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Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study.

Sahal G, Woerdenbag HJ, Hinrichs WLJ, Visser A, Tepper PG, Quax WJ, van der Mei HC, Bilkay IS.

J Ethnopharmacol. 2019 Aug 27;246:112188. doi: 10.1016/j.jep.2019.112188. [Epub ahead of print]


Respiratory syncytial virus subunit vaccines based on the viral envelope glycoproteins intended for pregnant women and the elderly.

Beugeling M, De Zee J, Woerdenbag HJ, Frijlink HW, Wilschut JC, Hinrichs WLJ.

Expert Rev Vaccines. 2019 Sep;18(9):935-950. doi: 10.1080/14760584.2019.1657013. Epub 2019 Aug 25.


Oromucosal films: from patient centricity to production by printing techniques.

Tian Y, Orlu M, Woerdenbag HJ, Scarpa M, Kiefer O, Kottke D, Sjöholm E, Öblom H, Sandler N, Hinrichs WLJ, Frijlink HW, Breitkreutz J, Visser JC.

Expert Opin Drug Deliv. 2019 Sep;16(9):981-993. doi: 10.1080/17425247.2019.1652595. Epub 2019 Aug 8.


Structural and biochemical analysis of a phosin from Streptomyces chartreusis reveals a combined polyphosphate- and metal-binding fold.

Werten S, Rustmeier NH, Gemmer M, Virolle MJ, Hinrichs W.

FEBS Lett. 2019 Aug;593(15):2019-2029. doi: 10.1002/1873-3468.13476. Epub 2019 Jun 17.


The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor.

van Dijk F, Teekamp N, Post E, Schuppan D, Kim YO, Zuidema J, Steendam R, Klose MHM, Meier-Menches SM, Casini A, Horvatovich PL, Sijbrandi NJ, Frijlink HW, Hinrichs WLJ, Poelstra K, Beljaars L, Olinga P.

J Control Release. 2019 Feb 28;296:250-257. doi: 10.1016/j.jconrel.2018.12.039. Epub 2019 Jan 22.


Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle.

Grasmeijer N, Tiraboschi V, Woerdenbag HJ, Frijlink HW, Hinrichs WLJ.

Eur J Pharm Sci. 2019 Feb 1;128:152-157. doi: 10.1016/j.ejps.2018.11.027. Epub 2018 Dec 3.


siRNA-mediated protein knockdown in precision-cut lung slices.

Ruigrok MJR, Xian JL, Frijlink HW, Melgert BN, Hinrichs WLJ, Olinga P.

Eur J Pharm Biopharm. 2018 Dec;133:339-348. doi: 10.1016/j.ejpb.2018.11.005. Epub 2018 Nov 7.


Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge.

Tomar J, Biel C, de Haan CAM, Rottier PJM, Petrovsky N, Frijlink HW, Huckriede A, Hinrichs WLJ, Peeters B.

Eur J Pharm Biopharm. 2018 Dec;133:85-95. doi: 10.1016/j.ejpb.2018.10.008. Epub 2018 Oct 9.


Orodispersible films based on blends of trehalose and pullulan for protein delivery.

Tian Y, Visser JC, Klever JS, Woerdenbag HJ, Frijlink HW, Hinrichs WLJ.

Eur J Pharm Biopharm. 2018 Dec;133:104-111. doi: 10.1016/j.ejpb.2018.09.016. Epub 2018 Sep 29.


The mechanism behind the biphasic pulsatile drug release from physically mixed poly(dl-lactic(-co-glycolic) acid)-based compacts.

Beugeling M, Grasmeijer N, Born PA, van der Meulen M, van der Kooij RS, Schwengle K, Baert L, Amssoms K, Frijlink HW, Hinrichs WLJ.

Int J Pharm. 2018 Nov 15;551(1-2):195-202. doi: 10.1016/j.ijpharm.2018.09.025. Epub 2018 Sep 14.


Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge.

Tomar J, Patil HP, Bracho G, Tonnis WF, Frijlink HW, Petrovsky N, Vanbever R, Huckriede A, Hinrichs WLJ.

J Control Release. 2018 Oct 28;288:199-211. doi: 10.1016/j.jconrel.2018.09.006. Epub 2018 Sep 12.


Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice.

Amssoms K, Born PA, Beugeling M, De Clerck B, Van Gulck E, Hinrichs WLJ, Frijlink HW, Grasmeijer N, Kraus G, Sutmuller R, Simmen K, Baert L.

PLoS One. 2018 Aug 30;13(8):e0202961. doi: 10.1371/journal.pone.0202961. eCollection 2018.


Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations.

Visser JC, Ten Seldam IEJ, van der Linden IJ, Hinrichs WLJ, Veenendaal RFH, Dijkers ECF, Woerdenbag HJ.

Int J Pharm Compd. 2018 May-Jun;22(3):247-251.


Pulmonary delivery of influenza vaccine formulations in cotton rats: site of deposition plays a minor role in the protective efficacy against clinical isolate of H1N1pdm virus.

Bhide Y, Tomar J, Dong W, de Vries-Idema J, Frijlink HW, Huckriede A, Hinrichs WLJ.

Drug Deliv. 2018 Nov;25(1):533-545. doi: 10.1080/10717544.2018.1435748.


Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver.

van Dijk F, Teekamp N, Beljaars L, Post E, Zuidema J, Steendam R, Kim YO, Frijlink HW, Schuppan D, Poelstra K, Hinrichs WLJ, Olinga P.

J Control Release. 2018 Jan 10;269:258-265. doi: 10.1016/j.jconrel.2017.11.029. Epub 2017 Nov 21.


Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle.

Kauppinen A, Broekhuis J, Grasmeijer N, Tonnis W, Ketolainen J, Frijlink HW, Hinrichs WLJ.

Eur J Pharm Biopharm. 2018 Feb;123:50-58. doi: 10.1016/j.ejpb.2017.11.009. Epub 2017 Nov 21.


Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney.

Teekamp N, Van Dijk F, Broesder A, Evers M, Zuidema J, Steendam R, Post E, Hillebrands JL, Frijlink HW, Poelstra K, Beljaars L, Olinga P, Hinrichs WLJ.

Int J Pharm. 2017 Dec 20;534(1-2):229-236. doi: 10.1016/j.ijpharm.2017.09.072. Epub 2017 Oct 14.


Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions.

Teekamp N, Tian Y, Visser JC, Olinga P, Frijlink HW, Woerdenbag HJ, Hinrichs WLJ.

Carbohydr Polym. 2017 Nov 15;176:374-380. doi: 10.1016/j.carbpol.2017.08.084. Epub 2017 Aug 24.


siRNA-Mediated RNA Interference in Precision-Cut Tissue Slices Prepared from Mouse Lung and Kidney.

Ruigrok MJR, Maggan N, Willaert D, Frijlink HW, Melgert BN, Olinga P, Hinrichs WLJ.

AAPS J. 2017 Nov;19(6):1855-1863. doi: 10.1208/s12248-017-0136-y. Epub 2017 Sep 11.


Thermal Gradient Mid- and Far-Infrared Spectroscopy as Tools for Characterization of Protein Carbohydrate Lyophilizates.

Mensink MA, Šibík J, Frijlink HW, van der Voort Maarschalk K, Hinrichs WLJ, Zeitler JA.

Mol Pharm. 2017 Oct 2;14(10):3550-3557. doi: 10.1021/acs.molpharmaceut.7b00568. Epub 2017 Sep 15.


Assemblins as maturational proteases in herpesviruses.

Zühlsdorf M, Hinrichs W.

J Gen Virol. 2017 Aug;98(8):1969-1984. doi: 10.1099/jgv.0.000872. Epub 2017 Jul 31. Review.


Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation.

Patil HP, Herrera Rodriguez J, de Vries-Idema J, Meijerhof T, Frijlink HW, Hinrichs WLJ, Huckriede A.

Vaccines (Basel). 2017 Jul 27;5(3). pii: E19. doi: 10.3390/vaccines5030019.


Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.

Wehr MC, Hinrichs W, Brzózka MM, Unterbarnscheidt T, Herholt A, Wintgens JP, Papiol S, Soto-Bernardini MC, Kravchenko M, Zhang M, Nave KA, Wichert SP, Falkai P, Zhang W, Schwab MH, Rossner MJ.

EMBO Mol Med. 2017 Oct;9(10):1448-1462. doi: 10.15252/emmm.201707691.


Antibiotic resistance: Blocking tetracycline destruction.

Petkovic S, Hinrichs W.

Nat Chem Biol. 2017 Jul;13(7):694-695. doi: 10.1038/nchembio.2396. Epub 2017 May 8. No abstract available.


How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions.

Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL.

Eur J Pharm Biopharm. 2017 May;114:288-295. doi: 10.1016/j.ejpb.2017.01.024. Epub 2017 Feb 9. Review.


A Quantitative Real-Time RT-PCR Assay for the Detection of Venezuelan equine encephalitis virus Utilizing a Universal Alphavirus Control RNA.

Vina-Rodriguez A, Eiden M, Keller M, Hinrichs W, Groschup MH.

Biomed Res Int. 2016;2016:8543204. doi: 10.1155/2016/8543204. Epub 2016 Nov 29.


Structural evidence of intramolecular propeptide inhibition of the aspzincin metalloendopeptidase AsaP1.

Bogdanović X, Palm GJ, Schwenteit J, Singh RK, Gudmundsdóttir BK, Hinrichs W.

FEBS Lett. 2016 Sep;590(18):3280-94. doi: 10.1002/1873-3468.12356. Epub 2016 Sep 6.


Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability.

Mensink MA, Nethercott MJ, Hinrichs WLJ, van der Voort Maarschalk K, Frijlink HW, Munson EJ, Pikal MJ.

AAPS J. 2016 Sep;18(5):1225-1232. doi: 10.1208/s12248-016-9937-7. Epub 2016 Jun 14.


Pulmonary administration of small interfering RNA: The route to go?

Ruigrok MJR, Frijlink HW, Hinrichs WLJ.

J Control Release. 2016 Aug 10;235:14-23. doi: 10.1016/j.jconrel.2016.05.054. Epub 2016 May 25. Review.


Dry influenza vaccines: towards a stable, effective and convenient alternative to conventional parenteral influenza vaccination.

Tomar J, Born PA, Frijlink HW, Hinrichs WL.

Expert Rev Vaccines. 2016 Nov;15(11):1431-1447. Epub 2016 May 21. Review.


Modular organisation of inducer recognition and allostery in the tetracycline repressor.

Werten S, Schneider J, Palm GJ, Hinrichs W.

FEBS J. 2016 Jun;283(11):2102-14. doi: 10.1111/febs.13723. Epub 2016 Apr 20.


Development and potential application of an oral ColoPulse infliximab tablet with colon specific release: A feasibility study.

Maurer JM, Hofman S, Schellekens RC, Tonnis WF, Dubois AO, Woerdenbag HJ, Hinrichs WL, Kosterink JG, Frijlink HW.

Int J Pharm. 2016 May 30;505(1-2):175-86. doi: 10.1016/j.ijpharm.2016.03.027. Epub 2016 Mar 17.


Correction: Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease.

Zühlsdorf M, Werten S, Klupp BG, Palm GJ, Mettenleiter TC, Hinrichs W.

PLoS Pathog. 2016 Mar 11;12(3):e1005506. doi: 10.1371/journal.ppat.1005506. eCollection 2016 Mar. No abstract available.


Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4.

Werten S, Kohler C, Bayer NJ, Steinmetz I, Hinrichs W.

Gene. 2016 Feb 15;577(2):140-7. doi: 10.1016/j.gene.2015.11.037. Epub 2015 Nov 25.


In-line near infrared spectroscopy during freeze-drying as a tool to measure efficiency of hydrogen bond formation between protein and sugar, predictive of protein storage stability.

Mensink MA, Van Bockstal PJ, Pieters S, De Meyer L, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL, De Beer T.

Int J Pharm. 2015 Dec 30;496(2):792-800. doi: 10.1016/j.ijpharm.2015.11.030. Epub 2015 Nov 23.


Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications.

Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL.

Carbohydr Polym. 2015 Dec 10;134:418-28. doi: 10.1016/j.carbpol.2015.08.022. Epub 2015 Aug 13. Review.


Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease.

Zühlsdorf M, Werten S, Klupp BG, Palm GJ, Mettenleiter TC, Hinrichs W.

PLoS Pathog. 2015 Jul 10;11(7):e1005045. doi: 10.1371/journal.ppat.1005045. eCollection 2015 Jul. Erratum in: PLoS Pathog. 2016 Mar;12(3):e1005506.


Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics.

Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL.

Carbohydr Polym. 2015 Oct 5;130:405-19. doi: 10.1016/j.carbpol.2015.05.026. Epub 2015 May 20. Review.


Comparison of adjuvants for a spray freeze-dried whole inactivated virus influenza vaccine for pulmonary administration.

Patil HP, Murugappan S, de Vries-Idema J, Meijerhof T, de Haan A, Frijlink HW, Wilschut J, Hinrichs WL, Huckriede A.

Eur J Pharm Biopharm. 2015 Jun;93:231-41. doi: 10.1016/j.ejpb.2015.04.004. Epub 2015 Apr 17.


Structure and catalytic mechanism of the evolutionarily unique bacterial chalcone isomerase.

Thomsen M, Tuukkanen A, Dickerhoff J, Palm GJ, Kratzat H, Svergun DI, Weisz K, Bornscheuer UT, Hinrichs W.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):907-17. doi: 10.1107/S1399004715001935. Epub 2015 Mar 27.


Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films.

Visser JC, Dohmen WM, Hinrichs WL, Breitkreutz J, Frijlink HW, Woerdenbag HJ.

Int J Pharm. 2015 May 15;485(1-2):70-6. doi: 10.1016/j.ijpharm.2015.03.005. Epub 2015 Mar 5.


Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization.

Stanković M, Frijlink HW, Hinrichs WL.

Drug Discov Today. 2015 Jul;20(7):812-23. doi: 10.1016/j.drudis.2015.01.012. Epub 2015 Feb 7. Review.


Production methods and stabilization strategies for polymer-based nanoparticles and microparticles for parenteral delivery of peptides and proteins.

Teekamp N, Duque LF, Frijlink HW, Hinrichs WL, Olinga P.

Expert Opin Drug Deliv. 2015 Aug;12(8):1311-31. doi: 10.1517/17425247.2015.1003807. Epub 2015 Jan 19. Review.


Size and molecular flexibility of sugars determine the storage stability of freeze-dried proteins.

Tonnis WF, Mensink MA, de Jager A, van der Voort Maarschalk K, Frijlink HW, Hinrichs WL.

Mol Pharm. 2015 Mar 2;12(3):684-94. doi: 10.1021/mp500423z. Epub 2015 Jan 26.


Protein release from water-swellable poly(D,L-lactide-PEG)-b-poly(ϵ-caprolactone) implants.

Stanković M, Hiemstra C, de Waard H, Zuidema J, Steendam R, Frijlink HW, Hinrichs WL.

Int J Pharm. 2015 Mar 1;480(1-2):73-83. doi: 10.1016/j.ijpharm.2015.01.007. Epub 2015 Jan 6.


A novel aerosol generator for homogenous distribution of powder over the lungs after pulmonary administration to small laboratory animals.

Tonnis WF, Bagerman M, Weij M, Sjollema J, Frijlink HW, Hinrichs WL, de Boer AH.

Eur J Pharm Biopharm. 2014 Nov;88(3):1056-63.


Enhanced pulmonary immunization with aerosolized inactivated influenza vaccine containing delta inulin adjuvant.

Murugappan S, Frijlink HW, Petrovsky N, Hinrichs WL.

Eur J Pharm Sci. 2015 Jan 23;66:118-22. doi: 10.1016/j.ejps.2014.10.008. Epub 2014 Oct 20.


Orodispersible films in individualized pharmacotherapy: The development of a formulation for pharmacy preparations.

Visser JC, Woerdenbag HJ, Crediet S, Gerrits E, Lesschen MA, Hinrichs WLJ, Breitkreutz J, Frijlink HW.

Int J Pharm. 2015 Jan 15;478(1):155-163. doi: 10.1016/j.ijpharm.2014.11.013. Epub 2014 Nov 7.


Tetracycline repressor allostery does not depend on divalent metal recognition.

Werten S, Dalm D, Palm GJ, Grimm CC, Hinrichs W.

Biochemistry. 2014 Dec 23;53(50):7990-8. doi: 10.1021/bi5012805. Epub 2014 Dec 9.


Structural and biochemical characterization of the dual substrate recognition of the (R)-selective amine transaminase from Aspergillus fumigatus.

Skalden L, Thomsen M, Höhne M, Bornscheuer UT, Hinrichs W.

FEBS J. 2015 Jan;282(2):407-15. doi: 10.1111/febs.13149. Epub 2014 Dec 2.

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