, Hirabayashi M, Mamada T, Nishimoto M, Iyo M.

Schizophr Res. 2018 Dec;202:398-400. doi: 10.1016/j.schres.2018.06.038. Epub 2018 Jun 21. No abstract available.

PMID:
29937327
49.

Recurrent meningitis caused by idiopathic cerebrospinal fluid rhinorrhoea from the sphenoid sinus.

Hirabayashi M, Omura K, Otori N, Tanaka Y.

BMJ Case Rep. 2018 Jun 11;2018. pii: bcr-2017-222296. doi: 10.1136/bcr-2017-222296. No abstract available.

50.

Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.

Yamagata A, Miyazaki Y, Yokoi N, Shigematsu H, Sato Y, Goto-Ito S, Maeda A, Goto T, Sanbo M, Hirabayashi M, Shirouzu M, Fukata Y, Fukata M, Fukai S.

Nat Commun. 2018 Apr 18;9(1):1546. doi: 10.1038/s41467-018-03947-w.

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