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Items: 30


Study of MAIT Cell Activation in Viral Infections In Vivo.

Hinks TSC, van Wilgenburg B, Wang H, Loh L, Koutsakos M, Kedzierska K, Corbett AJ, Chen Z.

Methods Mol Biol. 2020;2098:261-281. doi: 10.1007/978-1-0716-0207-2_17.


Influenza A Virus-Infected Lung Epithelial Cell Co-Culture with Human Peripheral Blood Mononuclear Cells.

Loh L, Koutsakos M, Kedzierska K, Hinks TSC.

Methods Mol Biol. 2020;2098:141-147. doi: 10.1007/978-1-0716-0207-2_9.


CD8+ Tc2 cells: underappreciated contributors to severe asthma.

Hinks TSC, Hoyle RD, Gelfand EW.

Eur Respir Rev. 2019 Nov 20;28(154). pii: 190092. doi: 10.1183/16000617.0092-2019. Print 2019 Dec 31. Review.


Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality.

Hinks TSC, Marchi E, Jabeen M, Olshansky M, Kurioka A, Pediongco TJ, Meehan BS, Kostenko L, Turner SJ, Corbett AJ, Chen Z, Klenerman P, McCluskey J.

Cell Rep. 2019 Sep 17;28(12):3249-3262.e5. doi: 10.1016/j.celrep.2019.07.039.


TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.

Leng T, Akther HD, Hackstein CP, Powell K, King T, Friedrich M, Christoforidou Z, McCuaig S, Neyazi M, Arancibia-Cárcamo CV, Hagel J, Powrie F; Oxford IBD Investigators, Peres RS, Millar V, Ebner D, Lamichhane R, Ussher J, Hinks TSC, Marchi E, Willberg C, Klenerman P.

Cell Rep. 2019 Sep 17;28(12):3077-3091.e5. doi: 10.1016/j.celrep.2019.08.050.


Is there a role for type 2 CD8+ T cells in patients with steroid-resistant asthma?

Gelfand EW, Hinks TSC.

J Allergy Clin Immunol. 2019 Sep;144(3):648-650. doi: 10.1016/j.jaci.2019.07.022. Epub 2019 Jul 31. No abstract available.


Correction: Synergistic activation of pro-inflammatory type-2 CD8 + T lymphocytes by lipid mediators in severe eosinophilic asthma.

Hilvering B, Hinks TSC, Stöger L, Marchi E, Salimi M, Shrimanker R, Liu W, Chen W, Luo J, Go S, Powell T, Cane J, Thulborn S, Kurioka A, Leng T, Matthews J, Connolly C, Borg C, Bafadhel M, Willberg CB, Ramasamy A, Djukanović R, Ogg G, Pavord ID, Klenerman P, Xue L.

Mucosal Immunol. 2019 Mar;12(2):581. doi: 10.1038/s41385-018-0121-5.


MAIT cells contribute to protection against lethal influenza infection in vivo.

van Wilgenburg B, Loh L, Chen Z, Pediongco TJ, Wang H, Shi M, Zhao Z, Koutsakos M, Nüssing S, Sant S, Wang Z, D'Souza C, Jia X, Almeida CF, Kostenko L, Eckle SBG, Meehan BS, Kallies A, Godfrey DI, Reading PC, Corbett AJ, McCluskey J, Klenerman P, Kedzierska K, Hinks TSC.

Nat Commun. 2018 Nov 9;9(1):4706. doi: 10.1038/s41467-018-07207-9.


OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma.

Reinke SN, Galindo-Prieto B, Skotare T, Broadhurst DI, Singhania A, Horowitz D, Djukanović R, Hinks TSC, Geladi P, Trygg J, Wheelock CE.

Anal Chem. 2018 Nov 20;90(22):13400-13408. doi: 10.1021/acs.analchem.8b03205. Epub 2018 Nov 2.


MAIT cells protect against pulmonary Legionella longbeachae infection.

Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.

Nat Commun. 2018 Aug 22;9(1):3350. doi: 10.1038/s41467-018-05202-8.


Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma.

Hilvering B, Hinks TSC, Stöger L, Marchi E, Salimi M, Shrimanker R, Liu W, Chen W, Luo J, Go S, Powell T, Cane J, Thulborn S, Kurioka A, Leng T, Matthews J, Connolly C, Borg C, Bafadhel M, Willberg CB, Ramasamy A, Djukanović R, Ogg G, Pavord ID, Klenerman P, Xue L.

Mucosal Immunol. 2018 Sep;11(5):1408-1419. doi: 10.1038/s41385-018-0049-9. Epub 2018 Jun 15. Erratum in: Mucosal Immunol. 2018 Dec 5;:.


Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.

Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau LCK, Wilson SJ, Ward JA, Chauhan A, Sousa AR, De Meulder B, Loza MJ, Baribaud F, Sterk PJ, Chung KF, Sun K, Guo Y, Adcock IM, Payne D, Dahlen B, Chanez P, Shaw DE, Krug N, Hohlfeld JM, Sandström T, Djukanovic R, James A, Hinks TSC, Howarth PH, Vaarala O, van Geest M, Olsson H; Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group.

J Allergy Clin Immunol. 2019 Feb;143(2):577-590. doi: 10.1016/j.jaci.2018.05.026. Epub 2018 Jun 11.


Cytometric Gating Stringency Impacts Studies of Type 2 Innate Lymphoid Cells in Asthma.

Hinks TSC, Batty P, Klenerman P, Pavord ID, Xue L.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):745-747. doi: 10.1165/rcmb.2017-0201LE. No abstract available.


Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma.

Singhania A, Wallington JC, Smith CG, Horowitz D, Staples KJ, Howarth PH, Gadola SD, Djukanović R, Woelk CH, Hinks TSC.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):261-270. doi: 10.1165/rcmb.2017-0162OC.


Coal mine dust lung disease in the modern era.

Perret JL, Plush B, Lachapelle P, Hinks TS, Walter C, Clarke P, Irving L, Brady P, Dharmage SC, Stewart A.

Respirology. 2017 May;22(4):662-670. doi: 10.1111/resp.13034. Epub 2017 Mar 30. Review.


Metabolomics analysis identifies different metabotypes of asthma severity.

Reinke SN, Gallart-Ayala H, Gómez C, Checa A, Fauland A, Naz S, Kamleh MA, Djukanović R, Hinks TS, Wheelock CE.

Eur Respir J. 2017 Mar 29;49(3). pii: 1601740. doi: 10.1183/13993003.01740-2016. Print 2017 Mar.


Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection.

Hinks TS, Wallington JC, Williams AP, Djukanović R, Staples KJ, Wilkinson TM.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1208-1218.


Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.

Hinks TSC, Brown T, Lau LCK, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanović R, Kurukulaaratchy RJ, Chauhan A, Howarth PH.

J Allergy Clin Immunol. 2016 Jul;138(1):61-75. doi: 10.1016/j.jaci.2015.11.020. Epub 2016 Feb 3.


Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease.

Hinks TS.

Immunology. 2016 May;148(1):1-12. doi: 10.1111/imm.12582. Epub 2016 Feb 9. Review.


Reduced Numbers and Proapoptotic Features of Mucosal-associated Invariant T Cells as a Characteristic Finding in Patients with Inflammatory Bowel Disease.

Hinks TS.

Inflamm Bowel Dis. 2015 Dec;21(12):E30. doi: 10.1097/MIB.0000000000000637. No abstract available.


A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs.

Nicholas B, Staples KJ, Moese S, Meldrum E, Ward J, Dennison P, Havelock T, Hinks TS, Amer K, Woo E, Chamberlain M, Singh N, North M, Pink S, Wilkinson TM, Djukanović R.

J Immunol. 2015 Jun 15;194(12):6144-54. doi: 10.4049/jimmunol.1402283. Epub 2015 May 1.


Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms.

Hinks TS, Zhou X, Staples KJ, Dimitrov BD, Manta A, Petrossian T, Lum PY, Smith CG, Ward JA, Howarth PH, Walls AF, Gadola SD, Djukanović R.

J Allergy Clin Immunol. 2015 Aug;136(2):323-33. doi: 10.1016/j.jaci.2015.01.014. Epub 2015 Mar 5.


High background rates of positive tuberculosis-specific interferon-γ release assays in a low prevalence region of UK: a surveillance study.

Hinks TS, Varsani N, Godsiff DT, Bull TC, Nash KL, McLuckie L, Maule C, Flower T, Warley A.

BMC Infect Dis. 2012 Dec 6;12:339. doi: 10.1186/1471-2334-12-339.


Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.

Staples KJ, Hinks TS, Ward JA, Gunn V, Smith C, Djukanović R.

J Allergy Clin Immunol. 2012 Dec;130(6):1404-12.e7. doi: 10.1016/j.jaci.2012.07.023. Epub 2012 Sep 14.


Mycobacterium tuberculosis-specific cellular immune profiles suggest bacillary persistence decades after spontaneous cure in untreated tuberculosis.

Millington KA, Gooding S, Hinks TS, Reynolds DJ, Lalvani A.

J Infect Dis. 2010 Dec 1;202(11):1685-9. doi: 10.1086/656772. Epub 2010 Oct 19.


Frequencies of region of difference 1 antigen-specific but not purified protein derivative-specific gamma interferon-secreting T cells correlate with the presence of tuberculosis disease but do not distinguish recent from remote latent infections.

Hinks TS, Dosanjh DP, Innes JA, Pasvol G, Hackforth S, Varia H, Millington KA, Liu XQ, Bakir M, Soysal A, Davidson RN, Gunatheesan R, Lalvani A.

Infect Immun. 2009 Dec;77(12):5486-95. doi: 10.1128/IAI.01436-08. Epub 2009 Sep 14.


Rapid diagnosis of Mycobacterium tuberculosis meningitis by enumeration of cerebrospinal fluid antigen-specific T-cells.

Thomas MM, Hinks TS, Raghuraman S, Ramalingam N, Ernst M, Nau R, Lange C, Kösters K, Gnanamuthu C, John GT, Marshall B, Lalvani A.

Int J Tuberc Lung Dis. 2008 Jun;12(6):651-7.


Improved diagnostic evaluation of suspected tuberculosis.

Dosanjh DP, Hinks TS, Innes JA, Deeks JJ, Pasvol G, Hackforth S, Varia H, Millington KA, Gunatheesan R, Guyot-Revol V, Lalvani A.

Ann Intern Med. 2008 Mar 4;148(5):325-36. Erratum in: Ann Intern Med.2008 Apr 15;148(8):635.


Ends never justify means.

Hinks TS.

BMJ. 2007 May 26;334(7603):1072. No abstract available.


Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load.

Millington KA, Innes JA, Hackforth S, Hinks TS, Deeks JJ, Dosanjh DP, Guyot-Revol V, Gunatheesan R, Klenerman P, Lalvani A.

J Immunol. 2007 Apr 15;178(8):5217-26.

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