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Items: 1 to 50 of 257

1.

Correction: Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo.

Zeidan Q, He F, Zhang F, Zhang H, Jacobson A, Hinnebusch AG.

PLoS Genet. 2019 Jul 23;15(7):e1008299. doi: 10.1371/journal.pgen.1008299. eCollection 2019 Jul.

2.

Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo.

Sen ND, Gupta N, K Archer S, Preiss T, Lorsch JR, Hinnebusch AG.

Nucleic Acids Res. 2019 Jul 12. pii: gkz595. doi: 10.1093/nar/gkz595. [Epub ahead of print]

PMID:
31299079
3.

A network of eIF2β interactions with eIF1 and Met-tRNAi promotes accurate start codon selection by the translation preinitiation complex.

Thakur A, Marler L, Hinnebusch AG.

Nucleic Acids Res. 2019 Mar 18;47(5):2574-2593. doi: 10.1093/nar/gky1274.

4.

Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo.

Zeidan Q, He F, Zhang F, Zhang H, Jacobson A, Hinnebusch AG.

PLoS Genet. 2018 Dec 7;14(12):e1007806. doi: 10.1371/journal.pgen.1007806. eCollection 2018 Dec. Erratum in: PLoS Genet. 2019 Jul 23;15(7):e1008299.

5.

Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.

Llácer JL, Hussain T, Saini AK, Nanda JS, Kaur S, Gordiyenko Y, Kumar R, Hinnebusch AG, Lorsch JR, Ramakrishnan V.

Elife. 2018 Nov 30;7. pii: e39273. doi: 10.7554/eLife.39273.

6.

Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner.

Gupta N, Lorsch JR, Hinnebusch AG.

Elife. 2018 Oct 3;7. pii: e38892. doi: 10.7554/eLife.38892.

7.

Tma64/eIF2D, Tma20/MCT-1, and Tma22/DENR Recycle Post-termination 40S Subunits In Vivo.

Young DJ, Makeeva DS, Zhang F, Anisimova AS, Stolboushkina EA, Ghobakhlou F, Shatsky IN, Dmitriev SE, Hinnebusch AG, Guydosh NR.

Mol Cell. 2018 Sep 6;71(5):761-774.e5. doi: 10.1016/j.molcel.2018.07.028. Epub 2018 Aug 23.

8.

SWI/SNF and RSC cooperate to reposition and evict promoter nucleosomes at highly expressed genes in yeast.

Rawal Y, Chereji RV, Qiu H, Ananthakrishnan S, Govind CK, Clark DJ, Hinnebusch AG.

Genes Dev. 2018 May 1;32(9-10):695-710. doi: 10.1101/gad.312850.118. Epub 2018 May 21.

9.

eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex.

Thakur A, Hinnebusch AG.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4159-E4168. doi: 10.1073/pnas.1800938115. Epub 2018 Apr 16.

10.

Gcn4 Binding in Coding Regions Can Activate Internal and Canonical 5' Promoters in Yeast.

Rawal Y, Chereji RV, Valabhoju V, Qiu H, Ocampo J, Clark DJ, Hinnebusch AG.

Mol Cell. 2018 Apr 19;70(2):297-311.e4. doi: 10.1016/j.molcel.2018.03.007. Epub 2018 Apr 5.

11.

Please do not recycle! Translation reinitiation in microbes and higher eukaryotes.

Gunišová S, Hronová V, Mohammad MP, Hinnebusch AG, Valášek LS.

FEMS Microbiol Rev. 2018 Mar 1;42(2):165-192. doi: 10.1093/femsre/fux059. Review.

12.

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast.

Martin-Marcos P, Zhou F, Karunasiri C, Zhang F, Dong J, Nanda J, Kulkarni SD, Sen ND, Tamame M, Zeschnigk M, Lorsch JR, Hinnebusch AG.

Elife. 2017 Dec 5;6. pii: e31250. doi: 10.7554/eLife.31250.

13.

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity.

Yourik P, Aitken CE, Zhou F, Gupta N, Hinnebusch AG, Lorsch JR.

Elife. 2017 Nov 30;6. pii: e31476. doi: 10.7554/eLife.31476.

14.

Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation.

Hinnebusch AG.

Trends Biochem Sci. 2017 Aug;42(8):589-611. doi: 10.1016/j.tibs.2017.03.004. Epub 2017 Apr 22. Review.

PMID:
28442192
15.

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.

Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K.

Cell Rep. 2017 Mar 14;18(11):2651-2663. doi: 10.1016/j.celrep.2017.02.052.

16.

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons.

Dong J, Aitken CE, Thakur A, Shin BS, Lorsch JR, Hinnebusch AG.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2126-E2135. doi: 10.1073/pnas.1620569114. Epub 2017 Feb 21.

17.

Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo.

Visweswaraiah J, Hinnebusch AG.

Elife. 2017 Feb 7;6. pii: e22572. doi: 10.7554/eLife.22572.

18.

Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex.

Aitken CE, Beznosková P, Vlčkova V, Chiu WL, Zhou F, Valášek LS, Hinnebusch AG, Lorsch JR.

Elife. 2016 Oct 26;5. pii: e20934. doi: 10.7554/eLife.20934.

19.

eIF4B stimulates translation of long mRNAs with structured 5' UTRs and low closed-loop potential but weak dependence on eIF4G.

Sen ND, Zhou F, Harris MS, Ingolia NT, Hinnebusch AG.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10464-72. doi: 10.1073/pnas.1612398113. Epub 2016 Sep 6.

20.

Translational control by 5'-untranslated regions of eukaryotic mRNAs.

Hinnebusch AG, Ivanov IP, Sonenberg N.

Science. 2016 Jun 17;352(6292):1413-6. doi: 10.1126/science.aad9868. Review.

PMID:
27313038
21.

Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation.

Qiu H, Chereji RV, Hu C, Cole HA, Rawal Y, Clark DJ, Hinnebusch AG.

Genome Res. 2016 Feb;26(2):211-25. doi: 10.1101/gr.196337.115. Epub 2015 Nov 24.

22.

Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo.

Young DJ, Guydosh NR, Zhang F, Hinnebusch AG, Green R.

Cell. 2015 Aug 13;162(4):872-84. doi: 10.1016/j.cell.2015.07.041.

23.

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.

Llácer JL, Hussain T, Marler L, Aitken CE, Thakur A, Lorsch JR, Hinnebusch AG, Ramakrishnan V.

Mol Cell. 2015 Aug 6;59(3):399-412. doi: 10.1016/j.molcel.2015.06.033. Epub 2015 Jul 23.

24.

The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo.

Visweswaraiah J, Pittman Y, Dever TE, Hinnebusch AG.

Elife. 2015 Jul 2;4:e07939. doi: 10.7554/eLife.07939.

25.

Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.

Sen ND, Zhou F, Ingolia NT, Hinnebusch AG.

Genome Res. 2015 Aug;25(8):1196-205. doi: 10.1101/gr.191601.115. Epub 2015 Jun 29.

26.

Cell biology. Blocking stress response for better memory?

Hinnebusch AG.

Science. 2015 May 29;348(6238):967-8. doi: 10.1126/science.aac4832. No abstract available.

PMID:
26023119
27.

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex.

Saini AK, Nanda JS, Martin-Marcos P, Dong J, Zhang F, Bhardwaj M, Lorsch JR, Hinnebusch AG.

Nucleic Acids Res. 2015 Jun 23;43(11):5673-4. doi: 10.1093/nar/gkv510. Epub 2015 May 18. No abstract available.

28.

Translational control 1995-2015: unveiling molecular underpinnings and roles in human biology.

Hinnebusch AG.

RNA. 2015 Apr;21(4):636-9. doi: 10.1261/rna.049957.115. No abstract available.

29.

Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.

Lageix S, Zhang J, Rothenburg S, Hinnebusch AG.

PLoS Genet. 2015 Feb 19;11(2):e1004991. doi: 10.1371/journal.pgen.1004991. eCollection 2015 Feb.

30.

Conformational changes in the P site and mRNA entry channel evoked by AUG recognition in yeast translation preinitiation complexes.

Zhang F, Saini AK, Shin BS, Nanda J, Hinnebusch AG.

Nucleic Acids Res. 2015 Feb 27;43(4):2293-312. doi: 10.1093/nar/gkv028. Epub 2015 Feb 10.

31.

Structural changes enable start codon recognition by the eukaryotic translation initiation complex.

Hussain T, Llácer JL, Fernández IS, Munoz A, Martin-Marcos P, Savva CG, Lorsch JR, Hinnebusch AG, Ramakrishnan V.

Cell. 2014 Oct 23;159(3):597-607. doi: 10.1016/j.cell.2014.10.001. Epub 2014 Oct 16.

32.

NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.

Ginsburg DS, Anlembom TE, Wang J, Patel SR, Li B, Hinnebusch AG.

J Biol Chem. 2014 Nov 21;289(47):32656-70. doi: 10.1074/jbc.M114.585588. Epub 2014 Oct 9.

33.

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex.

Saini AK, Nanda JS, Martin-Marcos P, Dong J, Zhang F, Bhardwaj M, Lorsch JR, Hinnebusch AG.

Nucleic Acids Res. 2014 Sep;42(15):9623-40. doi: 10.1093/nar/gku653. Epub 2014 Aug 11. Erratum in: Nucleic Acids Res. 2015 Jun 23;43(11):5673-4.

34.

Accumulation of a threonine biosynthetic intermediate attenuates general amino acid control by accelerating degradation of Gcn4 via Pho85 and Cdk8.

Rawal Y, Qiu H, Hinnebusch AG.

PLoS Genet. 2014 Jul 31;10(7):e1004534. doi: 10.1371/journal.pgen.1004534. eCollection 2014 Jul.

35.

Rps5-Rps16 communication is essential for efficient translation initiation in yeast S. cerevisiae.

Ghosh A, Jindal S, Bentley AA, Hinnebusch AG, Komar AA.

Nucleic Acids Res. 2014 Jul;42(13):8537-55. doi: 10.1093/nar/gku550. Epub 2014 Jun 19.

36.

Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells.

Lageix S, Rothenburg S, Dever TE, Hinnebusch AG.

PLoS Genet. 2014 May 8;10(5):e1004326. doi: 10.1371/journal.pgen.1004326. eCollection 2014 May.

37.

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.

Dong J, Munoz A, Kolitz SE, Saini AK, Chiu WL, Rahman H, Lorsch JR, Hinnebusch AG.

Genes Dev. 2014 Mar 1;28(5):502-20. doi: 10.1101/gad.236547.113.

38.

The scanning mechanism of eukaryotic translation initiation.

Hinnebusch AG.

Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29. Review.

PMID:
24499181
39.

Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy.

Martin-Marcos P, Nanda JS, Luna RE, Zhang F, Saini AK, Cherkasova VA, Wagner G, Lorsch JR, Hinnebusch AG.

RNA. 2014 Feb;20(2):150-67. doi: 10.1261/rna.042069.113. Epub 2013 Dec 13.

40.

Identification and characterization of functionally critical, conserved motifs in the internal repeats and N-terminal domain of yeast translation initiation factor 4B (yeIF4B).

Zhou F, Walker SE, Mitchell SF, Lorsch JR, Hinnebusch AG.

J Biol Chem. 2014 Jan 17;289(3):1704-22. doi: 10.1074/jbc.M113.529370. Epub 2013 Nov 27. Erratum in: J Biol Chem. 2014 Apr 25;289(17):11860.

41.

Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing.

Kong KY, Tang HM, Pan K, Huang Z, Lee TH, Hinnebusch AG, Jin DY, Wong CM.

Nucleic Acids Res. 2014 Jan;42(1):643-60. doi: 10.1093/nar/gkt888. Epub 2013 Oct 3.

42.

β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo.

Martin-Marcos P, Nanda J, Luna RE, Wagner G, Lorsch JR, Hinnebusch AG.

J Biol Chem. 2013 Sep 20;288(38):27546-62. doi: 10.1074/jbc.M113.498642. Epub 2013 Jul 26.

43.

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3.

Martin M, Maßhöfer L, Temming P, Rahmann S, Metz C, Bornfeld N, van de Nes J, Klein-Hitpass L, Hinnebusch AG, Horsthemke B, Lohmann DR, Zeschnigk M.

Nat Genet. 2013 Aug;45(8):933-6. doi: 10.1038/ng.2674. Epub 2013 Jun 23.

44.

Vps factors are required for efficient transcription elongation in budding yeast.

Gaur NA, Hasek J, Brickner DG, Qiu H, Zhang F, Wong CM, Malcova I, Vasicova P, Brickner JH, Hinnebusch AG.

Genetics. 2013 Mar;193(3):829-51. doi: 10.1534/genetics.112.146308. Epub 2013 Jan 18.

45.

Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.

Nanda JS, Saini AK, Muñoz AM, Hinnebusch AG, Lorsch JR.

J Biol Chem. 2013 Feb 22;288(8):5316-29. doi: 10.1074/jbc.M112.440693. Epub 2013 Jan 4.

46.

Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains.

Walker SE, Zhou F, Mitchell SF, Larson VS, Valasek L, Hinnebusch AG, Lorsch JR.

RNA. 2013 Feb;19(2):191-207. doi: 10.1261/rna.035881.112. Epub 2012 Dec 12.

47.

Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo.

Park EH, Walker SE, Zhou F, Lee JM, Rajagopal V, Lorsch JR, Hinnebusch AG.

J Biol Chem. 2013 Jan 25;288(4):2340-54. doi: 10.1074/jbc.M112.398537. Epub 2012 Nov 26.

48.

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.

Visweswaraiah J, Lee SJ, Hinnebusch AG, Sattlegger E.

J Biol Chem. 2012 Nov 2;287(45):37757-68. doi: 10.1074/jbc.M112.368266. Epub 2012 Aug 10.

49.

The mechanism of eukaryotic translation initiation: new insights and challenges.

Hinnebusch AG, Lorsch JR.

Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544. Review.

50.

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.

Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, O'Day EM, Yi T, Marintchev A, Hinnebusch AG, Lorsch JR, Asano K, Wagner G.

Cell Rep. 2012 Jun 28;1(6):689-702. doi: 10.1016/j.celrep.2012.04.007. Epub 2012 May 24.

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