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ELQ-331 as a prototype for extremely durable chemoprotection against malaria.

Smilkstein MJ, Pou S, Krollenbrock A, Bleyle LA, Dodean RA, Frueh L, Hinrichs DJ, Li Y, Martinson T, Munar MY, Winter RW, Bruzual I, Whiteside S, Nilsen A, Koop DR, Kelly JX, Kappe SHI, Wilder BK, Riscoe MK.

Malar J. 2019 Aug 27;18(1):291. doi: 10.1186/s12936-019-2921-9.


Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone.

Lawres LA, Garg A, Kumar V, Bruzual I, Forquer IP, Renard I, Virji AZ, Boulard P, Rodriguez EX, Allen AJ, Pou S, Wegmann KW, Winter RW, Nilsen A, Mao J, Preston DA, Belperron AA, Bockenstedt LK, Hinrichs DJ, Riscoe MK, Doggett JS, Ben Mamoun C.

J Exp Med. 2016 Jun 27;213(7):1307-18. doi: 10.1084/jem.20151519. Epub 2016 Jun 6.


Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.

Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, Nilsen A.

Am J Trop Med Hyg. 2015 Jun;92(6):1195-201. doi: 10.4269/ajtmh.14-0553. Epub 2015 Apr 27.


Absence of the memory response to encephalitogen following intergender adoptively transferred experimental autoimmune encephalomyelitis.

Archie Bouwer HG, Gregory CR, Wegmann KW, Hinrichs DJ.

J Neuroimmunol. 2015 Jan 15;278:194-9. doi: 10.1016/j.jneuroim.2014.11.006. Epub 2014 Nov 13.


Eluding anaphylaxis allows peptide-specific prevention of the relapsing stage of experimental autoimmune encephalomyelitis.

Wegmann KW, Archie Bouwer HG, Whitham RH, Hinrichs DJ.

J Neuroimmunol. 2014 Sep 15;274(1-2):46-52. doi: 10.1016/j.jneuroim.2014.06.011. Epub 2014 Jun 26.


Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.

Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.

J Med Chem. 2014 May 8;57(9):3818-34. doi: 10.1021/jm500147k. Epub 2014 Apr 18.


Alternative splice forms of CTLA-4 induced by antisense mediated splice-switching influences autoimmune diabetes susceptibility in NOD mice.

Mourich DV, Oda SK, Schnell FJ, Crumley SL, Hauck LL, Moentenich CA, Marshall NB, Hinrichs DJ, Iversen PL.

Nucleic Acid Ther. 2014 Apr;24(2):114-26. doi: 10.1089/nat.2013.0449. Epub 2014 Feb 4.


Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro.

Janowsky A, Eshleman AJ, Johnson RA, Wolfrum KM, Hinrichs DJ, Yang J, Zabriskie TM, Smilkstein MJ, Riscoe MK.

Psychopharmacology (Berl). 2014 Jul;231(14):2771-83. doi: 10.1007/s00213-014-3446-0. Epub 2014 Feb 2.


Targeting T cells responsive to the priming epitope prevent the relapsing phase of experimental autoimmune encephalomyelitis.

Wegmann KW, Bouwer HG, Gregory CR, Whitham RH, Hinrichs DJ.

J Neuroimmunol. 2013 Jul 15;260(1-2):74-81. doi: 10.1016/j.jneuroim.2013.04.001. Epub 2013 Apr 20.


Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis.

Doggett JS, Nilsen A, Forquer I, Wegmann KW, Jones-Brando L, Yolken RH, Bordón C, Charman SA, Katneni K, Schultz T, Burrows JN, Hinrichs DJ, Meunier B, Carruthers VB, Riscoe MK.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41. Epub 2012 Sep 10.


Sontochin as a guide to the development of drugs against chloroquine-resistant malaria.

Pou S, Winter RW, Nilsen A, Kelly JX, Li Y, Doggett JS, Riscoe EW, Wegmann KW, Hinrichs DJ, Riscoe MK.

Antimicrob Agents Chemother. 2012 Jul;56(7):3475-80. doi: 10.1128/AAC.00100-12. Epub 2012 Apr 16.


Using a framework for spread of best practices to implement successful venous thromboembolism prophylaxis throughout a large hospital system.

Morgenthaler TI, Lovely JK, Cima RR, Berardinelli CF, Fedraw LA, Wallerich TJ, Hinrichs DJ, Varkey P.

Am J Med Qual. 2012 Jan-Feb;27(1):30-8. doi: 10.1177/1062860611411518. Epub 2011 Aug 10.


Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?

Zhang Z, Rosenbaum JT, Zhong W, Lim C, Hinrichs DJ.

Semin Immunopathol. 2010 Mar;32(1):55-70. doi: 10.1007/s00281-009-0190-3. Epub 2010 Jan 30. Review.


Inflammatory skin disease in K5.hTGF-beta1 transgenic mice is not dependent on the IL-23/Th17 inflammatory pathway.

Fitch EL, Rizzo HL, Kurtz SE, Wegmann KW, Gao W, Benson JM, Hinrichs DJ, Blauvelt A.

J Invest Dermatol. 2009 Oct;129(10):2443-50. doi: 10.1038/jid.2009.88. Epub 2009 Apr 9.


Discovery of dual function acridones as a new antimalarial chemotype.

Kelly JX, Smilkstein MJ, Brun R, Wittlin S, Cooper RA, Lane KD, Janowsky A, Johnson RA, Dodean RA, Winter R, Hinrichs DJ, Riscoe MK.

Nature. 2009 May 14;459(7244):270-3. doi: 10.1038/nature07937. Epub 2009 Apr 8.


Antisense targeting of cFLIP sensitizes activated T cells to undergo apoptosis and desensitizes responses to contact dermatitis.

Mourich DV, Jendrzejewski JL, Marshall NB, Hinrichs DJ, Iversen PL, Brand RM.

J Invest Dermatol. 2009 Aug;129(8):1945-53. doi: 10.1038/jid.2009.16. Epub 2009 Feb 19.


Synthetic Peptide dendrimers block the development and expression of experimental allergic encephalomyelitis.

Wegmann KW, Wagner CR, Whitham RH, Hinrichs DJ.

J Immunol. 2008 Sep 1;181(5):3301-9.


A drug-selected Plasmodium falciparum lacking the need for conventional electron transport.

Smilkstein MJ, Forquer I, Kanazawa A, Kelly JX, Winter RW, Hinrichs DJ, Kramer DM, Riscoe MK.

Mol Biochem Parasitol. 2008 May;159(1):64-8. doi: 10.1016/j.molbiopara.2008.01.002. Epub 2008 Jan 19.


Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1beta and tumor necrosis factor-alpha.

Loftis JM, Huckans M, Ruimy S, Hinrichs DJ, Hauser P.

Neurosci Lett. 2008 Jan 17;430(3):264-8. Epub 2007 Nov 6.


Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.

Kelly JX, Smilkstein MJ, Cooper RA, Lane KD, Johnson RA, Janowsky A, Dodean RA, Hinrichs DJ, Winter R, Riscoe M.

Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. Epub 2007 Sep 10.


After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease?

Zhang Z, Hinrichs DJ, Lu H, Chen H, Zhong W, Kolls JK.

Int Immunopharmacol. 2007 Apr;7(4):409-16. Epub 2006 Nov 13. Review.


Selective killing of the human malaria parasite Plasmodium falciparum by a benzylthiazolium dye.

Kelly JX, Winter RW, Braun TP, Osei-Agyemang M, Hinrichs DJ, Riscoe MK.

Exp Parasitol. 2007 Jun;116(2):103-10. Epub 2006 Dec 21.


Cutting edge: identification of hepatitis C virus-specific CD8+ T cells restricted by donor HLA alleles following liver transplantation.

Rosen HR, Hinrichs DJ, Leistikow RL, Callender G, Wertheimer AM, Nishimura MI, Lewinsohn DM.

J Immunol. 2004 Nov 1;173(9):5355-9.


The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40.

Montfort MJ, Bouwer HG, Wagner CR, Hinrichs DJ.

J Immunol. 2004 Sep 15;173(6):4084-90.


Listeria monocytogenes as a vaccine vector: virulence attenuation or existing antivector immunity does not diminish therapeutic efficacy.

Starks H, Bruhn KW, Shen H, Barry RA, Dubensky TW, Brockstedt D, Hinrichs DJ, Higgins DE, Miller JF, Giedlin M, Bouwer HG.

J Immunol. 2004 Jul 1;173(1):420-7.


Antileishmanial drug development: exploitation of parasite heme dependency.

Kelly JX, Ignatushchenko MV, Bouwer HG, Peyton DH, Hinrichs DJ, Winter RW, Riscoe M.

Mol Biochem Parasitol. 2003 Jan;126(1):43-9.


The kinetics of uptake and accumulation of 3,6-bis-omega-diethylamino-amyloxyxanthone by the human malaria parasite Plasmodium falciparum.

Kelly JX, Winter RW, Cornea A, Peyton DH, Hinrichs DJ, Riscoe M.

Mol Biochem Parasitol. 2002 Aug 7;123(1):47-54.


Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages.

Rosen HR, Miner C, Sasaki AW, Lewinsohn DM, Conrad AJ, Bakke A, Bouwer HG, Hinrichs DJ.

Hepatology. 2002 Jan;35(1):190-8.


Optimization of xanthones for antimalarial activity: the 3,6-bis-omega-diethylaminoalkoxyxanthone series.

Kelly JX, Winter R, Peyton DH, Hinrichs DJ, Riscoe M.

Antimicrob Agents Chemother. 2002 Jan;46(1):144-50.


Association of multispecific CD4(+) response to hepatitis C and severity of recurrence after liver transplantation.

Rosen HR, Hinrichs DJ, Gretch DR, Koziel MJ, Chou S, Houghton M, Rabkin J, Corless CL, Bouwer HG.

Gastroenterology. 1999 Oct;117(4):926-32.


Genetic immunization of mice against Listeria monocytogenes using plasmid DNA encoding listeriolysin O.

Cornell KA, Bouwer HG, Hinrichs DJ, Barry RA.

J Immunol. 1999 Jul 1;163(1):322-9.


Listeria monocytogenes-infected hepatocytes are targets of major histocompatibility complex class Ib-restricted antilisterial cytotoxic T lymphocytes.

Bouwer HG, Bai A, Forman J, Gregory SH, Wing EJ, Barry RA, Hinrichs DJ.

Infect Immun. 1998 Jun;66(6):2814-7.


Acquired immunity to an intracellular pathogen: immunologic recognition of L. monocytogenes-infected cells.

Bouwer HG, Barry RA, Hinrichs DJ.

Immunol Rev. 1997 Aug;158:137-46. Review.


Potentiation of an antimalarial oxidant drug.

Winter RW, Ignatushchenko M, Ogundahunsi OA, Cornell KA, Oduola AM, Hinrichs DJ, Riscoe MK.

Antimicrob Agents Chemother. 1997 Jul;41(7):1449-54.


Xanthones as antimalarial agents; studies of a possible mode of action.

Ignatushchenko MV, Winter RW, Bächinger HP, Hinrichs DJ, Riscoe MK.

FEBS Lett. 1997 Jun 2;409(1):67-73.


Experimental allergic encephalomyelitis and vaccination-induced resistance in DA rats.

Bouwer HG, Hinrichs DJ.

Cell Immunol. 1997 Jan 10;175(1):92-8.


Potentiation of the antimalarial agent rufigallol.

Winter RW, Cornell KA, Johnson LL, Ignatushchenko M, Hinrichs DJ, Riscoe MK.

Antimicrob Agents Chemother. 1996 Jun;40(6):1408-11.


An H2-T MHC class Ib molecule presents Listeria monocytogenes-derived antigen to immune CD8+ cytotoxic T cells.

Bouwer HG, Lindahl KF, Baldridge JR, Wagner CR, Barry RA, Hinrichs DJ.

J Immunol. 1994 Jun 1;152(11):5352-60.


Antilisterial immunity includes specificity to listeriolysin O (LLO) and non-LLO-derived determinants.

Bouwer HG, Gibbins BL, Jones S, Hinrichs DJ.

Infect Immun. 1994 Mar;62(3):1039-45.


Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants.

Marquis H, Bouwer HG, Hinrichs DJ, Portnoy DA.

Infect Immun. 1993 Sep;61(9):3756-60.


Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity.

Makler MT, Ries JM, Williams JA, Bancroft JE, Piper RC, Gibbins BL, Hinrichs DJ.

Am J Trop Med Hyg. 1993 Jun;48(6):739-41.


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