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Items: 1 to 50 of 140

1.

Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes.

Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, McCullough SS, James LP, Hinson JA.

Toxicol Rep. 2017;4:134-142. doi: 10.1016/j.toxrep.2017.02.005.

2.

An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure.

Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP.

Clin Gastroenterol Hepatol. 2017 Apr;15(4):555-562.e3. doi: 10.1016/j.cgh.2016.09.007. Epub 2016 Sep 15.

3.

The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes.

Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, Letzig LG, James LP, Hinson JA.

Free Radic Biol Med. 2015 Dec;89:750-7. doi: 10.1016/j.freeradbiomed.2015.09.022. Epub 2015 Oct 9.

4.

Mouse liver protein sulfhydryl depletion after acetaminophen exposure.

Yang X, Greenhaw J, Shi Q, Roberts DW, Hinson JA, Muskhelishvili L, Davis K, Salminen WF.

J Pharmacol Exp Ther. 2013 Jan;344(1):286-94. doi: 10.1124/jpet.112.199067. Epub 2012 Oct 23.

5.

Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice.

Chaudhuri S, McCullough SS, Hennings L, Brown AT, Li SH, Simpson PM, Hinson JA, James LP.

Toxicol Appl Pharmacol. 2012 Oct 15;264(2):192-201. doi: 10.1016/j.taap.2012.08.001. Epub 2012 Aug 10.

6.

Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells.

Yuan Q, Tang W, Zhang X, Hinson JA, Liu C, Osei K, Wang J.

PLoS One. 2012;7(4):e35098. doi: 10.1371/journal.pone.0035098. Epub 2012 Apr 3.

7.

Changes in mouse liver protein glutathionylation after acetaminophen exposure.

Yang X, Greenhaw J, Ali A, Shi Q, Roberts DW, Hinson JA, Muskhelishvili L, Beger R, Pence LM, Ando Y, Sun J, Davis K, Salminen WF.

J Pharmacol Exp Ther. 2012 Feb;340(2):360-8. doi: 10.1124/jpet.111.187948. Epub 2011 Nov 1.

8.

Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.

Agarwal R, Hennings L, Rafferty TM, Letzig LG, McCullough S, James LP, MacMillan-Crow LA, Hinson JA.

J Pharmacol Exp Ther. 2012 Jan;340(1):134-42. doi: 10.1124/jpet.111.184192. Epub 2011 Oct 14.

9.

Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice.

Milesi-Hallé A, McCullough S, Hinson JA, Kurten RC, Lamps LW, Brown A, James LP.

Basic Clin Pharmacol Toxicol. 2012 Apr;110(4):327-34. doi: 10.1111/j.1742-7843.2011.00812.x. Epub 2011 Nov 9.

10.

Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.

Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP.

Toxicol Appl Pharmacol. 2011 May 1;252(3):211-20. doi: 10.1016/j.taap.2011.02.005. Epub 2011 Feb 24.

11.

Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase.

Agarwal R, MacMillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, Hinson JA.

J Pharmacol Exp Ther. 2011 Apr;337(1):110-6. doi: 10.1124/jpet.110.176321. Epub 2010 Dec 30.

12.

Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity.

Milesi-Hallé A, Abdel-Rahman SM, Brown A, McCullough SS, Letzig L, Hinson JA, James LP.

Chem Biol Interact. 2011 Feb 1;189(3):222-9. doi: 10.1016/j.cbi.2010.12.001. Epub 2010 Dec 9.

13.

Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite.

Holthoff JH, Woodling KA, Doerge DR, Burns ST, Hinson JA, Mayeux PR.

Biochem Pharmacol. 2010 Oct 15;80(8):1260-5. doi: 10.1016/j.bcp.2010.06.027. Epub 2010 Jun 25.

14.

Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes.

Burke AS, MacMillan-Crow LA, Hinson JA.

Chem Res Toxicol. 2010 Jul 19;23(7):1286-92. doi: 10.1021/tx1001755.

15.

Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity.

Donahower BC, McCullough SS, Hennings L, Simpson PM, Stowe CD, Saad AG, Kurten RC, Hinson JA, James LP.

J Pharmacol Exp Ther. 2010 Jul;334(1):33-43. doi: 10.1124/jpet.109.163840. Epub 2010 Apr 2.

16.

Mechanisms of acetaminophen-induced liver necrosis.

Hinson JA, Roberts DW, James LP.

Handb Exp Pharmacol. 2010;(196):369-405. doi: 10.1007/978-3-642-00663-0_12. Review.

17.

Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.

James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, Davern TJ, Lee WM.

Drug Metab Dispos. 2009 Aug;37(8):1779-84. doi: 10.1124/dmd.108.026195. Epub 2009 May 13.

18.

Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose.

James LP, Capparelli EV, Simpson PM, Letzig L, Roberts D, Hinson JA, Kearns GL, Blumer JL, Sullivan JE; Network of Pediatric Pharmacology Research Units, National Institutes of Child Health and Human Development.

Clin Pharmacol Ther. 2008 Dec;84(6):684-90. doi: 10.1038/clpt.2008.190. Epub 2008 Oct 15.

19.

Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.

Burke AS, Redeker K, Kurten RC, James LP, Hinson JA.

J Toxicol Environ Health A. 2007 Nov;70(22):1936-45.

PMID:
17966065
20.

Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.

James LP, Alonso EM, Hynan LS, Hinson JA, Davern TJ, Lee WM, Squires RH; Pediatric Acute Liver Failure Study Group.

Pediatrics. 2006 Sep;118(3):e676-81.

PMID:
16950959
21.

Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity.

Donahower B, McCullough SS, Kurten R, Lamps LW, Simpson P, Hinson JA, James LP.

Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G102-9. Epub 2006 Mar 24.

22.

Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.

Davern TJ 2nd, James LP, Hinson JA, Polson J, Larson AM, Fontana RJ, Lalani E, Munoz S, Shakil AO, Lee WM; Acute Liver Failure Study Group.

Gastroenterology. 2006 Mar;130(3):687-94. Erratum in: Gastroenterology. 2006 May;130(6):1933.

PMID:
16530510
23.

Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress.

James LP, Donahower B, Burke AS, McCullough S, Hinson JA.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):171-6. Epub 2006 Mar 3.

PMID:
16530163
24.

Are oxidative mechanisms primary in ethanol induced Purkinje neuron death of the neonatal rat?

Pierce DR, Cook CC, Hinson JA, Light KE.

Neurosci Lett. 2006 May 29;400(1-2):130-4. Epub 2006 Mar 3.

PMID:
16516384
25.

Cytokines and toxicity in acetaminophen overdose.

James LP, Simpson PM, Farrar HC, Kearns GL, Wasserman GS, Blumer JL, Reed MD, Sullivan JE, Hinson JA.

J Clin Pharmacol. 2005 Oct;45(10):1165-71.

PMID:
16172181
26.
27.

Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition.

Hinson JA, Reid AB, McCullough SS, James LP.

Drug Metab Rev. 2004 Oct;36(3-4):805-22. Review.

PMID:
15554248
28.
29.

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.

Reid AB, Kurten RC, McCullough SS, Brock RW, Hinson JA.

J Pharmacol Exp Ther. 2005 Feb;312(2):509-16. Epub 2004 Oct 1.

PMID:
15466245
30.

Correlation of MCP1 with toxicity in acetaminophen overdose.

James LP, Simpson PM, Farrar HC, Wasserman G, Kearns GL, Hinson JA.

J Ark Med Soc. 2004 Jun;100(12):424-5. No abstract available.

PMID:
15200281
31.

NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia.

Gujral JS, Hinson JA, Farhood A, Jaeschke H.

Am J Physiol Gastrointest Liver Physiol. 2004 Jul;287(1):G243-52. Epub 2004 Mar 25.

32.

Chlorotyrosine protein adducts are reliable biomarkers of neutrophil-induced cytotoxicity in vivo.

Gujral JS, Hinson JA, Jaeschke H.

Comp Hepatol. 2004 Jan 14;3 Suppl 1:S48.

33.

Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.

James LP, McCullough SS, Knight TR, Jaeschke H, Hinson JA.

Free Radic Res. 2003 Dec;37(12):1289-97.

PMID:
14753753
34.

Acetaminophen-induced hepatotoxicity.

James LP, Mayeux PR, Hinson JA.

Drug Metab Dispos. 2003 Dec;31(12):1499-506. Review.

PMID:
14625346
35.

Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice.

Gujral JS, Liu J, Farhood A, Hinson JA, Jaeschke H.

Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G499-507. Epub 2003 Oct 16.

36.

Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse.

James LP, Lamps LW, McCullough S, Hinson JA.

Biochem Biophys Res Commun. 2003 Oct 3;309(4):857-63.

PMID:
13679052
37.

Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.

James LP, McCullough SS, Lamps LW, Hinson JA.

Toxicol Sci. 2003 Oct;75(2):458-67. Epub 2003 Jul 25.

PMID:
12883092
38.
39.

Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice.

Hinson JA, Bucci TJ, Irwin LK, Michael SL, Mayeux PR.

Nitric Oxide. 2002 Mar;6(2):160-7.

PMID:
11890740
40.

Mechanisms of hepatotoxicity.

Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ.

Toxicol Sci. 2002 Feb;65(2):166-76. Review.

PMID:
11812920
41.

Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity.

Michael SL, Mayeux PR, Bucci TJ, Warbritton AR, Irwin LK, Pumford NR, Hinson JA.

Nitric Oxide. 2001;5(5):432-41.

PMID:
11587558
42.

Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents.

James LP, Farrar HC, Darville TL, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Simpson PM, Hinson JA; Pediatric Pharmacology Research Unit Network, National Institute of Child Health and Human Development.

Clin Pharmacol Ther. 2001 Sep;70(3):280-6.

PMID:
11557916
43.

Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. .

James LP, Farrar HC, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Walson PD, Hinson JA, Pumford NR; Pediatric Pharmacology Research Unit Network, NICHD.

J Clin Pharmacol. 2001 Aug;41(8):846-51.

PMID:
11504272
44.

Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress.

Knight TR, Kurtz A, Bajt ML, Hinson JA, Jaeschke H.

Toxicol Sci. 2001 Aug;62(2):212-20.

PMID:
11452133
45.

Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Pediatric Pharmacology Research Unit Network.

James LP, Wilson JT, Simar R, Farrar HC, Kearns GL, Simpson PM, Hinson JA, Pumford NR; Pediatric Pharmacology Research Unit Network.

Clin Pediatr (Phila). 2001 May;40(5):243-8.

PMID:
11388672
46.

Oxidant stress in rat liver after lipopolysaccharide administration: effect of inducible nitric-oxide synthase inhibition.

Zhang C, Walker LM, Hinson JA, Mayeux PR.

J Pharmacol Exp Ther. 2000 Jun;293(3):968-72.

PMID:
10869399
47.

Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice.

Hinson JA, Michael SL, Ault SG, Pumford NR.

Toxicol Sci. 2000 Feb;53(2):467-73.

PMID:
10696795
48.
49.

Deferoxamine delays the development of the hepatotoxicity of acetaminophen in mice.

Schnellmann JG, Pumford NR, Kusewitt DF, Bucci TJ, Hinson JA.

Toxicol Lett. 1999 May 20;106(1):79-88.

PMID:
10378453
50.

Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice.

Hinson JA, Pike SL, Pumford NR, Mayeux PR.

Chem Res Toxicol. 1998 Jun;11(6):604-7.

PMID:
9625727

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