Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 122

1.

3D organ models-Revolution in pharmacological research?

Weinhart M, Hocke A, Hippenstiel S, Kurreck J, Hedtrich S.

Pharmacol Res. 2019 Jan;139:446-451. doi: 10.1016/j.phrs.2018.11.002. Epub 2018 Nov 3. Review.

PMID:
30395949
2.

Generation of a 3D Liver Model Comprising Human Extracellular Matrix in an Alginate/Gelatin-Based Bioink by Extrusion Bioprinting for Infection and Transduction Studies.

Hiller T, Berg J, Elomaa L, Röhrs V, Ullah I, Schaar K, Dietrich AC, Al-Zeer MA, Kurtz A, Hocke AC, Hippenstiel S, Fechner H, Weinhart M, Kurreck J.

Int J Mol Sci. 2018 Oct 12;19(10). pii: E3129. doi: 10.3390/ijms19103129.

3.

Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus.

Berg J, Hiller T, Kissner MS, Qazi TH, Duda GN, Hocke AC, Hippenstiel S, Elomaa L, Weinhart M, Fahrenson C, Kurreck J.

Sci Rep. 2018 Sep 17;8(1):13877. doi: 10.1038/s41598-018-31880-x.

4.

A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential.

Grund C, Hoffmann D, Ulrich R, Naguib M, Schinköthe J, Hoffmann B, Harder T, Saenger S, Zscheppang K, Tönnies M, Hippenstiel S, Hocke A, Wolff T, Beer M.

Emerg Microbes Infect. 2018 Jul 19;7(1):132. doi: 10.1038/s41426-018-0130-1.

5.

PGE2 enhanced TNFα-mediated IL-8 induction in monocytic cell lines and PBMC.

Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Hippenstiel S, Püschel GP.

Cytokine. 2019 Jan;113:105-116. doi: 10.1016/j.cyto.2018.06.020. Epub 2018 Jun 19.

PMID:
29929938
6.

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J.

Sci Rep. 2018 Apr 10;8(1):5723. doi: 10.1038/s41598-018-24152-1.

7.

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS Study Groups ‡ .

Am J Respir Crit Care Med. 2018 Jul 15;198(2):220-231. doi: 10.1164/rccm.201708-1733OC.

PMID:
29447449
8.

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Imai-Matsushima A, Meyer TF, Paasch L, Mitchell TJ, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC.

Sci Rep. 2018 Jan 9;8(1):182. doi: 10.1038/s41598-017-18468-7.

9.

Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group.

Crit Care Med. 2018 Mar;46(3):e258-e267. doi: 10.1097/CCM.0000000000002916.

PMID:
29298188
10.

THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B.

Sci Rep. 2017 Sep 20;7(1):11988. doi: 10.1038/s41598-017-12154-4.

11.

Human Pulmonary 3D Models For Translational Research.

Zscheppang K, Berg J, Hedtrich S, Verheyen L, Wagner DE, Suttorp N, Hippenstiel S, Hocke AC.

Biotechnol J. 2018 Jan;13(1). doi: 10.1002/biot.201700341. Epub 2017 Sep 20. Review.

PMID:
28865134
12.

Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.

Berg J, Zscheppang K, Fatykhova D, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Gruber AD, Suttorp N, Hippenstiel S, Hocke AC.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601953. doi: 10.1183/13993003.01953-2016. Print 2017 Jul.

13.

Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment.

Peter A, Fatykhova D, Kershaw O, Gruber AD, Rueckert J, Neudecker J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Suttorp N, Hocke AC, Hippenstiel S.

Histochem Cell Biol. 2017 Jun;147(6):707-719. doi: 10.1007/s00418-017-1551-y. Epub 2017 Mar 1.

PMID:
28247028
14.

Human lung ex vivo infection models.

Hocke AC, Suttorp N, Hippenstiel S.

Cell Tissue Res. 2017 Mar;367(3):511-524. doi: 10.1007/s00441-016-2546-z. Epub 2016 Dec 20. Review.

PMID:
27999962
15.

Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.

Tabeling C, Herbert J, Hocke AC, Lamb DJ, Wollin SL, Erb KJ, Boiarina E, Movassagh H, Scheffel J, Doehn JM, Hippenstiel S, Maurer M, Gounni AS, Kuebler WM, Suttorp N, Witzenrath M.

Allergy. 2017 Jul;72(7):1061-1072. doi: 10.1111/all.13101. Epub 2017 Jan 12.

PMID:
27906453
16.

Lung perfusion and emphysema distribution affect the outcome of endobronchial valve therapy.

Thomsen C, Theilig D, Herzog D, Poellinger A, Doellinger F, Schreiter N, Schreiter V, Schürmann D, Temmesfeld-Wollbrueck B, Hippenstiel S, Suttorp N, Hubner RH.

Int J Chron Obstruct Pulmon Dis. 2016 Jun 9;11:1245-59. doi: 10.2147/COPD.S101003. eCollection 2016.

17.

MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation.

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B.

J Infect Dis. 2016 Jul 15;214(2):288-99. doi: 10.1093/infdis/jiw109. Epub 2016 Mar 16.

PMID:
26984146
18.

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.

Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M.

J Vasc Res. 2015;52(4):279-88. doi: 10.1159/000443402. Epub 2016 Feb 19.

PMID:
26890419
19.

Outcomes of Endobronchial Valve Treatment Based on the Precise Criteria of an Endobronchial Catheter for Detection of Collateral Ventilation under Spontaneous Breathing.

Herzog D, Thomsen C, Poellinger A, Doellinger F, Schreiter N, Froeling V, Schuermann D, Temmesfeld-Wollbruck B, Hippenstiel S, Suttorp N, Huebner RH.

Respiration. 2016;91(1):69-78. doi: 10.1159/000442886. Epub 2015 Dec 24.

20.

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B.

PLoS One. 2015 Aug 28;10(8):e0137108. doi: 10.1371/journal.pone.0137108. eCollection 2015.

21.

Modifying Post-Operative Medical Care after EBV Implant May Reduce Pneumothorax Incidence.

Herzog D, Poellinger A, Doellinger F, Schuermann D, Temmesfeld-Wollbrueck B, Froeling V, Schreiter NF, Neumann K, Hippenstiel S, Suttorp N, Hubner RH.

PLoS One. 2015 May 26;10(5):e0128097. doi: 10.1371/journal.pone.0128097. eCollection 2015.

22.

Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54. doi: 10.1165/rcmb.2014-0024OC.

PMID:
25756955
23.

Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol.

Zahlten J, Kim YJ, Doehn JM, Pribyl T, Hocke AC, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner RH.

J Infect Dis. 2015 Jun 1;211(11):1822-30. doi: 10.1093/infdis/jiu806. Epub 2014 Dec 15.

PMID:
25512625
24.

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AD, Kershaw O, Mayer K, Suttorp N, Witzenrath M.

J Antimicrob Chemother. 2015 Mar;70(3):830-40. doi: 10.1093/jac/dku446. Epub 2014 Nov 17.

PMID:
25406299
25.

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R.

Ann Anat. 2014 Sep;196(5):365-71. doi: 10.1016/j.aanat.2014.04.001. Epub 2014 May 4.

PMID:
24862691
26.

Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin.

Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M.

Crit Care. 2014 Apr 14;18(2):R73. doi: 10.1186/cc13830.

27.

The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue.

Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T.

MBio. 2013 Oct 8;4(5):e00601-13. doi: 10.1128/mBio.00601-13. Erratum in: MBio. 2014;5(4):doi:10.1128/mBio.01555-14.

28.

Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs.

Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-6. doi: 10.1164/rccm.201305-0954LE. No abstract available.

PMID:
24083868
29.

Anti-human neutrophil antigen-3a induced transfusion-related acute lung injury in mice by direct disturbance of lung endothelial cells.

Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2538-48. doi: 10.1161/ATVBAHA.113.301206. Epub 2013 Sep 5.

PMID:
24008160
30.

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

Doehn JM, Fischer K, Reppe K, Gutbier B, Tschernig T, Hocke AC, Fischetti VA, Löffler J, Suttorp N, Hippenstiel S, Witzenrath M.

J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

PMID:
23633685
31.

Reply to Fujino et al.

Hocke AC, Berg J, Becher A, Knepper J, Klauschen F, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Hippenstiel S, Wolff T.

J Infect Dis. 2013 Feb 15;207(4):693-5. doi: 10.1093/infdis/jis740. Epub 2012 Nov 29. No abstract available.

PMID:
23204172
32.

Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta.

Sendeski MM, Persson AB, Liu ZZ, Busch JF, Weikert S, Persson PB, Hippenstiel S, Patzak A.

Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1592-8. doi: 10.1152/ajprenal.00471.2012. Epub 2012 Oct 17.

33.

NF-κB-dependent IL-8 induction by prostaglandin E(2) receptors EP(1) and EP(4).

Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Hippenstiel S, Kracht M, Püschel GP.

Br J Pharmacol. 2013 Feb;168(3):704-17. doi: 10.1111/j.1476-5381.2012.02182.x.

34.

Influenza A viruses target type II pneumocytes in the human lung.

Weinheimer VK, Becher A, Tönnies M, Holland G, Knepper J, Bauer TT, Schneider P, Neudecker J, Rückert JC, Szymanski K, Temmesfeld-Wollbrueck B, Gruber AD, Bannert N, Suttorp N, Hippenstiel S, Wolff T, Hocke AC.

J Infect Dis. 2012 Dec 1;206(11):1685-94. doi: 10.1093/infdis/jis455. Epub 2012 Jul 24.

PMID:
22829640
35.

TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.

Eur Respir J. 2013 Feb;41(2):384-91. doi: 10.1183/09031936.00196311. Epub 2012 May 31.

36.

Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.

Müller-Redetzky HC, Kummer W, Pfeil U, Hellwig K, Will D, Paddenberg R, Tabeling C, Hippenstiel S, Suttorp N, Witzenrath M.

PLoS One. 2012;7(5):e35832. doi: 10.1371/journal.pone.0035832. Epub 2012 May 1.

37.

Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue.

Szymanski KV, Toennies M, Becher A, Fatykhova D, N'Guessan PD, Gutbier B, Klauschen F, Neuschaefer-Rube F, Schneider P, Rueckert J, Neudecker J, Bauer TT, Dalhoff K, Drömann D, Gruber AD, Kershaw O, Temmesfeld-Wollbrueck B, Suttorp N, Hippenstiel S, Hocke AC.

Eur Respir J. 2012 Dec;40(6):1458-67. doi: 10.1183/09031936.00186911. Epub 2012 Mar 22.

38.

Streptococcus pneumoniae induces human β-defensin-2 and -3 in human lung epithelium.

Scharf S, Zahlten J, Szymanski K, Hippenstiel S, Suttorp N, N'Guessan PD.

Exp Lung Res. 2012 Mar;38(2):100-10. doi: 10.3109/01902148.2011.652802.

PMID:
22296408
39.

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N'Guessan PD, Suttorp N, Opitz B.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.

40.

The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.

Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N'Guessan PD, Rosseau S, Suttorp N, Witzenrath M.

Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23.

PMID:
21419858
41.

Adrenomedullin attenuates ventilator-induced lung injury in mice.

Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S.

Thorax. 2010 Dec;65(12):1077-84. doi: 10.1136/thx.2010.135996. Epub 2010 Oct 22.

PMID:
20971983
42.

Simvastatin attenuates ventilator-induced lung injury in mice.

Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Crit Care. 2010;14(4):R143. doi: 10.1186/cc9209. Epub 2010 Jul 30.

43.

Legionella pneumophila-induced IκBζ-dependent expression of interleukin-6 in lung epithelium.

Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N'Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.

Eur Respir J. 2011 Mar;37(3):648-57. doi: 10.1183/09031936.00200009. Epub 2010 Jul 22.

44.

Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N'Guessan PD.

Respir Res. 2010 Jul 8;11:93. doi: 10.1186/1465-9921-11-93.

45.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

Zahlten J, Steinicke R, Opitz B, Eitel J, N'guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

J Immunol. 2010 Jul 1;185(1):597-604. doi: 10.4049/jimmunol.0901798. Epub 2010 Jun 4.

46.

Induction of human β-defensin-2 in pulmonary epithelial cells by Legionella pneumophila: involvement of TLR2 and TLR5, p38 MAPK, JNK, NF-κB, and AP-1.

Scharf S, Hippenstiel S, Flieger A, Suttorp N, N'Guessan PD.

Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L687-95. doi: 10.1152/ajplung.00365.2009. Epub 2010 Feb 12.

47.

Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells.

Buss C, Opitz B, Hocke AC, Lippmann J, van Laak V, Hippenstiel S, Krüll M, Suttorp N, Eitel J.

J Immunol. 2010 Mar 15;184(6):3072-8. doi: 10.4049/jimmunol.0902947. Epub 2010 Feb 12.

48.

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3.

Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, N'Guessan P, Witzenrath M, Netea MG, Chakraborty T, Suttorp N, Opitz B.

J Immunol. 2010 Jan 15;184(2):922-30. doi: 10.4049/jimmunol.0901346. Epub 2009 Dec 11.

49.

Adrenomedullin reduces intestinal epithelial permeability in vivo and in vitro.

Temmesfeld-Wollbrück B, Brell B, zu Dohna C, Dorenberg M, Hocke AC, Martens H, Klar J, Suttorp N, Hippenstiel S.

Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G43-51. doi: 10.1152/ajpgi.90532.2008. Epub 2009 May 7.

50.

PKC(alpha) and PKC(epsilon) differentially regulate Legionella pneumophila-induced GM-CSF.

Vardarova K, Scharf S, Lang F, Schmeck B, Opitz B, Eitel J, Hocke AC, Slevogt H, Flieger A, Hippenstiel S, Suttorp N, N'guessan PD.

Eur Respir J. 2009 Nov;34(5):1171-9. doi: 10.1183/09031936.00171908. Epub 2009 Mar 26.

Supplemental Content

Loading ...
Support Center