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Pediatric autoimmune encephalitis: Recognition and diagnosis.

de Bruijn MAAM, Bruijstens AL, Bastiaansen AEM, van Sonderen A, Schreurs MWJ, Sillevis Smitt PAE, Hintzen RQ, Neuteboom RF, Titulaer MJ; CHANCE Study Group.

Neurol Neuroimmunol Neuroinflamm. 2020 Feb 11;7(3). pii: e682. doi: 10.1212/NXI.0000000000000682. Print 2020 May.


Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes.

Wong YYM, Bruijstens AL, Barro C, Michalak Z, Melief MJ, Wierenga AF, van Pelt ED, Neuteboom RF, Kuhle J, Hintzen RQ.

Neurology. 2019 Sep 3;93(10):e968-e974. doi: 10.1212/WNL.0000000000008057. Epub 2019 Aug 5.


Induction of brain-infiltrating T-bet-expressing B cells in multiple sclerosis.

van Langelaar J, Rijvers L, Janssen M, Wierenga-Wolf AF, Melief MJ, Siepman TA, de Vries HE, Unger PA, van Ham SM, Hintzen RQ, van Luijn MM.

Ann Neurol. 2019 Aug;86(2):264-278. doi: 10.1002/ana.25508. Epub 2019 Jun 19.


The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults.

de Mol CL, Wong Y, van Pelt ED, Wokke B, Siepman T, Neuteboom RF, Hamann D, Hintzen RQ.

Mult Scler. 2019 May 16:1352458519845112. doi: 10.1177/1352458519845112. [Epub ahead of print]


Time Is Brain and Spine-Reply.

van der Vuurst de Vries RM, Hintzen RQ.

JAMA Neurol. 2019 May 1;76(5):623-624. doi: 10.1001/jamaneurol.2019.0149. No abstract available.


Real-world validation of the 2017 McDonald criteria for pediatric MS.

Wong YYM, de Mol CL, van der Vuurst de Vries RM, van Pelt ED, Ketelslegers IA, Catsman-Berrevoets CE, Neuteboom RF, Hintzen RQ.

Neurol Neuroimmunol Neuroinflamm. 2018 Dec 14;6(2):e528. doi: 10.1212/NXI.0000000000000528. eCollection 2019 Mar.


Response to Vilariño-Güell et al.

Mescheriakova JY, Verkerk J, Amin N, Uitterlinden AG, van Duijn CM, Hintzen RQ.

Mult Scler. 2019 Jun;25(7):1013-1015. doi: 10.1177/1352458518803794. Epub 2018 Oct 9. No abstract available.


Paediatric multiple sclerosis: early diagnosis as a first step.

Hintzen RQ.

Lancet Child Adolesc Health. 2018 Mar;2(3):161-162. doi: 10.1016/S2352-4642(18)30028-2. Epub 2018 Feb 1. No abstract available.


The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis.

Rijvers L, Melief MJ, van der Vuurst de Vries RM, Stéphant M, van Langelaar J, Wierenga-Wolf AF, Hogervorst JM, Geurts-Moespot AJ, Sweep FCGJ, Hintzen RQ, van Luijn MM.

Eur J Immunol. 2018 Nov;48(11):1861-1871. doi: 10.1002/eji.201847623. Epub 2018 Sep 25.


Application of the 2017 Revised McDonald Criteria for Multiple Sclerosis to Patients With a Typical Clinically Isolated Syndrome.

van der Vuurst de Vries RM, Mescheriakova JY, Wong YYM, Runia TF, Jafari N, Samijn JP, de Beukelaar JWK, Wokke BHA, Siepman TAM, Hintzen RQ.

JAMA Neurol. 2018 Nov 1;75(11):1392-1398. doi: 10.1001/jamaneurol.2018.2160.


Chemical and genetic control of IFNγ-induced MHCII expression.

Wijdeven RH, van Luijn MM, Wierenga-Wolf AF, Akkermans JJ, van den Elsen PJ, Hintzen RQ, Neefjes J.

EMBO Rep. 2018 Sep;19(9). pii: e45553. doi: 10.15252/embr.201745553. Epub 2018 Jul 18.


T-cell activation marker sCD27 is associated with clinically definite multiple sclerosis in childhood-acquired demyelinating syndromes.

Wong YYM, van der Vuurst de Vries RM, van Pelt ED, Ketelslegers IA, Melief MJ, Wierenga AF, Catsman-Berrevoets CE, Neuteboom RF, Hintzen RQ.

Mult Scler. 2018 Nov;24(13):1715-1724. doi: 10.1177/1352458518786655. Epub 2018 Jul 18.


Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family.

Mescheriakova JY, Verkerk AJ, Amin N, Uitterlinden AG, van Duijn CM, Hintzen RQ.

Mult Scler. 2019 Jun;25(7):909-917. doi: 10.1177/1352458518777202. Epub 2018 Jun 6.


High neurofilament levels are associated with clinically definite multiple sclerosis in children and adults with clinically isolated syndrome.

van der Vuurst de Vries RM, Wong YYM, Mescheriakova JY, van Pelt ED, Runia TF, Jafari N, Siepman TA, Melief MJ, Wierenga-Wolf AF, van Luijn MM, Samijn JP, Neuteboom RF, Hintzen RQ.

Mult Scler. 2019 Jun;25(7):958-967. doi: 10.1177/1352458518775303. Epub 2018 May 18.


T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention.

van Langelaar J, van der Vuurst de Vries RM, Janssen M, Wierenga-Wolf AF, Spilt IM, Siepman TA, Dankers W, Verjans GMGM, de Vries HE, Lubberts E, Hintzen RQ, van Luijn MM.

Brain. 2018 May 1;141(5):1334-1349. doi: 10.1093/brain/awy069.


Incidence and outcome of acquired demyelinating syndromes in Dutch children: update of a nationwide and prospective study.

de Mol CL, Wong YYM, van Pelt ED, Ketelslegers IA, Bakker DP, Boon M, Braun KPJ, van Dijk KGJ, Eikelenboom MJ, Engelen M, Geleijns K, Haaxma CA, Niermeijer JMF, Niks EH, Peeters EAJ, Peeters-Scholte CMPCD, Poll-The BT, Portier RP, de Rijk-van Andel JF, Samijn JPA, Schippers HM, Snoeck IN, Stroink H, Vermeulen RJ, Verrips A, Visscher F, Vles JSH, Willemsen MAAP, Catsman-Berrevoets CE, Hintzen RQ, Neuteboom RF.

J Neurol. 2018 Jun;265(6):1310-1319. doi: 10.1007/s00415-018-8835-6. Epub 2018 Mar 22.


Smoking at time of CIS increases the risk of clinically definite multiple sclerosis.

van der Vuurst de Vries RM, Mescheriakova JY, Runia TF, Siepman TAM, Wokke BHA, Samijn JPA, Hintzen RQ.

J Neurol. 2018 May;265(5):1010-1015. doi: 10.1007/s00415-018-8780-4. Epub 2018 Feb 20.


Paediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome.

Wong YYM, Hacohen Y, Armangue T, Wassmer E, Verhelst H, Hemingway C, van Pelt ED, Catsman-Berrevoets CE, Hintzen RQ, Deiva K, Lim MJ, Rostásy K, Neuteboom RF.

Eur J Neurol. 2018 May;25(5):782-786. doi: 10.1111/ene.13602. Epub 2018 Mar 9.


Elevated EBNA-1 IgG in MS is associated with genetic MS risk variants.

Kreft KL, Van Nierop GP, Scherbeijn SMJ, Janssen M, Verjans GMGM, Hintzen RQ.

Neurol Neuroimmunol Neuroinflamm. 2017 Oct 12;4(6):e406. doi: 10.1212/NXI.0000000000000406. eCollection 2017 Nov.


No excess of autoimmune diseases in multiple sclerosis families from the Netherlands.

Mescheriakova JY, Hintzen RQ.

Acta Neurol Scand. 2018 May;137(5):531-537. doi: 10.1111/ane.12896. Epub 2018 Jan 7.


Specific myelopathy diagnoses using advancing diagnostics: Idiopathic no more.

Yeh EA, Hintzen RQ.

Neurology. 2018 Jan 9;90(2):51-52. doi: 10.1212/WNL.0000000000004812. Epub 2017 Dec 15. No abstract available.


Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS.

Bruinsma IB, van Dijk M, Bridel C, van de Lisdonk T, Haverkort SQ, Runia TF, Steinman L, Hintzen RQ, Killestein J, Verbeek MM, Teunissen CE, de Jong BA.

J Neuroinflammation. 2017 Dec 4;14(1):235. doi: 10.1186/s12974-017-1006-3.


Decreased Neuro-Axonal Proteins in CSF at First Attack of Suspected Multiple Sclerosis.

Stoop MP, Runia TF, Stingl C, van der Vuurst de Vries RM, Luider TM, Hintzen RQ.

Proteomics Clin Appl. 2017 Dec;11(11-12). doi: 10.1002/prca.201700005. Epub 2017 Oct 23.


Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients.

van Nierop GP, van Luijn MM, Michels SS, Melief MJ, Janssen M, Langerak AW, Ouwendijk WJD, Hintzen RQ, Verjans GMGM.

Acta Neuropathol. 2017 Sep;134(3):383-401. doi: 10.1007/s00401-017-1744-4. Epub 2017 Jun 17.


Burden of genetic risk variants in multiple sclerosis families in the Netherlands.

Mescheriakova JY, Broer L, Wahedi S, Uitterlinden AG, van Duijn CM, Hintzen RQ.

Mult Scler J Exp Transl Clin. 2016 May 6;2:2055217316648721. doi: 10.1177/2055217316648721. eCollection 2016 Jan-Dec.


Fatigue after a first attack of suspected multiple sclerosis.

van der Vuurst de Vries RM, van den Dorpel JJ, Mescheriakova JY, Runia TF, Jafari N, Siepman TA, Rizopoulos D, Steyerberg EW, Hintzen RQ.

Mult Scler. 2018 Jun;24(7):974-981. doi: 10.1177/1352458517709348. Epub 2017 May 23.


Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis.

Toussaint-Duyster LC, Wong YYM, Van der Cammen-van Zijp MH, Van Pelt-Gravesteijn D, Catsman-Berrevoets CE, Hintzen RQ, Neuteboom RF.

Mult Scler. 2018 Jun;24(7):982-990. doi: 10.1177/1352458517706038. Epub 2017 Apr 26.


Axonal transport deficits in multiple sclerosis: spiraling into the abyss.

van den Berg R, Hoogenraad CC, Hintzen RQ.

Acta Neuropathol. 2017 Jul;134(1):1-14. doi: 10.1007/s00401-017-1697-7. Epub 2017 Mar 18. Review.


Genetic susceptibility to multiple sclerosis: Brain structure and cognitive function in the general population.

Ikram MA, Vernooij MW, Roshchupkin GV, Hofman A, van Duijn CM, Uitterlinden AG, Niessen WJ, Hintzen RQ, Adams HH.

Mult Scler. 2017 Nov;23(13):1697-1706. doi: 10.1177/1352458516682104. Epub 2016 Dec 21.


Soluble CD27 Levels in Cerebrospinal Fluid as a Prognostic Biomarker in Clinically Isolated Syndrome.

van der Vuurst de Vries RM, Mescheriakova JY, Runia TF, Jafari N, Siepman TA, Hintzen RQ.

JAMA Neurol. 2017 Mar 1;74(3):286-292. doi: 10.1001/jamaneurol.2016.4997.


Disease course after clinically isolated syndrome in children versus adults: a prospective cohort study.

van der Vuurst de Vries RM, van Pelt ED, Mescheriakova JY, Wong YY, Ketelslegers IA, Siepman TA, Catsman CE, Neuteboom RF, Hintzen RQ.

Eur J Neurol. 2017 Feb;24(2):315-321. doi: 10.1111/ene.13196. Epub 2016 Nov 9.


Evolution of MRI abnormalities in paediatric acute disseminated encephalomyelitis.

Wong YYM, van Pelt ED, Ketelslegers IA, Catsman-Berrevoets CE, Hintzen RQ, Neuteboom RF; Dutch Study Group for Paediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis.

Eur J Paediatr Neurol. 2017 Mar;21(2):300-304. doi: 10.1016/j.ejpn.2016.08.014. Epub 2016 Sep 6.


Pediatric acquired CNS demyelinating syndromes: Features associated with multiple sclerosis.

Hintzen RQ, Dale RC, Neuteboom RF, Mar S, Banwell B.

Neurology. 2016 Aug 30;87(9 Suppl 2):S67-73. doi: 10.1212/WNL.0000000000002881. Review.


Environmental and genetic factors in pediatric inflammatory demyelinating diseases.

Waubant E, Ponsonby AL, Pugliatti M, Hanwell H, Mowry EM, Hintzen RQ.

Neurology. 2016 Aug 30;87(9 Suppl 2):S20-7. doi: 10.1212/WNL.0000000000003029. Review.


Immunopathophysiology of pediatric CNS inflammatory demyelinating diseases.

Bar-Or A, Hintzen RQ, Dale RC, Rostasy K, Brück W, Chitnis T.

Neurology. 2016 Aug 30;87(9 Suppl 2):S12-9. doi: 10.1212/WNL.0000000000002821. Review.


International Pediatric MS Study Group Global Members Symposium report.

Wassmer E, Chitnis T, Pohl D, Amato MP, Banwell B, Ghezzi A, Hintzen RQ, Krupp LB, Makhani N, Rostásy K, Tardieu M, Tenembaum S, Waldman A, Waubant E, Kornberg AJ.

Neurology. 2016 Aug 30;87(9 Suppl 2):S110-6. doi: 10.1212/WNL.0000000000002880. Review.


Incidence of AQP4-IgG seropositive neuromyelitis optica spectrum disorders in the Netherlands: About one in a million.

Daniëlle van Pelt E, Wong YYM, Ketelslegers IA, Siepman DA, Hamann D, Hintzen RQ.

Mult Scler J Exp Transl Clin. 2016 Jan 26;2:2055217315625652. doi: 10.1177/2055217315625652. eCollection 2016 Jan-Dec.


Rotarod motor performance and advanced spinal cord lesion image analysis refine assessment of neurodegeneration in experimental autoimmune encephalomyelitis.

van den Berg R, Laman JD, van Meurs M, Hintzen RQ, Hoogenraad CC.

J Neurosci Methods. 2016 Mar 15;262:66-76. doi: 10.1016/j.jneumeth.2016.01.013. Epub 2016 Jan 16.


Elevated Expression of the Cerebrospinal Fluid Disease Markers Chromogranin A and Clusterin in Astrocytes of Multiple Sclerosis White Matter Lesions.

van Luijn MM, van Meurs M, Stoop MP, Verbraak E, Wierenga-Wolf AF, Melief MJ, Kreft KL, Verdijk RM, 't Hart BA, Luider TM, Laman JD, Hintzen RQ.

J Neuropathol Exp Neurol. 2016 Jan;75(1):86-98.


Neuromyelitis optica spectrum disorders: comparison of clinical and magnetic resonance imaging characteristics of AQP4-IgG versus MOG-IgG seropositive cases in the Netherlands.

van Pelt ED, Wong YY, Ketelslegers IA, Hamann D, Hintzen RQ.

Eur J Neurol. 2016 Mar;23(3):580-7. doi: 10.1111/ene.12898. Epub 2015 Nov 22.


Neurogenic lower urinary tract dysfunction in the early disease phase of paediatric multiple sclerosis.

Scheepe JR, Wong YY, van Pelt ED, Ketelslegers IA, Catsman-Berrevoets CE, van den Hoek J, Hintzen RQ, Neuteboom RF.

Mult Scler. 2016 Oct;22(11):1490-1494. Epub 2015 Nov 20.


Intrathecal CD4(+) and CD8(+) T-cell responses to endogenously synthesized candidate disease-associated human autoantigens in multiple sclerosis patients.

van Nierop GP, Janssen M, Mitterreiter JG, van de Vijver DA, de Swart RL, Haagmans BL, Verjans GM, Hintzen RQ.

Eur J Immunol. 2016 Feb;46(2):347-53. doi: 10.1002/eji.201545921. Epub 2015 Nov 9.


Female sexual dysfunction in multiple sclerosis: Results of a survey among Dutch urologists and patients.

Scheepe JR, Alamyar M, Pastoor H, Hintzen RQ, Blok BF.

Neurourol Urodyn. 2017 Jan;36(1):116-120. doi: 10.1002/nau.22884. Epub 2015 Oct 23.


Gray matter-related proteins are associated with childhood-onset multiple sclerosis.

Singh V, van Pelt ED, Stoop MP, Stingl C, Ketelslegers IA, Neuteboom RF, Catsman-Berrevoets CE, Luider TM, Hintzen RQ.

Neurol Neuroimmunol Neuroinflamm. 2015 Sep 24;2(5):e155. doi: 10.1212/NXI.0000000000000155. eCollection 2015 Oct.


Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins.

van Nierop GP, Mautner J, Mitterreiter JG, Hintzen RQ, Verjans GM.

Mult Scler. 2016 Mar;22(3):279-91. doi: 10.1177/1352458515588581. Epub 2015 Jun 3.


Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis.

van Luijn MM, Kreft KL, Jongsma ML, Mes SW, Wierenga-Wolf AF, van Meurs M, Melief MJ, der Kant Rv, Janssen L, Janssen H, Tan R, Priatel JJ, Neefjes J, Laman JD, Hintzen RQ.

Brain. 2015 Jun;138(Pt 6):1531-47. doi: 10.1093/brain/awv080. Epub 2015 Mar 29.


Proteomics urine analysis of pregnant women suffering from multiple sclerosis.

Singh V, Stingl C, Stoop MP, Zeneyedpour L, Neuteboom RF, Smitt PS, Hintzen RQ, Luider TM.

J Proteome Res. 2015 May 1;14(5):2065-73. doi: 10.1021/pr501162w. Epub 2015 Mar 30.


Anti-MOG antibodies plead against MS diagnosis in an Acquired Demyelinating Syndromes cohort.

Ketelslegers IA, Van Pelt DE, Bryde S, Neuteboom RF, Catsman-Berrevoets CE, Hamann D, Hintzen RQ.

Mult Scler. 2015 Oct;21(12):1513-20. doi: 10.1177/1352458514566666. Epub 2015 Feb 6.


The influence of vitamin D on postpartum relapse and quality of life in pregnant multiple sclerosis patients.

Runia TF, Neuteboom RF, de Groot CJ, de Rijke YB, Hintzen RQ.

Eur J Neurol. 2015 Mar;22(3):479-84. doi: 10.1111/ene.12594. Epub 2014 Nov 28.


Abundant kif21b is associated with accelerated progression in neurodegenerative diseases.

Kreft KL, van Meurs M, Wierenga-Wolf AF, Melief MJ, van Strien ME, Hol EM, Oostra BA, Laman JD, Hintzen RQ.

Acta Neuropathol Commun. 2014 Oct 3;2:144. doi: 10.1186/s40478-014-0144-4.

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