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Human IgM monoclonal antibodies block HIV-transmission to immune cells in cervico-vaginal tissues and across polarized epithelial cells in vitro.

Devito C, Ellegård R, Falkeborn T, Svensson L, Ohlin M, Larsson M, Broliden K, Hinkula J.

Sci Rep. 2018 Jul 5;8(1):10180. doi: 10.1038/s41598-018-28242-y.


Detection of rotavirus- and norovirus-specific IgG memory B cells in tonsils.

Sharma S, Hagbom M, Nordgren J, Frodlund J, Hinkula J, Ledin T, Svensson L.

J Med Virol. 2019 Feb;91(2):326-329. doi: 10.1002/jmv.25247. Epub 2018 Jul 16.


Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity.

Latanova AA, Petkov S, Kilpelainen A, Jansons J, Latyshev OE, Kuzmenko YV, Hinkula J, Abakumov MA, Valuev-Elliston VT, Gomelsky M, Karpov VL, Chiodi F, Wahren B, Logunov DY, Starodubova ES, Isaguliants MG.

Sci Rep. 2018 May 24;8(1):8078. doi: 10.1038/s41598-018-26281-z.


Complement-Opsonized HIV-1 Alters Cross Talk Between Dendritic Cells and Natural Killer (NK) Cells to Inhibit NK Killing and to Upregulate PD-1, CXCR3, and CCR4 on T Cells.

Ellegård R, Khalid M, Svanberg C, Holgersson H, Thorén Y, Wittgren MK, Hinkula J, Nyström S, Shankar EM, Larsson M.

Front Immunol. 2018 Apr 30;9:899. doi: 10.3389/fimmu.2018.00899. eCollection 2018.


Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth.

Younis S, Kamel W, Falkeborn T, Wang H, Yu D, Daniels R, Essand M, Hinkula J, Akusjärvi G, Andersson L.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3808-E3816. doi: 10.1073/pnas.1722333115. Epub 2018 Apr 2.


HIVIS-DNA or HIVISopt-DNA priming followed by CMDR vaccinia-based boosts induce both humoral and cellular murine immune responses to HIV.

Hinkula J, Petkov S, Ljungberg K, Hallengärd D, Bråve A, Isaguliants M, Falkeborn T, Sharma S, Liakina V, Robb M, Eller M, Moss B, Biberfeld G, Sandström E, Nilsson C, Markland K, Blomberg P, Wahren B.

Heliyon. 2017 Jun 29;3(6):e00339. doi: 10.1016/j.heliyon.2017.e00339. eCollection 2017 Jun.


Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice.

Latanova A, Petkov S, Kuzmenko Y, Kilpeläinen A, Ivanov A, Smirnova O, Krotova O, Korolev S, Hinkula J, Karpov V, Isaguliants M, Starodubova E.

J Immunol Res. 2017;2017:7407136. doi: 10.1155/2017/7407136. Epub 2017 Jun 22.


Immunization with HIV-1 envelope T20-encoding DNA vaccines elicits cross-clade neutralizing antibody responses.

Stenler S, Lundin KE, Hansen L, Petkov S, Mozafari N, Isaguliants M, Blomberg P, Smith CIE, Goldenberg DM, Chang CH, Ljungberg K, Hinkula J, Wahren B.

Hum Vaccin Immunother. 2017 Dec 2;13(12):2849-2858. doi: 10.1080/21645515.2017.1338546. Epub 2017 Jul 11.


The intranasal adjuvant Endocine™ enhances both systemic and mucosal immune responses in aged mice immunized with influenza antigen.

Falkeborn T, Hinkula J, Olliver M, Lindberg A, Maltais AK.

Virol J. 2017 Mar 3;14(1):44. doi: 10.1186/s12985-017-0698-4.


Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice.

Hinkula J, Devignot S, Åkerström S, Karlberg H, Wattrang E, Bereczky S, Mousavi-Jazi M, Risinger C, Lindegren G, Vernersson C, Paweska J, van Vuren PJ, Blixt O, Brun A, Weber F, Mirazimi A.

J Virol. 2017 Apr 28;91(10). pii: e02076-16. doi: 10.1128/JVI.02076-16. Print 2017 May 15.


Impaired NK Cell Activation and Chemotaxis toward Dendritic Cells Exposed to Complement-Opsonized HIV-1.

Ellegård R, Crisci E, Andersson J, Shankar EM, Nyström S, Hinkula J, Larsson M.

J Immunol. 2015 Aug 15;195(4):1698-704. doi: 10.4049/jimmunol.1500618. Epub 2015 Jul 8.


Predictive performance of telenursing complaints in influenza surveillance: a prospective cohort study in Sweden.

Timpka T, Spreco A, Eriksson O, Dahlström Ö, Gursky EA, Strömgren M, Holm E, Ekberg J, Hinkula J, Nyce JM, Eriksson H.

Euro Surveill. 2014 Nov 20;19(46). pii: 20966.


Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3.

Ellegård R, Crisci E, Burgener A, Sjöwall C, Birse K, Westmacott G, Hinkula J, Lifson JD, Larsson M.

J Immunol. 2014 Nov 1;193(9):4590-601. doi: 10.4049/jimmunol.1401781. Epub 2014 Sep 24.


Increased generation of HIV-1 gp120-reactive CD8+ T cells by a DNA vaccine construct encoding the chemokine CCL3.

Øynebråten I, Hinkula J, Fredriksen AB, Bogen B.

PLoS One. 2014 Aug 14;9(8):e104814. doi: 10.1371/journal.pone.0104814. eCollection 2014.


Performance of eHealth data sources in local influenza surveillance: a 5-year open cohort study.

Timpka T, Spreco A, Dahlström Ö, Eriksson O, Gursky E, Ekberg J, Blomqvist E, Strömgren M, Karlsson D, Eriksson H, Nyce J, Hinkula J, Holm E.

J Med Internet Res. 2014 Apr 28;16(4):e116. doi: 10.2196/jmir.3099.


Intranasally administered Endocine formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets.

Maltais AK, Stittelaar KJ, Veldhuis Kroeze EJ, van Amerongen G, Dijkshoorn ML, Krestin GP, Hinkula J, Arwidsson H, Lindberg A, Osterhaus AD.

Vaccine. 2014 May 30;32(26):3307-15. doi: 10.1016/j.vaccine.2014.03.061. Epub 2014 Mar 30.


Intentions to perform non-pharmaceutical protective behaviors during influenza outbreaks in Sweden: a cross-sectional study following a mass vaccination campaign.

Timpka T, Spreco A, Gursky E, Eriksson O, Dahlström Ö, Strömgren M, Ekberg J, Pilemalm S, Karlsson D, Hinkula J, Holm E.

PLoS One. 2014 Mar 7;9(3):e91060. doi: 10.1371/journal.pone.0091060. eCollection 2014.


Endocine™, N3OA and N3OASq; three mucosal adjuvants that enhance the immune response to nasal influenza vaccination.

Falkeborn T, Bråve A, Larsson M, Akerlind B, Schröder U, Hinkula J.

PLoS One. 2013 Aug 8;8(8):e70527. doi: 10.1371/journal.pone.0070527. eCollection 2013.


Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions.

Tjomsland V, Ellegård R, Kjölhede P, Wodlin NB, Hinkula J, Lifson JD, Larsson M.

Eur J Immunol. 2013 Sep;43(9):2361-72. doi: 10.1002/eji.201243257. Epub 2013 Jun 25.


Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells.

Tjomsland V, Ellegård R, Burgener A, Mogk K, Che KF, Westmacott G, Hinkula J, Lifson JD, Larsson M.

Eur J Immunol. 2013 Jun;43(6):1470-83. doi: 10.1002/eji.201242935. Epub 2013 Apr 24.


DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant.

Nyström S, Bråve A, Falkeborn T, Devito C, Rissiek B, Johansson DX, Schröder U, Uematsu S, Akira S, Hinkula J, Applequist SE.

Vaccines (Basel). 2013 Sep 25;1(4):415-43. doi: 10.3390/vaccines1040415.


Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model.

Veldhuis Kroeze EJ, Stittelaar KJ, Teeuwsen VJ, Dijkshoorn ML, van Amerongen G, de Waal L, Kuiken T, Krestin GP, Hinkula J, Osterhaus AD.

Vaccine. 2012 Dec 7;30(51):7391-4. doi: 10.1016/j.vaccine.2012.10.008. Epub 2012 Oct 17.


Mycobacterium tuberculosis infection interferes with HIV vaccination in mice.

Ignatowicz L, Mazurek J, Leepiyasakulchai C, Sköld M, Hinkula J, Källenius G, Pawlowski A.

PLoS One. 2012;7(7):e41205. doi: 10.1371/journal.pone.0041205. Epub 2012 Jul 23.


A novel class of anti-HIV agents with multiple copies of enfuvirtide enhances inhibition of viral replication and cellular transmission in vitro.

Chang CH, Hinkula J, Loo M, Falkeborn T, Li R, Cardillo TM, Rossi EA, Goldenberg DM, Wahren B.

PLoS One. 2012;7(7):e41235. doi: 10.1371/journal.pone.0041235. Epub 2012 Jul 23.


p38 Mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cells.

Che KF, Shankar EM, Muthu S, Zandi S, Sigvardsson M, Hinkula J, Messmer D, Larsson M.

Mol Med. 2012 Oct 24;18:1169-82. doi: 10.2119/molmed.2012.00103.


Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration.

Buonaguro L, Tagliamonte M, Visciano ML, Andersen H, Lewis M, Pal R, Tornesello ML, Schroeder U, Hinkula J, Wahren B, Buonaguro FM.

Clin Vaccine Immunol. 2012 Jun;19(6):970-3. doi: 10.1128/CVI.00068-12. Epub 2012 Mar 29.


Receptor Binding by Cholera Toxin B-Subunit and Amino Acid Modification Improves Minimal Peptide Immunogenicity.

Boberg A, Stålnacke A, Bråve A, Hinkula J, Wahren B, Carlin N.

ISRN Mol Biol. 2012 Jul 15;2012:170676. doi: 10.5402/2012/170676. eCollection 2012.


Accumulation and activation of natural killer cells in local intraperitoneal HIV-1/MuLV infection results in early control of virus infected cells.

Johansson SE, Brauner H, Hinkula J, Wahren B, Berg L, Johansson MH.

Cell Immunol. 2011;272(1):71-8. doi: 10.1016/j.cellimm.2011.09.005. Epub 2011 Sep 22.


NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients.

Johansson SE, Rollman E, Chung AW, Center RJ, Hejdeman B, Stratov I, Hinkula J, Wahren B, Kärre K, Kent SJ, Berg L.

Viral Immunol. 2011 Oct;24(5):359-68. doi: 10.1089/vim.2011.0025. Epub 2011 Sep 29.


Complement opsonization of HIV-1 enhances the uptake by dendritic cells and involves the endocytic lectin and integrin receptor families.

Tjomsland V, Ellegård R, Che K, Hinkula J, Lifson JD, Larsson M.

PLoS One. 2011;6(8):e23542. doi: 10.1371/journal.pone.0023542. Epub 2011 Aug 11.


Assessment of mucosal immunity to HIV-1.

Jespers V, Harandi AM, Hinkula J, Medaglini D, Le Grand R, Stahl-Hennig C, Bogers W, El Habib R, Wegmann F, Fraser C, Cranage M, Shattock RJ, Spetz AL.

Expert Rev Vaccines. 2010 Apr;9(4):381-94. doi: 10.1586/erv.10.21. Review.


Induction of HIV-1-specific cellular and humoral immune responses following immunization with HIV-DNA adjuvanted with activated apoptotic lymphocytes.

Brave A, Johansson U, Hallengärd D, Heidari S, Gullberg H, Wahren B, Hinkula J, Spetz AL.

Vaccine. 2010 Feb 25;28(9):2080-7. doi: 10.1016/j.vaccine.2009.12.040. Epub 2009 Dec 29.


NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients.

Johansson SE, Hejdeman B, Hinkula J, Johansson MH, Romagné F, Wahren B, Wagtmann NR, Kärre K, Berg L.

Clin Immunol. 2010 Feb;134(2):158-68. doi: 10.1016/j.clim.2009.10.001. Epub 2009 Nov 1.


Neutralizing activity and cellular immune responses induced in mice after immunization with apoptotic HIV-1/murine leukemia virus infected cells.

Hinkula J, Walther-Jallow L, Laurén A, Mäkitalo B, Oberg M, Wahren B, Fenyö EM, Spetz AL.

Vaccine. 2009 Oct 30;27(46):6424-31. doi: 10.1016/j.vaccine.2009.06.016. Epub 2009 Jun 21.


Feeding of mice with Arabidopsis thaliana expressing the HIV-1 subtype C p24 antigen gives rise to systemic immune responses.

Lindh I, Kalbina I, Thulin S, Scherbak N, Sävenstrand H, Bråve A, Hinkula J, Strid A, Andersson S.

APMIS. 2008 Nov;116(11):985-94. doi: 10.1111/j.1600-0463.2008.00900.x.


Maternal immune status influences HIV-specific immune responses in pups after DNA prime protein boost using mucosal adjuvant.

Bråve A, Johansen K, Palma P, Benthin R, Hinkula J.

Vaccine. 2008 Nov 5;26(47):5957-66. doi: 10.1016/j.vaccine.2008.08.060. Epub 2008 Sep 16.


Parenteral administration of RF 8-2/6/7 rotavirus-like particles in a one-dose regimen induce protective immunity in mice.

Istrate C, Hinkula J, Charpilienne A, Poncet D, Cohen J, Svensson L, Johansen K.

Vaccine. 2008 Aug 18;26(35):4594-601. doi: 10.1016/j.vaccine.2008.05.089. Epub 2008 Jun 25.


Safety and immunogenicity, after nasal application of HIV-1 DNA gagp37 plasmid vaccine in young mice.

Hinkula J, Hagbom M, Wahren B, Schroder U.

Vaccine. 2008 Sep 19;26(40):5101-6. doi: 10.1016/j.vaccine.2008.03.098. Epub 2008 Apr 25.


Intranasal immunization of young mice with a multigene HIV-1 vaccine in combination with the N3 adjuvant induces mucosal and systemic immune responses.

Bråve A, Hallengärd D, Schröder U, Blomberg P, Wahren B, Hinkula J.

Vaccine. 2008 Sep 19;26(40):5075-8. doi: 10.1016/j.vaccine.2008.03.066. Epub 2008 Apr 15.


Murine models for HIV vaccination and challenge.

Boberg A, Bråve A, Johansson S, Wahren B, Hinkula J, Rollman E.

Expert Rev Vaccines. 2008 Feb;7(1):117-30. doi: 10.1586/14760584.7.1.117. Review.


Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals.

Istrate C, Hinkula J, Hammarström L, Svensson L.

J Med Virol. 2008 Mar;80(3):531-5. doi: 10.1002/jmv.21101.


Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.

Johansson E, Istrate C, Charpilienne A, Cohen J, Hinkula J, Poncet D, Svensson L, Johansen K.

Vaccine. 2008 Feb 6;26(6):778-85. doi: 10.1016/j.vaccine.2007.11.089. Epub 2007 Dec 26.


The Vpu-regulated endocytosis of HIV-1 Gag is clathrin-independent.

Harila K, Salminen A, Prior I, Hinkula J, Suomalainen M.

Virology. 2007 Dec 20;369(2):299-308. Epub 2007 Sep 5.


Candidate HIV-1 gp140DeltaV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge.

Bråve A, Hinkula J, Cafaro A, Eriksson LE, Srivastava IK, Magnani M, Ensoli B, Barnett SW, Wahren B, Rollman E.

Vaccine. 2007 Sep 28;25(39-40):6882-90. Epub 2007 Jul 27.


DNA-VLP prime-boost intra-nasal immunization induces cellular and humoral anti-HIV-1 systemic and mucosal immunity with cross-clade neutralizing activity.

Buonaguro L, Devito C, Tornesello ML, Schröder U, Wahren B, Hinkula J, Buonaguro FM.

Vaccine. 2007 Aug 10;25(32):5968-77. Epub 2007 Jun 11.


Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: study of immunological memory and long-term toxicology.

Bråve A, Gudmundsdotter L, Gasteiger G, Hallermalm K, Kastenmuller W, Rollman E, Boberg A, Engström G, Reiland S, Cosma A, Drexler I, Hinkula J, Wahren B, Erfle V.

Infect Agent Cancer. 2007 Jul 10;2:14.


Bone marrow dendritic cells internalize live RF-81 bovine rotavirus and rotavirus-like particles (RF 2/6-GFP-VLP and RF 8*2/6/7-VLP) but are only activated by live bovine rotavirus.

Istrate C, Douagi I, Charpilienne A, McInerney GM, Hidmark A, Johansen K, Larsson M, Magnusson KE, Poncet D, Svensson L, Hinkula J.

Scand J Immunol. 2007 Jun;65(6):494-502.


Immunization with HIV protease peptides linked to syngeneic erythrocytes.

Boberg A, Dominici S, Brave A, Hallermalm K, Hinkula J, Magnani M, Wahren B.

Infect Agent Cancer. 2007 Apr 18;2:9.


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