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Items: 1 to 50 of 119

1.

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity.

Ikegami R, Shimizu I, Sato T, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen NZ, Scheele C, Soga T, Minamino T.

Cell Rep. 2018 Sep 11;24(11):2827-2837.e5. doi: 10.1016/j.celrep.2018.08.024.

2.

Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.

Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Manabe T, Ishigaki Y, Ohno M, Hinoi E.

Stem Cell Reports. 2018 Jul 10;11(1):228-241. doi: 10.1016/j.stemcr.2018.05.020. Epub 2018 Jun 28.

3.

The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis.

Iezaki T, Fukasawa K, Horie T, Park G, Robinson S, Nakaya M, Fujita H, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Yoneda Y, Takarada T, Guo XE, Kurose H, Hinoi E.

Development. 2018 Jul 26;145(14). pii: dev164004. doi: 10.1242/dev.164004.

PMID:
29986870
4.

Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory.

Zhang T, Deyama S, Domoto M, Wada S, Yanagida J, Sasase H, Hinoi E, Nishitani N, Nagayasu K, Kaneko S, Kaneda K.

Biol Pharm Bull. 2018;41(7):1084-1088. doi: 10.1248/bpb.b18-00221.

5.

The synthetic cannabinoid 5F-AMB changes the balance between excitation and inhibition of layer V pyramidal neurons in the mouse medial prefrontal cortex.

Domoto M, Sasase H, Wada S, Ito S, Deyama S, Hinoi E, Kaneko S, Kaneda K.

Psychopharmacology (Berl). 2018 Aug;235(8):2367-2376. doi: 10.1007/s00213-018-4933-5. Epub 2018 Jun 2.

PMID:
29858613
6.

Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice.

Ito Y, Fukui M, Kanda M, Morishita K, Shoji Y, Kitao T, Hinoi E, Shirahase H.

J Pharmacol Sci. 2018 May;137(1):38-46. doi: 10.1016/j.jphs.2018.03.001. Epub 2018 Mar 6.

7.

SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.

Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K.

Biochem Biophys Res Commun. 2018 Feb 2. pii: S0006-291X(18)30144-X. doi: 10.1016/j.bbrc.2018.01.129. [Epub ahead of print]

PMID:
29402405
8.

Hypoxic Stress Upregulates the Expression of Slc38a1 in Brown Adipocytes via Hypoxia-Inducible Factor-1α.

Horie T, Fukasawa K, Iezaki T, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Hinoi E.

Pharmacology. 2018;101(1-2):64-71. doi: 10.1159/000480405. Epub 2017 Oct 25.

PMID:
29065407
9.

Disruption of Bmal1 Impairs Blood-Brain Barrier Integrity via Pericyte Dysfunction.

Nakazato R, Kawabe K, Yamada D, Ikeno S, Mieda M, Shimba S, Hinoi E, Yoneda Y, Takarada T.

J Neurosci. 2017 Oct 18;37(42):10052-10062. doi: 10.1523/JNEUROSCI.3639-16.2017. Epub 2017 Sep 14.

10.

Amelioration of the Development of Osteoarthritis by Daily Intake of β-Cryptoxanthin.

Park G, Horie T, Fukasawa K, Ozaki K, Onishi Y, Kanayama T, Iezaki T, Kaneda K, Sugiura M, Hinoi E.

Biol Pharm Bull. 2017;40(7):1116-1120. doi: 10.1248/bpb.b17-00161.

11.

Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain.

Park G, Horie T, Iezaki T, Okamoto M, Fukasawa K, Kanayama T, Ozaki K, Onishi Y, Sugiura M, Hinoi E.

Biosci Biotechnol Biochem. 2017 May;81(5):1014-1017. doi: 10.1080/09168451.2017.1280661. Epub 2017 Jan 23.

PMID:
28110620
12.

The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes.

Park G, Horie T, Kanayama T, Fukasawa K, Iezaki T, Onishi Y, Ozaki K, Nakamura Y, Yoneda Y, Takarada T, Hinoi E.

FEBS J. 2017 Mar;284(5):784-795. doi: 10.1111/febs.14019. Epub 2017 Feb 10.

13.

Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.

Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R, Hida A, Tei H, Takeda S, Hinoi E.

J Bone Miner Res. 2017 Apr;32(4):872-881. doi: 10.1002/jbmr.3053. Epub 2017 Mar 3.

14.

The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.

Onishi Y, Park G, Iezaki T, Horie T, Kanayama T, Fukasawa K, Ozaki K, Hinoi E.

Biochem Biophys Res Commun. 2017 Jan 8;482(2):329-334. doi: 10.1016/j.bbrc.2016.11.063. Epub 2016 Nov 14.

PMID:
27856249
15.

The intrinsic microglial clock system regulates interleukin-6 expression.

Nakazato R, Hotta S, Yamada D, Kou M, Nakamura S, Takahata Y, Tei H, Numano R, Hida A, Shimba S, Mieda M, Hinoi E, Yoneda Y, Takarada T.

Glia. 2017 Jan;65(1):198-208. doi: 10.1002/glia.23087. Epub 2016 Oct 11.

PMID:
27726182
16.

ATF3 controls proliferation of osteoclast precursor and bone remodeling.

Fukasawa K, Park G, Iezaki T, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Yoneda Y, Takarada T, Kitajima S, Vacher J, Hinoi E.

Sci Rep. 2016 Aug 2;6:30918. doi: 10.1038/srep30918.

17.

[Regulation of bone homeostasis by glucose].

Fukasawa K, Hinoi E.

Clin Calcium. 2016 Aug;26(8):1165-70. doi: CliCa160811651170. Japanese.

PMID:
27461500
18.

Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-κB/NFATc1 Pathway.

Iezaki T, Fukasawa K, Park G, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Nakamura Y, Takarada T, Yoneda Y, Nakamura T, Vacher J, Hinoi E.

Mol Cell Biol. 2016 Sep 12;36(19):2451-63. doi: 10.1128/MCB.01075-15. Print 2016 Oct 1.

19.

ATF3 deficiency in chondrocytes alleviates osteoarthritis development.

Iezaki T, Ozaki K, Fukasawa K, Inoue M, Kitajima S, Muneta T, Takeda S, Fujita H, Onishi Y, Horie T, Yoneda Y, Takarada T, Hinoi E.

J Pathol. 2016 Aug;239(4):426-37. doi: 10.1002/path.4739. Epub 2016 Jun 14.

PMID:
27159257
20.

Protective upregulation of activating transcription factor-3 against glutamate neurotoxicity in neuronal cells under ischemia.

Takarada T, Kou M, Hida M, Fukumori R, Nakamura S, Kutsukake T, Kuramoto N, Hinoi E, Yoneda Y.

J Neurosci Res. 2016 May;94(5):378-88. doi: 10.1002/jnr.23723. Epub 2016 Feb 22.

PMID:
26900013
21.

Circadian Clock Regulates Bone Resorption in Mice.

Xu C, Ochi H, Fukuda T, Sato S, Sunamura S, Takarada T, Hinoi E, Okawa A, Takeda S.

J Bone Miner Res. 2016 Jul;31(7):1344-55. doi: 10.1002/jbmr.2803. Epub 2016 Mar 4.

22.

GDF1 is a novel mediator of macrophage infiltration in brown adipose tissue of obese mice.

Onishi Y, Fukasawa K, Ozaki K, Iezaki T, Yoneda Y, Hinoi E.

Biochem Biophys Rep. 2015 Dec 21;5:216-223. doi: 10.1016/j.bbrep.2015.12.008. eCollection 2016 Mar.

23.

Genetic analysis of Runx2 function during intramembranous ossification.

Takarada T, Nakazato R, Tsuchikane A, Fujikawa K, Iezaki T, Yoneda Y, Hinoi E.

Development. 2016 Jan 15;143(2):211-8. doi: 10.1242/dev.128793. Epub 2015 Dec 10.

24.

Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro.

Takarada T, Nakamichi N, Nakazato R, Kakuda T, Kokubo H, Ikeno S, Nakamura S, Kuramoto N, Hinoi E, Yoneda Y.

Biochem Biophys Rep. 2015 Dec 1;5:89-95. doi: 10.1016/j.bbrep.2015.09.021. eCollection 2016 Mar.

25.

Involvement of calpain in 4-hydroxynonenal-induced disruption of gap junction-mediated intercellular communication among fibrocytes in primary cultures derived from the cochlear spiral ligament.

Yamaguchi T, Yoneyama M, Hinoi E, Ogita K.

J Pharmacol Sci. 2015 Oct;129(2):127-34. doi: 10.1016/j.jphs.2015.09.005. Epub 2015 Oct 8.

26.

The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption.

Iezaki T, Onishi Y, Ozaki K, Fukasawa K, Takahata Y, Nakamura Y, Fujikawa K, Takarada T, Yoneda Y, Yamashita Y, Shioi G, Hinoi E.

J Bone Miner Res. 2016 Mar;31(3):573-84. doi: 10.1002/jbmr.2720. Epub 2015 Oct 22.

27.

Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice.

Ozaki K, Okamoto M, Fukasawa K, Iezaki T, Onishi Y, Yoneda Y, Sugiura M, Hinoi E.

J Pharmacol Sci. 2015 Sep;129(1):72-7. doi: 10.1016/j.jphs.2015.08.003. Epub 2015 Aug 22. Review.

28.

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.

Wei J, Shimazu J, Makinistoglu MP, Maurizi A, Kajimura D, Zong H, Takarada T, Lezaki T, Pessin JE, Hinoi E, Karsenty G.

Cell. 2015 Jun 18;161(7):1576-1591. doi: 10.1016/j.cell.2015.05.029. Erratum in: Cell. 2015 Aug 27;162(5):1169.

29.

Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine.

Takarada T, Ogura M, Nakamichi N, Kakuda T, Nakazato R, Kokubo H, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y.

Neurochem Res. 2016 Feb;41(1-2):5-15. doi: 10.1007/s11064-015-1591-4. Epub 2015 May 10.

PMID:
25957749
30.

Daily oral intake of theanine prevents the decline of 5-bromo-2'-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress.

Takarada T, Nakamichi N, Kakuda T, Nakazato R, Kokubo H, Ikeno S, Nakamura S, Hinoi E, Yoneda Y.

J Pharmacol Sci. 2015 Mar;127(3):292-7. doi: 10.1016/j.jphs.2014.12.018. Epub 2015 Feb 17.

31.

Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP.

Nakazato R, Takarada T, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y.

J Cell Physiol. 2015 Oct;230(10):2510-21. doi: 10.1002/jcp.24988.

PMID:
25802132
32.

[Regulation of osteoclastogenesis by osteocytes through growth differentiation factor-15].

Hinoi E.

Yakugaku Zasshi. 2014;134(12):1259-63. Review. Japanese.

33.

Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.

Hinoi E, Iezaki T, Ozaki K, Yoneda Y.

Biochem Biophys Res Commun. 2014 Oct 3;452(4):974-9. doi: 10.1016/j.bbrc.2014.09.022. Epub 2014 Sep 16.

PMID:
25223801
34.

PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.

Hinoi E, Iezaki T, Fujita H, Watanabe T, Odaka Y, Ozaki K, Yoneda Y.

Biochem Biophys Res Commun. 2014 Jul 18;450(1):255-60. doi: 10.1016/j.bbrc.2014.05.108. Epub 2014 Jun 2.

PMID:
24944017
35.

Constitutive and functional expression of runt-related transcription factor-2 by microglial cells.

Nakazato R, Takarada T, Watanabe T, Nguyen BT, Ikeno S, Hinoi E, Yoneda Y.

Neurochem Int. 2014 Jul;74:24-35. doi: 10.1016/j.neuint.2014.04.010. Epub 2014 Apr 24.

PMID:
24768841
37.

[Toward a new era of pharmacological therapeutics].

Ikegaya Y, Hinoi E.

Yakugaku Zasshi. 2013;133(12):1335-6. Japanese. No abstract available.

38.

Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure.

Hinoi E, Nakamura Y, Takada S, Fujita H, Iezaki T, Hashizume S, Takahashi S, Odaka Y, Watanabe T, Yoneda Y.

Diabetes. 2014 Jan;63(1):162-75. doi: 10.2337/db13-0808. Epub 2013 Sep 23.

39.

Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells.

Le NQ, Binh NT, Takarada T, Takarada-Iemata M, Hinoi E, Yoneda Y.

J Pharmacol Sci. 2013;122(4):318-25. Epub 2013 Jul 25.

40.

Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons.

Fukumori R, Takarada T, Nakazato R, Fujikawa K, Kou M, Hinoi E, Yoneda Y.

PLoS One. 2013 Jul 16;8(7):e69718. doi: 10.1371/journal.pone.0069718. Print 2013.

41.

Myosin VI reduces proliferation, but not differentiation, in pluripotent P19 cells.

Takarada T, Kou M, Nakamichi N, Ogura M, Ito Y, Fukumori R, Kokubo H, Acosta GB, Hinoi E, Yoneda Y.

PLoS One. 2013 May 17;8(5):e63947. doi: 10.1371/journal.pone.0063947. Print 2013.

42.

An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice.

Takarada T, Hinoi E, Nakazato R, Ochi H, Xu C, Tsuchikane A, Takeda S, Karsenty G, Abe T, Kiyonari H, Yoneda Y.

J Bone Miner Res. 2013 Oct;28(10):2064-9. doi: 10.1002/jbmr.1945.

43.

Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia.

Nakamura Y, Hinoi E, Iezaki T, Takada S, Hashizume S, Takahata Y, Tsuruta E, Takahashi S, Yoneda Y.

Biochim Biophys Acta. 2013 Aug;1832(8):1117-28. doi: 10.1016/j.bbadis.2013.03.010. Epub 2013 Mar 18.

44.

Prevention of bone loss after ovariectomy in mice with preferential overexpression of the transcription factor paired box-5 in osteoblasts.

Fujita H, Hinoi E, Watanabe T, Iezaki T, Takamori M, Ogawa S, Yoneda Y.

Biol Pharm Bull. 2013;36(3):481-4.

45.

In vivo and in vitro treatment with edaravone promotes proliferation of neural progenitor cells generated following neuronal loss in the mouse dentate gyrus.

Kikuta M, Shiba T, Yoneyama M, Kawada K, Yamaguchi T, Hinoi E, Yoneda Y, Ogita K.

J Pharmacol Sci. 2013;121(1):74-83. Epub 2012 Dec 26.

46.

[Regulatory mechanism of glycolipid metabolism by bone tissue].

Hinoi E.

Nihon Yakurigaku Zasshi. 2012 Aug;140(2):96. Review. Japanese. No abstract available.

PMID:
23136695
47.

Promotion of both proliferation and neuronal differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter slc38a1.

Ogura M, Kakuda T, Takarada T, Nakamichi N, Fukumori R, Kim YH, Hinoi E, Yoneda Y.

PLoS One. 2012;7(10):e48270. doi: 10.1371/journal.pone.0048270. Epub 2012 Oct 24.

48.

Clock genes influence gene expression in growth plate and endochondral ossification in mice.

Takarada T, Kodama A, Hotta S, Mieda M, Shimba S, Hinoi E, Yoneda Y.

J Biol Chem. 2012 Oct 19;287(43):36081-95. doi: 10.1074/jbc.M112.408963. Epub 2012 Aug 30.

49.

Positive regulation by γ-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4.

Takahata Y, Hinoi E, Takarada T, Nakamura Y, Ogawa S, Yoneda Y.

J Biol Chem. 2012 Sep 28;287(40):33293-303. Epub 2012 Aug 9.

50.

The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osterix and Osteocalcin.

Hinoi E, Nakatani E, Yamamoto T, Iezaki T, Takahata Y, Fujita H, Ishiura R, Takamori M, Yoneda Y.

J Bone Miner Res. 2012 Dec;27(12):2526-34. doi: 10.1002/jbmr.1708.

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