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Items: 22

1.

Molecular and structural architecture of polyQ aggregates in yeast.

Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3446-E3453. doi: 10.1073/pnas.1717978115. Epub 2018 Mar 26.

PMID:
29581260
2.

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R.

Cell. 2018 Feb 8;172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1.

3.

High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins.

Vincenz-Donnelly L, Holthusen H, Körner R, Hansen EC, Presto J, Johansson J, Sawarkar R, Hartl FU, Hipp MS.

EMBO J. 2018 Feb 1;37(3):337-350. doi: 10.15252/embj.201695841. Epub 2017 Dec 15.

PMID:
29247078
4.

Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function.

Hosp F, Gutiérrez-Ángel S, Schaefer MH, Cox J, Meissner F, Hipp MS, Hartl FU, Klein R, Dudanova I, Mann M.

Cell Rep. 2017 Nov 21;21(8):2291-2303. doi: 10.1016/j.celrep.2017.10.097.

5.

In Situ Architecture and Cellular Interactions of PolyQ Inclusions.

Bäuerlein FJB, Saha I, Mishra A, Kalemanov M, Martínez-Sánchez A, Klein R, Dudanova I, Hipp MS, Hartl FU, Baumeister W, Fernández-Busnadiego R.

Cell. 2017 Sep 21;171(1):179-187.e10. doi: 10.1016/j.cell.2017.08.009. Epub 2017 Sep 7.

PMID:
28890085
6.

The endoplasmic reticulum: A hub of protein quality control in health and disease.

Vincenz-Donnelly L, Hipp MS.

Free Radic Biol Med. 2017 Jul;108:383-393. doi: 10.1016/j.freeradbiomed.2017.03.031. Epub 2017 Mar 29. Review.

PMID:
28363604
7.

Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.

De Smet F, Saiz Rubio M, Hompes D, Naus E, De Baets G, Langenberg T, Hipp MS, Houben B, Claes F, Charbonneau S, Delgado Blanco J, Plaisance S, Ramkissoon S, Ramkissoon L, Simons C, van den Brandt P, Weijenberg M, Van England M, Lambrechts S, Amant F, D'Hoore A, Ligon KL, Sagaert X, Schymkowitz J, Rousseau F.

J Pathol. 2017 May;242(1):24-38. doi: 10.1002/path.4872. Epub 2017 Mar 23.

PMID:
28035683
8.

The formation, function and regulation of amyloids: insights from structural biology.

Landreh M, Sawaya MR, Hipp MS, Eisenberg DS, Wüthrich K, Hartl FU.

J Intern Med. 2016 Aug;280(2):164-76. doi: 10.1111/joim.12500. Epub 2016 May 30. Review.

9.

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS.

Science. 2016 Jan 8;351(6269):173-6. doi: 10.1126/science.aad2033. Epub 2015 Dec 3.

10.

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.

Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI.

EMBO J. 2015 Sep 14;34(18):2334-49. doi: 10.15252/embj.201591711. Epub 2015 Jul 29.

11.

Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome.

Ripaud L, Chumakova V, Antonin M, Hastie AR, Pinkert S, Körner R, Ruff KM, Pappu RV, Hornburg D, Mann M, Hartl FU, Hipp MS.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18219-24. doi: 10.1073/pnas.1421313111. Epub 2014 Dec 8.

12.

Proteostasis impairment in protein-misfolding and -aggregation diseases.

Hipp MS, Park SH, Hartl FU.

Trends Cell Biol. 2014 Sep;24(9):506-14. doi: 10.1016/j.tcb.2014.05.003. Epub 2014 Jun 16. Review.

PMID:
24946960
13.

Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease.

Bersuker K, Hipp MS, Calamini B, Morimoto RI, Kopito RR.

J Biol Chem. 2013 Aug 16;288(33):23633-8. doi: 10.1074/jbc.C113.481945. Epub 2013 Jul 9.

14.

PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone.

Park SH, Kukushkin Y, Gupta R, Chen T, Konagai A, Hipp MS, Hayer-Hartl M, Hartl FU.

Cell. 2013 Jul 3;154(1):134-45. doi: 10.1016/j.cell.2013.06.003. Epub 2013 Jun 20.

15.

Molecular chaperone functions in protein folding and proteostasis.

Kim YE, Hipp MS, Bracher A, Hayer-Hartl M, Hartl FU.

Annu Rev Biochem. 2013;82:323-55. doi: 10.1146/annurev-biochem-060208-092442. Review.

PMID:
23746257
16.

Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease.

Hipp MS, Patel CN, Bersuker K, Riley BE, Kaiser SE, Shaler TA, Brandeis M, Kopito RR.

J Cell Biol. 2012 Mar 5;196(5):573-87. doi: 10.1083/jcb.201110093. Epub 2012 Feb 27.

17.

Live-cell imaging of ubiquitin-proteasome system function.

Hipp MS, Bersuker K, Kopito RR.

Methods Mol Biol. 2012;832:463-72. doi: 10.1007/978-1-61779-474-2_33.

18.

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.

Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR.

J Cell Biol. 2010 Nov 1;191(3):537-52. doi: 10.1083/jcb.201005012.

19.

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10.

Schmidtke G, Kalveram B, Weber E, Bochtler P, Lukasiak S, Hipp MS, Groettrup M.

J Biol Chem. 2006 Jul 21;281(29):20045-54. Epub 2006 May 17.

20.

FAT10, a ubiquitin-independent signal for proteasomal degradation.

Hipp MS, Kalveram B, Raasi S, Groettrup M, Schmidtke G.

Mol Cell Biol. 2005 May;25(9):3483-91.

21.

NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation.

Hipp MS, Raasi S, Groettrup M, Schmidtke G.

J Biol Chem. 2004 Apr 16;279(16):16503-10. Epub 2004 Feb 2.

22.

Proteasome inhibition leads to NF-kappaB-independent IL-8 transactivation in human endothelial cells through induction of AP-1.

Hipp MS, Urbich C, Mayer P, Wischhusen J, Weller M, Kracht M, Spyridopoulos I.

Eur J Immunol. 2002 Aug;32(8):2208-17.

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