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Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System.

Lin TC, Wang LC, Yue L, Zhang Y, Falabella P, Zhu D, Hinton DR, Rao NA, Birch DG, Spencer R, Dorn JD, Humayun MS.

Transl Vis Sci Technol. 2019 May 30;8(3):31. doi: 10.1167/tvst.8.3.31. eCollection 2019 May.


Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells.

Wang M, Lau LI, Sreekumar PG, Spee C, Hinton DR, Sadda SR, Kannan R.

Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):500-516. doi: 10.1167/iovs.18-25686.


Stereological Method in Optical Coherence Tomography for In Vivo Evaluation of Laser-Induced Choroidal Neovascularization.

Trujillo-Sanchez GP, Martinez-Camarillo JC, Spee CK, Hinton DR, Humayun MS, Weitz AC.

Ophthalmic Surg Lasers Imaging Retina. 2018 Sep 1;49(9):e65-e74. doi: 10.3928/23258160-20180907-09.


A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells.

Thomas BB, Zhu D, Lin TC, Kim YC, Seiler MJ, Martinez-Camarillo JC, Lin B, Shad Y, Hinton DR, Humayun MS.

Graefes Arch Clin Exp Ophthalmol. 2018 Nov;256(11):2113-2125. doi: 10.1007/s00417-018-4134-2. Epub 2018 Sep 13.


Mechanism of cytokinesis failure in ovarian cystadenomas with defective BRCA1 and P53 pathways.

Austria T, Marion C, Yu V, Widschwendter M, Hinton DR, Dubeau L.

Int J Cancer. 2018 Dec 1;143(11):2932-2942. doi: 10.1002/ijc.31659. Epub 2018 Oct 3.


Intra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration.

Sreekumar PG, Li Z, Wang W, Spee C, Hinton DR, Kannan R, MacKay JA.

J Control Release. 2018 Aug 10;283:94-104. doi: 10.1016/j.jconrel.2018.05.014. Epub 2018 May 18.


A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration.

Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin CM, Mitra D, Zhu D, Thomas BB, Hikita ST, Pennington BO, Johnson LV, Clegg DO, Hinton DR, Humayun MS.

Sci Transl Med. 2018 Apr 4;10(435). pii: eaao4097. doi: 10.1126/scitranslmed.aao4097.



Jiao C, Eliott D, Spee C, He S, Wang K, Mullins RF, Hinton DR, Sohn EH.

Retina. 2019 Feb;39(2):265-273. doi: 10.1097/IAE.0000000000001952.


cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.

Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J.

Nat Med. 2018 Jan;24(1):50-61. doi: 10.1038/nm.4450. Epub 2017 Nov 27.


Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium.

Fernandes RAB, Stefanini FR, Falabella P, Koss MJ, Wells T, Diniz B, Ribeiro R, Schor P, Maia M, Penha FM, Hinton DR, Tai YC, Humayun M.

Int J Retina Vitreous. 2017 Oct 30;3:41. doi: 10.1186/s40942-017-0095-6. eCollection 2017.


Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models.

Lin TC, Seiler MJ, Zhu D, Falabella P, Hinton DR, Clegg DO, Humayun MS, Thomas BB.

Stem Cells Int. 2017;2017:9428176. doi: 10.1155/2017/9428176. Epub 2017 Aug 27. Review.


Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.

Minasyan L, Sreekumar PG, Hinton DR, Kannan R.

Oxid Med Cell Longev. 2017;2017:1675230. doi: 10.1155/2017/1675230. Epub 2017 Jul 26. Review.


Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease.

Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Ashfaq A, Frautschy S, Cole GM, Miller CA, Hinton DR, Verdooner SR, Black KL, Koronyo-Hamaoui M.

JCI Insight. 2017 Aug 17;2(16). pii: 93621. doi: 10.1172/jci.insight.93621. eCollection 2017 Aug 17.


Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin.

Sreekumar PG, Hinton DR, Kannan R.

Neural Regen Res. 2017 Jan;12(1):35-38. doi: 10.4103/1673-5374.198970. Review.


Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes.

Huang AS, Saraswathy S, Dastiridou A, Begian A, Legaspi H, Mohindroo C, Tan JC, Francis BA, Caprioli J, Hinton DR, Weinreb RN.

Transl Vis Sci Technol. 2016 Nov 10;5(6):5. eCollection 2016 Nov.


Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.

Matsunaga D, Sreekumar PG, Ishikawa K, Terasaki H, Barron E, Cohen P, Kannan R, Hinton DR.

PLoS One. 2016 Oct 26;11(10):e0165150. doi: 10.1371/journal.pone.0165150. eCollection 2016.


Differential Regulation of Self-reactive CD4+ T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis.

Savarin C, Bergmann CC, Hinton DR, Stohlman SA.

Front Immunol. 2016 Sep 21;7:370. eCollection 2016.


Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes.

Huang AS, Saraswathy S, Dastiridou A, Begian A, Mohindroo C, Tan JC, Francis BA, Hinton DR, Weinreb RN.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4558-65. doi: 10.1167/iovs.16-19644.


Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs.

Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS.

Graefes Arch Clin Exp Ophthalmol. 2016 Aug;254(8):1553-1565. doi: 10.1007/s00417-016-3386-y. Epub 2016 Jun 22.


Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats.

Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton DR, Humayun MS.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2877-87. doi: 10.1167/iovs.16-19238.


The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.

Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR.

Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1238-53. doi: 10.1167/iovs.15-17053.


Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis.

Valentin-Torres A, Savarin C, Hinton DR, Phares TW, Bergmann CC, Stohlman SA.

J Neuroinflammation. 2016 Feb 22;13:46. doi: 10.1186/s12974-016-0513-y.


αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition.

Ishikawa K, Sreekumar PG, Spee C, Nazari H, Zhu D, Kannan R, Hinton DR.

Am J Pathol. 2016 Apr;186(4):859-73. doi: 10.1016/j.ajpath.2015.11.014. Epub 2016 Feb 12.


Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging.

Saraswathy S, Tan JC, Yu F, Francis BA, Hinton DR, Weinreb RN, Huang AS.

PLoS One. 2016 Jan 25;11(1):e0147176. doi: 10.1371/journal.pone.0147176. eCollection 2016.


Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy.

Ishikawa K, He S, Terasaki H, Nazari H, Zhang H, Spee C, Kannan R, Hinton DR.

Sci Rep. 2015 Nov 10;5:16386. doi: 10.1038/srep16386.


Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy.

He S, Barron E, Ishikawa K, Nazari Khanamiri H, Spee C, Zhou P, Kase S, Wang Z, Dustin LD, Hinton DR.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5579-89. doi: 10.1167/iovs.14-16258.


SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization.

Zhang H, He S, Spee C, Ishikawa K, Hinton DR.

Cytokine. 2015 Dec;76(2):549-552. doi: 10.1016/j.cyto.2015.06.019. Epub 2015 Jul 11.


Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis.

Butchi N, Kapil P, Puntambekar S, Stohlman SA, Hinton DR, Bergmann CC.

J Virol. 2015 Sep;89(18):9299-312. doi: 10.1128/JVI.01199-15. Epub 2015 Jul 1.


Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination.

Puntambekar SS, Hinton DR, Yin X, Savarin C, Bergmann CC, Trapp BD, Stohlman SA.

Glia. 2015 Nov;63(11):2106-2120. doi: 10.1002/glia.22880. Epub 2015 Jun 30.


Stem cell based therapies for age-related macular degeneration: The promises and the challenges.

Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani AH, Hinton DR, Humayun MS.

Prog Retin Eye Res. 2015 Sep;48:1-39. doi: 10.1016/j.preteyeres.2015.06.004. Epub 2015 Jun 23. Review.


Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration.

Kannan R, Sreekumar PG, Hinton DR.

Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):258-68. doi: 10.1016/j.bbagen.2015.05.016. Epub 2015 May 27. Review.


Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis.

Savarin C, Hinton DR, Valentin-Torres A, Chen Z, Trapp BD, Bergmann CC, Stohlman SA.

J Neuroinflammation. 2015 Apr 22;12:79. doi: 10.1186/s12974-015-0293-9.


Attenuation of choroidal neovascularization by histone deacetylase inhibitor.

Chan N, He S, Spee CK, Ishikawa K, Hinton DR.

PLoS One. 2015 Mar 25;10(3):e0120587. doi: 10.1371/journal.pone.0120587. eCollection 2015.


Molecular mechanisms of subretinal fibrosis in age-related macular degeneration.

Ishikawa K, Kannan R, Hinton DR.

Exp Eye Res. 2016 Jan;142:19-25. doi: 10.1016/j.exer.2015.03.009. Epub 2015 Mar 13. Review.


Sodium iodate induced retinal degeneration: new insights from an old model.

Kannan R, Hinton DR.

Neural Regen Res. 2014 Dec 1;9(23):2044-5. doi: 10.4103/1673-5374.147927. No abstract available.


TGF-β2 secretion from RPE decreases with polarization and becomes apically oriented.

Hirsch L, Nazari H, Sreekumar PG, Kannan R, Dustin L, Zhu D, Barron E, Hinton DR.

Cytokine. 2015 Feb;71(2):394-6. doi: 10.1016/j.cyto.2014.11.014. Epub 2014 Dec 10.


IL-18 is not therapeutic for neovascular age-related macular degeneration.

Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton DR, Ambati J.

Nat Med. 2014 Dec;20(12):1372-5. doi: 10.1038/nm.3671. No abstract available.


Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.

Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J.

Science. 2014 Nov 21;346(6212):1000-3. doi: 10.1126/science.1261754.


Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α.

Sur A, Kesaraju S, Prentice H, Ayyanathan K, Baronas-Lowell D, Zhu D, Hinton DR, Blanks J, Weissbach H.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16754-9. doi: 10.1073/pnas.1419576111. Epub 2014 Nov 10.


DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16082-7. doi: 10.1073/pnas.1403814111. Epub 2014 Oct 27.


Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis.

Hwang M, Phares TW, Hinton DR, Stohlman SA, Bergmann CC, Min B.

Immunology. 2015 Mar;144(3):374-386. doi: 10.1111/imm.12378.


IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination.

de Aquino MT, Kapil P, Hinton DR, Phares TW, Puntambekar SS, Savarin C, Bergmann CC, Stohlman SA.

J Immunol. 2014 Jul 1;193(1):285-94. doi: 10.4049/jimmunol.1400058. Epub 2014 Jun 2.


Protection of retina by αB crystallin in sodium iodate induced retinal degeneration.

Zhou P, Kannan R, Spee C, Sreekumar PG, Dou G, Hinton DR.

PLoS One. 2014 May 29;9(5):e98275. doi: 10.1371/journal.pone.0098275. eCollection 2014.


Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells.

Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin YA, Cui H, Kannan R, Hinton DR, MacKay JA.

J Control Release. 2014 Oct 10;191:4-14. doi: 10.1016/j.jconrel.2014.04.028. Epub 2014 Apr 26.


Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells.

Sonoda S, Nagineni CN, Kitamura M, Spee C, Kannan R, Hinton DR.

Cytokine. 2014 Aug;68(2):137-40. doi: 10.1016/j.cyto.2014.03.011. Epub 2014 Apr 20.


PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis.

Kapil P, Stohlman SA, Hinton DR, Bergmann CC.

J Neuroimmunol. 2014 May 15;270(1-2):1-12. doi: 10.1016/j.jneuroim.2014.02.012. Epub 2014 Mar 4.


Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system.

de Aquino MT, Puntambekar SS, Savarin C, Bergmann CC, Phares TW, Hinton DR, Stohlman SA.

Virology. 2013 Dec;447(1-2):112-20. doi: 10.1016/j.virol.2013.08.030. Epub 2013 Sep 24.


Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.

Butchi NB, Hinton DR, Stohlman SA, Kapil P, Fensterl V, Sen GC, Bergmann CC.

J Virol. 2014 Jan;88(2):1051-64. doi: 10.1128/JVI.02272-13. Epub 2013 Nov 6.

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